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動的天然物化学の総合的研究

Research Project

Project/Area Number 04220102
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionTohoku University

Principal Investigator

小倉 協三  東北大学, 反応化学研究所, 教授 (80006303)

Co-Investigator(Kenkyū-buntansha) 砂本 順三  京都大学, 工学部, 教授 (80037811)
大橋 守  電気通信大学, 電気通信学部, 教授 (70015535)
杉浦 幸雄  京都大学, 化学研究所, 教授 (40025698)
楠本 正一  大阪大学, 理学部, 教授 (30028253)
市原 耿民  北海道大学, 農学部, 教授 (20000820)
Project Period (FY) 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥17,000,000 (Direct Cost: ¥17,000,000)
Fiscal Year 1993: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1992: ¥14,000,000 (Direct Cost: ¥14,000,000)
Keywords動的天然物化学 / 生物発光 / 分子認識 / 生理活性化合物 / 糖質 / 核酸 / 酵素 / 人工細胞 / 精密構造認識 / 生体低分子 / 励起分子 / 細胞表層
Research Abstract

重点領域研究「動的天然物化学」は、これまでの天然物化学が主流としてきた「構造」と「合成」を二本柱とした研究から脱却して、生物活性化合物による生物活性発現機構の本質を追求することを目標として、平成2年度に開始され、4年度を以て終了した。その間、多大の成果をあげることができた。それらは生命現象解明への寄与にとどまらず、動的天然物化学の概念を基盤とした「天然超分子の化学」なる新学問分野の萌芽をもたらした。また、当初の期待通り、班内のみならず班間にまたがる多くの協同研究が生まれた。それらは、ますます新分野の発展に大きく貢献するものと考えられる。そこで、本年度は3年間の本領域研究を総括するとともに、これらの成果を一般に公開し、批判をあおぐために、6月に名古屋大学において動的天然物化学とりまとめのシンポジウムを開催した。シンポジウムでは、6名の班長が各班の研究成果の要約とコメントを行ったのち、近藤忠雄、渡辺裕、平間正博、三川潮、磯部稔、砂本順三の各氏が詳細な成果報告を行った。このシンポジウムは名古屋大学で開催されたEschenmoser教授(スイス、ETH)の特別講演会と日時を接するようにプログラムを組み、同教授にも出席を招請した。また、班員全員が同教授の講演会にも出席できるように企画したため、収穫大きいシンポジウムとなった。また、3年間の成果報告書の和文版と英文版を作製し、内外の研究者に送付したほか、班員の3年間の活動状況をまとめた資料を作成した。

Report

(2 results)
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] 小倉協三ほか: "Dynamic Aspects of Natural Product Chemistry" 「動的天然物化学」事務局, 141 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Sagami: "Studies on Geranylgeranyl Diphosphate Synthase from Rat Liver" Arch.Biochem.Biophys.297. 314-320 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Gotoh: "Farnesyl Diphosphate Synthase and Solanesyl Diphosphate Synthase Reactions of Diphosphhate-Modified Allylic Analogs" J.Biochem.112. 20-27 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] H.Sagami: "Separation of Dolichol from Dehydrodolichol by a Simple Two-Plate Thein-Layer Chromatography" J.Lipid.Res.33. 1857-1862 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Ohnuma: "Chain Length Distribution of the Products Formed in Solanesyl Diphosphate Synthase Reaction" J.Biochem.112. 743-749 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Koyama: "Thermostable Farnesyl Diphosphate Synthase of Bacillus Stearothermophilus:Molecular Cloning,Sequence Determination,Overproduction,and Purification" J.Biochem.113. 355-363 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] H.Sagami: "Formation of Dolichol from Dehydrodolichol is Catalyzed by NADPH-Dependent Reductase Localized in Microsomes of Rat Liver" J.Biol.Chem.

    • Related Report
      1992 Annual Research Report
  • [Publications] H.Oikawa: "Biosynthetic Study of Chaetoglobosin A:Origins of the Oxygen and Hydrogen Atoms,and Indirect Evidence for Biological Diels-Alder Reaction" J.Chem.Soc.,Perkin Trans.I. 2955-2959 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 市原 耿民: "先導的バイオサイエンスのための有機合成化学的展開ー生体内Diels-Alder反応の可能性ー" 有機合成化学協会誌. 50. 96-111 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] H.-M.Kuhn: "Characterization of Epitope Specificity of Murine Monoclonal Antibodies Directed against Lipid A" Infect.Immun.60. 2201-2210 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Fukase: "Synthetic Study on Lipoteichoic Acid of Gram Negative Bacteria.1.Synthesis of Proposed Fundamental Structure of Streptococcus pyogenes Lipoteichoic Acid" Bull.Chem.Soc.Jpn.65. 2643-2654 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] A.Ichikawa: "Activation of DNA Cleavage by Dynemicin A in a B-Z Conformational Junction" Biochemistry. 31. 6784-6787 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Shiraki: "C-1'Hydrogen Abstraction of Deoxyribose in DNA Strand Scission by Dynemicin A" Biochem.Biophys.Res.Commun.188. 584-589 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] M.Uesugi: "DNA Cleaving Modes in Minor Groove of DNA Helix by Esperamicin and Calicheamicin Antitumor Antibiotics" Nucleic Acids Res.(Sym.Ser.). 27. 1-2 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] M.Tokuda: "Synthesis of a Hybrid Molecule Containing Neocarzino-statin Chromophore Analogue and Minor Groove Binder" Tetrachedron Lett.34. 669-672 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Kurono: "Detection of Molecular Ions of Cyclodextrin Inclusion Complexes" Org Mass Spectrom.27. 1157-1160 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Tsujimoto: "Stereoselective Photoisomerization of 4-Retinal" J.Photochem.Phtobiol.A:Chem.65. 73-78 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Hirano: "Chemiluminescence of Coelenterazine Analogues-Struc-tures of Emitting Species" Tetrahedron Letters. 33. 5771-5774 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Ohmiya: "Two Excited States in Acquorin Bioluminescence Induced by Tryptophan Modification" FEBS Lett.301. 197-201 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] C.F.Qi: "Chemi-and Bioluminescence of Coelenterazine Analogues with Phenyl Homologues an the C-2 Position" J.Chem.Soc.Perkin Trans I. 1607-1611 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] F.Q.Chen: "3-Benzoyl-5-(4-hydroxyphenyl)-2-[4-(1-azi-2,2,2-trifluoroethyl)phenylacetamido]phrazine.A Photoreactive Analogue of Coelenteramide.Synthesis and Photolysis" Chemistry Lett.287-290 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] M.Goto: "Effect of Artificial Boundary Lipid on the Membrane Dynamics of Human Glycophorin-Containing Liposome" Bull.Chem.Soc.Jpn.65. 3331-3334 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] J.Sunamoto: "Direct Transfer of Membrane Proteins from B16 Melanoma Cell to Artificial Cell Liposome" Proc.Japan Acad.68. 69-74 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] J.Sunamoto: "Effective Reconstitution of Cell Membrane Proteins into Artificial Cell Liposomes" Progress in Pacific Polymer Sciences. 2. 223-233 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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