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Noninvasive studies of higher brain functions related to voluntary movement

Research Project

Project/Area Number 04044096
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionKyoto University

Principal Investigator

SHIBASAKI Hiroshi  Kyoto University, Faculty of Medicine, professor, 医学部, 教授 (30037444)

Co-Investigator(Kenkyū-buntansha) POLICH J.  Scripps Institute, San Diego, USA, 研究室長
EISEN A.A.  University of British Columbia, Faculty of Medicine, Canada, 医学部, 教授
HARI Riitta  Helsinki University of Technology, Finland, 低温研究所, 教授
LUDERS H.O.  Cleveland Clinic, USA, 神経内科, 部長
HALLETT Mark  National Institutes of Health, NINDS, USA, NINDS, 部長
FREUND H.-J.  University of Dusseldorf Faculty of Medicine, Germany, 医学部, 教授
BARRETT Geoff  National Hospital, Queen Square, London, UK, 国立神経病院・神経心理部門, 主任研究員
MAGATA Yasuhiro  Kyoto University, Faculty of Medicine, 医学部, 助手 (20209399)
IKEDA Akio  Kyoto University, Faculty of Medicine, 医学部, 助手 (90212761)
NAGAMINE Takashi  Kyoto University, Faculty of Medicine, 医学部, 助手 (10231490)
YONEKURA Yoshiharu  Kyoto University, Faculty of Medicine, 医学部, 助教授 (60135572)
FREUND H ーJ  ドイツ, デュッセルドルフ大学・医学部, 教授
BARRETT Geof  英国ロンドン大学国立神経病院, 神経心理学, 主任研究員
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 1993: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 1992: ¥8,800,000 (Direct Cost: ¥8,800,000)
KeywordsVoluntary movement / Higher brain function / Noninvasive study / Movement-related cortical potential / Contingent negative variation / Movement-related magnetic field / PET / Regional cerebral blood flow / 頭皮上分布 / 硬膜下記録
Research Abstract

Having been supported by this International Scientific Research Program for the two years, the following achievements related to cortical mechanisms of motor control were obtained through collaborative studies with investigators from USA, UK, Germany, Canada and Finland by using various noninvasive techniques.
1. Elucidation of generator sources of movement-related cortical potentials
By subdural recording in patients with intractable epilepsy in collaboration with Dr.Luders in Cleveland Clinic, the early electric potential starting about 2 s before the onset of voluntary finger movement (readiness potential) was found to be generated from the hand area of the supplementary motor area (SMA) and that of the primary motor area (M1), both bilaterally. The late negative slope preceding the movement onset by 300 ms was generated more from the contralateral SMA and M1.
2. Comparison of simple and complex movements
Scalp potentials preceding complex sequential finger movements were compared with … More those preceding simple simultaneous movements, and the former was found to be associated with more activation not only of SMA but also of bilateral M1 than the latter.
3. Studies on generator mechanisms of contingent negative variation (CNV)
In collaboration with Dr.Barrett of UK and Dr.Polich of USA, CNV was found not to be affected by cerebellar efferent lesion while the readiness potential was absent.
4. Recording of movement-related magnetic field
In collaboration with Dr.Hallett at NIH of USA and with Dr.Hari at Helsinki, magnetic field associated with voluntary finger movement was recorded by 7-as well as by 37-channel magnetometer, respectively, and the generator sources of components immediately preceding and following the movement onset were clarified.
5. Functional imaging by PET
In collaboration with Dr.Hallett of USA and Prof.Freund of German, simple and complex finger movements were compared by measuring an increase of regional cerebral blood flow with PET, and showed an evidence supporting the above electrophysiological findings.
Thus, these noninvasive studies clarified the important roles played by not only SMA but also M1 in the planning and/or execution of voluntary finger movements in humans. Less

Report

(2 results)
  • 1993 Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] Ikeda,A.: "Movement-related potentials recorded from supplementary motor area and primary motor area.Role of SMA in voluntary movements." Brain. 115. 1017-1043 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ikeda,A.: "Invasive recording of movement-related cortical potentials in humans." Journal of Clinical Neurophysiology. 9. 509-520 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ikeda,A.: "Movement-related potentials associated with single and repetitive movements recorded from human supplementary motor area." Electroencephalography and clinical Neurophysiology. 89. 269-277 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kitamura,J.: "Enhanced negative slope of cortical potentials before sequential as comared with simultaneous extensions of two fingers." Electroencephalography and clinical Neurophysiology. 86. 176-182 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kitamura,J.: "A cortical slow potential is larger before an isolated movement of a single finger than simultaneous movement of two fingers." Electroencephalography and clinical Neurophysiology. 86. 252-258 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shibasaki,H.: "Recent advances in non-invasive studies of higher brain functions." Brain & Development. 15. 423-427 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shibasaki,H.: "Both primary motor cortex and supplementary motor area play an important role in complex finger movement." Brain. 116. 1387-1398 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sadato,N.: "Noninvasive measurement of regional cerebral blood flow change with H2-150 and PET using a mechanical injector and a standard arterial input function." IEEE Transactions on Medical Imaging. 12. 703-710 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ikeda,A.: "Dissociation between contingent negative variation and readiness potential in a patient with cerebellar efferent lesion." Electroencephalography and clinical Neurophysiology. (in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Miyazaki,M.: "Generator mechanism of pain-related evoked potentials following CO2 laser stimulation of hand: scalp topography and effect of predictive warning signal." Journal of Clinical Neurophysiology. (in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nagamine,T.: "Cortical magnetic and electric fields associated with voluntary finger movements." Brain Topography. (in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shibasaki,H.: "Cortical reflex negative myoclonus." Brain. (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 柴崎 浩(分担): "誘発電位-基礎から臨床応用まで-(下地 恒毅 編)" 西村書店, 9 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shibasaki,H.(分担): "Evoked Potentials in Clinical Testing(edited by Halliday,A.M.)" Churchill Livingstone,Edinburgh, 15 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ikeda,A. et al: "Movement-related potentials recorded from supplementary motor area and primary motor area. Role of SMA in voluntary movements." Brain. 115. 1017-1043 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ikeda,A. et al: "Invasive recording of movement-related cortical potentials in humans." Journal of Clinical Neurophysiology. 9. 509-520 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ikeda,A. et al: "Movement-related potentials associated with single and repetitive movements recorded from human supplementary motor area." Electroencephalography and clinical Neurophysiology. 89. 169-277 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kitamura,J. et al: "Enhanced negative slope of cortical potentials before sequential as compared simultaneous extensions of two fingers." Electroencephalography and clinical Neurophysiology. 86. 176-182 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kitamura,J. et al: "A cortical slow potential is larger before an isolated movement of a single finger than simultaneous movement of two fingers." Electroencephalography and clinical Neurophysiology. 86. 252-258 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shibasaki,H.: "Recent advances in non-invasive studies of higher brain functions." Brain & Development. 15. 423-427 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shibasaki,H. et al: "Both primary motor cortex and supplementary motor area play an important role in complex finger movement." Brain. 116. 1387-1398 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sadato,N. et al: "Noninvasive measurement of regional cerebral blood flow change with H2-150 and PET using a mechanical injector and a standard arterial input function." IEEE Transactions on Medical Imaging. 12. 703-710 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ikeda,A. et al: "Dissociation between contingent negative variation and readiness potential in a patient with cerebellar efferent lesion." Electroencephalography and clinical Neurophysiology. (in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Miyazaki,M. et al: "Generator mechanism of apin-related evoked potentials following CO2 laser stimulation of hand : scalp topography and effect of predictive warning signal." Journal of Clinical Neurophysiology. (in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nagamine, T. et al: "Cortical magnetic and electric fields associated with voluntary finger movements." Brain Topography. (in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shibasaki,H.: "Cortical reflex negative myoclonus." Brain. (in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shibasaki, H.: Churchill Livingstone, Edinburgh. Evoked Potentials in clinical Testing (edited by Halliday, A.M.), 523-537 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 中村 政俊,小野 英明,柴崎 浩: "視標追跡運動機能の加速度特性の解析とモデル構成-小脳失調症と基底核障害の相違について-" 医用電子と生体工学. 30. 130-140 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] SHIBASAKI, H.: "Noninvasive studies of higher brain functions related to voluntary movement in human" Biomedical Research. 13(Suppl). 1-3 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] IKEDA, A., Luders, H.O., Burgess, R.C.and SHIBASAKI, H.: "Movement-related potentials recorded from supplementary motor area and primary motor area.Role of supplementary motor area in voluntary movements" Brain. 115. 1017-1043 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] IKEDA, A.and SHIBASAKI, H.: "Invasive recording of movement-related cortical potentials in humans" Journal of Clinical Neurophysiology. 9. 509-520 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] KITAMURA, J., SHIBASAKI, H., TAKAGI, A., NABESHIMA, H.and YAMAGUCHI, A.: "Enhanced negative slope of cortical potentials before sequential as compared with simultaneous extension of two fingers" Electroencephalography and clinical Neurophysiology. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] KITAMURA, J., SHIBASAKI, H.and KONDO, T.: "Cortical slow potential is larger before isolated movement of a single finger than simultaneous movement of two fingers" Electroencephalography and clinical Neurophysiology. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 柴崎 浩(分担): "誘発電位-基礎から臨床応用まで-(下地垣毅編)" 西村書店,新潟, 316 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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