| Project/Area Number |
04045047
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | University-to-University Cooperative Research |
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| Research Institution | KITASATO University |
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Principal Investigator |
YOSHIKAWA Takashi KITASATO University, 獣医畜産学部, 教授 (80050467)
吉川 堯 (1994) 北里大学, 獣医畜産学部, 教授
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| Co-Investigator(Kenkyū-buntansha) |
WEI Xubin Changchun University, China, 助教授
王 水琴 長春農牧大学, 教授
LI Yangxian Changchun University, China, 教授
OYAMADA Toshifumi KITASATO University, 獣医畜産学部, 講師 (20160947)
OGASAWARA Toshimi KITASATO University, 獣医畜産学部, 講師 (90050674)
YOSHIKAWA Hiroyasu KITASATO University, 獣医畜産学部, 助教授 (70101516)
WANG Shuiqin Changchun University, China
李 毓義 長春農牧大学, 獣医学部, 教授
劉 宝岩 長春農牧大学, 獣医学部, 教授
小山 弘之 北里大学, 獣医畜産学部, 教授 (00072372)
椿 志郎 北里大学, 獣医畜産学部, 教授 (70050507)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 1994: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1993: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1992: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Copper deficiency / sika deer (Cervus nippon) / enzootic spinal ataxia / histopathology / China / 中国 / 脱髄 / 弾性線維 / ミトコンドリア / ペルオキシゾーム / 運動性失調症 / 脊髄白質変性 / 免疫異常 |
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| Research Abstract |
Enzootic spinal ataxia in deer has been described by workers in many parts of the world, but there have been no previous reports of this disease occurring in China.
This report deal with histopathology of enzootic spinal ataxia in sika deer (Cervus nippon Temminck), encountered at stock farm in the Northeastern District of China.
Clinical findings : Enzootic spinal ataxia occurred about 10% of all Sika deer on one stock farm where 1,500-2,000 deer were farmed. Affected deer showed progressive lumber weakness, posterior wobbling, and/or unsteady gait. These condition developed progressively and chronically. In severe cases, growth was retarded, and depigmentation of and alopecia of ordinary hair, especially around eyes were also observed. In some cases deformity of the extremities and bone fracture were observed.
Histological findings : Thirteen sika deer aged from 4 to 9 years were examined. The principal pathologic changes were (1) spongy vacuolation and myelin deficiency in white matter of the spinal cord and brain stem, (2) fibrosis and rupture of elastic fibers of the spinal arterioles, and (3) mesothelial hyperplasia in the spinal aracroid.
Serum copper values were significantly lower than those of normal Sika deer.
Pathogenesis of the demyelinating change in spinal white matter are discussed in relation to the arterial lesions. The possible role of copper deficiency in the etiology of the condition is discussed.
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