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Basic Mechanisms of Genetic Recombination

Research Project

Project/Area Number 04262103
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionOsaka University

Principal Investigator

OGAWA Hideyuki  Osaka University, Faculty of Sience, Prof., 理学部, 教授 (70028207)

Co-Investigator(Kenkyū-buntansha) SHIROISHI Tosihiko  Nation. Insti. of Genet., Asso. Prof., 助教授 (90171058)
SHIBATA Takehiko  Insti. of Physi. Chemi. Res., Chief Inves., 研究者 (70087550)
OHTSUBO Eiichi  University of Tokyo, Insti. of Mol. & Cellu. Biol., Prof., 分子細胞生物学研究所, 教授 (10158800)
IKEDA Hideo  University of Tokyo, Insti. of Medical Sci., Prof., 医科学研究所, 教授 (10012775)
HOTTA Yasuo  Nara Insti. of Sci. & Tech., Gradu. School of Biosci., Prof., 教授 (30190218)
関口 睦夫  九州大学, 生体防御医学研究所, 教授 (00037342)
柳田 充弘  京都大学, 理学部, 教授 (80025428)
Project Period (FY) 1991 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥42,600,000 (Direct Cost: ¥42,600,000)
Fiscal Year 1994: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1993: ¥24,000,000 (Direct Cost: ¥24,000,000)
Fiscal Year 1992: ¥15,600,000 (Direct Cost: ¥15,600,000)
KeywordsGenetic recombination / RecA protein / RecA homologues / Rad51 protein / Transposon / Shufflon / Illegitimate recombination / Recombination hot spot / プラスミドシャフロンのDNA逆位 / 組み換えホットスッポット / 抗原受容体遺伝子再構成 / 相同的組換え / RecA蛋白質 / ジャイレース依存の組換え / 遺伝子ターゲッティング / シャフロン / 部位特異的組換え / トランスポゾン
Research Abstract

Genetic recombination is a fundamental mechanism by which parental traits of an organism are distributed to offspring. It provides a means of spreading a favorable allele and of eliminating an unfavorable allele in aspecies. Recombination must therefore have playd a crucial role in evolution of the genome. Recombination is also involved in various biological functions in a cell. It participates in repair of DNA damage, a primer formation of DNA replication, production of gene product diversities, alternative gene expression, and chromosome disjunction in meiosis I.Thus the study of recombination is crucial for thge understanding of the mechanisms of biological functions. To further our knowledge of fundamental problems of genetic recombination, a research group was organized supported by this grant. Main distingushed results obtained by this reserach group are as follows.
1. The homologues of the recombination gene, recA, were successfully cloned from yeasts, chicken, mouse and human.
2. … More A process of resolution of recombination intermediates formed by RecA to recombinant molecules are revealed.
3. A recombinaion hot spot specific to mouse female was found and identified at the nucleotide sequence level on the chromosome 17.
4. Two novel methods useful for study of genetic recombination were established.
(1) A simple and easy method to get various chimera genes between homologues using a recE pathway of E.coli.
(2) A comprehensive method to clone a specific site that made a genetic rearrangement from higher eukaryotes was estabilshed using in-gel competitive reassociation method.
5. Various kinds of recombination proteins were identified and analyzed : for instance, Dhpl (S.pombe homologue of STPbeta in S.cerevisiae), Lim15 (lily homologues of Dmcl in S.cerevisiae), and RBP-Jkappa(mouse homologue of Su(H) in D.melanogaster).
Thus a great advancement was made in analysis of basic recombination mechanism, methodology, and analysis of recombination mechanism in higher eukaryotes by this project. Less

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (66 results)

All Other

All Publications (66 results)

  • [Publications] Ryuichi Kato and Hideyuki Ogawa: "An essential gene,ESR1,is required for mitotic cell growth,DNA repair and meiotic recombination in Saccharomyces cerevisiae" Nucleic Acids Research. 22. 3104-3112 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Katsyki Johzuka and Hideyuki Ogawa: "Interaction of Mre11 and Rad5- : Two protein required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae" Genetics. 139(in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Ogawa,K.Johzuka,T.Nakagawa,S-H,Leem and A.H.Hagiwara: "Functions of the yeast meiotic recombination genes,MRE11B and MRE2" Adv.Biophysics. 39. 67-76 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Ogawa,A.Shinohara,A.Nabetani,T.ikeya,X.Yu,E.H.Egelman and H.Ogawa: "Rec A-like Recombination Proteins in Eukaryotes : Functions and Structures of RAD51 Genes." Cold Spring Harbor Symp.Quant.Biol.58. 567-576 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tomoko Ogawa Akira Shinohara and Tomoatsu Ikeya: "A apecies-specific interaction of Rad51 and Rad52 proteins" Adv.Biophysics. 31. 93-100 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Terasawa,A.Shinohara,Y.Hotta,H.Ogawa and T.Ogawa.: "Cooperation of RecA-like Rad51 and Lim15 proteins for searching and paring of homologous chromosomes in meiotic chromosomes of the Lily." Genes & Development.9(in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shibata,T.,Nakagawa,K.-l.and Morishima,N: "Multi-site-specific endonucleases and the initiation of homologous genetic recombination in yeast..31 : 77-91." Adv.Biophysics. 31. 77-91 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ohta,K.,Shibata,T.and Nicolas,A.: "Changes in chromatin structure at recombination initiation sites during yeast meiosis" EMBO J.13. 5754-5763 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Kurumizaka,S.Ikawa,T.Ikeya,T.Ogawa and T.Shibata: "A chimera RecA protein exhibiis altered double-stranded DNA-binding" J.Biol.Chem.269. 3068-3075 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Kurumizaka,B.J.Rao,T.Ogawa,C.M.Radding and T.Shibata: "A chimeric RecA protein that implicates non-Watson-Crick interaction in homologous pairing" Nucleic Acid Res.22. 3387-3391 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] S.Sugano,T.Shobuike,T.Takeda,A.Sugino & H.Ikeda: "Molecular Analysis of the dhp1+ Gene of Schizosaccharomyces pombe : An Essential Gene that Has Homology to the DST2 and RAT1 Genes of Saccharomyces cerevisiae." Mol.Gen.Genet. 243. 1-8 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Yoshino,T.Sagai,K.F.Lindahl,Y.Toyoda & T.Shiroishi: "No Dosage Effect of Recombinational Hotspots in the Mouse Major Histocompatibility Complex." Immunogenetics,. 39. 381-389 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Kusano,Y.Sunohara,N.Takahashi H.Yoshikura & I.Kobayashi: "DNA Double-strand Break Repair : Genetic Deteminants of Flanking Crossing-over." Proc.Natl.Acad.Sci.USA,91,1173-1177,(1994).91. 1173-1177 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Kume,K.Tsuneizumi,T.Watanabe,M.L.Thomas & M.Oishi: "Induction of Specific Protein Tyrosine Phosphatase Transcripts during Differentiation of Mouse Erytheroleukemia Cells." J.Biol.Chem.269. 4709-4712 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Sekine,N.Eisaki & E.Ohtsubo: "Translational Control in Production of Transposase and in Trasposition of Insertion Sequence IS3." J.Mol.Biol.235. 1406-1420 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Horie,S.Nishiguchi,S.Maeda & K.Shimada: "Structures of Replacement Vectors for Efficient Gene Targeting." J.Biochem. 115. 477-485 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 小川智子 篠原彰 小川英行: "真核生物の組換え蛋白質Rad51とRad52の機能と構造" 実験医学(羊土社)「トッピクス」. 12. 527-547 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 小川英行、小川智子: "酵母に観る最新の真核生物像 VI.組換え機構 減数分裂期組換え-関与する遺伝子とその普遍性-" 蛋白質 核酸 酵素(共立出版)「臨時増刊号」. 39. 568-578 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 篠原彰 小川英行 小川智子: "真核生物の組換え(修復)に働く遺伝子" 細胞工学(秀潤社). 13. 710-719 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 小川智子: "真核生物の組換え蛋白質の機能と構造" 第25回 放射性総合医学研究所シンポジウム. 25. 25-37 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 篠原彰 小川英行 小川智子: "真核生物RAD51遺伝子の構造と機能" 日本医学(日本臨床社). 53. 239-249 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ryuichi Kato and Hideyuki Ogawa: "An essential gene,ESR1,is required for mitotic cell growth,DNA repair and meiotic recombination in Saccharomyces cerevisiae" Nucleic Acids Research. 22. 3104-3112 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Katsyki Johzuka and Hideyuki Ogawa: "Interaction of Mre11 and Rad5-:Two protein required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae" Genetics. 139(in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] H.Ogawa,K.Johzuka,T.Nakagawa,S-H,Leem and A.H.Hagiwara: "Functions of the yeast meiotic recombination genes,MRE11 and MRE2" Adv.Biophysics. 39. 67-76 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Ogawa,A.Shinohara,A.Nabetani,T.Ikeya,X.Yu,E.H.Egelman and H.Ogawa: "RecA-like Recombination Proteins in Eukaryotes:Functions and Structures of RAD51 Genes." Cold spring Harbor Symp.Quant.Biol.58. 567-576 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tomoko Ogawa Akira Shinohara and Tomoatsu Ikeya: "A species-specific interaction of Rad51 and Rad52 proteins" Adv.Biophysics. 31. 93-100 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] M.Terasawa,A.Shinohara,Y.Hotta,H.Ogawa and T.Ogawa.: "Cooperation of RecA-like Rad51 and Lim15 proteins for searching and paring of homologous chromosomes in meiotic chromosomes of the Lily." Genes & Development.9(in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Shibata,T.,Nakagawa,K.-1.and Morishima,N: "Multi-site-specific endonucleases and the initiation of homologous genetic recombination in yeast..31:77-91." Adv.Biophysics. 31. 77-91 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ohta,K.,Shibata,T.and Nicolas,A.: "Changes in chromatin structure at recombination initiation sites during yeast meiosis" EMBO J.13. 5754-5763 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] H.Kurumizaka,S.Ikawa,T.Ikeya,T.Ogawa and T.Shibata: "A chimera RecA protein exhibits altered double-stranded DNA-binding" J.Biol.Chem.269. 3068-3075 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] H.Kurumizaka,B.J.Rao,T.Ogawa,C.M.Radding and T.Shibata: "A chimeric RecA protein that implicates non-Watson-Crick interaction in homologous pairing" Nucleic Acid Res.22. 3387-3391 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] S.Sugano,T.Shobuike,T.Takeda,A.Sugino & H.Ikeda: "Molecular Analysis of the dhp1+Gene of Schizosaccharomyces pombe:An Essential Gene that Has Homology to the DST2 and RAT1 Genes of Saccharomyces cerevisiae." Mol.Gen.Genet. 243. 1-8 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] M.Yoshino,T.Sagai,K.F.Lindahl,Y.Toyoda & T.Shiroishi: "No Dosage Effect of Recombinational Hotspots in the Mouse Major Histocompatibility Complex." Immunogenetics,. 39. 381-389 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Kusano,Y.Sunohara,N.Takahashi,H.Yoshikura & I.Kobayashi: "DNA Double-strand Break Repair:Genetic Determinants of Flanking Crossing-over." Proc.Natl.Acad.Sci.USA,. 91. 1173-1177 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Kume,K.Tsuneizumi,T.Watanabe,M.L.Thomas & M.Oishi: "Induction of Specific Protein Tyrosine Phosphatase Transcripts during Differentiation of Mouse Erytheroleukemia Cells." J.Biol.Chem.269. 4709-4712 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Y.Sekine,N.Eisaki & E.Ohtsubo: "Translational Control Production of Transposase and in Trasposition of Insertion Sequence 1S3." J.Mol.Biol.235. 1406-1420 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Horie,S.Nishiguchi,S.Maeda & K.Shimada: "Structures of Replacement Vectors for Efficient Gene Targeting" J.Biochem. 115. 477-485 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 小川智子 篠原彰 小川英行: "真核生物の組換え蛋白質Rad51とRad52の機能と構造" 実験医学(羊土社)「トッピクス」. 12. 527-547 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 小川英行 小川智子: "酵母に観る最新の真核生物像 VI.組換え機構 減数分裂期組換え-関与する遺伝子とその普遍性-" 蛋白質 核酸 酵素(共立出版)「臨時増刊号」. 39. 568-578 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 篠原 彰 小川英行 小川智子: "真核生物の組換え(修復)に働く遺伝子" 細胞工学(秀潤社). 13. 710-719 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 小川智子: "真核生物の組換え蛋白質の機能と構造" 第25回 放射性総合医学研究所シンポジウム. 25. 25-37 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 篠原 彰 小川英行 小川智子: "真核生物RAD51遺伝子の構造と機能" 日本医学(日本臨床社). 53. 239-249 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Ogawa,A.Shinohara,A.Nabetani,T.Ikeya,X.Yu,E.H.Egelman and H.Ogawa: "RecA-like Recombination Proteins in Eukarvotes:Functions and structures of RAD 51 Genes" Cold Spring HarborSymp.Quant.Biol.in press.

    • Related Report
      1993 Annual Research Report
  • [Publications] M.Ajimura,S-H.Leem and H.Ogawa: "Identification of new genes required for meiotic recombination in Saccharomyses cerevisiae" Genetics. 133. 51-66 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Furukawa and Y.Hotta: "_cDNA cloning of a germ cell specific lamin B_3 from mouse spermatocyte and its functional and ectopic expression in somatic culture cells" EMBO J.12. 97-106 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] M.Kumagai,T.Yamashita,M.Honda and H.Ikeda: "Effects of uvsX,uvxY,and DNA topoisomerase on the formation of tandem duplications of the rII gene in bacteriophage T4." Genetics. 135. 255-264 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Iwasaki,M.Takahagi,A.Nakata and H.Shinagawa: "Escherchia coli RuvA and RuvB protiens specifically interact with Holliday junctions and promate branch migration" Genes Dev.6. 2214-2220 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Furukawa,S.Maruyama,M.Kawaichi and T.Honjo: "The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development" Cell. 69. 1191-1197 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Horii,N.Ozawa,T.Ogawa and H.Ogawa: "Inhibitory effects of N-and C- ternimal truncated Escherichia coli recA gene products on functions of the wild-type recA gene." J.Mol.Biol.223. 105-114 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Leem and H.Ogawa: "The MRE4 gene encodes a novel protein kinase homologue required for meiotic recombination in Saccharomyces cerevisiae." Nucleic Acids Res.20. 449-457 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] M.Ajimura,S.Leem and H.Ogawa: "Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae." Genetics. 133. 51-66 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] A.Shinohara,H.Ogawa and T.Ogawa: "Rad51 protein involved in repair and recombination in S.cerevisiae is a RecA-like protein." Cell. 69. 457-470 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Ogawa,A.Shinohara,H.Ogawa and J.Tomizawa: "Functional structures of the RecA protein found by chimera analysis." J.Mol.Biol.226. 651-660 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Ogawa,H.Yu,A.Shinohara and E.H.Egelman: "Simiarity of the yeast Rad51 filament to the bacterial RecA filament." Science.

    • Related Report
      1992 Annual Research Report
  • [Publications] J.Watanabe,K.Nakata,H.Nashimoto,and H.Ikeda.: "Cloning and characterization of a repetitive sequence from Pneumocystis carinii." Rarasitol.Res.78. 23-27 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Mochizaki,K.,Umeda,K.,Ohtsubo,H.,and Ohtsubo,E.: "Characterization of a plant SINE,p-SINE1,in rice genomes." Jpn.J.Genetics,. 67. 155-166 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takahashi,Noriko Kenji Yamamoto,Yoshihiro Kitamura Si-Qin Luo,Hiroshi Yoshikura,Ichizo Kobayashi: "Nonconservative recombination in Escherichia coli." Proc.Natl.Acad.Sci.USA. 89. 5912-5916 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yamamoto,Kenji,Kohji Kusano Noriko Takahashi,Hiroshi Yoshikura,Ichizo Kobayashi: "Gene conversion in the Excherichia coli RecF pathway:A successive half crossing over model" M01.Gen.Genet.234. 1-13 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ikeda,M.,Hamano,K.adn Shibata,T.: "Epitope mapping of anti-recA protein IgGs by region spectified polymerase chain reaction mutagenesis." J.Biol.Chem.267. 6291-6296 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Arai,N.,Kawsaki,K.,Iwabuchi,M.and Shibata,T: "Phenoltreatment and a homologous pairing-assay." Nucleic Acids Res.20. 3679-3684 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Arei,N.,Kawasaki,K.and Shibata,T.: "A multi-component protein of a fission yeast which promotes joint molecule formation from homologous DNAs." J.Biol.Chem.267. 3514-3522 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Nonaka,M.,Matsuda,Y.,Shiroishi,T.,Moriwaki,K.,and Natsuume-Sakai,S.: "Molecular cloning of mouse b2-glycoprotein 1 and mapping of the gene to chromosome 11." Genomics. 13. 1082-1087 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Watanabe,T.,Kume,T.,Tsuneizumi,K.,Kondo,K.,Shiraishi,T.and Oishi,M.: "Synergistic induction of erythroid differentiation of mouse erythroleukemia (MEL) cells by inhibitors of topoisomerases and protein tyrosine kinases." Exp.Cell Res.199. 269-274 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Murakami,S.Maeda,S.Yi,S.Ikegawa,E.Kawashima,S.Onodera,K.Shimada,S.Araki: "A novel transthyretin mutation associated with familial amyloidotic polyneuropathy" Biochem.Biophys.Res.Comm.,. 82. 520-526 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kobayashi,Ichizo: ""Mechanisms for gene conversion and homologous recombination:The double-strand break repair model and the successive half crossing-over model."Advances in BioPhysics.Ed.Masao Kotani." Tokyo and Limerick:Japan Scientific Societies Press and Elsevier, 81-133 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Yamamura,F.Tashiro,S.Wakasugi,S.Yi,S.Maeda,K.Shimada: "Analysis of the pathological process of dominant disease:Familial amyloidotic polyneuropathy In"Molecular Approaches to the Study and Treatment of Human Diseases"eds.T.O.Yoshida & J.M.Wilson" Elsevier Science publishers B.V., 377-384 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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