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生体素材,組織の構造・構成と力学特性に関する研究

Research Project

Project/Area Number 04237104
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionTohoku University

Principal Investigator

阿部 博之  東北大学, 工学部, 教授 (00005266)

Co-Investigator(Kenkyū-buntansha) 安田 和則  北海道大学, 医学部, 講師 (20166507)
村上 澄男  名古屋大学, 工学部, 教授 (10023053)
升田 利史郎  京都大学, 工学部, 教授 (10026007)
立石 哲也  工業技術院, 機械技術研究所, 首席研究官
佐藤 正明  東北大学, 工学部, 教授 (30111371)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥62,900,000 (Direct Cost: ¥62,900,000)
Fiscal Year 1994: ¥17,000,000 (Direct Cost: ¥17,000,000)
Fiscal Year 1993: ¥14,700,000 (Direct Cost: ¥14,700,000)
Fiscal Year 1992: ¥31,200,000 (Direct Cost: ¥31,200,000)
Keywords左心室 / 残留応力 / 内皮細胞 / 骨芽細胞 / 機械的刺激 / レオロジー / 構成式 / 膝蓋腱 / 心筋力学 / 残留ひずみ / 力学的刺激 / 骨形成 / 生体材料 / 酸素消費量 / 細胞接着 / 力学的講成式 / 腱・靭帯組織
Research Abstract

1.収縮期におけるイヌ左心室の残留ひずみをスライス法により計測し,内膜側で圧縮,外膜側で引張の残留ひずみの存在を明らかにした.この結果を,残留応力を考慮した力学モデルに応用し,酸素消費量の分布と調和性の高い応力分布を得た.従来問題になっていた,内膜側の異常な応力集中を大幅に緩和した結果である.(阿部)
2.ウシ大動脈由来の培養内皮細胞を用い,流れの方向が細胞の形態と細胞骨格構造に及ぼす影響について検討し,細胞が流れの方向性をも感知して形態を変化させることを明らかにした.さらに,細胞を疎な状態で培養すると細胞は流れに反応しないことを見いだした.(佐藤) 3.骨の組織形成における機械的刺激の影響を探るため,骨芽細胞様細胞に機械的刺激を負荷し,細胞増殖率および骨芽細胞の活性が有意に高くなること,およびこの刺激がcAMP,cGMP,PGE_2セカンドメッセンジャー系へと伝達されていることを示した.(立石) 4.コラーゲン分子の溶液中での会合による組織化をレオロジー的に調べ,会合と_PHとの関係を明らかにした.また,イヌの頚動脈と腹部大動脈について,血管の組織構造,組織要素が及ぼす力学特性の影響について明らかにした.(升田) 5.興奮収縮連関の素過程の検討を通じて活性化パラメータの発展式を改良し,受動的特性や等尺性収縮時の変形特性のみならず,従来記述困難であった等張性収縮時の収縮量の時間変化を含む種々の条件下での心筋の挙動を記述できる心筋構成式モデルを定式化した.(村上) 6.除負荷は細胞の代謝を介さず凍結処理膝蓋腱の超微細構造を速やかに変化させ,力学的特性を低下させた.一方,負荷は繊維芽細胞の活動を介して,除負荷によって低下した膝蓋腱の力学的特性を回復させた.こうして,代用材料としての自家移植腱は,生体内の力学的環境の影響を受け,旺盛なリモデリングを起こすことが証明された.(安田)

Report

(3 results)
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (110 results)

All Other

All Publications (110 results)

  • [Publications] 木村光男: "カリウム停止心における左心室壁内残留ひずみ" 医用電子と生体工学. 32特. 388- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 阿部博之: "イヌ左心室の残留ひずみの計測" 日本機械学会東北支部講演論文集. 941-2. 37-39 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 阿部博之: "残留応力を考慮した左心室の力学モデルの構築" 日本機械学会論文集. 60-578A. 2452-2458 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] M.A.Abd EI-Haleem: "Effects of cholesterol feeding periods on aortic mechanical properties of rabbits" JSME Intl.J.Ser.A. 7. 79-86 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] M.Sato: "Flow-induced changes in shape and cytoskeletal structure of vascular endothelial cells" Biorheology. 31. 143-153 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] N.Kataoka: "Application of the pipette aspiration technique to the measurement of local elastic moduli of cholesterol-fed rabbit aortas" Theoretical and Applied Mechanics. 43. 233-238 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] N.Kataoka: "Flow direction affects shape and cytoskeletal structure of cultured bovine aortic endothelial cells" Proc.the 3rd Int.Symp.on Biofluid Mechanics. 17. 551-556 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 佐藤正明: "〈特集〉血流と内皮細胞 1.血流と内皮細胞の物理的応答概論" 血管と内皮. 4. 9-18 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 佐藤正明: "血液レオロジーと血栓(5)微小循環系における血小板と白血球の挙動" 血栓と循環. 2. 394-397 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Tateishi: "Simulator tset of artificial joints" Material Science and Engingneering. 1. 121-126 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 立石哲也: "科学技術の融合化を目指すバイオニックデザイン" 精密工学会誌. 60. 473-474 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 立石哲也: "骨の力学的試験" The Bone. 8. 31-37 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 立石哲也: "関節のバイオメカニクス" リウマチ. 34. 914-920 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 牛田多加志: "高重力負荷に対する骨原性細胞の活性化" 日本臨床バイオメカニクス学会誌. 15. 85-88 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 立石哲也: "新しい生体金属材料" VEGA. 36. 28-29 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 立石哲也: "生体機能の解明と人工組織機構の道" VEGA. 38. 64-65 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 立石哲也: "医用セラミックス複合材料の人工骨・関節への応用" セラミックス. 30. 140-145 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岡崎義光: "生体用新Ti合金の組織と力学特性に及ぼす熱処理の効果" 日本金属学会誌. 95. 108-115 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Y.Okazaki: "Effect of alloying elements on anodic polarization properties of titanium alloys in acid solution" Materials Transactions,JIM. 35. 58-66 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Takigawa: "Time dependent Poisson's ratio of polymer gels in solvent" Polymer Journal. 26. 225-227 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Takigawa: "Theoretical studies on the stress relaxation of polymer gels under uniaxial elongation" Polymer Gels and Networks. 2. 59-64 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Urayama: "Stress relaxation and creep of polymer gels in solvent under uniaxial and biaxial deformations" Rheologica Acta. 33. 89-98 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 川井正弘: "アルギン酸ゲルのレオロジー的性質" 日本化学会誌. 1994. 108-114 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] H.Yamada: "Mechanical evaluation of growth and rupture of abdominal aorta" JSME Intl.J.Ser.A. 37. 181-187 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 田中 英一: "興奮収縮連関を考慮に入れた心筋の力学モデル" 日本機械学会論文集B. 60. 3726-3731 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 田中 英一: "心筋構成式の定式化と左心室のシミュレーション" 日本機械学会講演論文集. 940-37,B. 275-276 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 田中 英一: "心筋モデルと心臓左心室へのその適用" 日本機械学会講演論文集. 95-3. 3-4 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Majima: "Deterioration of mechanical properties of the autograft in controlled stress-shielded augmentation procedures" Am.J.Sports Med.22. 821-829 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Tsuchida: "Effects of stress shielding on the ultrastructure of the in situ frozen patellar tendon in the rabbit" Trans.Orthop.Res.Soc.19. 638- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] H.Ishida: "Does restressing recover the mechanical strength of a patellar tendon autograft reduced by stress shielding?-An experimental study-" Trans.Orthop.Res.Soc.20. 611- (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Tsuchida: "Effects of stress shielding on the ultrastructure of normal and in situ frozen rabbit patellar tendons-A role of fibroblasts-" Trans.Orthop.Res.Soc.20. 613- (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 土田隆政: "除負荷した凍結家兎膝蓋腱における断面積および引張強度の経時的変化" 日本臨床バイオメカニクス学会誌. 15. 321-325 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 佐藤正明(著者分担): "臨床血栓止血学" 医歯薬出版, 489 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Ushida(著者分担): "Clinical Biomechanics and Related Research" Springer-Verlag, 495 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Yasuda(著者分担): "Clinical Biomechanics and Related Research" Springer-Verlag, 495 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 阿部博之: "残留応力を考慮した左心室の壁内応力" 日本機械学会東北支部第28期講演論文集. 93-1. 114-116 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 佐藤正明: "壁ずり応力による血管内皮細胞の形態と機能の変化" 病理と臨床. 11. 805-812 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 佐藤正明: "血液循環系における物質移動現象" 伝熱研究. 32. 32-38 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 松本健郎: "血液循環系モデル化のための生体定数" バイオメカニズム学会誌. 14. 203-208 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Ookawa: "Morphological changes of endothelial cells after exposure to fluid-imposed shear stress:differential responses induced by extracellular matrices" Biorheology. 30. 131-140 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Ookawa: "Time course changes in cytoskeletal structures of cultured endothelial cells exposed to shear stress" Frontiers Med.Biol.Engng.5. 121-125 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] S.Homma: "Flow behavior of erythrocyte in living microvessels:analysis of the distribution of dynamic hematocrits measured in vivo" Int.J.Multiphase Flow. 19. 897-904 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 大島宣雄: "近赤外光を利用する蛍光生体顕微鏡法の開発" 脈管学. 33. 1011-1015 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 佐藤正明: "血流と内皮細胞の物理的応答概論" 血管と内皮. 4. 9-18 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] M.A.Abd El-Haleem: "Effect of cholesterol feeding periods on aortic mechanical properties of rabbit" JSME Int.J.,Ser.A. 7. 79-86 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] M.Sato: "Flow-induced changes in shape and cytoskeletal structure of vascular endothelial cells" Biorheology. 31. 143-153 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Tateishi: "A mechanical aspect of functional adaptation of hard tissue" Materials Science & Engineering. 1. 11-16 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] A.Ito: "In-vitro evaluation of the cytocompatibility of wear particles generated by UHMWPE/Zirconia friction" Clinical Materials. 12. 203-209 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Tateishi: "Research and development of alumina and zirconia artificial hip joint" Clinical Materials. 12. 219-225 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Y.Akai: "Viscoelastic properties of stiff joints" Bio-Medical Materials and Engineering. 3. 67-73 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Hyodo: "Application of thermoelastic stress analysis method to joint biomechanics" Hip Biomechanics. 277-285 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 牛田多加志: "高重力負荷に対する骨原性細胞の活性化" 整形外科バイオメカニクス学会誌. (印刷中). (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 熱田智香: "毛髪の引張特性に対する水の影響" 日本バイオレオロジー学会誌. 7. 31-36 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Urayama: "Poisson's ratio of poly(vinyl alcohol)gels" Macromolecules. 26. 3092-3096 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] M.Takahashi: "Measurements of biaxial and uniaxial extensional flow behavior of polymer melts at constant strain rates" J.Rheology. 37. 827-846 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Takigawa: "Simultaneous swelling and stress relaxation behavior of uniaxially stretched polymer gels" Polymer J.25. 929-937 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Ohmae: "Molecular characterization and crystalline structure of ethylene-dimethylamino methacrylate copolymers" Pure and Applied Chemistry. 65. 1825-1847 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 川合正弘: "アルギン酸水溶液のMg^<2+>イオンによるゲル化に及ぼすマンヌロン酸/グルロン酸比の影響" 日本化学会誌. 1993. 978-981 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Yamada: "Mechanical evaluation of growth and rupture of aneurysm in abdominal aorta" JSME Int.J.Ser.A. 37(in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 田中英一: "興奮収縮連関を考慮に入れた心筋の力学挙動のモデル化" 日本機械学会講演論文集. 930-63. 207-209 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 田中英一: "有限要素法による脊椎分離症の力学的評価" 日本機械学会講演論文集. 930-63. 216-218 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 田中英一: "第4・第5腰椎に対する有限要素解析と脊椎分離症の力学的評価" 日本機械学会講演論文集. 943-1. 98-100 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] N.Yamamoto: "Effects of stress shielding on the mechanical properties of rabbit patellar tendon" Tr.ASME J.Biomech.Eng.115. 23-28 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Ohno: "Effects of complete stress-shielding on the mechanical properties and histology on in situ frozen patellar tendon" J.Orthop.Res.11. 592-602 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Majima: "Effects of controlled stress shielding on the mechanical properties of the rabbits patellar tendon - Role of fibroblasts -" Trans.ORS. 18. 365 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 土田隆政: "凍結家兎膝蓋腱の超微細構造に及ぼす負荷軽減の影響" 日本整形外科学会誌. 67. S1401 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 石田博英: "凍結処理後除負荷した家兎膝蓋腱の力学的特性に対する再負荷の効果" 日本整形外科学会誌. 67. S1514 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Majima: "Deterioration of mechanical properties of autograft in controlled stress-shielded augmentation procedures - An experimental studies -" Am.J.Sports Med.(in press).

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Tsuchida: "Effects of stress shielding on the ultrastructure of the in situ frozen patellar tendon in the rabbit" Trans ORS. (in press).

    • Related Report
      1993 Annual Research Report
  • [Publications] 土田隆政: "除負荷した凍結家兎膝蓋腱における断面積および引張り強度の経時的変化" 日本臨床バイオメカニクス学会誌. (印刷中).

    • Related Report
      1993 Annual Research Report
  • [Publications] 阿部博之(分担): "バイオメカニクス概説" 日本機械学会, 209 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 佐藤正明(分担): "新生化学実験講座第10巻血管-内皮と平滑筋" 日本生化学会, 497 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 立石哲也(分担): "バイオメカニクス概説" 日本機械学会, 209 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 立石哲也(分担): "生体材料学" 日本機械学会, 220 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 立石哲也(分担): "生体適合材料" 日本規格協会, 325 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 阿部 博之: "残留応力を考慮した左心室モデル" 第3回バイオメカニクスカンファレンス講演論文集. 930-1. 59-60 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 松田 光生: "大動脈の弾性特性と弾性成分に及ぼす継続的運動の効果" 脈管学. 32. 39-43 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] M.A.Abd El-Haleem: "家兎大動脈の力学的性質に及ぼすコレステロール投与期間の影響" 日本機械学会論文集. 58. 1128-1133 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Keiko Ookawa: "Changes in microstructure of cultured porcine aortic endothelial cells in the early stage after applying fluid-imposed shear stress." Journal of Biomechanics. 25. 1321-1328 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 境 広志: "高コレステロール・高脂肪食で飼育した成長期ラット大動脈の弾性成分と弾性特性に及ぼす長期自発走の影響" いばらき体育・スポーツ科学. 8. 25-31 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 佐藤 正明: "動脈硬化の発生・進展と血管壁の動的力学応答" 日本ME学会雑皮BME. 6. 19-26 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 佐藤 正明: "壁ずり応力による血管内皮細胞の形態と機能の変化" 病理と臨床.

    • Related Report
      1992 Annual Research Report
  • [Publications] 佐藤 正明: "血液循環系における物質移動現象" 伝熱研究.

    • Related Report
      1992 Annual Research Report
  • [Publications] Masaaki Sato: "Platelet thrombi produced on cultured endothelial cells by the dye/light method" Biorheology.

    • Related Report
      1992 Annual Research Report
  • [Publications] Keiko Ookawa: "Morphological changes of endothelial cells after exposure to fluidimposed shear stress:Differential responses induced by extracellular matrices." Biorheology.

    • Related Report
      1992 Annual Research Report
  • [Publications] Keiko Ookawa: "Time course changes in cytoskeletal structure of cultured endothelial cells exposed to shear stress." Frontiers of Medical and Biological Engineering.

    • Related Report
      1992 Annual Research Report
  • [Publications] M.A.Abd El-Haleem: "Effects of cholestorel feeding periods on aortic mechanical porperties of rabbits." JSME International Journal.

    • Related Report
      1992 Annual Research Report
  • [Publications] Tetsuya Tateishi: "Round-Robin test for standardization of biocompatibility test procedure by cell culture method." Advances in Biomaterials. 10. 89-97 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takashi Ushida: "Cell adhesion strength to biomateriasls and influence of fibronectin" Advances in Biomaterials. 10. 99-103 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Takigawa: "Comparison of model prediction with experiment for concentration modulus of poly(vinyl alcohol)(PVA)gels near the gelation point" Chemical Physics Letters. 33. 509-512 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 服部 高明: "低密度ポリエチレン/ポリスチレン系ブレンドの一軸及び二軸伸長流動" 日本レオロジー学会誌. 20. 141-145 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Matsumoto: "Viscoelastic and SAXS investigation of fractal structure of alginate aqueous systems" J.Chem.Soc.,Faradat Trans.88. 2673-2676 (1992)

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      1992 Annual Research Report
  • [Publications] T.Masuda: "Fatigue behavior of segmented polyurethanes under repeated strains" Bull.Inst.Chem.Res.,Kyoto Univ.70. 169-177 (1992)

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      1992 Annual Research Report
  • [Publications] T.Matsumoto: "Influence of concentration and mannuronate/gluronate ratio on steady flow porperties of alginate aqueous systems" Biorheology. 29. 411-417 (1992)

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      1992 Annual Research Report
  • [Publications] 川井 正弘: "水溶液中のアルギン酸分子におけるマンヌロン酸及びグルロン酸残基当りの分子鎖長" 日本バイオレオロジー学会誌. 6. 87-92 (1992)

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      1992 Annual Research Report
  • [Publications] 山田 宏: "腹部大動脈りゅうの成長と破裂に対する力学的評価" 日本機械学会論文集. 58. 1087-1092 (1992)

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      1992 Annual Research Report
  • [Publications] H.Yamada: "Mechanical evaluation for the growth and repture of aneurysm in abolominal aorta" JSME International Journal.

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      1992 Annual Research Report
  • [Publications] T.Majima: "Effects of stress shielding on the mechanical properties of in situ frozen patellar tendon augmented with polyester artificial ligament." Orthopaedic Transactions. 16. 585-586 (1992)

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      1992 Annual Research Report
  • [Publications] 真島 任史: "自家移植腱モデルにおいて人工靭帯による補強を行った後の荷重分散の変化" 整形外科バイオメカニクス. 13. 249-252 (1992)

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      1992 Annual Research Report
  • [Publications] 真島 任史: "膝蓋腱の力学的特性におよぼす負荷軽減の影響" 日本機械学会講演論文集(第2回バイオエンジニアリングシンポジウム). 920. 57-58 (1992)

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      1992 Annual Research Report
  • [Publications] 真島 任史: "膝蓋腱の力学的特性に及ぼす定量的負荷軽減の影響ー線維芽細胞壊死処理の有無によるリモデリングの相違ー" 日本整形外科学会誌. 66. S1335 (1992)

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      1992 Annual Research Report
  • [Publications] 阿部 博之(著者分担): "バイオメカニクス概説(バイオメカニクスシリーズ)" 日本機械学会編,オーム社, 209 (1993)

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      1992 Annual Research Report
  • [Publications] 佐藤 正明(著者分担): "血液レオロジー最近の進歩" メディカルレビュー社, 477 (1992)

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      1992 Annual Research Report
  • [Publications] 佐藤 正明(著者分担): "バイオエンジニアリングー最近の話題を集めてー" 培風館, 277 (1992)

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      1992 Annual Research Report
  • [Publications] 佐藤 正明(著者分担): "新生化変実験講座第10巻血管一内皮と平滑筋" 東京化学同人,

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      1992 Annual Research Report
  • [Publications] 佐藤 正明(著者分担): "臨床血栓止血学" 医歯薬出版,

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      1992 Annual Research Report
  • [Publications] 佐藤 正明(著者分担): "血栓形成と血栓溶解" 日本科学技術協会,

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      1992 Annual Research Report
  • [Publications] 升田 利史郎(著者分担): "PVAの世界" 高分子刊行会, 167 (1992)

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      1992 Annual Research Report
  • [Publications] 替田 利史郎(編集及び著者分担): "講座・レオロジー" 高分子刊行会, 263 (1992)

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      1992 Annual Research Report
  • [Publications] T.Majima(著者分担): "Proceeding of 7th International Conference of Biomedical Engineering" JCH Goh & A Narher,Singapor, 582 (1992)

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      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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