Grant-in-Aid for international Scientific Research
|Allocation Type||Single-year Grants |
|Research Institution||YAMANASHI MEDICAL UNIVERSITY |
SUZUKI Hiroshi YAMANASHI MEDICAL UNIVERSITY,President, 学長 (40107511)
黄 祖瑚 南京医学院, 医学系, 講師
陳 錫慰 南京医学院, 医学系, 講師
賈 輔忠 南京医学院, 医学系, 教授
TAKEDA Kiyoshi YAMANASHI MEDICAL UNIVERSITY, 医学部, 助手 (90242635)
SHO Masanori YAMANASHI MEDICAL UNIVERSITY, 医学部, 助手 (90154682)
MINAI Masaru YAMANASHI PREFECTURAL INSTITUTE FOR PUBLIC HEALTH, 生物部, 部長
AKAHANE Yoshihiro YAMANASHI MEDICAL UNIVERSITY, 医学部, 助教授 (60092855)
ARAKI Kunioki THE INSTITUTE OF PUBLIC HEALTH, 衛生微生物学部, 室長 (40107800)
MAYUMI Makoto JICHI MEDICAL SCHOOL, SCHOOL OF MEDICINE, 医学部, 教授 (00049016)
NAKAJIMA Yasuo YAMANASHI MEDICAL UNIVERSITY, 医学部, 教授 (20039845)
HUANG Zu-Hu NANJING MEDICAL COLLEGE
CHEN Xi-Wei NANJING MEDICAL COLLEGE
JIA Fu-Zhong NANJING MEDICAL COLLEGE
徐 道寅 南京医学院, 予防医学系, 副教授
山中 太郎 山梨医科大学, 医学部, 助手 (10240053)
小林 一久 山梨厚生連, 健康管理センター, 所長 (30153597)
|Project Period (FY)
1992 – 1994
Completed (Fiscal Year 1993)
|Budget Amount *help
¥10,400,000 (Direct Cost: ¥10,400,000)
Fiscal Year 1993: ¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 1992: ¥5,300,000 (Direct Cost: ¥5,300,000)
|Keywords||chronic liver disease / HBV infection / HCV infection / acute hepatitis / schistosomiasis japonica / ELISA / general population / endemic area|
To estimate the seroepidemiology of HBV and HCV infection in the Yangtse River region of China where were endemic for schistosomiasis japonica, we performed the collaborative studies with Nanjing Medical College.
A total of 1,010 serum samples from three general populations in China, and 228 samples from Wakakusa, Yamanashi, Japan, where were endemic for schistosomiasis japonica, were tested for HBV and HCV markers. And we have studied 147 serum samples from patients with chronic liver diseases and 63 samples with acute viral hepatitis in Nanjing Medical College.
Among 1,010 serum samples, 247 (24.5%) were positive for HBsAg, and 360 (35.6%) were negative for all HBV markers. But Anti-HCV was not detected in these 1,010 samples with a second-generation ELISA kit. In Wakakusa, 1 (0.4%) was positive for HBsAg, 16 (7.0%) were positive for HCV and 154 (67.5%) were negative for all markers. In chronic liver diseases, HBsAg was detected in 123 cases (83.6%) from 147 examined cases. Anti-HCV was positive in 13 cases (8.8%). Among the Anti-HCV positive cases, HBsAg was found to be positive in 10 cases (76.9%). In acute hepatitis, HBsAg was positive in 13 cases (20.6%) and Anti-HCV was positive in 14 cases (22.2%)
ELISA using Schistosoma egg antigen (SEA) was used for the screening of schistosomiasis. 76 (15.5%) out of 385 samples from the old endemic area of "river region" in Jiangsu, 245 (75.4%) out of 325 from the endemic area of "hill region" in Sichuan, 77 (25.6%) out of 300 from the endemic area of "lake region" in Anhui, and 44 (14.9%) out of 228 samples from the old endemic area in Yamanashi were positive.
These results suggest that (1) HBV infection was popular in the Yangtse River region of China where were endemic for schistosomiasis japonica, but HCV infection was rare, (2) superinfection of HCV in HBV carriers might have occurred in the course of medical setting.