| Project/Area Number |
03680040
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Osaka University Rrsearch Institute for Microbial Siseases, Vrant-in-Aid for Scientific Research (c) |
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Principal Investigator |
DOHMAE Kayoko Research Institute for Microbial Diseases, Osaka University Department of Science for Laboratory Animal Experimentation Instructor, 微生物病研究所, 助手 (80127266)
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| Co-Investigator(Kenkyū-buntansha) |
YAMANISHI Kohichi Research Institute for Microbial Diseases, Osaka University Department of Birolo, 微生物病研究所, 教授 (10029811)
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| Project Period (FY) |
1991 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1992: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1991: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | HFRS virus / Seoul type B-1 strain / maternal immunity / natural transmission / antibody titer / T-cill deficient nude rat |
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| Research Abstract |
1. In order to study the mechanism of prevalence of Hantavirus infection, protecting effect of antibodies transferred form mother to infant was assessed. antibodys to hantavirus Seolul type B-1 strain. maternally transferred to neonates prevented lethal infection. However, the antibodies were not necessarily active enough to protect against persistent virus infection in neonates, Establishment of persisstent infection depends upon the level of virus titers inoculated,
Neonates completely protected form active virus infection by maternal immunity do not show immune response to a secondary challenge of the same virus.
2. We have developed a new natural transmission system of hantavirus in laboratory rats between immunologically intact (rnu/+) and their congenitally T-cell deficient nude (rnu/rnu) littermates.
Nude rats dicharge more of active infectious viruses to cause prevalence of infection and die when infected. Furthermore, immunologically normal serpositive rats never cause infection to cagemate nude rats. Thus, nude rats are highly susceptible to the hantavirus infection.
These laboratory animals and experimental system are useful models to study the mechanism of hantavirus infection.
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