| Project/Area Number |
04042011
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Special Cancer Research |
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| Research Institution | Niigata University |
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Principal Investigator |
WATANABE Hidenobu Niigata University School of Medicine, Professor, 医学部, 教授 (70037381)
渡邉 英伸 (1993) 新潟大学, 医学部, 教授
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| Co-Investigator(Kenkyū-buntansha) |
IVAN Roa Temuco Hospital, chief La.Furontera University school of Medicine, Professer, ラ・フロンテラ大学, 部長 教授
IVAN Serra Chile University school of Medicine Professor, 医学部, 教授
ALFONSO Calvo Sotero del Rio Hospital, Chief, デル・リオ病院, 部長
SUGANUMA Masami National Cancer Center Research Institute, Cancer Prevention Division, Researche, がん予防研究部, 研究員 (20196695)
TAJIMA Kazuo Aichi Cancer Research Institute, Division of Epidemiology, Chief, 疫学部, 部長 (30150212)
YAMAMOTO Masaharu Niigata University school of Medicine, Professor, 医学部, 教授 (40018693)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥12,200,000 (Direct Cost: ¥12,200,000)
Fiscal Year 1993: ¥7,000,000 (Direct Cost: ¥7,000,000)
Fiscal Year 1992: ¥5,200,000 (Direct Cost: ¥5,200,000)
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| Keywords | Gallbladder / Cancer / Japan / Chile / p53 protein / Carcinogens / Pathology / Epidemiology / Biochemistry / 日本・チリ比較 / 病理・疫学・生化学 / 遺伝子異常 / 前癌病変 |
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| Research Abstract |
Standarized Mortality Ratios(SMRs)for biliary tract cancers are very high in Japan and Chile. The SMRs in Japan ranked second in males and fifth in females among 39 countries, while the SMRs in Chile ranked first in both sexes. However, there are some differences in backgrounds of biliary tract cancers between the two countries ; (1)90% of the biliary tract cancer is gallbladder cancer in Chile(gallbladder cancer and extrahepatic bile duct cancer are equal in incidence in Japan), (2)higher incidence of gallstones in Chilean autopsy cases without gallbladder cancers(female 44-61% or male 20-29% in Chile, and 4.3% or 2.6%, respectively, in Japan), (3)growing bacterial infection including typhoid and paratyphoid fever in Chile, and (4) different environmental factors including agricultural chemicals, dietary patterns and geological characteristics of the soil and drinking water.
On the base of these backgrounds of biliary tract cancers, we are carrying out a cooperative project with Chilean researchers to reveal the differences or similarities in carcinogens, mutagens, precancerous lesions, and gene abnormalities of gallbladder cancers between the two countries from pathological, epidemiological and biochemical view-points.
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