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Study on Naturally Occurring Drug Materials in Indonesia -4

Research Project

Project/Area Number 04041069
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionField Research
Research InstitutionOsaka University

Principal Investigator

KITAGAWA Isao  Professor, Faculty of Pharmaceutical Sciences, Osaka University, 薬学部, 教授 (20028830)

Co-Investigator(Kenkyū-buntansha) ROEMANTYO Ha  インドネシア国立生物学研究所, ボゴール植物標本館, 講師
UJI Tahan  Senior Researcher, Herbarium Bogoriense, Research and Development Center for Bio, ボゴール植物標本館, 講師
RISWAN Soedarsono  Head of Ecology, Herbarium Bogoriense, Research and Development Center for Biolo, ボゴール植物標本館, 主席研究員
HORI Kazuyuki  Research Associate, Faculty of Pharmaceutical Sciences, Osaka University, 薬学部, 助手 (50181516)
OHASHI Kazuyoshi  Research Associate, Faculty of Science, Shizuoka University, 理学部, 助手 (90213826)
SHIBUYA Hirotaka  Professor, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 薬学部, 教授 (50116042)
ROEMANTYO Harini-Muruni  Senior Researcher, Herbarium Bogoriense, Research and Development Center for Bio
ROEMANCYO Ha  インドネシア国立生物学研究所, ボゴール植物標本館, 講師
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 1993: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1992: ¥7,500,000 (Direct Cost: ¥7,500,000)
KeywordsIndonesia / Maluku Province / Central Sulawesi Province / Naturally occurring drug materials / Medicinal plant / Folk remedy
Research Abstract

Indonesia is perhaps one of the richest countries in the world in natural product resources, particularly in botanical resources. Indonesian people have been using medicinal plants as traditional medicines for long time, although most of them have not yet been verified on the basis of modern science.
Our research project entitled "Study on Naturally Occurring Drug Materials in Indonesia-4" aims at revealing the naturally occurring drug materials, i.e. medicinal plants, in Indonesia and anticipates the development of the academic exchange between Japan and Indonesia.
In 1992 expedition, we first collected the information about Maluku spices in the market of Maluku Province. Next, we visited Central Sulawesi Province and collected information about 200 kinds of traditionally used medicinal plants from the local people and collected 23 kinds of medicinal plants for chemical investigations.
In 1993, all the plants collected by us were botanically identified at Herbarium Bogoriense, Bogor, Indonesia. Furthermore, the alcoholic extracts of these specimens were subjected to several chromatographic analyses at Osaka University to isolate the chemical constituents for examination of their biological activities. Those analytical studies are in progress. We have so far obtained some promising evidence, which suggests that the chemical and biological studies of those materials collected in our survey may lead us to find new substances of pharmacological importance.
The collaboration with the Research and Development Center for Biology-LIPI, Indonesia, the Indonesian participating organization, will certainly be continued in this manner hereafter.

Report

(2 results)
  • 1993 Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Isao KITAGAWA: "Chemical Structures of Carotroposides A and B,Two New Oxypregnane-Oligo-glycosides from the Roots of Calotropis gigantea(Asclepiadaceae)" Chemical and Pharmaceutical Bulletin. 40. 2007-2013 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Isao KITAGAWA: "Chemical Structures of Pongapinones A and B,Two New Prenylflavonoids from the Bark of Pongamia pinnata(Papillionaceae)" Chemical and Pharmaceutical Bulletin. 40. 2041-2043 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirotaka SHIBUYA: "On the Constituents of the Bark of Fagara rhetza(Rutaceae).(1):Alkaloids,Phenylpropanoids,and Acid Amide" Chemical and Pharmaceutical Bulletin. 40. 2325-2330 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirotaka SHIBUYA: "On the Constituents of the Bark of Fagara rhetza(Rutaceae).(2):Lignan Glycosides and Two Apio-glucosides" Chemical and Pharmaceutical Bulletin. 40. 2639-2642 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirotaka SHIBUYA: "Chemical Structures of Calotropo-sides C,D,E,F,and G.Five Additional New Oxypregnane-Oligoglycosides from the Roots of Calotropis gigantea(Asclepiadaceae)" Chemical and Pharmaceutical Bulletin. 40. 2647-2653 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Isao KITAGAWA: "Dehatrine,an Antimalarial Bisben-zylisoquinoline Alkaloid from the Indonesian Medicinal Plant Beilsch-miedia madang,Isolated as a Mixture of Two Rotational Isomers" Chemical and Pharmaceutical Bulletin. 40. 997-999 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Masayuki YOSHIKAWA: "On the Chemical Constituents of the Bark of Picrasma javanica B1.(Sim-aroubaceae)from Flores Island.Absolute Stereostructures of Picrajavanins A and B" Chemical and Pharmaceutical Bulletin. 41. 2101-2105 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Isao KITAGAWA: "Seven New Clerodane-Type Diterpeno-ids,Peronemins A2,A3,B1,B2,B3,C1,and D1,from the Leaves of Peronema canescens(Verbenaceae)" Chemical and Phaemaceutical Bulletin. 42. in press (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Isao KITAGAWA: "Chemical Strucutures of Three New Triterpenoids,Bruceajavanin A,Dihydrobruceajavanin A,and Brucea-javanin B,and a New Alkaloidal Gly-coside Bruceacanthinoside,from the Stems of Brucea javanica(Simaroubaceae)" Chemical and Pharmaceutical Bulletin. 42. in press (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kazuyoshi OHASHI: "Chemical Structures of Gogganoside A,B,and C.Three New Quinovic Acid Glycosides from the Bark of Bhesa paniculata(Celastraceae)" Chemical and Pharmaceutical Bulletin. (submitted).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Isao KITAGAWA: "Chemical Structures of Caesaldeka-rins a and b,Two New Cassane-type Furanoditerpenes from the Roots of Caesalpinia major(Fabaceae)" Chemical and Pharmacetical Bulletin. (submitted).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 北川 勲: "「インドネシアの天然薬物調査研究」学振新書14 海外の学術調査(1)-アジアの自然と文化-" 日本学術振興会(丸善), 16 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Isao KITAGAWA: "Chemical Structures of Calotroposides A and B, two New Oxypregnane-Oligoglycosides from the Roots of Calotropis gigantea (Asclepiadaceae)" Chemical and Pharmaceutical Bulletin. 40. 2007-2013 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Isao KITAGAWA: "Chemical Structures of Pongapinones A and B, Two New Prenylflavonoids from the Bark of Pongamia pinnata (Papillionaceae)" Chemical and Pharmaceutical Bulletin. 40. 2041-2043 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirotaka SHIBUYA: "On the Constitents of the Bark of Fagara rhetza (Rutaceae). (1) : Alkaloids, Phenylpropanoids, and Acid Amide" Chemical and Pharmaceutical Bulletin. 40. 2325-2330 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirotaka SHIBUYA: "On the Constituents of the Bark of Fagara rhetza (Rutaceae). (2) : Lignan Glycosides and Two Apioglucosides" Chemical and Pharmaceutical Bulletin. 40. 2639-2642 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirotaka SHIBUYA: "Chemical Structures of Calotroposides C, D, E, F, and G.Five Additional New Oxypregnane-Oligoglycosides from the Roots of Calotropis gigantea (Asclepiadaceae)" Chemical and Pharmaceutical Bulletin. 40. 2647-2653 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Isao KITAGAWA: "Dehatrine, an Antimalarial Bisbenzylisoquinoline Alkaloid from the Indonesian Medicinal Plant Beilschmiedia madang, Isolated as a Mixture of Two Rotatinal Isomers" Chemical and Pharmaceutical Bulletin. 41. 997-999 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Masayuki YOSHIKAWA: "On the Chemical Constituents of the Bark of Picrasma javanica Bl. (Simaroubaceae) from Flores Island. Absolute Stereostructures of Picrajavanins A and B" Chemical and Pharmaceutical Bulletin. 41. 2101-2105 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Isao KITAGAWA: "Seven New Clerodane-Type Diterpenoids, Peronemins A2, A3, B1, B2, B3, C1, and D1, from the leaves of Peronema canescens (Verbenaceae)" Chemical and Pharmaceutical Bulletin. 42(in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Isao KITAGAWA: "Chemical Structures of Three New Triterpenoids, Bruceajavanin A, Dihydrobruceajavanin A, and Bruceajavanin B, and a New Alkaloid Glycoside Bruceacanthinoside, from the Stems of Bruceajavanica (Simaroubaceae)" Chemical and Pharmaceutical Bulletin. 42(in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kazuyoshi OHASHI: "Chemical Structures of Gogganosides A, B, and C. Three New Quinovic Acid Glycosides from the Bark of Bhesa paniculata (Calastraceae)" Chemical and Pharmaceutical Bulletin. (submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Isao KITAGAWA: "Chemical Structures of Caesaldekarins a and b, Two New Cassane-type Furanoditerpenes from the Roots of Caesalpinia major(Fabaceae)" Chemical and Pharmaceutical Bulletin. (submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Isao KITAGAWA: JSPS (Japan Society for the Promotion of Sciences)-Maruzen Pub.Investigation of Naturally Occurring Drug Materials in Indonesia (Gakushin Shinsyo-14), 31-46(16) (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Isao KITAGAWA: "Indonesian Medicinal Plants. I. Chemical Structures of Calotroposides A and B, Two Oxypregnane-Oligoglycosides from the Root of Calotropis giganter (Asclepiadaceae)" Chemical and Pharmaceutical Bulltain. 40. 2007-2013 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Isao KITAGAWA: "Indonesian Madicinal Planst. II. Chemical Structures of Pongapinones A and B, Two New Phenylpropanoids from the Bark of Pongamia Pinnata (Papilionaceae)" Chemical and Pharmaceutical Bulltain. 40. 2041-2043 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Isao KITAGAWA: "Indonesian Medicinal Plants. III. On the Constituents of the Bark of Fagara rhetza (Rutaceae). (1):Alkaloids,Phenylpropanoids,and Acid Amide" Chemical and Pharmaceutical Bulltain. 40. 2325-2330 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Hirotaka SHIBUYA: "Indonesian Medicinal Plants. IV. On the Constituents of Fagara rhetza (Rutaceae). (2): Lignan Glycosides and Two Apioglucosides" Chemical and Pharmaceutical Bulltain. 40. 2639-2642 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Hirotaka SHIBUYA: "Indonesian Medicinal Plants. V. Chemical Structures of Calotroposides C,D, E,F, and G, Five Additional New Oxy-pregnane-Oligoglycosides from Calotropis gigantea" Chemical and Pharmaceutical Bulltain. 40. 2647-2653 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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