| Project/Area Number |
04041033
|
|---|
| Research Category |
Grant-in-Aid for international Scientific Research
|
| Allocation Type | Single-year Grants |
|---|
| Section | Field Research |
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
OMOTO Keiichi Professor, The University of Tokyo Faculty of Science, 理学部, 教授 (10011503)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
DASHNYAM Bumbein Director, Institute of Biotechnology, Academy of Sciences, Mongolia, バイオテクノロジー研究所・バイオテクノロジー部門, 部長
BATSSUR Jamy (モンゴル)国立人類学センター, 所長
SAITOU Naruya Associate Professor, National Institute of Genetics, 進化遺伝部門, 助教授 (30192587)
SUGITA Shigeo Research Fellow, Equine Research Institute, The Japan Racing Association, 栃木支所, 疫学研究員
NEROME Kuniaki Chef, National Institute of Health, ウィルスリケッチア部, 室長 (00072934)
ISHIDA Takafumi Assistant, The University of Tokyo Faculty of Science, 理学部, 助手 (20184533)
HIRAI Momoki Professor, The University of Tokyo Faculty of Science, 理学部, 教授 (60156635)
BATSUUR Jamyangiin Head, The National Center of Anthropology
|
|---|
| Project Period (FY) |
1992
|
| Project Status |
Completed (Fiscal Year 1992)
|
| Budget Amount *help |
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1992: ¥6,000,000 (Direct Cost: ¥6,000,000)
|
|---|
| Keywords | Mongolians / Population Genetics / Anthropology / Blood Groups / Viral Epidemiology / Genetic Polymorphism / Horse / Mitochondrial DNA |
|---|
| Research Abstract |
This research project aims at obtaining data of blood genetic markers such as blood groups and protein types as well as DNA types of Mongolians in order to clarify the phylogenetic relationships of Mongolians among other Asian peoples. Also planned are epidemiological studies of viruses as HTLV, HBV and HCV and genetic studies of horses and other domestic animals.
The results so far obtained are as follows.
(1) Blood samples of 194 Mongolians, most of which are from Khalha ethnic group, and 150 horses as well as 30 camels were collected during the field study.
(2) Eight blood groups systems were examined and the results indicated that Mongolians are nor so closely related to Japanese as Koreans.
(3) As to mitochondrial DNA, frequencies of HincII morphs and Asian specific 9 base deletion were determined on Mongolians. The HincII morph 6 which has been reported only in American Indians was found with remarkably high frequency (21.4%). The frequency of 9 base deletion was 5.9%, which is much
… More
lower than in Japanese (16%). A rare case of insertion in 3 out of 136 Mongolians.
(4) HTLV positive sera was not found, in accordance with the theory that this virus occurs in descendants of proto-Mongoloids, but not in neo-Mongoloids. HBV had frequency of about 10%, while very high incidence of HCV (40%)was noted. This finding partially explains the high incidence of hepatitis and hepatic cancer in Mongolia.
(5) Adult lactose absorption test was carried out on 20 human subjects, and one subject was found to be the absorber. This result is in accordance with the theory that among livestock breeders frequency of absorbers is high while among agriculturists it is very low.
(6) Blood samples were collected from 150 horses and 30 camels. Antibody tests for equine influenza viruses A/eq/Miami/1/63 and A/eq/prague/1/56 showed that all the horses ahd camels tested were negative careers. Also, no animal was positive for antibody of bird influenza virus A/duck/Ukraine/1/63, which caused a severe prevalence of influenza among horses of northern China during 1989-1990. Less
|
