| Project/Area Number |
04042012
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Special Cancer Research |
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| Research Institution | Gifu University |
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Principal Investigator |
SHIMIZU Hiroyuki Gifu University, School of Medicine, 医学部, 教授 (90073139)
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| Co-Investigator(Kenkyū-buntansha) |
BERNSTEIN Leslie University of Southern California, School of Med., 医学部, 教授
ROSS Ronald K. University of Southern California, School of Med., 医学部, 教授
HENDERSON Br ソーク研究所, 所長
ITOH Yoshinori Fujita Health University, School of Health Science, 衛生学部, 教授 (50087665)
KABUTO Michinori National Institute for Environmental Studies, 都市環境影響評価チーム, 総合研究官 (00113481)
HENDERSON Brian E. The Salk Institute for Biological Studies
LESLIE Berns 南カリフォルニア大学, 医学部, 助教授
RONALD Ross 南カリフォルニア大学, 医学部, 教授
BRIAN E Hend 南カリフォルニア大学, ノリスがんセンター, 所長
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥7,100,000 (Direct Cost: ¥7,100,000)
Fiscal Year 1993: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1992: ¥3,700,000 (Direct Cost: ¥3,700,000)
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| Keywords | Japanese American / Whites / Cancer / Dietary habits / Carotenoid / Sex hormone / Pepsinogen / Chronic atrophic gastritis / 生活習慣 / 栄養 / 脂肪 / β-カロチン / カルシウム |
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| Research Abstract |
To compare life style, particularly nutrients intake, we collected the information on the dietary habits from Japanese and whites randomly selected from the list of drivers' license in Los Angeles County. We also collected blood samples from the subjects (48 and 51 Japanese male and females ; 48 and 52 white males and females). The serum samples were stored -80^ﾟC and they were packed with dry ice and sent to Japanese investigators' laboratories.
The analysis of the nutrients intake for each subject has not yet been completed, but the pilot survey shows that Japanese American has less saturated fat, fiber and calcium than whites for both men and women. Serum levels of beta-carotene, alpha-carotene, lycopene, cryptoxanthin, and zeaxanthin/lutein were higher (1.2-1.7 times) in Japanese than those in whites in Los Angeles, although the levels of retinol were somewhat lower in Japanese. The ratios of the prevalence rate of chronic atrophic gastritis for Japanese American to that for whites estimated from the serum pepsinogen levels were 1.37 for males and 1.27 for females. The estimated ratios of the prevalence rates in T-city, Gifu Prefecture was 3.06 for males and 2.85 for females. One can see that Japanese American shows the intermediate rates of both chronic atrophic gastritis and stomach cancer between whites in the U.S. and Japanese in Japan.
We are analyzing serum sex hormone levels and keep communication with the investigators in Los Angeles to get more precise information on smoking and drinking histories, reproductive history and history of menstruation for women as well as dietary habits for each subject.
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