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Studies on the metabolism and action of thyroid hormone with emphasis on its role in neurotransmission

Research Project

Project/Area Number 03671147
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 内分泌・代謝学
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

TANAKA Kiyoshi  Assistant Professor Radioisotope Research Center Kyoto University, 放射性同位元素総合センター, 助手 (90227132)

Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1992: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1991: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsThyroid Hormone / Metabolism / Brain / Pituitary / Pineal / deiodinase / Sublingual Gland / Deiodinase / 5'ーdeiodinase
Research Abstract

Studies of the thyroid hormone metabolism in the brain have been hampered by its extreme complexity and heterogenity. Thus we tried to establish more simplified systems to study the metabolism and action of thyroid hormone in the brain.
We found that type-III 5-deiodinase (5D-III), which specifically inactivates thyroxine and is abundant in the brain, in rat posterior pituitary and pineal gland. The activity in the pituitary was localized in the neural lobe and was not found in the intermediate lobe. These two organs also have type-II 5'-deiodinase (5'D-II), which specifically activates thyroxine. Pineal 5'D-II also has a marked beta-adrenergically mediated nyctohemeral rhythm. Isozyme distribution in these organs are quite similar to that in the brain. These data suggest that thyroid hormone is likely to have previously unrecognized role in these organs and these can be suitable models to study thyroid hormone metabolism in the brain.
Most studies on thyroid hormone metabolism in cultured cells have employed glial cells, although 5'D-II were initially reported to be localized in neurons. Astrocytes exibit only 5D-III and 5'D- I, which has low affinity for thyroxine. 5'D-II is induced only after stimulation by dbcAMP. We used cultured neuronal cells and found 5'D-II and 5D-III under steady condition. Thus astrocytes and neurons are likely to belong to different metabolic compartment.
Regulatory mechanism of deiodinases are now under study.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] Tanaka K,Imura: "Iodothyronine 5′-deiodinase is present in mouse sublingual gland" Endocrinology. 132. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tanaka K,Shimatsu Imura H: "A,Iodothyronine 5-deiodinase in rat posterior pituitary" Bichem Biophys Res Comm. 188. 272-277 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tanaka K et.al.: "Generalized ressistance to thyroid hormone in a family" Endocrinol Japon. 39. 533-538 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sasaki S et.al.: "A point mutaion of the T3 receptor β1 gene in a kindred of generalized resistance to thyroid hormone" Mol Cell Endocrinol. 84. 159-166 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Greer MA et.al.: "Neuroendocrine relations in thyroid hormone metabolism" Thyroid Hormone Metabolism(ed.Wu S-Y)Blackwell Scientific Publishers,Boston MA,USA. 321-335 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 田中 清: "代謝研究法" 新生化学実験法講座(9)ホルモンII東京化学同人. 31-40 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tanaka K, Imura H.: "Iodothyronine 5'-deiodinase is present in mouse sublingual gland." Endocrinology. 132. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tanaka K, Shimatsu A, Imura H.: "Iodothyronine 5-deiodinase in rat posterior pituitary." Biochem.Biophys.Res.Comm.188. 272-277 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tanaka K. eet. al.: "Generalized ressistance to thyroid hormone in a family." Endocrinol.Japon.39. 533-538 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sasaki S.: "A point mutation of the T3 receptor beta1 gene in a kindred of generalized resistance to thyroid hormone.Mol.Cell." Endocrinol.84. 159-166 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Greer M.A. et.al.: "Neuroendocrine relations in thyroid hormone metabolism." Thyroid Hormone Metabolism (ed. Wu S-y) Blackwell Scientific Publishers, Boston, MA USA. 321-335 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tanaka K,Imura H: "Iodothyronine 5´-deiodinase is present in mouse sublingual gland" Endocrinology. 132. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tanaka K,Shimatsu A,Imura H: "Iodothyronine 5-deiodinase in rat posterior pituitary" Bichem Biophys Res Comm. 188. 272-277 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tanaka K et.al.: "Generalized ressistance to thyroid hormone in a family" Endocrinol Japon. 39. 533-538 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Sasaki S et.al.: "A point mutation of the T3 receptor β1 gene in a kindred of generalized resistance to thyroid hormone" Mol Cell Endocrinol. 84. 159-166 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 田中 清: "代謝研究法" 新生化学実験法講座(9)ホルモンII 東京化学同人. 31-40 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tanaka K,Imura H: "Iodothyronine 5'ーdeiodinase is Present in mouse sublingual gland." Endocrinology.

    • Related Report
      1991 Annual Research Report
  • [Publications] Tanaka K.Imura H: "Prorylthiouracil(PTU)ーincensitive iodothyronine 5ーdeiodinase in rat posterior pituitary" Endocrinology.

    • Related Report
      1991 Annual Research Report
  • [Publications] Tanaka,Imura H: "TypeーIII 5ーdeiodinase is present in rat pineal gland." Endocrinology.

    • Related Report
      1991 Annual Research Report
  • [Publications] Tanaka,Imura: "Different structural reguirement of 2ーthiouracil dorivatives to inhibit typeーI and typeーII 5'ーdeiodinases" Endocrinology.

    • Related Report
      1991 Annual Research Report
  • [Publications] 田中 清: "甲状腺ホルモン代謝研究法" 新生化学実験講座. (1992)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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