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Molecular mechanism of long-term effects of neurotransmitters

Research Project

Project/Area Number 04044143
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionThe University of the Air

Principal Investigator

KITO Shozo  Div.of Health Sciences, the University of the Air, Professor, 教養学部, 教授 (00010140)

Co-Investigator(Kenkyū-buntansha) MAGGI A.  Ins.of Pharmacology Science, University of Milano, Associate Professor, University o, Associate
MIYOSHI Rie  Royal Free Hospital School of Medicine, London, Research Asscoiate, Research A (80209965)
SEMBA Jun'ichi  Div.of Health Sciences, University of the Air Associate Professor, 教養学部, 助教授 (30183429)
BARNARD Elic.a.  Royal Free Hospital School of Medicine, London, Professor, Professor
JOH Tong h.  Cornell University Medical College, Professor, Professor
TOHYAMA Masaya  Institute of Medicine, Osaka University, Professor, 医学部, 教授 (40028593)
OLSEN Richard w.  UCLA School of Medicine, Professor, Professor
VENTER Graig  National Institute of Health, Chief Prof
JOH Tong H  Cornell University Medical College, Professor
佐藤 公道  京都大学, 薬学部, 教授 (80025709)
GRAIG J.Vent  National Institute of Health, Chief
TONG H.Joh  Cornell University, Medical College, Professor
RICHARD W.Ol  UCLA School of Medicine, Professor
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥10,300,000 (Direct Cost: ¥10,300,000)
Fiscal Year 1994: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1993: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1992: ¥3,400,000 (Direct Cost: ¥3,400,000)
Keywordsestrogen / immediate early gene / glucocortitoid / c-fos / Ca^<2+> / hepatocyte growth factor / nothern blotting / kainic acid / steroid hormon / dexamethasone / in vivo microdialysis / glutamate / 海馬 / Ca^<2+> / 扁桃核 / セルレイン / Nothern blotting / C-fos / Zif / 268 / ペンチレントラゾール / エストロゲン / 原癌遺伝子 / mRNA
Research Abstract

As a part of the study on how biologically active substances in the brain cause long-term effects through immediate early genes, effects of steroid hormones on survival rate of cultured rat limbic neurons were investigated.
It was previously confirmed that in cultured limbic neurons glucocorticoid increased kainic acid-induced cytotoxicity dose-dependently, while estrogen increased survival rate of cultured neurons at concentrations lower than 10^<-6>M.To elucidate this effect of estrogen, in situ hybridization of c-fos was performed on the rat limbic system after general administration of estrogen.
As the results, we confirmed that estrogen induced c-fos activation, while glucocorticoid administration did not. It has been known that glucocorticoid inhibits AP-1 site. These results suggested that estrogen and glucocorticoid reciprocally regulated immediate early genes. Such effect of estrogen is probably related with our experimental data that estrogen sometimes causes long-term elevation of Ca^<2+> within cultured hippocampal neurons.
Our hypothesis is that the next targent gene to the immediate early gene may be hepatocyte growth factor (HGF) gene since HGF is related with repairing also nervous tissue after injury and glucocorticoid inhibits HGF mRNA activation. Northern blotting analysis of HGF and c-met mRNA was performed on the rat hippocampus after general administration of kainic acid. HGF and c-met mRNA were induced 6 to 48 hours after kainic acid injection. Effect of steroid hormones on this kainic acid-induced HGF mRNA was under progress.
To confirm the effect of estrogen on neurons more precisely, neuroblastoma cell line into which estrogen receptor gene was transfected was used. By adding estrogen to this cell line, the neuroblastoma cells differentiated into matured neurons. We are experimenting the effect of estrogen on neurons using this cell line differentiated by estrogen.

Report

(3 results)
  • 1994 Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (167 results)

All Other

All Publications (167 results)

  • [Publications] Semba,J.: "Behavioral and neurochemical effects of OPC-14597,a novel antipsychotics drugs,on dopaminergic mechanism in rat brain." Neuropharmacology. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba,J.: "Effect of systemic dexamethasone on extracellular amino acids(glutamate,aspartate,glycine and GABA)and acetylcholine release in rat hippocampus in vivo microdialysis." Functional Neurology. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba,J.: "Characterisation of extracellular amino acids in striatum of freely moving rats by in vivo microdialysis." J.of Neural Transmission. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kito,S.: "Effect of nicotine on glucocorticoid toxicity on hippocampal neurons." Neurochemical Research. 19. 888-889 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kito,S.: "Effects of glucocorticoid on hippocampal neurons:in vivo and in vitro studies." Neurochemical Research. 18. 832 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Miyoshi,R.: "Effect of caerulein on expression of the immediate early genes,c-fos and zif/268 in the rat brain." Neurochemical Letters. 145. 205-208 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Miyoshi,R.: "Cholecystokinin increases intracellular Ca^<2+> concentration in cultured striatal neurons." Neuropeptides. 18. 115-119 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Miyoshi,R.: "Influence of age on N-methyl-D-aspartate antagonist binding sites in the rat brain studied by in vitro autoradiography." Synapse. 8. 212-217 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Miyoshi,R.: "Effect of age on α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid(AMPA)binding sites in the rat brain studied by in vitroautoradiography." Neurochemical Research. 16. 848-854 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tyndale,R.F.: "Distinctive patterns of GABAA receptor subunit mRNAs in 13 cell lines." J.Neurosci.14. 5417-5428 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Smith,G.B.: "Identification of a [3H]muscimol photoaffinity substrate in the bovine gamma-aminobutyric acid A receptor alpha subunit." J.Biol.Chem.269. 20380-20387 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kim,H.Y.: "GABA alters GABAA receptor mRNAs and increases ligand binding." J.Neurochem.61. 2334-2337 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Machu,T.K.: "Immunochemical characterization of the beta 2 subunit of the GABAA receptor." J.Neurochem.61. 2034-2040 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Bureau,M.H.: "GABAA receptor subtypes:ligand binding heterogeneity demonstrated by photoaffinity labeling and autoradiography." J.Neurochem.61. 1479-1491 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kokka,N.: "The kindling model of alcohol dependence:similar persistent reduction in seizure threshold to pentylenetetrazol in animals receiving chronic ethanol or chronic pentyenetetrazol." Alcohol Clin.Exp.Res.17. 525-531 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kokka,N.: "Sex differences in sensitivity to pentylenetetrazol but not in GABAA receptor binding." Pharmacol.Biochem.Behav.43. 441-447 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Olsen,R.W.: "GABA/benzodiazepine receptors in human focal epilepsy." Epilepsy Res.Suppl.8. 383-391 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Olsen,R.W.: "The GABAA receptor family in the mammalian brain." Neurochem.Res.16. 317-325 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yuguchi,T.: "Messenger RNA and protein expression of basic fibroblast growth factor receptor after cortical ablation." Brain Res.Mol.Brain Res.25. 50-56 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mushiake,S.: "Genes for members of the GATA-binding protein family(GATA-GT1 and GATA-GT2)together with H+/K(+)-ATPase are specifically transcribed in gastric parietal cells." FEBS Lett.340. 117-120 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shimizu,H.: "Effect of dibutyryl cyclic ANP on morphologic features and marker production of human cervical argyrophil small-cell carcinoma cell line." Int.J.Cancer. 56. 766-771 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kiyama,H.: "Growth factors and extracellular signalregulatedkinases(mitogen-activated protein kinase)in the rat pineal gland." Neuroendocrinology. 59. 152-155 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Araki,T.: "Differential immunocytochemical localization of GABAA receptor gamma 1 and gamma 2 subunits in the rat brain." Brain Res.Mol.Brain Res.20. 263-266 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tohyama,M.: "Aneurysmal dilatation of ductus arteriosus during lipo-prostaglandin E1 therapy for diaphragmatic hernia." Eur.J.Pediatr.152. 877-879 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sato,K.: "Gene expression of KA type and NMDA receptors and glycine transporter in the rat pineal gland." Neuroendocrinology. 58. 77-79 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Panula,P.: "Histamine-containing nerve fibers innervate human cerebellum." Neurosci.Lett.160. 53-56 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kiyama,H.: "Sympathetic ganglia express non-NMDA type glutamate receptors:distinct receptor subunit composition in the principle and SIF cells." Brain Res.Mol.Brain Res.19. 345-348 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sato,K.: "AMPA,KA and NMDA receptors are expressed in the rat DRG neurones." Neuroreport. 4. 1263-1265 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kiyama,H.: "Substance P receptor(NK-1)in the central nervous system:possible functions from a morphological aspect." Regul.Pept.46. 114-123 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Umemori,H.: "Specific expressions of Fyn and Lyn,lymphocyte antigen receptor-associated tyrosine kinases in the central nervous system." Brain Res.Mol.Brain Res.16. 303-310 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Miyamoto,L.Y.: "Purification and characterization of neurotensin receptor from rat brain with special reference to comparison between newborn and adult age rats." Peptides. 12. 1001-1006 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Son,J.H.: "Drastic and selective hyperinnervation of central serotonergic neurons in a lethal neurodevelopmental mouse mutant,Anorexia(anx)." Brain Res.Mol.Brain Res.25. 129-134 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kim,K.S.: "The cAMP-dependent protein kinase regulates transcription of the dopamine betahydroxylase gene." J.Neurosci.14. 7200-7207 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Park,D.H.: "Acute effects of reserpine on tryptophan hydroxylase activity and mRNA in rat brain." Brain Res.620. 331-334 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shikimi,T.: "Demonstration of a human urinary trypsin inhibitor(urinastatin)-like substance in the murine brain." Brain Res.616. 230-235 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kang,U.J.: "Regulation of dopamine production by genetically modified primary fibroblasts." J.Neurosci.13. 5203-5211 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Webb.T.E.: "Transient expression of the recombinant chick brain P2y1 purinoceptor and localization of th corresponding mRNA." Cell Mol.Biol.40. 437-442 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nayeem,M.: "Quaternary structure of the native GABAA receptor determined by electron microscopic image analysis." J.Neurochem.62. 815-818 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Glencorse,T.A.: "Sequence and novel distribution of the chicken homologue of the mammalian gamma-aminobutyric acid A receptor gamma 1 subunit." J.Neurochem.61. 2294-2302 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Fujita,R.: "Blocking effect of serotonin on betaadrenoceptor activity in follicle-enclosed Xenopus oocytes." Eur.J.Pharmacol.240. 213-217 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba,J.: "Behavioral and neurochemical effects of OPC-14597,a novel antipsychotics drugs,on dopaminergic mechanism in rat brain." Neuropharmacology. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba,J.: "Effect of systemic dexamethasone on extracellular amino acids(glutamate,aspartate,glycine and GABA)and acetylcholine release in rat hippocampusin vivo microdialysis." Functional Neurology. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba,J.: "Characterisation of extracellular amino acids in striatum of freely moving rats by in vivo microdialysis." J.of Neural Transmission. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kto,S.: "Effect of nicotine on glucocorticoid toxicity on hippocampal neurons." Neurochemical Research. 19. 888-889 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba,J.: "Antiepileptic drug pharmacokinetics and neuropharmacokinetics in individual rats by repetitive withdrawal of blood and cerebrospinal fluid:milacemide." Br.J.Pharmacol.108. 1117-1124 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba,J.: "Milacemide effects on the temporal interrelationship of amino acids and monoamine metabolites in rat cerebrospinal fluid." European Journal of Pharmacology. 230. 321-326 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba,J.: "Behavioral and neurochemical effects of OPC-14597,a novel antipsychotics drugs,on dopaminergic mechanism in rat brain." Neuropharmacology. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba,J.: "Effect of systemic dexamethasone on extracellular amino acids(glutamate,aspartate,glycine and GABA)and acetylcholine release in rat hippocampus in vivo microdialysis." Functional Neurology. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba,J.: "Characterisation of extracellular amino acids in striatum of freely moving rats by in vivo microdialysis." J.of Neural Transmission. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kito,S.: "Effect of nicotine on glucocorticoid toxicity on hippocampal neurons." Neurochemical Research. 19. 888-889 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kito,S.: "Effects of glucocorticoid on hippocampal neurons:in vivo and in vitro studies." Neurochemical Reserach. 18. 832 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ma,Z.Q.: "Insulin-like growth factors activate estrogen receptor to control the growth and differentiation of the human neuroblastoma cell line SK-ER3." Mol.Endocrinol.8. 910-918 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Santagati,S.: "Estrogen receptor is expressed in different types of glial cells in culture." J.Neurochem.63. 2058-2064 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ma.Z.Q.: "Estrogen modulation of catecholamine synthesis and monoamine oxidase A activity in the human neuroblastoma cell line SK-ER3." J.Steroid Biochem.Mol.Biol.47. 207-211 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Santagati,S.: "Theoretical considerations for the application of competitive polymerase chain reaction to the quantitation of a low abundance mRNA:estrogenreceptor." Biochem.Pharmacol.46. 1797-1803 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Canonaco,M.: "Steroid hormones and receptors of the GABAA supramolecular complex.II.Progesterone and estrogen inhibitory effects on the chloride ion channel receptor in different forebrain areas of the female rat." Neuroendocrinology. 57. 974-984 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ma.Z.Q.: "Activated estrogen receptor mediates growth arrest and differentiation of a neuroblastoma cell line." Proc.Natl.Acad.Sci.USA. 90. 3740-4744 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Spreafico,E.: "Nucleotide sequence of estrogen receptor cDNA from Sprague-Dawley rat." Eur.J.Pharmacol.227. 353-356 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kito,S.: "Biochemistry,Pharmacology and Behavior edited by Kameyama,T.,Nabeshima,T.,Domino,E.F.," NPP Books, 9 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kito,S.: "Neuroreceptor Mechanisms in Brain,edited by Kito,S.,Segawa,T.and Olsen,R.W." Plenum Press,New York, 10 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Miyoshi,R.: "The Basal.Ganglia III,edited by Bernardi,G.,Carpenter,M.B.,Di Chiara,G.,Morelli,M.and Stanzione,P.," Plenum Press,New York,7 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba, J.: "Behavioral and neurochemical effects of OPC-14597, a novel antipsychotics drugs, on dopaminergic mechanisms in rat brain." Neuropharmacology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba, J.: "Effect of systemic dexamethasone on extracellular amino acids (glutamate, aspartate, glycine and GABA) and acetylcholine release in rat hippocampus in vivo microdialysis." Functional Neurology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba, J.: "Characterisation of extracellular amino acids in striatum of freely moving rats by in vivo microdialysis." J.of Neural Transmission. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kito, S.: "Effect of nicotine on glucocorticoid toxicity on hippocampal neurons." Neurochemical Research. 19. 888-889 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kito, S.: "Effects of glucocorticoid on hippocampal neurons : in vivo and in vitro studies." Neurochemical Research. 18. 832- (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Miyoshi, R.: "Effect of caerulein on expression of the immediate early genes, c-fos and zif/268 in the rat brain." Neuroscience Letters. 145. 205-208 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Miyoshi, R.: "Cholecystokinin increases intracellular Ca^<2+> concentration in cultured striatal neurons." Neuropeptides. 18. 115-119 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Miyoshi, R.: "Influence of age on N-methyl-D-aspartate antagonist binding sites in the rat brain studied by in vitro autoradiography." Synapse. 8. 212-217 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Miyoshi, R.: "Effect of age on alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) binding sites in the rat brain studied by in vitro autoradiography." Neurochemical Research. 16. 848-854 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tyndale, R.F.: "Distinctive patterns of GABAA receptor subunit mRNAs in 13 cell lines" J.Neurosci.14. 5417-5428 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Smith, G.B.: "Identification of a [3H] muscimol photoaffinity substrate in the bovine gamma-aminobutyric acid A receptor alpha subunit." J.Biol.Chem.269. 20380-20387 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kim, H.Y.: "GABA alters GABAA receptor mRNAs and increases ligand binding." J.Neurochem.61. 2334-2337 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Machu, T.K.: "Immunochemical characterization of the beta 2 subunit of the GABAA receptor." J.Neurochem.61. 2034-2040 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Bureau, M.H.: "GABAA receptor subtypes : ligand binding heterogeneity demonstrated by photoaffinity labeling and autoradiography." J.Neurochem.61. 1479-1491 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kokka, N.: "The kindling model of alcohol dependence : similar persistent reduction in seizure threshold to pentylenetetrazol in animals receiving chronic ethanol or chronic pentylenetetrazol." Alcohol Clin.Exp.Res.17. 525-531 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kokka, N.: "Sex differences in sensitivity to pentylenetetrazol but not in GABAA receptor binding." Pharmacol.Biochem.Behav.43. 441-447 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Olsen, R.W.: "GABA/benzodiazepine receptors in human focal epilepsy." Epilepsy Res.Suppl.8. 383-391 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Olsen, R.W.: "The GABAA receptor family in the mammalian brain." Neurochem.Res.16. 317-325 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yuguchi, T.: "Messenger RNA and protein expression of basic fibroblast growth factor receptor after cortical ablation." Brain Res.Mol.Brain Res.25. 50-56 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mushiake, S: "Genes for members ther with H+/K (+)-ATPase are specifically transcribed in gastric parietal cells." FEBS Lett.340. 117-120 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shimizu, H.: "Effect of dibutyryl cyclic ANP on morphologic features and marker production of human cervical argyrophil-small-cell carcinoma cell line." Int.J.Cancer. 56. 766-771 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kiyama, H.: "Growth factors and extracellular signal-regulated kinases (mitogen-activated protein kinase) in the rat pineal gland." Neuroendocrinology. 59. 152-155 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Araki, T.: "Differential immunocytochemical localization of GABAA receptor gamma 1 and gamma 2 subunits in the rat brain." Brain Res.Mol.Brain Res.20. 263-266 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tohyama, M.: "Aneurysmal dilatation of ductus arteriosus during lipoprostaglandin E1 therapy for diaphragmatic hernia." Eur.J.Pediatr.152 :. 877-879 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Miyamoto, L.Y.: "Purification and characterization of neurotensin receptor from rat brain with special reference to comparison between newborn and adult age rats." Peptides. 12. 1001-1006 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Son, J.H.: "Drastic and selective hyperinnervation of central serotonergic neurons in a lethal neurodevelopmental mouse mutant, Anorexia (anx)." Brain Res.Mol.Brain Res.25. 129-134 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kim, K.S.: "The cAMP-dependent protein kinase regulates transcription of the dopamine beta-hydroxylase gene." J.Neurosci.14. 7200-7207 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Park, D.H.: "Acute effects of reserpine on tryptophan hydroxylase activity and mRNA in rat brain." Brain Res.620. 331-334 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shikimi, T.: "Demonstration of a human urinary trypsin inhibitor (urinastatin)-ike substance in the murine brain." Brain Res.616. 230-235 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kang, U.J.: "Regulation of dopamine production by genetically modified primary fibroblasts." J.Neurosci.13. 5203-5211 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sato, K.: "Gene expression of KA type and NMDA receptors and glycine transporter in the rat pineal gland." Neuroendocrinology. 58. 77-79 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Panuia, P.: "Histamine-containing nerve fibers innervate human cerebellum." Neurosci.Lett.160. 53-56 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kiyama, H.: "Sympathetic ganglia express non-NMDA type glutamate receptors : distinct receptor subunit composition in principle and SIF cells." Brain Res.Mol.Brain Res.19. 345-348 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sato, K.: "AMPA,KA and NMDA receptors are expressed in the rat DRG neurones." Neuroreport. 4. 1263-1265 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kiyama, H.: "Substance P receptor (NK-1) in the central nervous system : possible functions from a morphological aspect." Requl.Pept.46. 114-123 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Umemori, H.: "Specific expressions of Fyn and Lyn, lymphocyte antigen receptor-associated tyrosine kinases in the central nervous system." Brain Res.Mol.Brain Res.16. 303-310 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Webb.T.E.: "Transient expression of the recombinant chick brain P2y1 purinoceptor and localization of the corresponding mRNA." Cell Mol.Biol.40. 437-442 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nayem, N.: "Quaternary structure of the native GABAA receptor determined by electron microscopic image analysis." J.Neurochem.62. 815-818 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Glencorse, T.A.: "Sequence and novel distribution of the chicken homologue of the mammalian gamma-aminobutyric acid A receptor gamma 1 subunit." J.Neurochem.61. 2294-2302 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Fujita, R.: "Blocking effect of serotonin on beta-adrenoceptor activity in follicle-enclosed Xenopus oocytes." Eur.J.Pharmacol.240. 213-217 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba, J.: "Behavioral and neurochemical effects of OPC-14597, a novel antipsychotics drugs, on dopaminergic mechanisms in rat brain." Neuropharmacology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba, J.: "Effect of systemic dexamethasone on extracellularamino acids (glutamate, aspartate, glycine and GABA) and acetylcholine release in rat hippocampus in vivo microdialysis." Functional Neurology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba, J.: "Characterisation of extracellular amino acids in striatum of freely moving rats by in vivo microdialysis." J.Neural Transmissionin. (press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kito, S.: "Effect of nicotine on glucocorticoid toxicity on hippocampal neurons." Neurochemical Research. 19. 888-889 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba, J.: "Antiepileptic drug pharmacokinetics and neuropharmacokinetics in individual rats by repetitive withdrawal of blood and cerebrospinal fluid milacemide." Br.J.Pharmacol.108. 1117-1124 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba, J.: "Milacemide effects on the temporal interrelationship of amino acids and monoamine metabolites in rat cerebrospinal fluid." European Journal of Pharmacology. 230. 321-326 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba, J.: "Behavioral and neurochemical effects of OPC-14597, a novel antipsychotics drugs, on dopaminergic mechanisms in rat brain." Neuropharmacology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba, J.: "Effect of systemic dexamethasone on extracellular amino acids (glutamate, aspartate, glycine and GABA) and acetylcholine release in rat hippocampus in vivo microdialysis." Functional Neurology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Semba, J.: "Characterisation of extracellular amino acids in striatum of freely moving rats by in vivo microdialysis." J.of Neural Transmission. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kito, S.: "Effect of nicotine on glucocorticoid toxicity on hippocampal neurons." Neurochemical Research. 19. 888-889 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kito, S.: "Effects of glucocorticoid on hippocampal neurons : in vivo and in vitro studies." Neurochemical Research. 18. 832 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ma.Z.Q.: "Insulin-like growth factors activate estrogen receptor to control the growth and differentiation of the human neuroblastoma cell line SK-ER3." Mol.Endocrinol.8. 910-918 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Santagati, S.: "Estrogen receptor is expressed in different types of glial cells in culture." J.Neurochem.63. 2058-2064 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ma, Z.Q.: "Estrogen modulation of catecholamine synthesis and monoamine oxidase A activity in the human neuroblastoma cell line SK-ER3." J.Steroid Biochem.Mol.Biol.47. 207-211 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Santagati, S.: "Theoretical considerations for the application of competitive polymerase chain reaction to the quantitation of a low abundance mRNA : estrogenreceptor." Biochem.Pharmacol.46. 1797-1803 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Canonaco, M.: "Steroid hormones and receptors of the GABAA supramolecular complex. II.Progesterone and estrogen inhibitory effects on the chloride ion channel receptor in different forebrain areas of the female rat." Neuroendocrinology. 57. 974-984 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ma.Z.Q.: "Activated estrogen receptor mediates growth arrest and differentiation of a neuroblastoma cell line." Proc.Natl.Acad.Sci.USA. 90. 3740-3744 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Spreafico, E.: "Nucleotide sequence of estrogen receptor cDNA from Sprague-Dawley rat." Eur.J.Pharmacol.227. 353-356 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kito, S.: NPP Books. Biochemistry, Pharmacology and Behavior edited by Kameyama, T., Nabeshima, T., Domino, E.F., 299-308 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kito, S.: Plenum Press, New York. Neuroreceptor Mechanisms in Brain, edited by Kito, S., Segawa, T.and Olsen, R.W., 1-11 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Miyoshi, R.: Plenum Press, New York. The Basal.Ganglia III,edited by Bernardi, G., Carpenter, M.B., Di Chiara, G., Morelli, M.and Stanzione, P., 371-378 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Miyoshi,R.: "Effect of caerulein on expression of the immediate-early genes c-fos and zif/268 in the rat brain." Neuroscience Letters. 145. 205-208 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Miyoshi,R.: "Effect of estrogen on immediate early gene exprssion in the rat brain." Society for Neuroscience Abstracts. 18. 57.1 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kito,S.: "Effect of glucocorticoid on in vivo release of neurotransmitters from the rat hippocampus." Society for Neuroscience Abstracts. 18. 57.4 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Shimoyama,M.: "Effect of mineralcorticoid on in vivo release of neurotransmitters from the rat hippocampus." Society for Neuroscience Abstracts. 18. 57.3 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kito,S.: "A cytoprotective effect of nicotine on hippocampal neurons." Society for Neuroscience Abstracts. 19. 772.15 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Miyoshi,R.: "Effect of nicotine on neurotransmitter release from the rat hippocampus." Society for Neuroscience Abstracts. 19. 384.6 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kito,S.: "Effect of glucocorticoid on hippocampal neurons:in vivo and in vitro studies." Neurochemical Research. 18. 801-860 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kokka,N.: "The kindling model of alcohol dependence:similar persistent reduction in seizure threshold to pentylenetetrazol in animals receiving chronic ethanol" Alcohol clin.Exp.Res.17. 525-531 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kokka,N.: "The kindling model of alcohol dependence:similar persistent reduction in seizure threshold to pentylenetetrazol in animals receiving chronic ethanol" Alcohol clin.Exp.Res.17. 525-531 (1993)"or chronic pentylenetrazol"

    • Related Report
      1993 Annual Research Report
  • [Publications] Longoni,B.: "Enhancement of gamma-aminobutyric acidA receptor function and binding by the volatile anesthetic halothane" J.Pharmacol.Exp.Ther.266. 153-159 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Browning,M.D.: "Phosphorylation of the GABAA receptor by CAMP-dependent protein kinase and by protein kinase C:analysis of the substrate domain" Neurochem.Res.18. 95-100 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Maeda,T.: "Bidirectional modulation of long-term potentiation by carbachol via M_1 and M_2 muscarinic receptors in guinea pig hippocampal mossy liber‐CA3 synapses." Brain Research Biophysical Research Communications. 619. 324-330 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ozaki,M.: "A vaccinia virus vector for efficiently introducing into hippocampal slices." Biochemical and. 193. 653-660 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Nakamura,S.: "Potentiation of a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid(AMPA)-selective glutamate receptor function by a nootropic drug.idebenone." Biol.Pharm.Bull.17. 70-73 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Masana Y: "Localization of trkB mRNA in postnatal brain development." J Neurosci Res. 35. 468-79 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshimura R: "Localization of oxytocin receptor messenger ribonucleic acid in the rat brain." Endocrinology. 133. 1239-46 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Takatsuji K: "Differential effects on substance P immunoreactivity in rat suprachiasmatic and olivary pretectal nuclei." Neuroreport. 4. 647-50 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kito,S.: "A cytoprotective effect of nicotine on hippocampal neurons." Society for Neuroscience Abstracts. 19. 772.15 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Miyoshi,R.: "Effect of nicotine on neurotransmitter release from the rat hippocampus." Society for Neuroscience Abstracts. 19. 384.6 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kito,S.: "Effect of glucocorticoid on hippocampal neurons:in vivo and in vitro studies." Neurochemical Research. 18. 801-860 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Weiser,M.: "Differntial spatial and temporal gene expression in response to axotomy and differentation following transection of the medial forebrain bundle" J.Neurosci.13. 3472-3484 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kim,K.S.: "Both the basal and inducible transcription of the tyrosine hydroxylase gene are dependent upon a cAMP response element" J.Biol.Chem.268. 15689-15695 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Weiser,M.: "Axotomy-induced differential gene induction in neurons of the locus ceruleus and substantia nigra." Brain Res.Mol.Brain Res.17. 319-327 (1993)

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      1993 Annual Research Report
  • [Publications] Fraser,C.M.: "Beta-adrenergic and muscarinic cholinergic receptors:relationship between primary structure,receptor function and regulation" American Review of Respiratory Disease. 141. (1990)

    • Related Report
      1993 Annual Research Report
  • [Publications] Venter,J.C.: "Isolation,purification and molecular biology of cell membrane receptors" Comprehensive Medicinal Chemistry. 3. (1990)

    • Related Report
      1993 Annual Research Report
  • [Publications] Venter,J.C.: "Genome sequencing conference I:Summary" Genomics. 8. (1990)

    • Related Report
      1993 Annual Research Report
  • [Publications] Usherwood,P.N.: "Channels formed:by M2 peptides of a putative glutamate receptor subunit of locust." EXS. 63. 241-249 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kerry,C.J.: "Reconstitution of glutamate receptor proteins purified from xenopus central nervous system into artificial bilayers." Mol.Pharmacol.44. 142-152 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Webb,T.E.: "Cloning and functional expression of a brain G-proteincoupled ATP receptor." FEBS Lett.324. 219-225 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Semba,J.: "Antiepileptic drug phrmacokinetics and neuropharmacokinetics in individual rats by repetitive withdrawal of blood and cerebrospinal fluid:milacemide." Br.J.Pharmacol.108. 1117-1124 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Semba,J.: "Milacemide effcts on the temporal interrelationship of amino acids and monoamine metabolites in rat cerebrospinal fluid." European Journal of Pharmacology. 230. 321-326 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoneda,Y Ogita,K: "Heterogeneity of the N-methy1-D-aspartate receptor ionophore complex in rat brain,as revealed by ligand binding techniques." J.Pharmacol Exp Ther. 259. 86-96 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoneda,Y.,Ogita,K.,Emoto,R.,Suzuki,T.,Kito,S.: "Identification and characterization of specific binding site of〔^3H〕spermidine in synaptic membranes of rat brain" Brain Research. 563. 17-27 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tamaru,M.,Yoneda,Y.,Ogita,K.,Shimizu,J.,Nagata,Y.: "Age-related decreases of the N-methy1-D-aspartate receptor complex in the rat cerebral cortex and hippocampus." Brain Res.542. 83-90 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoneda,Y.,Ogita,K.: "Inhibitory modulation by sodium ions of the N-methy1-D-aspartate recognition site in brain synaptic membranes." J.Neurochem.57. 2036-2046 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoneda,Y.: "Neurochemical aspects of the N-methy1-D-aspartate receptor complex" J.Neurosci.10. 1-33 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Miyoshi,R.,Kito,S.,: "Effect of cerulein expression of the immediate early genes,c-fos and zif/268 in the rat brain" Neuroscience・Letter. 145. 205-208 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoneda,Y.: "N-methy1-D-aspartate-sensitive〔^3H〕glutamate binding sites in brain synaptic membranes treated with Triton X-100." Biochem.1012. 74-80 (1989)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoneda,Y.: "Interaction of strychnine-insensitive glycine binding with MK-801 binding in synaptic membranes." J.Neurochem.55. 237-244 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kito,S.,Miyoshi,R.,Nomoto,T.: "Influence of age on NMDA receptor complex in rat brain studied by in vitro autoradiography" J.Histochemistry and Cytochemistry. 38/12. 1725-1731 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] Miyoshi,R.,Kito,S.,Doudou,N.Nomoto,T.: "Age-related changes of strychnine-insensitive glycine receptors in the rat brain studied by in vitro autoradiography" SYNAPSE. 6. 338-343 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] Miyoshi,R.,Kito,S.,Doudou,N.,Nomoto,T.: "Influence of age on N-methy1-D-aspartate antagonist binding sites in the rat brain studied by in vitro autoradiogradiography" SYNAPSE. 8/3. 212-217 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Miyoshi,R.,Kito,S.,Doudou,N.,Nomoto,T.: "Effect of age on α-amino-3-hydroxy-5 methylisoxazole-4-propionic acid(AMPA)binding sites in the rat brain studied by in vitro autoradiography" Neurochem.Res.,. 16. 848-854 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kito,S.,Miyoshi,R.,Nomoto,T: "NMDA Receptor Related Agents" NPP Books, 414 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kito,S.,Miyoshi,R: "Neurotransmitter Receptors:Neuroreceptors Mechanism in Brain" Plenum Press, 495 (1991)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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