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Regulation of IL-3 and GM-CSF genes and their receptors

Research Project

Project/Area Number 04044054
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionTHE UNIVERSITY OF TOKYO

Principal Investigator

ARAI Ken-ichi  The University of Tokyo Professor THE INSTITUTE OF MEDICAL SCIENCE, 医科学研究所, 教授 (00012782)

Co-Investigator(Kenkyū-buntansha) 中川 菜峰子 (小谷野 菜)  東京大学, 医科学研究所, 教務職員
WATANABE Sumiko  INSTITUTE OF MEDICAL SCIENCE,UNIV.OF TOKYO Research Associate, 医科学研究所, 教務職員 (60240735)
YOKOTA Takashi  INSTITUTE OF MEDICAL SCIENCE,UNIV.OF TOKYO Associate Professor, 医科学研究所, 助教授 (50134622)
ARAI Naoko  DNAX RESEARCH INSTITUTE Vice director & Senior Scientist, 副部長
JAN de Vries  DNAX分子細胞生物学研究所, 部長
WOLFRAM Oste  ハンブルグ大学, Heinrich Pette研究所, 教授
MIYAJIMA Atsushi  DNAX RESEARCH INSTITUTE Vice director & Senior Scientist, 主任研究員
KOYANO Naoko (NAKAGAWA Na)  INSITUTE OF MEDICAL SCIENCE,UNIV.OF TOKYO Research Associate
DEVRIES Jan  DNAX RESEARCH INSTITUTE Director
OSTERTAG Walfram  HEINRICH PETTE INST., HAMBRUG UNIV.Professor
DE Vries Jan  DNAX分子細胞生物学研究所, 部長
OSTERTAG Wol  ハンブルグ大学, Heinrich Pette研究所, 教授
DEVRIES Jan  DNAX分子細胞生物学研究所, 部長
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥12,900,000 (Direct Cost: ¥12,900,000)
Fiscal Year 1994: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 1993: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1992: ¥3,800,000 (Direct Cost: ¥3,800,000)
KeywordsGM-CSF receptor / IL-3 receptor / Signal transduction / Transcription factor / Transactivator / Tyrosine phosphorylation / Gene transfer / Early response genes / トランスアクチベーター
Research Abstract

1.Regulation of cytokine genes in T cells. Using human and mouse T cell clones with TH1, TH2, and TH0 phenotype, we have been working on the coordinate and differential expression of the IL-3, IL-4, IL-5 and GM-CSF genes. The CLE2/GC-box and CLE0 of the mouse GM-CSF promoter are essential for transcriptional activation in response to PMA and Ca ionophore. CLE2 defines a binding site for NF-kappaB.The major GC-box binding activity A1 was purified and was identified as Sp1. We purified a human NF-AT protein from activated Jurkat extract and showed that it strongly bound to the CLE0 within the GM-CSF promoter in association with AP1. We isolated a novel protein with zinc finger motifs which binds to the CT/GC-rich region of the IL-3 promoter. We also identified cis-regulatory elements within IL-5, IL-4 and IL-2 promoters. These works were done in collaboration with Drs.Naoko Arai and de Vries Jan in DNAX.
2.Receptor and Signal transduction. We have been working on the structure and function of GM-CSF/IL-3 receptors. There are several signal pathways downstream of the GM-CSF receptor. The membrane proximal region of betac is essential for proliferation, c-myc and pim-1 induction and Jak2 association. The C-terminal region of betac is important for the suppression of apoptosis, Ras, Raf, MAPK activation and c-fos, c-jun induction. We have also shown that bone marrow cells derived from transgenic mice which constitutively express hGM-CSF receptor have the proliferative capacity to induce all the myeloid cell lineages in response to hGM-CSF.Furthermore, we have generated mice carrying a null mutation of betac and betaIL-3. betac mutant mice also showed lung pathology consisting of lymphocytic infiltration and areas resembling alveolar proteinosis. These works were done in collaboration with Dr.Atsushi Miyajima in DNAX and Dr.Ostertag Wolfram in Hamburg University.

Report

(3 results)
  • 1994 Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (103 results)

All Other

All Publications (103 results)

  • [Publications] Miyajima,A.: "Cytokine receptors and signal transduction" Ann.Rev.Immunol.10. 295-331 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Arai,K.: "Regulation of allergic response by cytokine receptor network" Allergy and Clinical Immunology News. 4. 113-120 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Arai,K.: "Cytokine network:Control of allergic response and hemopoisis by hemopoietic..." J.Dermatology. 19. 575-583 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nakayama,N.: "Use of mammalian cell expression clonig systems to idntify cytokines,..." Curr.Opin.Biotechnology. 3. 497-505 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ozu,M.: "Regulation of the IL-3 gene and structure and function of the IL-3 receptor" Advance in Neuroimmunology. 2. 32-52 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Arai,N.: "Activation of lymphokine genes in T cells:Role of cis-acting DNA elements..." Pharmacology and Therapeutics. 55. 303-318 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Koyano-Nakagawa,N.: "Reconstitution of the functional GM-CSF promoter:Evidence for distinct..." Int.Immunology. 5. 345-352 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] "The granulocyte-macrophage colony stimulating factor promoter..." Mol.Cell.Biol.13. 7399-7407 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tokumitsu,H.: "Purification of the 120kDa component of the human nuclear factor..." Biochem.Biophys.Res.Commun.196. 737-744 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Lee,H-J.: "cAMP activates the IL-5 promoter synergistically with phorbol..." J.Immunol.151. 6135-6142 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Watanabe,S.: "Reconstituted human granulocyto-macrophage colony stimulating factor receptor..." Mol.Cell.Biol.13. 1440-1448 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sato,N.: "Signal transduction by the high affinity GM-CSF receptor:two distinct...." EMBOJ.12. 4181-4189 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sato,N.: "Expression and factor dependent modulation of the IL-3 receptor subunits..." Blood. 82. 752-761 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Watanabe,S.: "Differential regulation of c-fos,c-jun and c-myc protooncogenes..." Mol.Biol.Cell.4. 983-992 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kondo,M.: "Sharing of the interleukin-2 receptor γ chain between receptors for IL-2 and IL-4." Science. 262. 1874-1877 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kinoshita,T.: "Suppression of apoptotic death in hematopoietic cells by signalling...21GC16:EMBOJ." 14. 266-275 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kinoshita,T.: "Regulation of Bcl-2 expression by oncogenic Ras protein in hemopoietic cells" Oncogene.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Koyano-Nakagawa,N.: "Molecular cloning of a novel human cDNA encoding a zinc finger protein..." Mol.Cell.Biol.14. 5099-5107 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nishijima,I.: "A human GM-CSF receptor expressed in transgenic mice stimulates..." Mol.Biol.Cell.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tsuruta,L.: "cAMP inhibits expression of the IL-2 gene through the NF-AT sequence..." J.Immunol.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Quelle,F.W.: "Jak2 associates with the β chain of the receptor for granulocyte-....21GC21:Mol.Cell.Biol." 14. 4335-4341 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sato,N.: "Multimeric cytokine receptors:common versus specific functions." Curr.Opin.Cell.Biol.6. 174-179 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tsuboi,A.: "Calcineurin activates transcription from the GM-CSF promoter in..." Biochem.Biohpys.Res.Commun.198. 1054-1062 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Watanabe.S.: "Effects of prostaglandin E1 on Th0-type human T cell clones:modulation..." Int.Immunol.6. 523-532 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kurata,H.: "GM-CSF receptor:structure,function,and signal transduction." Advances in Biochemistry and Biology of Cells.3. 111-155 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Lee,H-J.: "Signals and nuclear factors that regulate the expression of interleukin-4…" J.Allergy Clinic.Immunol. 94. 595-604 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Masuda,E.S.: "NF-ATx:a functional member of the NF-AT family that is predominantly..." Mol.Cell.Biol.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Masuda,E.S.: "The transcription factor Spl is required for induction of the murine GM-CSF..." Biochem.Biophys.Res.Commun.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Muto,A.: "High affinity chimeric human granulocyte-macrophage colony-stimulating..." Biochem.Biophys.Res.Commun.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nishinakamura,R.: "Mice deficient for the IL-3/GM-CSF/IL-5 receptor exhibit lung pathology.." Immunity. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Watanabe,S.: "Granulocyte macrophage colony stimulating factor dependent replication.." J.Biol.Chem.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsuda,I.: "Characterization of NF(P),the nuclear factor that interacts with...." Biochem.Biophys.Res.Commun.199. 439 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Watanabe,S.: "Characterization of cis-regulatory elements of the c-myc promoter..." Mol.Biol.Cell.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Chen,J.X.: "Activation of early response genes and cell proliferation by human inetrleukin-3..." J.Allergy Clinic.Immunol.94. 606-611 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kosugi,H.: "Structure of the gene encoding the α subunit of the human interleukin-3 receptor" Biochem.Biophys.Res.Commun.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nakagawa,Y.: "Structure of gene encoding the α subunit of the human granulocyte-macrophage.." J.Biol.Chem.269. 10905-10912 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Watanabe,M.: "HTLV-I encoded Tax in association with NF-kB precursor p105 enhances...." Oncogene. 8. 2949-2958 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kosugi,H.: "Gene structures of the a subunits of the human interleukin-3 and..." J.Allergy Clinic.Immunol.in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Muto,A.: "Roles of the cytoplasmic domain of the α subunits of human granulocyte.." J.Allergy Clinic.Immunol.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Masuda,E.S.: "Expression of lymphokine genes in T cells" The Immunologist. 1. 198-203 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Muto,A.: "Roles of the cytoplasmic domain of the α subunits of human granulocyte.." J.Allergy Clinic.Immunol.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Masuda,E.S.: "Expresion of lymphokine genes in T cells" The Immunologist. 1. 198-203 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Watanabe,M.: "HTLV-I encoded Tax in association with NF-kB precursor p105 enhances...." Oncogene. 8. 2949-2958 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kosugi,H.: "Gene structures of the subunits of the human interleukin-3 and..." J.Allergy Clinic.Immunol.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Koyano-Nakagawa, N.: "Reconstitution of the functional GM-CSF promoter : Evidence for distinct..." Int.Immunology. 5. 345-352 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Masuda, E.S.: "The granulocyte-macrophage colony stimulating factor promoter..." Mol.Cell.Biol.13. 7399-7407 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tokumitsu, H.: "Purification of the 120kDa component of the human nuclear factor..." Biochem.Biophys.Res.Commun.196. 737-744 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Lee, H-J.: "cAMP activates the IL-5 promoter synergistically with phorbol..." J.Immunol.151. 6135-6142 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Watanabe, S.: "Reconstituted human granulocyto-macrophage colony stimulating factor receptor..." Mol.Cell.Biol.13. 1440-1448 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sato, N.: "Signal transduction by the high affinity GM-CSF receptor : two distinct...." EMBOJ.12. 4181-4189 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sato, N.: "Expression and factor dependent modulation of the IL-3 receptor subunits..." Blood. 82. 752-761 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Watanabe, S.: "Differential regulation of c-fos, c-jun and c-myc protooncogenes...." Mol.Biol.Cell.4. 983-992 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kondo, M.: "Sharing of the interleukin-2 receptor gamma chain between receptors for IL-2 and IL-4." Science. 262. 1874-1877 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kinoshita, T.: "Suppression of apoptotic death in hematopoietic cells by signalling..." EMBOJ.14. 266-275 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kinoshita, T.: "Regulation of Bcl-2 expression by oncogenic Ras protein in hemopoietic cells" Oncogene.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Koyano-Nakagawa, N.: "Molecular cloning of a novel human cDNA encoding a zinc finger protein..." Mol.Cell.Biol.14. 5099-5107 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kurata, H.: "GM-CSF receptor : structure, function, and signal transduction." Advances in Biochemistry and Biology of Cells.3. 111-155 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Lee, H-J.: "Signals and nuclear factors that regulate the expression of interleukin-4..." J.Allergy Clinic.Immunol. 94. 595-604 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Masuda, E.S.: "NF-ATx : a functional member of the NF-AT family that is predominantly..." Mol.Cell.Biol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Masuda, E.S.: "The transcription factor Spl is required for induction of the murine GM-CSF..." Biochem.Biophys.Res.Commun.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Muto, A.: "High affinity chimeric human granulocyte-macrophage colony-stimulating..." Biochem.Biophys.Res.Commun.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nishinakamura, R.: "Mice deficient for the IL-3/GM-CSF/IL-5 receptor exhibit lung pathology.." Immunity. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nishijima, I.: "A human GM-CSF receptor expressed in transgenic mice stimulates..." Mol.Biol.Cell.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tsuruta, L.: "cAMP inhibits expression of the IL-2 gene through the NF-AT sequence..." J.Immunol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Quelle, F.W.: "Jak2 associates with the beta chain of the receptor for granulocyte-..." Mol.Cell.Biol.14. 4335-4341 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sato, N.: "Multimeric cytokine receptors : common versus specific functions." Curr.Opin.Cell.Biol.6. 174-179 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tsuboi, A.: "Calcineurin activates transcription from the GM-CSF promoter in..." Biochem.Biophys.Res.Commun.198. 1054-1062 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Watanabe.S.: "Effects of prostaglandin E2 on Th0-type human T cell clones : modulation..." Int.Immunol.6. 523-532 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Watanabe, S.: "Granulocyte macrophage colony stimulating factor dependent replication." J.Biol.Chem.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Matsuda, I.: "Chatacterization of NF (P), the nuclear factor that interacts with...." Biochem.Biophys.Res.Commun.199. 439 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Watanabe, S.: "Characterization of cis-regulatory elements of the c-myc promoter..." Mol.Biol.Cell.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Chen, J.X.: "Activation of early response genes and cell proliferation by human interleukin-3.." J.Allergy Clinic.Immunol.94. 606-611 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kosugi, H.: "Structure of the gene encoding the alpha subunit of the human interleukin-3 receptor" Biochem.Biophys.Res.Commun.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nakagawa, Y.: "Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage.." J.Biol.Chem.269. 10905-10912 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Watanabe, M.: "HTLV-I encoded Tax in association with NF-kB precursor p105 enhances...." Oncogene. 8. 2949-2958 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kosugi, H.: "Gene structures of the alpha subunits of the human interleukin-3 and..." J.Allergy Clinic.Immunol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Muto, A.: "Roles of the cytoplasmic domain of the alpha subunits of human granulocyte.." J.Allergy Clinic.Immunol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Masuda, E.S.: "Expression of lymphokine genes in T cells" The Immunologist. 1. 198-203 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ozu, M.: "Regulation of the IL-3 gene and structure and function of the IL-3 receptor" Advance in Neuroimmunology. 2. 32-52 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Arai, N.: "Activation of lymphokine genes in T cells : Role of cis-acting DNA elements..." Pharmacology and Therapeutics. 55. 303-318 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Miyajima, A.: "Cytokine receptors and signal transduction" Ann.Rev.Immunol.10. 295-331 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Arai, K.: "Regulation of allergic response by cytokine receptor network" Allergy and Clinical Immunology News. 4. 113-120 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Arai, K.: "Cytokine network : Control of allergic response and hemopoisis by hemopoietic..." J.Dermatology. 19. 575-583 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nakayama, N.: "Use of mammalian cell expression cloning systems to identify cytokines, ..." Curr.Opin.Biotechnology. 3. 497-505 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Koyano-Nakagawa,N.: "Reconstitution of the functional GM-CSF promoter" Int.Immunol.5. 345-352 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Masuda,E.S.: "The granulocyte-macrophage colony stimulating factor promoter cis-acting element CLE0 mediates induction signals in T cells and is recognized by factors related to AP1 and NF-AT." Mol.Cell.Biol.13. 7399-7407 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tokumitsu,H.: "Purification of the 120 kDa component of the human nuclear factor of activated T cells(NF-AT)" Biochem.Biophys.Res.Commun.196. 737-744 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Lee H-J.: "cAMP activates the IL-5 promoter synergistically with phorbol ester through the signaling pathway involving protein kinase A in mouse thymoma line EL-4." J.Immunol. 151. 6135-6142 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Watanabe,M.: "HTLV-I encoded Tax in association with NF-kB precursor p105 enhances nuclear localization of NF-kB p50 and p65 in transfected cells" Oncogene. 8. 2949-2958 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Watanabe,S.: "Reconstituted human granulocyte-macrophage colony-stimulating factor (GM-CSF)receptor transduces growth promoting signals in mouse NIH3T3 cells" Mol.Cell.Biol.13. 1440-1448 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sato,N.: "Signal transduction by the high affinity GM-CSF receptor" EMBOJ., 4181-4189 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sato,N.: "Expression and factor dependent modulation of the IL-3 receptor subunits on human hematopoietic cells." Blood, 752-61 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Watanabe,S.: "Differential Regulation of c-fos,c-jun and c-myc Protooncogenes through Human Granulocyte Macrophage Colony-Stimulating Factor Recepter in BA/F3 NIH3T3 cells pro-B cells and" Mol.Biol.Cell., 983-992 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Masuda,E.S.: "Expression of lymphokine genes in T cells" The Immunologist, 198-203 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tsuboi,A.: "Calcineurin potentiates activation of the granulocyte-macrophage colony-stimulating factor gene in T cells" Mol.Biol.Cell (in press), (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Abe,E.: "Eleven-base pair DNA sequence motif unique to human IL-4 gene confers responsiveness to T cell activation signals." Proc Natl Acad Sci USA., 2864-2868 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] MIYAJIMA,A.et al.: "Cytokine receptors and signal transduction." Annu.Rev.Immunology. 10. 295-331 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Garret,K.P.et al: "The C-terminus of rat RAP30 is similar in sequence to region 4 of bacterial sigma factos and is required for runction." J.Biol.Chem.267. 23942-9 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] ARAI,N.et al.: "Activation of lymphokine genes in T cells: role of cis-acting DNA elements that respond to T cell activation signals" Pharmacology and Therapeutics. 55. 303-318 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] WATANABE,S.: "Molecular biology of T cell derived cytokines and cytokine receptor network" Progress in Allergy and Clinical Immunology. 24. 213-218 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] M.OZU: "Regulation of the IL-3 gene and structure and function of the IL-3 receptor" Advance in Neuroimmunology. 2. 32-35 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Wang,H.M.: "Structure of mouse IL-3 binding protein (AIC2A): Amino acid residues critical for IL-3 binding" A.J.Biol.Chem.267. 979-983 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] KOYANO,N. et al.: "Reconstition of the functional GM-CSF promoter: evidence for distinct activation mechanisms that mediate the response to phorbol ester ..." International Immunology. 5. (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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