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ROLES OF CELL GROWTH FACTORS AND CYTOKINES IN POSTEMNOPAUSAL OSTEOPOROSIS

Research Project

Project/Area Number 03807110
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionSt.Marianna University School of medicine

Principal Investigator

SAGA Masahiko  St.Marianna University School of Medicine Department of Obstetrics and Gynecology Associate Professor, 医学部, 助教授 (60081767)

Co-Investigator(Kenkyū-buntansha) YONAMINE Kyoko  The same as above Associate, 医学部, 助手 (20210784)
OHNO Yuko  The same as above Associate, 医学部, 助手 (20233231)
KONDO Toshihiko  St. Marianna University School of Medicine Department of Obstetrics and Gynecolo, 医学部, 助手 (50215456)
佐藤 泉  聖マリアンナ医科大学, 医学部, 助手 (30187174)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1992: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1991: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordspostmenopausal / osteoporosis / growth factor / cytokine / PTH
Research Abstract

Inorder to elucidate the pathogenesis of postmenopausal osteoporosis, serum insulin-like growth factor (IGF)-1 level and the productions of interleukin(IL)-1 and tumor necrosis factor (TNF) by preipheral macrophages were examined, in addition to bone mineral content(BMC) of lumbar spine by quqntitative computed tomography, calcium regulating hormones and bone gla protein(BGP). BMC was significantly decreased along with age in osteoporotics and control group. Serum PTH-M showed apositive regression with age and a negative correlation with BMC in osteoporotics. There were no significant difference between osteoporotics and age-matched normals in serum PTH-intact and PTH-M. Vitamine D metabolites showed significant negative regressions with age and positive correlayions with BCM in osteoporotics. Serum BGP also negatively correlated with BMC in normals. Serum IGF tended to have a significant positive correlation with BMC both in osteoporotics and normals. However, there was no significant difference between osteoporotics and normals. The production of IL tended to be increased in osteoporotics compared to premenopausal normals.
Our studies as well as recent papers suggest that IGF, TNF and IL-1 may control bone metabolism with estrogen action.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Masahiko Saga, et al.: "systemic calcium-regulating factors in female involution osteoporosis(Japanese)" Obstetrical and gynecological practice. 42. 91-100 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kazutoshi Okano, et al.: "involution osteoporosis and nuclear medicine (Japanese)" Clinical Endocrinology. 39. 905-912 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kazutoshi Okano, et al.: "studies on insulin-like growth factor in involution osteoporosis. (Japanese)" The 13 th Kanagawa calcium-bone metabolism study group report. 13. 51-58 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Masahiko Saga, et al.: "growth factors and cytokines in post-menopausal osteoporosis. (Japanese)"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 佐賀 正彦: "女性退行期骨粗鬆症における全身性骨代謝調節因子の変動" 産婦人科の実際. 42. 91-100 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡野 一年: "退行期骨粗鬆症と核医学" ホルモンと臨床. 39. 905-912 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡野 一年: "退行期骨粗鬆症におけるInsulin-like Growth Factorの検討" 第13回神奈川Ca・骨代謝研究会報告雑誌. 13. 51-58 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 佐賀 正彦: "閉経後骨粗鬆症における細胞成長因子・サイトカインについて"

    • Related Report
      1992 Annual Research Report
  • [Publications] 佐賀 正彦: "閉経後骨粗鬆症における細胞成長因子およびサイトカインの役割(抄)" 日本産婦人科学会雑誌. 43. S728 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 佐賀 正彦: "Roles of cell qrowth factor and cytokines in postmenopausal osteoporosis.(Abstract)" 日本産婦人科学会雑誌. 43. 1049 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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