• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

機能性食品の解析と分子設計

Research Project

Project/Area Number 04265103
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionThe University of Tokyo

Principal Investigator

荒井 綜一  東京大学, 農学部, 教授 (20011934)

Co-Investigator(Kenkyū-buntansha) 軽部 征夫  東京大学, 先端科学技術研究センター, 教授 (50089827)
鵜高 重三  東京農業大学, 農学部, 教授 (70023463)
野口 忠  東京大学, 農学部, 教授 (50011937)
小清水 弘一  近畿大学, 生物理工学部, 教授 (90026518)
上野川 修一  東京大学, 農学部, 教授 (50011945)
多田 富雄  東京大学, 医学部, 教授 (10009136)
宇井 理生  東京大学, 薬学部, 教授 (50001037)
Project Period (FY) 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥198,800,000 (Direct Cost: ¥198,800,000)
Fiscal Year 1995: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1994: ¥54,000,000 (Direct Cost: ¥54,000,000)
Fiscal Year 1993: ¥67,300,000 (Direct Cost: ¥67,300,000)
Fiscal Year 1992: ¥74,500,000 (Direct Cost: ¥74,500,000)
Keywords機能性食品 / 食品の三次機能 / 生体調節因子 / 生体防御因子 / 機能性蛋白質 / 食品機能 / 食品の内因性物質 / 食品の外因性物質
Research Abstract

平成4年4月.同補助金による重点領域研究「機能性食品の解析と分子設計」が発足した。これは、既設の2つの大型研究の思想をプリンシプルとして継承しながらも、"機能性食品"という実体を具体的研究対象として念頭に置きつつ解析から設計までを網羅し、研究の新たな展開を意図したものであった。新機軸としては、生体の生理系統の調整(modulation)を生体調節(bioregulation)と生体防御(biodefence)に分けて取扱う点、そして機能性食品の素材を設計する技術基盤の確立をも目指し、しかもこれを収穫前(preharvest)から収穫後(postharvest)に至る一貫した研究として展開する点を挙げることができる。そのプログラムはI.食品の生体調節因子の解析と設計を目標としa顕在型調節因子を対象として1)内生因子の誘導を介して機能するものを研究する2)内生因子そのものの如く機能するものを研究するb潜在型調節因子を対象として1)腸管吸収前に機能するものを研究する2)腸管吸収後に機能するものを研究するII.食品の生体防御因子の解析と設計を目標としa免疫型防御因子を対象として1)免疫系を活性化するものを研究する2)免疫系を沈静化するものを研究するb非免疫型防御因子を対象として1)抗感染のために機能するものを研究する2)抗腫瘍のために機能するものを研究するIII.機能性食品設計の技術基盤の展開を目標としaミクロ構造設計を対象として1)分子ブリーディングを研究する2)分子テ-ラリングを研究するbマクロ構造設計を対象として1)新しい変換技術を研究する2)新しい計測技術を研究するのように集約することができる。これに対応して3つの計画研究班と企画・運営・評価を担当する総括班を組織し、総勢59名からなる陣容で3年間の研究を行った。これらの成果をまとめるために班長会議を2回開催し、その成書を完成した。

Report

(4 results)
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] K.lrie et al.: "Transgenic rice established to express corn cystatin exhibits strong inhibitory activity against insect gut proteinases.21GC01:Plant Mol.Biol." 30. 149-157 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] M.Kuroda et al.: "Oryzacystatins exhibit growth-inhibitory and lethal effects on differnt species of bean insect pests,Callosobruchus chinesis(Coleoptera)and Riptortus clavatus(Hemiptera)." Biosci.Biotech.Biochem.60. 209-212 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] I.Mastumoto et al.: "A putative digestive cysteine proteinase of an insect,Drosophila melanogaster,predominantly expressed in embryonic and larval midgut." Eur.J.Biochem.227. 582-587 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Asakura et al.: "Rice aspartic proteinase,oryzasin,expressed during seed ripening and germination,has a gene organization distinct from those of animal and microbial aspartic proteinases." Eur.J.Biochem.232. 77-83 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Y.Michigami et al.: "Significance of the C-terminal domain of Erwinia uredovoraice nucleation-active protein(lnaU)." J.Biochem.118. 1279-1284 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] H.Hosoyama et al.: "Introduction of a chimeric gene encoding an oryzacystatin-β-glucuronidase fusion protein into rice protoplasts and regeneration of transformed plants." Plant Cell Rep.15. 174-177 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K.Abe et al.: "Primary structure and cell-type specific expression of gustatory G protein-coupled receptor related to olfactory receptors." J. Biol. Chem.268. 12033-12039 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Y.Michigami et al.: "Cloning and sequencing of an ice nucleation active gene of Erwinia uredovora." Biosci. Biotech. Biochem.58. 762-764 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] H.Hosoyama et al.: "Oryzacystatin exogenously introduced into protoplasts and regeneration of a transgenic rice." Biosci. Biotech. Biochem.58. 1500-1506 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] N.Kishimoto et al.: "Identification of duplicated segments in rice chromosomes 1 and 5 by lincage analysis of cDNA makers of known functions." Theor. Appl. Genet.88. 722-726 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] M.Abe et al.: "Corn cystatin 1 expressed in Escherichia coli: Investigation of its inhibitory profile and occurrence in corn kernels." J.Biochem.116. 488-492 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] I.Matsumoto et al.: "A putative digestive cysteine proteinase of an insect, Drosophila melanogaster, predominantly expressed in embryonic and larval midgut." Eur. J. Biochem.227. 582-587 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Abe,K: "Multiple genes for G protein-coupled receptors and their expression in lingual epithelia." FEBS Lett.316. 253-256 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Emori,Y: "Expression of oryzacystatin cDNA using yeast artificial chromosome under ADH promoter in baker's yeast." Biochem.Mol.Biol.Internatl.30. 499-504 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Abe,K: "Primary structure and cell-type specific expression of a gustatory G protein-coupled receptor related to olfactory receptors." J.Biol.Chem.268. 12033-12039 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Watanabe,M: "Isolation and cultivation of a novel ice nucleation-active strain of Xanthomonas campestris." Biosci.Biotech.Biochem.57. 994-995 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Watabe,S: "Large-scale production and purification of an Erwinia ananas ice nucleation protein and evalution of its ice nucleation activity." Biosci.Biotech.Biochem.57. 603-606 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Watanabe,H: "Gibberellin-responsive gene expression taking place with oryzains α and γ as cysteine proteinases of rice seeds." Biosci.Biotech.Biochem.56. 1145-1155 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Makoto Abe: "Corn Kernal cysteine proteinase inhibitor as a novel cystatin superfamily member of plant origin Molccular cloning and cxpression studies" E.J.Biochem.209. 933-937 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Hiroto Kondo: "Inhibitory effect of oryzacystatins and a truncation mutant on the replication of poliovirus in infected Vero cells" FEBS Lett.299. 48-50 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Keiko Abe: "Molecular cloning of curculin,a novel taste-modifying protein with a sweet taste" Biochim.Biophys.Acta. 1130. 232-234 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Hirohito Watanabe: "Gibberellin-responsive Gene Expression Taking Place with Oryzains α and γ as Cysteine Proteinases of Rice Seeds" Biosci.Biotech.Biochem.56. 1154-1155 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Junko Funaki: "MODULATING THE CONDITIONING OF MEAT BY THE USE OF ORYZACYSTATIN,A CYSTEINE PROTEINASE INHIBITOR OF RICE SEED ORIGIN" J.Food BIochem.15. 253-262 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Hirohito Watanabe: "Molecular Cloning and Gibberellin-induced Expression of Multiple Cysteine Proteinases of Rice Seeds(Oryzains)" J.Biol.Chem.266. 16897-16902 (1991)

    • Related Report
      1992 Annual Research Report

URL: 

Published: 1992-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi