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The Role of Immure Cells in Liver Metastasis of Paucreatic Cariroma

Research Project

Project/Area Number 03807082
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionTohoku University

Principal Investigator

KOBARI Masao  Tohoku University School of Medicine First Department of Surgery Lecturer, 医学部附属病院, 講師 (30170369)

Co-Investigator(Kenkyū-buntansha) AMIKURA Katsumi  Tohoku University School of Medicne First Department of Surgery Research Associa, 医学部附属病院, 助手 (10231995)
AKAISHI Satoshi  Tohoku University School of Medicne First Department of Surgery Research Associa, 医学部, 助手 (70202504)
TAKEDA Kazunori  Tohoku University School of Medicine First Department of Surgery Lecturer, 医学部附属病院, 講師 (20171639)
椎葉 健一  東北大学, 医学部附属病院, 助手 (90196345)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1993: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1992: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
KeywordsPancreatic Cancer / Adoptite Immunorlorapy / LAK / Liver Metastasis / Basement Membrare Proteirs / NK / Kupffer細飽 / Kupffer細胞 / LAK細胞 / 膵癌肝転移
Research Abstract

The killing activities of LAK cells obtained from pancreatic cancer patients were 77.9% for NK sensitive cells, 72.9% for LAK sensitive cells, and 36.7%, 23.2%, 86.4% for cultured human pancreatic cancer cell lines PK-1, PK-9, and KLM-1 respectively. The growth of KLM-1 cells inoculated on nude mice was inhibited by LAK cells in vivo. LAK cells with high killing activity against pancreatic cancer cells can be obtained from patients with pancreatic cancer. Laminin and fibronection on the surface of hepatocytes can mediate pancreatic cancer cells attachment and migration in the early phase of liver metastasis. The liver metastasis model formed by a highly metastatic variant (KLM-1) is valuable for the study of the liver metastatic processes of human pancreatic cancer.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] 遊佐 透: "膵癌患者から誘導されるLAK細胞の抗腫瘍効果についての実験的検討" 膵臓. 11. 231-237 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 網倉 克己: "膵癌の肝転移形成初期における基底蛋白laminin,fibronection,typeIV Collagenの関与" 膵臓. 11. 205-214 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Y.Kimura: "Establishment of an experimental live metastasis model by intraportal injection of a nowly derived human pancreatic cancer cell live(KLM-1)." International Journal of Pancreatology. 20. 43-50 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yuca T,Kobari M,Shimamura H,Matsumoto G,Amikura K,Sunamura M,and Matsuro S: "In hibition of human pancreatic cancer cell growth in nude mice by bymphokine-activated killer cells derived from parraeatil cancer patients." Japanese Journal of Pancreatology. 11. 231-237 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Amikura K,Kobari M,and Matsuno S: "The mechanism of livermetastasis in caranoma of the pancreas-the role of laminir, fibronedin, type IV collagen in the attachment and migrotion of human pancreatic cancer cells." Japanese Journal of Pancreatology. 11. 205-214 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kimura Y,Kobari M,Yusa T,Sunamura M,Kimura M,Shimamura H,and Seiki M: "Establishment of an experimental liver metastesis madel by intraportal injection of a newly derived human paraetic cancer cell line (KLM-1)" International Journal of Paraeosology. 20. 43-50 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 小針 雅男: "膵胆道癌に対するLAK養子免疫療法の検討" 膵癌. 6. 596-604 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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