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Etiology of triiodothyronine-predominant Graves' disease and its optimal treatment

Research Project

Project/Area Number 03671169
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 内分泌・代謝学
Research InstitutionOsaka Medical College

Principal Investigator

TAKAMATSU Junta  Osaka Medical College, Dept.of Medicine, Assistant Professor, 医学部, 講師 (00140137)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Shigeru  Osaka Medical College, Dept.of Medicine, Resident, 医学部, 専攻医
SKANE Sadaki  Osaka Medical College, Dept.of Medicine, Assistant, 医学部, 助手 (10235161)
UTSUMI Takashi  Osaka Medical College, Dept.of Ophathalmology, Assistant Professor, 医学部, 講師 (30104300)
OHSAWA Nakaaki  Osaka Medical College, Dept.of Medicine, Professor, 医学部, 教授 (90010090)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1992: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1991: ¥900,000 (Direct Cost: ¥900,000)
KeywordsGraves' disease / Triiodothyronine(T_3) / Thyroglobulin antibody / Thyroid peroxidase / TSH receptor antibody / ^<131>I / Hyperthyroidism / Thyroid-stimulating antibody / 甲状腺機能元進症 / 甲状腺刺激抗体 / T_3優合型バセドウ病 / トリヨードサイロニン / 甲状腺ペルオキシターゼ / 甲状腺刺激性〓体 / 甲状腺 / 脱ヨード酵素 / アイソトープ治療 / T_3優位型バセドウ病 / トリヨ-ドサイロニン / 甲状腺ペルオキシダ-ゼ / 脱ヨ-ド酵素 / アイソト-プ治療
Research Abstract

1. Thyroid-Related Antibodies
Patients with T_3-predominant Graves' disease had greater levels of thyroid-peroxidase antibody, thyroid-microsomal antibody, TSH receptor antibody and thyroid-stimulating antibody than those in patients with common Graves' disease.
2. Thyroid Histology
Patients with T_3-Predominant Graves' disease had greater height of thyroid-epithelial cells and more intracolloidal vacuoles, suggesting an enhanced turnover of intrathyroidal iodine.
3. Combined Therapy with Methimazole and Thyroxine
After one year of combined therapy with antithyroid drug and 1-T_4, serum TSH receptor antibody activity was decreased significantly. However, the remission rate was not significantly increased.
4. Prognosis after Radioiodine Therapy
Late onset-hypothyroidism after radioiodine therapy occurred in 43% of patients with common type of Graves' disease within 5-10 years, while it occurred only in 17% of T_3-predominant Graves' disease patients, indicating that this treatment is beneficial, particularly in patients with T_3-predominant Graves' disease.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Takamatsu J.: "Treatment of heypotlsyroidism due to Hashimoto disease by lobenqarit disodium‥‥" 80 Years of Hashimoto Disease. 477-481 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takamatsu J: "Familial unresponsiveness to Thyrotropin by autosomal recessive inheritance." J.Clin.Endocrinol.Metab.77. 1569-1573 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Murakami Y: "Serum levels of antibodies against Thyroglobulin and microsomes in relation to Thyroid function‥‥" 80 Years of Hashimoto Disease. 235-239 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakane S: "Decrease in Thyroid volume of patients with Hashimoto disease during agncscorticoid Therapy for concomitant diseases." 80 Years of Hashimoto Disease. 205-209 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hosaka Y: "Individual difference in toxic difluse goiters assessed by heme-based specific activity and Km value." Endocrine Journal. 40. 141-181 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakata S: "Evaluotion of Thyroid function in patients with Thyroid buranone autoaustibodies." Clinica Chimica Acta. 219. 23-34 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 高松順太: "最近内科学大系13,内分泌症患2" 中山書店, 336 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takamatsu J: "Curreut Topics in Clinical Endocrinology" Research Trends(印刷中), (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takamatsu J., et al.: "Treatment of hypothyroidism due to Hashimoto disease by lobenzarit disodium..." 80 Years of Hashimoto Disease. 477-481 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takamatsu J., et al.: "Familial unresponsiveness to thyrotropin by autosomal recessive inheritance." J.Clin.Endocrinol.Metab.77. 1569-1573 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Murakami Y., et al.: "Serum levels of antibodies against thyroglobulin and microsomes in relation to thyroid function..." 80 Years of Hashimoto Disease. 235-239 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakane S., et al.: "Decrease in thyroid volume of patients with Hashimoto disease during glucocorticoid therapy for concomitant disease." 80 Years of Hashimoto Disease. 205-209 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hosaka Y., et al.: "Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value." Endocrine Journal. 40. 141-181 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakata S., et al.: "Evaluation of thyroid function in patients with thyroid hormone autoantibodies." Clinica Chimica Acta. 219. 23-34 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] TakamatsuJ.: "Treatmen of bypothyroidism due to Harhimato disease by lobenzarit disodlu……" 80Years of Hashimoto Disease. 477-481 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] TakamatsuJ: "Familial unrespousiveness to thyrotnopin by antosomal recessive inheritance." J.Clin.Endocrinol.Metah.77. 1569-1573 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Murakami Y: "Serm levels of antibodies against Thiyroglolulin and mirosomes in relation to thiyrod functioh……" 80 Years of Hashmoto Disease. 235-239 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sakane S: "Decrease in Thyroid Volume of patients with Hashimoto disease during afucacorticoid therapy for coucomitant diseasas." 80 Years of Hashimoto Disesase. 204-209 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Hosaka Y: "Individual difference in toxic diffuse goiters assessed by heme-hased specific activity and Km value." Endocrine Jourual. 40. 141-181 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sakata S: "Evaluation of thyroid function in patiets with Thyroid hormone auto outibodies." Clinica Chimica Acta. 219. 23-34 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Takamatsu J: "Desearch Treuds(印刷中)" Cureut Topics in Clinical Endcrinoloay. 1993.

    • Related Report
      1993 Annual Research Report
  • [Publications] 高松順太: "最近内科学大系13,内分泌疾患2" 中山書店, 336 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Takamatsu J.: "Hyperplastic ep:Thelium and decreased colloid content in thyroidglands from patients with triiodo Phyronine-predo- Sminant Graves disease." J.Clin.Endocrinol Metah.75. 1145-1150 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takamatsu J.: "Peroxidase and coupling activites of Thyroid peroxidose in being and maliguant Thyroid tumor tissues." Thyroid. 2. 193-196 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takamatsu J.: "Diagnosis of familial dysalburisnevie hyperthyroxineuric and investigation of the nature of the variant albumin" Bull.Osaka.Med.Colleae.36. 35-45 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] Sakame S.: "Biochemical studies of the relationship between iodothyromie 5'-deiobinace and protein disulphide isomerase in rat liver." Edocrimol Japan.39. 461-464 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takamatsu J: "Changes in serum antoantibodies to Flyroid peroxidese during antiFlyroid drng Fherapy for Grones'disease." Endocrinologia Japonica. 37. 275-283 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Sakane S(Eds:Lee,Koh): "Chiuical features and characteristcs of Flyroid furetion in Graves disease patiouts with multiple adenoumatous lypesplasia" Progress in Flyroidology 1989 Korea Medical Pulliling Co.Seoul,Korea. 403-406 (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] 高松 順太: "診断の進め方と治療方針:Basedow病" 臨床医. 16. 1302-1305 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Takamatsu J: "Hyperplastic epithelium and decreaeed colloid content in Flyriod gland from patiots with triiodoFhyronine- psedominant Groves'disease" J.Clin,Endocrinol.Metab.75. (1992)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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