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Joint Study to Solve the Basic Problems in Artificial Heart

Research Project

Project/Area Number 04044053
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionThe University of Tokyo

Principal Investigator

IMACHI Kou  Professor, Faculty of Medicine, The University of Tokyo, 医学部(医), 教授 (10010076)

Co-Investigator(Kenkyū-buntansha) TRUBEL Wolfgang  Research Associate, Faculty of Medicine, University of Vienna, 医学部, 助手
MULLER Michael  Research Associate, Faculty of Medicine, University of Vienna, 医学部, 助手
SCHIMA Heinrich  Research Associate, Faculty of Medicine, University of Vienna, 医学部, 助手
ROKITANSKY Alexander  Associate Professor, Faculty of Medicine, University of Vienna, 医学部, 助教授
MORITZ Anton  Associate Professor, Faculty of Medicine, University of Vienna, 医学部, 助教授
WOLNER Ernst  Professor, Faculty of Medicine, University of Vienna, 医学部, 教授
IMANISHI Kaoru  Research Associate, Faculty of Medicine, The University of Tokyo, 医学部, 助手 (70168516)
ABE Yusuke  Research Associate, Faculty of Medicine, The University of Tokyo, 医学部, 助手 (90193010)
CHINZEI Tsuneo  Research Associate, Research Center for Advanced Science and Technology, The Uni, 先端科学技術研究センター, 助手 (20197643)
MABUCHI Kunihiko  Associate professor, Research Center for Advanced Science and Technology, The Un, 先端科学技術研究センター, 助教授 (50192349)
FUJIMASA Iwao  Professor, Research Center for Advanced Science and Technology, The University o, 先端科学技術研究センター, 教授 (30010028)
ARNNOLD Prod  ウィーン大学, 医学部, 助手
HEINRICH Sch  ウィーン大学, 医学部, 助手
ALEXANDER Ro  ウィーン大学, 医学部, 助教授
ANTON Moritz  ウィーン大学, 医学部, 助教授
ERNST Wolner  ウィーン大学, 医学部, 教授
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥13,300,000 (Direct Cost: ¥13,300,000)
Fiscal Year 1993: ¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1992: ¥7,000,000 (Direct Cost: ¥7,000,000)
KeywordsArtificial heart / Blood pump / Circulatory control / Heart transplantation / Antithrombogenicity / Centrifugal blood pump / Animal experiment / Artificial valve / 血行動態
Research Abstract

The aim of this international joint study is to promote the artificial heart (AH) research and its clinical application at the points of control, pathophysiology and blood compatibility. During the past two years, both research staffs visited each others once a year and stayed for one week to perform a experiment and exchange the information through the effective discussion. As the consequence of these joint study, the following excellent results has obtained ;
1 Concerning the clinical application of AH as the bridge to heart transplantation, to which they had several case experience, we could get many information concerning the anatomical fitting of a blood pump, surgical operation techniques and post operative management.
2 The discussion about the AH animal experiments, the animal data got from the calf by Vienna group, and from the goats by our group were exchanged to clarity the data difference by the speceis and age.
3 They joined our total AH animal experiment using a goat and discussed about what is a bottle neck to obtain more longer survival.
4 Concerning the AH automatic control method, they had a strong interest to our new automatic control method named as 1/R control method, in which the AH goat herself can control her cardiac output at optimum value by changing her total peripheral resistance. And we discussed about the mechanism and meaning of this control method taking a lot of time.
5 We also discussed about two new types of AH produced by our group under the quite new ideas.
6 They tested the blood compatibility of our jellyfish valve with a acceleration test method developed by Vienna group.
7 To improve the antithrombogenicity of a centrifugal blood pump developed by Vienna group, we arranged to get a good blood compatible material, MPC polymer developed by Nakabayashi and Isihara.
As mention above, both group had a great advantages in the AH research through 2 year's joint study.

Report

(2 results)
  • 1993 Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Kou Imachi: "The second and third model of the flow transformed pulsatile total artificial heart" ASAIO Journal. 38(3). M717-M721 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kou Imachi: "Fabrication of a jellyfish valve for use in an artificial heart" ASAIO Journal. 38(3). M237-M242 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Iwao Fujimasa: "Micromechanical devices" Encyclopedia of Physical Science and Technology,Academic Press,Inc.10. 139-155 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kou Imachi: "The jellyfish valve:a polymer membrane valve for the artificial heart" Heart Replacement:Artificial Heart 4,Springer-Verlag Tokyo. 41-44 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yusuke Abe: "Reciprocal of the peripheral vascular resistance(1/R)control method for the total artificial heart" Heart Replacement:Artificial Heart 4,Springer-Verlag Tokyo. 349-351 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takashi Isoyama: "Development of a pulsatile total artificial heart using a single continuous flow pump:development of the third model" Heart Replacement:Artificial Heart 4,Springer-Verlag Tokyo. 287-290 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kou Imachi: "The second and third model of the flow transformed pulsatile total artificial heart" ASAIO Journal. 38(3). M717-M721 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kou Imachi: "Fabrication of a jellyfish valve for use in an artificial heart" ASAIO Journal. 38(3). M237-M242 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Iwao Fujimasa: "Micromechanical devices" Encyclopedia of Physical Science and Technology, Academic Press, Inc.10. 139-155 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kou Imachi: "The jellyfish valve : a polymer membrane valve for the artificial heart" Heart Replacement : Artificial Heart 4, Springer-Verlag Tokyo. 41-44 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yusuke Abe: "Reciprocal of the peripheral vascular resistance (1/R) control method for the total artificial heart" Heart Replacement : Artificial Heart 4, Springer-Verlag Tokyo. 349-351 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takashi Isoyama: "Development of a pulsatile total artificial heart using a single continuous flow pump : development of the third model" Heart Replacement : Artificial Heart 4, Springer-Verlag Tokyo. 287-290 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.IMACHI: "The second and third model of the flow transformed pulsatile total artificial heart" ASAIO Journal. 38(3). 717-721 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.IMACHI: "Fabrication of a jellyfish valve for use in an artificial heart" ASAIO Journal. 38(3). 237-242 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.MABUCHI: "Changes with respect to time in the in vivo adsorption of plasma proteins onto artificial heart blood pumps" ASAIO Journal. 38(3). 536-542 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 今西 薫: "心臓移植の手技で装着可能な完全一体成形人工心臓ポンプの開発" 薬理と臨床. 2(5). 397-398 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Abe: "Artificial Heart-The Development of Biomation in the 21st Century (Y.Sezai Ed)" Harcourt Brace Jovanovich Japan Inc.,Tokyo, 386 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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