| Project/Area Number |
04102006
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| Research Category |
Grant-in-Aid for Specially Promoted Research
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| Allocation Type | Single-year Grants |
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| Research Institution | University of Tokyo |
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Principal Investigator |
NATORI Shunji Tokyo Univ.Pharmaceutical Sci.Prof., 薬学部, 教授 (50012662)
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| Co-Investigator(Kenkyū-buntansha) |
KURATA S Tokyo Univ.Pharmaceutical Sci.Assistant Prof., 薬学部, 助手 (90221944)
KUBO T Tokyo Univ.Pharmaceutical Sci.Lecturer, 薬学部, 講師 (10201469)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥175,000,000 (Direct Cost: ¥175,000,000)
Fiscal Year 1994: ¥50,000,000 (Direct Cost: ¥50,000,000)
Fiscal Year 1993: ¥55,000,000 (Direct Cost: ¥55,000,000)
Fiscal Year 1992: ¥70,000,000 (Direct Cost: ¥70,000,000)
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| Keywords | Sarcophaga / Defense system / Development / Antibacterial protein / Sapecin / Imaginal disc / Ptassium channel / Proteinase / 個体発生 / カリウムチンネル / プロテア-ゼ / 転写因子 / Sarcophagaレクチン / レクチンリセプター |
|---|
| Research Abstract |
Insect have developed a unique defense system against various outside stimuli such as microbial infection and integmental injury. We have been studying various defense proteins of Sarcophaga peregrina (the flesh fly). These proteins include a lectin and several antibacterial proteins. Throughout these studies, we came to the conclusion that there are two important novel aspects of these defense proteins. One is that a single defense protein probably plays at least two roles in defense and development. Insects probably have the flexibility to use one defense protein in multiple ways. The other interesting aspect is the phylogenetical significance of the insect defense system. Insect defense system is possibly a prototype of the mammalian defense system. Except these two important aspects, we obtained various important findings on insect immnity. Most of these findings have been published.
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