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Pathophysiological Significance of IAPP in NIDDM

Research Project

Project/Area Number 03671159
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 内分泌・代謝学
Research InstitutionMiyazaki Medical College

Principal Investigator

MATSUKURA Shigeru  Miyazaki Medical College, Faculty of Medicine, Professor, 医学部, 教授 (70030939)

Co-Investigator(Kenkyū-buntansha) NAKAZATO Masamitsu  Miyazaki Medical College, Faculty of Medicine, Assistant Prof., 医学部, 助手 (10180267)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1991: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsIAPP / Amylin / NIDDM / Islet amyloid / ラ氏島アミロイドポリペプチド
Research Abstract

Islet amyloid polypeptide(IAPP/amylin) is a 37 amino acid long peptide, being a major component of islet amyloid in non-insulin-dependent diabetes mellitus(NIDDM) and insulinoma. To delineate the pathophysiological significance of IAPP in NIDDM, we studied tissue content, plasma level, gene expression, response to physiological stimulation and immunohistochemical localization of the peptide in diabetics and rat models of diabetes. We also clarified molecular forms of the peptide in the pancreas, gastrointestinal tract and plasma from mammals that form pancreatic amyloid(human and cat) and mammals that do not form it(rat and mouse). Eleven of thirteen insulinomas had both immunoreactivities for IAPP and insulin, but other two had only insulin-immunoreactivity. Amyloid deposits were noted in 5 insulinomas whose clinical features will be presented. In addition, we report pathological features of amyloid in NIDDM and the amyloid in a gastrinoma. Islet amyloid deposition might be a secondary manifestation of disordered islet function, although we can not exclude that amyloid deposits intensify islet dysfunction and may contribute to the progression of NIDDM.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (33 results)

All Other

All Publications (33 results)

  • [Publications] K Shiomi,S Matsukura,et al: "Establishment of hypersensitive radioimmunoassay for islet amyloid polypeptide using antiserum specific for its N-terminal region." Biochem Biophys Res Commun. 186. 1065-1073 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T Mitsukawa,S Matsukura,et al: "Effects of aging on plasma islet amyloid polypeptide basal level and response to oral glucose load." Diabetes Res Clin Pract. 15. 131-134 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] J Eriksson,S Matsukura,et al: "Islet amyloid polypeptide(IAPP)concentrations in insulin resistant individuals with increased risk of developing type 2(non-insulin-dependent)diabetes mellitus." Diabetologia. 35. 291-293 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] S Enoki,S Matsukura,et al: "Plasma islet amyloid polypeptide levels in obesity,impaired glucose tolerance and non-insulin-dependent diabetes mellitus." Diabetes Res Clin Pract. 15. 97-102 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M Miyazato,S Matsukura,et al: "Molecular forms of islet amyloid polypeptide(IAPP/amylin)in four mammals." Diabetes Res Clin Pract. 15. 31-36 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] R Narita,S Matsukura,et al: "Islet amyloid polypeptide(IAPP)and pancreatic islet amyloid deposition in diabetic and non-diabetic patients." Diabetes Res Clin Pract. 15. 3-14 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 中里 雅光、松倉 茂: "最新内科学大系" 中山書店,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 中里 雅光、松倉 茂 寒川 賢治、松尾 壽之: "Annual Review内分泌・代謝学" 中外医学社, 8 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H Toshimori, R Narita, M Nakazato, J Asai, T Mitsukawa, H Matsuo, K Takabashi and S Matsukura: "Islet amyloid polypeptide in insulinoma and in the islets of the pancreas of non-diabetic and diabetic subjects." Virchows Archiv A Pathol Anat. 418. 411-417 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M Miyazato, M Nakazato, K Shiomi, J Aburaya, H Toshimori, K Kangawa, H Matsuo and S Matsukura: "Identification and characterization of islet amyloid polypeptide in mammalian gastrointestinal tract." Biochem Biophys Res Commun. 181. 293-300 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] J Eriksson, M Nakazato, M Miyazato, K Shiomi, S Matsukura, L Groop: "Islet amyloid polypeptide(IAPP) concentrations in insulin resistant individuals with increased risk of developing type2(non-insulin-dependent) diabetes mellitus." Diabetologia. 35. 291-293 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K Shiomi, M Nakazato, M Miyazato, K Kangawa, H Matsuo, S Matsukura: "Establishment of hypersensitive radioimmunoassay for islet amyloid polypeptide using antiserum specific for its N-terminal region." Biochem Biophys Res Commun. 186. 1065-1073 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] R Narita, H Toshimori, M Nakazato, T Kuribayashi, T Toshimori, K Kawabata, K Takahashi and S Matsukura: "Islet amyloid polypeptide(IAPP) and pancreatic islet amyloid deposition on diabetic and non-diabetic patients." Diabetes Res Clin Pract. 15. 3-14 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M Miyazato, M Nakazato, K Shiomi, J Aburaya, K Kangawa, H Matsuo and S Matsukura: "Molecular forms of islet amyloid polypeptide (IAPP/amylin) in four mammals." Diabetes Res Clin Pract. 15. 31-36 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] S Enoki, T Mitsukawa, J Takemura, M Nakazato, J Aburaya, H Toshimori and S Matsukura: "Plasma islet amyloid polypeptide levels in obesity, impaired glucose tolerance and non-insulin dependent diabetes mellitus." Diabetes Res Clin Pract. 15. 97-102 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T Mitsukawa, J Takemura, M Nakazato, J Asai, K Kangawa, H Matsuo, S Matsukura: "Effects of aging on plasma islet amyloid polypeptide basal level and response to oral glucose load." Diabetes Res Clin Pract. 15. 131-134 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K Akimoto, M Nakazato, S Matsukura, K Hayakawa: "Plasma concentration of islet amyloid polypeptide in healthy children and patients with insulin-dependent diabetes mellitus." Acta Paediat.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K Shiomi,S Matsukura,et al: "Establishment of hypersensitive radioimmunoassay for islet amyloid polypeptide using antiserum specific for its N-terminal region." Biochem Biophys Res Commun. 186. 1065-1073 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T Mitsukawa,S Matsukura,et al: "Effects of aging on plasma islet amyloid polypeptide basal level and response to oral glucose load." Diabetes Res Clin Pract. 15. 131-134 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] J Eriksson,S Matsukura,et al: "Islet amyloid polypeptide(IAPP)concentrations in insulin resistant individuals with increased risk of developing type2(non-insulin-dependent)diabetes mellitt" Diabetologia. 35. 291-293 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S Enoki,S MAtsukura,et al: "Plasma islet amyloid polypepetide levels in obesity,impaired glucose tolerance and non-insulin-dependent diabetes mellitus." Diabetes Res Clin Pract. 15. 97-102 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] M Miyazato,S Matsukura,et al: "Molecular forms of islet amyloid polypeptide(IAPP/amylin)in four mammals." Diabetes Res Clin Pract. 15. 31-36 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] R Narita,S Matsukura,et al: "Islet amyloid polypeptide(IAPP)and pancreatic islet amyloid deposition in diabetic and non-diabetic patients." Diabetes Res Clin Pract. 15. 3-14 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 中里 雅光,松倉 茂: "最新内科学大系" 中山書店,

    • Related Report
      1992 Annual Research Report
  • [Publications] 中里 雅光,松倉 茂,寒川 賢治,松尾 壽之: "Annual Review 内分泌・代謝学" 中外医学社, 8 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Toshimori H,Nakazato M,et al Matsukura S: "Islet amyloid polypeptide(IAPP)in insulinoma and in the islets of the pancreas of nonーdiabetic and diabetic subjects." Virchow Arch A Path Anat and Histol. 418. 411-417 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Miyazato M,Nakazato M,et al Matsukura S: "Identification and characterization of islet amyloid polypeptide(IAPP/amylin)in mammalian gastrointestinal tract." Biochem Biophys Res Commun. 181. 293-300 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Narita R,Nakazato M,et al Matsukura s: "Islet amyloid polypeptide(IAPP)and pancreatic islet amyloid deposition in diabetic and nonーdiabetic patients." Diabetes Res Clin Pract.15. 3-14 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Miyazato M,Nakazato M,et al Matsukura S: "Molecular forms of islet amyloid polypeptide(IAPP/amylin)in four mammals." Diabetes Res Clin Pract.15. 31-36 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Enoki S,Nakazato M,et al Matsukura S: "Plasma islet amyloid polypeptide levels in obesity,impaired glucose tolerance and nonーinsulin dependent diabetes mellitus." Diabetes Res Clin Pract.15. 97-102 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Eriksson J,Nakazato M,et al Matsukura S: "Islet amyloid polypeptide(IAPP)concentrations in insulin resistant individuals with increased risk of developing type 2(nonーinsulinーdependent)diabetes mellitus." Diabetologia.

    • Related Report
      1991 Annual Research Report
  • [Publications] 中里 雅光,松倉 茂,寒川 賢治,松尾 壽之: "Annual Review内分泌・代謝学" 中外出版社, 8 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 塩見 一剛,中里 雅光,宮里 幹也,寒川 賢治,松尾 壽之,松倉 茂: "Peptide Hormones in Pancreas" Biomedical Research Foundation,

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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