| Project/Area Number |
04044098
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Institution | Kyoto University Faculty of Medicine, The Secoud Department of Surgery |
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Principal Investigator |
YAMAOKA Yoshio (1993) Kyoto Univ., Faculty of Medicine, Professor, 医学部, 教授 (90089102)
小澤 和恵 (1992) 京都大学, 医学部, 教授 (00026858)
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| Co-Investigator(Kenkyū-buntansha) |
ピッケルマイヤー ルドル ハノーファー医科大学, 教授
YAMABE Hirohiko Kyoto Univ., Faculty of Medicine, Assistant Professor, 助教授 (00135592)
TANAKA Akira Kyoto Univ., Faculty of Medicine, Assistant, 医学部, 助手 (00240820)
MORIMOTO Taisuke Kyoto Univ., Faculty of Medicine, Assistant, 医学部, 助手 (60135910)
HONDA Kazuo Kyoto Univ., Faculty of Medicine, Assistant, 医学部, 助手 (00209321)
SHIMAHARA Yasuyuki Kyoto Univ., Faculty of Medicine, Assistant Professor, 医学部, 助手 (30196498)
MORI Keiichiro Kyoto Univ., Faculty of Medicine, Assistant Professor, 医学部, 講師 (80159186)
INAMOTO Takashi Kyoto Univ., Faculty of Medicine, Assistant Professor, 医学部, 講師 (10135577)
TANAKA Koichi Kyoto Univ., Faculty of Medicine, Associate Professor, 医学部, 助教授 (20115877)
RUDOY Pichlmayr Hanover School of Veterinary Medicine, Professor
ルドルフ ピッケルマイヤ ハノーファー医科大学, 教授
山岡 義生 京都大学, 医学部, 助教授 (90089102)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥24,000,000 (Direct Cost: ¥24,000,000)
Fiscal Year 1993: ¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 1992: ¥13,000,000 (Direct Cost: ¥13,000,000)
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| Keywords | Liver Transplantation / Rejection / Lymphocyte MTT assay / Arterial Ketone Body Ratio (AKBR) / 血中ケトン体比 / リンパ球MTT活性 / 病理学的検討 |
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| Research Abstract |
Perioperative management in clinical liver transplantation
Histological changes comparing with energy metabolic changes in the rejection state after liver transplantation have not ever studied. In this plan, we have tried the MTT assay of lymphocyte comparing with the changes in arterial ketone body ratio (AKBR) which reflects the energy state of the liver mitochondria after liver transplantation in Hannover Medical Center. The activity of MTT decreased not only in the rejection state but also in the infectious state after liver transplantation. Therefore, MTT assay can not be good indicator of the rejection. However, in the patient with critically decreased in AKBR the MTT activity also decreased.
As the collaboration study we have been evaluating measuring the saturation ratio of hemoglobin through the liver graft just after reperfusion using the MCPD method.
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