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Totally Implantable artificial heart & its hemocompatibility

Research Project

Project/Area Number 04044192
Research Category

Grant-in-Aid for Overseas Scientific Survey.

Allocation TypeSingle-year Grants
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

TAKANO Hisateru  National Cardiovascular Center Research Institute, Dept. of Artificial Organs, 人工臓器部, 部長 (60028595)

Co-Investigator(Kenkyū-buntansha) YOON Shin Lee  Seoul National University, Dept. of Biomedical Engineering, 医学部生体医工学研究所, 特別研究員
CHEOL Sang Kim  Seoul National University, Dept. of Biomedical Engineering, 医学部生体医工学研究所, 講師
HAN Ik Jo  Seoul National University, Dept. of Biomedical Engineering, 医学部臨床病理学, 教授
KYUNG Phil Seo  Seoul National University, Dept. of Biomedical Engineering, 医学部胸部外科, 教授
IN Seon Shin  Seoul National University, Dept. of Biomedical Engineering, 医学部生体医工学研究所, 特別研究員
SEON Yang Park  Seoul National University, Dept. of Biomedical Engineering, 医学部内科医学, 准教授
BYOUNG-GOO Min  Seoul National University, Dept. of Biomedical Engineering, 医学部生体工学研究所, 教授
TAENAKA Yoshiyuki  National Cardiovascular Center Research Institute, Dept. of Artificial Organs, 人工臓器部, 室長 (00142183)
IMACHI Kou  University of Tokyo, Institute of Medical Electronics, 医用電子研究施設, 助教授 (10010076)
MATSUDA Takeshi  National Cardiovascular Center Research Institute, Dept. of Biomedical Engineeri, 生体工学部, 部長 (60142189)
KATO Hisao  National Cardiovascular Center Research Institute, Dept. of Etiology and Pathoge, 病因部, 部長 (80029959)
Project Period (FY) 1992
Project Status Completed (Fiscal Year 1992)
KeywordsArtificial heart / Hemocopatibility / Total implantation / Electrohydraulic artificial heart / Electromechanical artificial heart / Hybrid tissue / Centrifugal pump / Energy transfer
Research Abstract

The purposes of this international cooperative study are exchanging scientific ideas and discussing technological subjects to develop a totally implantable artificial heart. The technology includes the improvement of hemocompatibility, mainly antithrombogenicity, of a device and the establishment of basic technology for the development. In this fiscal year, The Second Korea-Japan Joint Conference was held in Suita, Osaka, Japan as a workshop to reach for the purposes and progresses of the technology were reported.
1.Basic research and development of components of a implantable artificial heart.
An electrohydraulic actuator to activate a total artificial heart was developed and improvements of output performance of the pump system was carried out in National Cardiovascular Center N(NCVC) of Japan. In Hokkaido Tokai University, an electro-mechanical ventricular assist device has evaluated in a mock loop. Research development of a moving-actuator-type total artificial heart was conducted in … More Seoul National University (SNU) in Korea. A transcutaneous energy transfer system was also designed and its in vitro and in vivo characteristics were evaluated in Japan. Concerning blood pumps, bilcaflet-type of SNU and jellyfish-like-shaped of Tokyo University polymer valves were investigated for application as artificial valves, and configuration of blood chambers of a sac-type pump of SNU and a centrifugal pump of NCVC was studied flow visualization techmiques.
2.Basic research in hemocompatibility of artificial organs and its application to blood pumps.
In order to improve the antithrombogenicity of a blood pump, a few investigations were carried out. They were development of an antithrombogenic polyurethane, application of a bioengineering technology of hybrid tissues, endothelial cell seeding onto extracellular matrix on polyurethane sheets, and lumbrokinase- immobilization on the surface of a blood pump. The first two were accomplished Japan and the latter two were in Korea. Basic research activities were molecular biological studies on tissue factor pathway inhibitor and adsorption of the surface in a total artificial heart and a left ventricular assist device.
3.Evaluation of the performance of artificial hearts.
An electrohydraulic total artificial heart and a centrifugal pump were applied to experimental animals and satisfactory in vivo performances were proved in NCVC. A moving-actuator-type artificial heart of SNU was implanted in a calf and the circulation of the animal was maintained for 10 hours. Postoperative management of an animal with an artificial heart was simulated by a computer in SNU. Less

Report

(1 results)
  • 1992 Final Research Report Summary
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Hisateru Takano,MD,PhD,Takeshi Nakatani,MD,PhD,Yoshiyuki Taenaka,MD,PhD: "Clinical Experience With Ventricular Assist Systems in Japan." Ann Thorac Surg. 55. 250-256 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Enjyoji,M.Emi,T.Mukai,H.Kato: "CDNA Cloning and expression of rat tissue factor path-way inhibitor(TFPI)." J.Biochem. 111. 681-687 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshiyuki Taenaka,Kazushige Inoue,Toru Masuzawa,Kenji Araki,Masayuki Sakaki,Hisateru Takano,et al.: "Infuluence of an Impeller Centrifugal Pump on Blood Components in Chronic Animal Experiments." Reprint from ASAIO TRANSACTIONS. 38. M577-M579 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Miwa,T.Matsuda,K.Kondo,N.Tani,Y.Fukaya,M.Morimoto,F.Iida: "Improved Patency of an Elastomeric Vascular Graft by Hybridization." ASAIO Journal. 38. M512-M515 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kou Imachi,Kunihiko Mabuchi,TsuneoChinzei,Yusuke Abe,Kaoru Imanishi,Takumi Yonezawa,Akimasa Kouno,et al: "Fabrication of a Jellyfish Valve for Use in an Artiticial Heart." ASAIO Journal. 38. M237-M242 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hisateru Takano, MD, PhD, Takeshi Nakatani, MD, PhDz, Yoshiyuki Taenaka, MD, PhD: "Clinical Experience With Ventricular Assist Systems in Japan." Ann Thorac Surg. 55. 250-256 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Enjyoji, M.Emi, T.Mukai, H.Kato: "CDNA Cloning and expression of rat tissue factor pathway inhibitor (TFPI)" J. Biochem. 111. 681-687 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshiyuki Taenaka, Kazushige Inoue, Toru Masuzawa, Kenji Araki, Masayuki Sakaki, Hisateru Takano, et: "Infuluence of an Impeller Centrifugal pump on Blood Components in Chronic Animal Experiments." Reprint from ASAIO TRANSACTIONS. 38. M577-M579 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Miwa, T.Matsuda, K.Kondo, N Tani, Y.Fukaya, M.Morimoto, F.Iida: "Improved Patency of an Elastomeric Vascular Graft by Hybridization." ASAIO Journal. 38. M512-M515 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kou Imachi, Kunihiko Mabuchi, Tsuneo Chinzei, Yusuke Abe, Kaoru Imanishi, Takumi Yonezawa, Akimasa Kouno, et al: "Fabrication of a Jellyfish Valve for Use in an Artificial Heart." ASAIO Journal. 38. M237-M242 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary

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Published: 1994-03-24   Modified: 2016-04-21  

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