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中枢シナプスの分子生物学

Research Project

Project/Area Number 04267102
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionThe University of Tokyo (1994-1995)
Niigata University (1992-1993)

Principal Investigator

三品 昌美  東京大学, 医科部(医), 教授 (80144351)

Co-Investigator(Kenkyū-buntansha) 伊藤 正男  理化学研究所, 国際フロンティア研究システム, システム長 (90009887)
津本 忠治  大阪大学, 医学部, 教授 (50028619)
阿部 輝雄  新潟大学, 脳研究所, 助教授 (50010103)
吉岡 亨 (吉岡 享)  早稲田大学, 人間科学部, 教授 (70046027)
清水 孝雄  東京大学, 医科部(医), 教授 (80127092)
山本 長三郎  金沢大学, 医学部, 教授 (50008231)
Project Period (FY) 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥80,400,000 (Direct Cost: ¥80,400,000)
Fiscal Year 1995: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1994: ¥29,400,000 (Direct Cost: ¥29,400,000)
Fiscal Year 1993: ¥28,000,000 (Direct Cost: ¥28,000,000)
Fiscal Year 1992: ¥20,000,000 (Direct Cost: ¥20,000,000)
Keywords脳 / 中枢シナプス / 記憶 / 学習 / シナプス可塑性 / シナプス機能分子 / 分子生物学 / 可塑性 / グルタミン酸受容体 / 逆行性伝達物質 / 神経伝達物質放出 / 長期増強 / 長期抑圧 / 総合的研究
Research Abstract

高次の生理機能を担う中枢シナプスにおける情報伝達の素過程および調節を分子レベルで明らかにすることを目的に、重点領域研究「中枢シナプスの分子生物学」では三つの研究計画班を、中枢シナプスの基本要素であるシナプス後部、シナプス前部および両者のクロストークに対応させて組織し、分子生物学、生理学、薬理学、解剖学、生化学、発生工学などの研究分野を包含する統合的研究を推進した結果、グルタミン酸受容体をはじめとする多くの重要な中枢シナプス機能分子の実体とその生理機能を解明し、その成果がNatureなどに公表され、多くが世界をリ-ドするレベルにあることが示されている。本研究は、平成4年度から平成6年度に渡って遂行している重点領域研究「中枢シナプスの分子生物学」の研究成果をとりまとめ、さらに研究成果を広く公開することを目的とする。研究成果のとりまとめとして、本重点領域研究によって得られた主要な成果を要約し、さらにすべての計画班員および公募班員について、1.研究目的、2.研究成果の要約、3.研究成果、4.研究成果の意義と展望、5.発表論文、という形式で各自の研究成果を記述することにより、重点領域研究「中枢シナプスの分子生物学」研究成果報告書(485頁)を作成した。さらに、班員による代表的な原著論文を取り上げ、重点領域研究「中枢シナプスの分子生物学」論文集(約560頁)を作成した。同時に、各班員の研究成果を最もよく表している和文総説をとりまとめ、重点領域研究「中枢シナプスの分子生物学」和文総説集(約480頁)を作成した。また、IBRO神経科学世界大会のサテライトシンポジウムをはじめ学会においてシンポジウムを開催し、広く研究成果を公開した。

Report

(4 results)
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (315 results)

All Other

All Publications (315 results)

  • [Publications] Ikeda,K.: "Reduced spontaneous activity of mice defective in the ε4 subunit of the NMDA receptor channel." Mol.Brain Res.33. 61-71 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mori,H.: "Structure and function of the NMDA receptor channel." Neuropharmacology. 34. 1219-1237 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Morita,T.: "Differential expression of two zebrafish emx homeoprotein mRNAs in the developing brain." Neurosci.Lett.198. 131-134 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kashiwabuchi,N.: "Impairment of motor coordination,Purkinje cell synapse formation and cerebellar long-term depression in GluRδ2 mutant mice." Cell. 81. 245-252 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sakimura,K.: "Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit." Nature. 373. 151-155 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kawamoto,S.: "N-linked glycosylation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate(AMPA)-selective glutamate receptor channel α2 subunit is essential for the acquisition of ligand-binding activity." J.Neurochem.64. 1258-1266 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Watanabe,S.: "Stable production of mutant mice from double gene converted ES cells with puromycin and neomycin." Biochem.Biophys.Res.Commun.213. 130-137 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hirano,T.: "Suppression of LTD in cultured purkinje cells deficient in the glutamate receptor δ2 subunit." NeuroReport. 6. 524-526 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yamakura,T.: "Different effects of propofol on various AMPA-,kainate-and NMDA-selective glutamate receptor channels expressed in Xenopus oocytes." Neurosci.Lett.188. 187-190 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Watanabe,M.: "Cerebellum of adult reeler mutant mouse contains two Purkinje cell populations with respect to gene expression for the N-methyl-D-aspartate receptor channel." Neurosci,Res.22. 335-345 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takayama,C.: "Light-and electron-microscopic localization of the glutamate receptor channel δ2 subunit in the mouse Purkinje cell." Neurosci,Lett.188. 89-92 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kawamoto,S.: "Expression and characterization of the ζ1 subunit of the N-methyl-D-aspartate(NMDA)receptor channel in a Baculovirus system." Mol.Brain Res.30. 137-148 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Watanabe,T.: "Prostaglandin F2a stimulates formation of the p21ras-GPT complex and mitogen-activated protein kinase activity in NIH-3T3 cells via a Gq-protein-coupled pathway,..." J.Biol.Chem.270. 8894-8990 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Honda,Z.: "Gq Pathway desensitizes chemotactic receptor-induced calcium signaling viainositol trisphosphate receptor dowm-regulation." J.Biol.Chem.270. 4840-4844 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] M.Nakamura: "Identification of two isoforms of mouse neuropeptide Y-Y1receptor generated by alternative splicing.Isolation,genomic structure,and functional expression of the receptors." J.Biol.Chem.270. 30101-30108 (1995)

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      1995 Annual Research Report
  • [Publications] Mutoh,H.: "Tissue-specific response of the human platelet-activating factor receptor gene to retinoic acid and thyroid hormone is directed by two distinct promoters." Proc.Natl.Acad.Sci.U.S.A.in press.

    • Related Report
      1995 Annual Research Report
  • [Publications] Yokomizo,T.: "CDNA cloning,expression,and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase." J.Biol.Chem.271. 2844-2850 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mori,M.: "Predominant expression of platelet-activating factor receptor in the rat brain microglia." J.Neurosci.(in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Bito,H.: "Platelet-activating factor(PAF)receptor in rat brain PAF mobilizes intracellular Ca^<2+>in hippocampal neurons." Neuron. 9. 285-294 (1992)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yokomizo,T.: "Enzymatic inactivation of leukotriene B_4 by a novel enzyme found in the porcine kidney.Purification and properties of leukotriene B_4 12-hydroxy-dehydrogenase." J.Biol.Chem.268. 18128-18135 (1993)

    • Related Report
      1995 Annual Research Report
  • [Publications] Honda,Z.: "Transfected platelet-activating factor receptor activates mitogen-activated protein(MAP)kinase and MAP kinase kinase in Chinese hamster ovary cells." J.Biol.Chem.269. 2307-2315 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Bito,H.: "Functional coupling of a rat hippocampal somatostatin receptor to inhibition of adentylate cyctase,activation of arachidonate release and mitogen-activated(MAP)kinase." J.Biol.Chem.269. 12727-12730 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takano,T.: "Role of cytoplasmic-tail phosphorylation sites of platelet-activating factor receptor in agonist-induced desensitization." J.Biol.Chem.269. 22453-22458 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ferby,I.: "Wormannin inhibits mitogen-activated protein kinase・induced by platelet-activating factor in guinea-pig neutrophils." J.Biol.Chem.269. 30485-30488 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kim,C.S.: "Alzhcimcr and β-amyloid-treated fibroblasts demonstratc a dccrease in a memory associated GTP-binding protcin,Cp20" Proc.Natl.Acad.Sci.USA. 92. (1995)

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      1995 Annual Research Report
  • [Publications] Inoue,H.: "A novel function for nucleoside diphosphate kinase in Drosophila" Biochem.Biophys.Res.Comm.(in press). 3060-3064

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      1995 Annual Research Report
  • [Publications] Olds,J.L.: "Imaging protcin kinase Cactivation in living sea urchin eggs after fertilization." Develop.Biol.(in press).

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      1995 Annual Research Report
  • [Publications] Hirata,K.: "Baclofen inhibits GABAergic transmission after treatment with type-specific calcium channel blockers in cultured rat hippocampal neurons." Neurosci.Lett.187. 208-208 (1995)

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      1995 Annual Research Report
  • [Publications] Kamiya,H.: "Activation of metabotropic glutamate receptor type 2/3 suppresses transmission at rat hippocampal mossy fiber synapse." J.Physiol.(in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Sekiyama,N.: "Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes" British Journal of Pharmacology. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Otsu,Y.: "Hebbin induction of LTP in visual cortex:A perfotated patch clamp syudy in cultured neurons." J.Neurophysiol.74. 2437-2444 (1995)

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      1995 Annual Research Report
  • [Publications] Sato,H.: "Machanisms underlying direction sdectivity of neurons in the primary visual cortex of the macaque." J.Neurophysiol.74. 1382-1394 (1995)

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      1995 Annual Research Report
  • [Publications] Torii,N.: "An inhibitor for calcineurin,FK506 blocks induction of long-term depression in rat visual cortex." Neurosci.Lett.185. 1-4 (1995)

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      1995 Annual Research Report
  • [Publications] Sato,H.: "Broad-tuned chromatic inputs to color-selective neurons in the monkey visual cortex." J.Neurophysiol.72. 163-168 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Funauchi,M.: "Effects of an inhibitor for calcium/calmodulin-dependent protein phosphatase.calcineurin,on induction of long-term potentiation in rat visual cortex." Neurosci.Res.19. 269-278 (19954)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yoshimura,Y.: "Deopendence of LTP induction on postsynaptic depolarization:A perforated patch clamp study in visual cortical slices of young rats." J.Neurophysiol.71. 1638-1645 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ayako Ajima: "A unique role of protein phosphatases in cerebellar long-term depression" Neuro Report. 6. 297-300 (1995)

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      1995 Annual Research Report
  • [Publications] Kazutoshi Nakazawa: "Transient and persistent phosphorylation of AMPA-Type Glutamate Receptor Subunits in Cerebellar Purkinje Cells" Neuron. 15. 697-709 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K.Nakazawa: "Antibody specific for phosphorylated AMPA-Type glutamate receptors at Glur2 Ser-696" Neuroscience Research. 24. 75-86 (1995)

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      1995 Annual Research Report
  • [Publications] Nagai,Y.: "The birth of glycobiology and glycotechnology;Studies of the third chain chain of Life" RIKEN Review. 8. 1-2 (1995)

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      1995 Annual Research Report
  • [Publications] Ohashi,Y.: "Adventures in glyco-mass-stectrometry.Seeking for a better method." RIKEN Review. 8. 45-46 (1995)

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      1995 Annual Research Report
  • [Publications] Nagai,Y.: "Functional roles of gangliosides in bio-signaling." Behavioural Brain Res.66. 99-104 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ii,T.: "Structural elucidation of underivatized gangliosides by electrospray-ionization tandem mass spectrometry(ESIMS/MS)" Carbohydrate Res.273. 27-40 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ii,T.: "Fast atom bombardment and electrospray ionization tandem mass spectrometry of sulfated lewis" J.Biochem.118. 526-533 (1995)

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      1995 Annual Research Report
  • [Publications] Nakanishi,S.: "Second-order neurons and receptor mechanisms in visual and olfactory information processing" Trends in Neurosciences. 18. 359-364 (1995)

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      1995 Annual Research Report
  • [Publications] Masu,M.: "Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene" Cell. 80. 757-765 (1995)

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      1995 Annual Research Report
  • [Publications] Kabe,H.: "Synaptic mechanisms of oifactory recognition memory" Reviews in the Neurosciences. 6. 125-141 (1995)

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      1995 Annual Research Report
  • [Publications] Yokoi,M: "Refinement of odor molecule tuning by dendrodendritic synaptic inhibition in the olfactory bulb" Proceedings of the National Academey of Sciences of the United Statesof America. 92. 3371-3375 (1995)

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      1995 Annual Research Report
  • [Publications] Tokita,Y.: "Characterization of excitatory amino acid neurotoxicity in N-methy1-D-aspartate receptor-deficient mouse cortical neuronal cells" European Journal of Neuroscience. (in press).

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      1995 Annual Research Report
  • [Publications] Moriyoshi,K.: "Labeling living neurons by adenovirus-mediated gene transfer of modified membrane-targeted green fluorescent protein" Neuron. (in press).

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      1995 Annual Research Report
  • [Publications] M.Kasai: "Effects of KC1 concentrations on gating properties of calcium release channels in sarcoplasmic reticulum vesicles." J.Biochem.117. 251-256 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Ide: "An anion channel from transverse tubular membranes incorporated into planar bilayers." Biochim.Biophys.Acta.1237. 115-120 (1995)

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      1995 Annual Research Report
  • [Publications] N.Yamaguchi: "DIDS binding 30-kDa protein regulates the calcium release channel in the sarcoplasmic reticulum." Biochem.Biophys.Res.Commun.210. 648-653 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] M.Ohkura: "Calsequestrin is essential for the Ca^<2+> release induced by miotoxin α in skeletal muscle sarcoplasmic reticulum." Can.J.Physiol.Pharmacol.73. 1181-1185 (1995)

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      1995 Annual Research Report
  • [Publications] S.B.Sato: "Enhancement of fluid-phase endocytosis by high-calcium medium and factors" Cell Physiology. (in press).

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      1995 Annual Research Report
  • [Publications] Hirota,J.: "Kinetics of calcium release by immunoaffinity-purified inositol 1,4,5-trisphosphate receptor in reconstituted lipid vesicles." J.Biol.Chem.270(32). 19046-19051 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ogawa,M.: "The reeler gene-associated antigen on cajal-retzius neurons is a crucial molecule for laminar organization of cortical neurons." Neuron. 14. 899-912 (1995)

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      1995 Annual Research Report
  • [Publications] Fukuda,M.: "Functional diversity of C2 domains of synaptotagmin family." J.Biol.Chem.270(44). 26523-26527 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Fukuda,M.: "Role of the C2B domain of synaptotagmin in vesicular release and recycling as determined by specific antibody injection into squid giant synapse preterminal." Proc.Natl.Acad.Sci.USA. 92. 10708-10712 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mikoshiba,K.: "Role of the C2A domain of synaptotagmin in transmitter release as determined by specific antibody injection into the squid giant synapse preterminal." Proc.Natl.Acad.Sci.USA. 92. 10703-10707 (1995)

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      1995 Annual Research Report
  • [Publications] Monkawa,T.: "Heterotetrameric complex formation of inositol 1,4,5-trisphosphate receptor subunits." J.Biol.Chem.270. 14700-14704 (1995)

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      1995 Annual Research Report
  • [Publications] Matsumoto,M.: "Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor." Nature. 379. 168-171 (1996)

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      1995 Annual Research Report
  • [Publications] Aruga,J.: "The mouse zic gene family(Homologues of the Drosophila pair-rule gene odd paired." J.Biol.Chem.271. 1043-1047 (1996)

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      1995 Annual Research Report
  • [Publications] S.Mochida: "Impairment of syntaxin by botulinum neurotoxin C1 or antibodies inhibits acetylcholine release but not ca ^<2+> channel activity." Neuroscience. 65. 905-915 (1995)

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      1995 Annual Research Report
  • [Publications] K.Ibaraki: "Identification of four different forms of syntaxin 3" Biochem.Biophys.Res.Commun.221. 997-1005 (1995)

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      1995 Annual Research Report
  • [Publications] H.Tokumaru: "A calcium channel from the presynaptic nerve terminal of the Narke japonica electric organ contains a non-N-type α_2δ subunit." J.Neurochemistry. 651. 831-836 (1995)

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      1995 Annual Research Report
  • [Publications] T.Ishizuka: "Synaphin:a protein associated with the docking/fusion complex in presynaptic terminals." Biochem.Biophys.Res.Commun.213. 1107-1114 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 吉岡 亮: "情報生物学シリーズ4「シナプス伝達のダイナミクス」" 培風館, 146 (1995)

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      1995 Annual Research Report
  • [Publications] Yagai,Y.: "″Cellular Biology of Gangliosides″in Biology of the Slalic Acids(eds.by Rosenberg,A.)" Plenum Press,New York, 197-241 (1995)

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      1995 Annual Research Report
  • [Publications] Hirota Junji,: "Genes for development,cell growth and infectious diseases(A decade of Pasteur Riken collaboration)" John Libbey EUROTEXT, 262(81-96) (1995)

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      1995 Annual Research Report
  • [Publications] Miyawaki Atsushi,: "Proceedings of the Yamada Conference XXXIX on Calcium as Cell Signal April 26-28,1994 Tokyo,Japan" IGAKU-SHOIN, 263(154-164) (1995)

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      1995 Annual Research Report
  • [Publications] Watanabe,M.: "Differential distributions of the NMDA receptor channel subunit mRNAs in the mouse retina." Brain Res.634. 328-332 (1994)

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      1994 Annual Research Report
  • [Publications] Watanabe,M.: "Distinct gene expression of the N-methyl-D-aspartate receptor channel subunit in peripheral neurons of the mouse sensory ganglia and adrenal gland." Neurosci. Lett.165. 183-186 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ishida,N.: "Circadian expression of NMDA receptor mRNAs, ε3 and ζ1, in the suprachiasmatic nucleus of rat brain." Neurosci. Lett.166. 211-215 (1994)

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      1994 Annual Research Report
  • [Publications] Watanabe,M.: "Distinct spatio-temporal expressions of five NMDA receptor channel subunit mRNAs in the cerebellum." J. Comp. Neurol.343. 513-519 (1994)

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      1994 Annual Research Report
  • [Publications] Watanabe,M.: "Distinct distributions of five NMDA receptor channel subunit mRNAs in the brainstem." J. Comp. Neurol.343. 520-531 (1994)

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      1994 Annual Research Report
  • [Publications] Watanabe,M.: "Distinct spatio-temporal distributions of the NMDA receptor channel subunit mRNAs in the mouse cervical cord." J. Comp. Neurol.345. 314-320 (1994)

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      1994 Annual Research Report
  • [Publications] Nakano,R.: "A novel mutation in Cu/Zn superoxide dismutase gane in Japanese familial amyotrophic lateral sclerosis." Biochem. Biophys. Res. Commun.200. 695-703 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kawamoto,S.: "Ligand binding properties and N-glycosylation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate(AMPA)-selective glutamate receptor channel expressed in a Baculovirus system." Eur. J. Biochem.223. 665-673 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Takahasi,H.: "Familial amyotrophic lateral sclerosis with a mutation in the Cu/Zn superoxide dismutase gene." Acta Neuropathol.88. 185-188 (1994)

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      1994 Annual Research Report
  • [Publications] Tsuzuki,K.: "Ion permeation properties of the cloned mouse ε2/ζ1 NMDA receptor channel." Mol. Brain Res.26. 37-46 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hattori,S.: "Expression and characterization of the α2 subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazole propinate(AMPA)-selective glutamate receptor channel in a Baculovirus system." Braih Res.666. 43-52 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Mori,H.: "Different spatio-temporal expressions of three otx homeoprotein transcripts during zebrafish embryogenesis." Mol. Brain Res.27. 221-231 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hirano,T.: "Involvement of the glutamate receptor δ2 subunit in the long-term depression of glutamate responsiveness in cultured Purkinje cells." Neurosci. Lett.182. 172-176 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Sakimura. K.: "Reduced hippocampal LTP and spatial learning of mice lacking NMDA receptor ε1 subunit." Nature. 373. 151-155 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hirano,T.: "Suppression of LTD in cultured Purkinje cells deficient of glutamate receptor δ2 subunit." Neuro Report. (印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kawamoto,S.: "N-linked glycosylation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate(AMPA)-selectivc glutamate receptor channel α2 subunit is essential for the acquisition of ligand-binding activity." J.Neurochem.(印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kawamoto,S.: "Expression and characterization of the ζ1 subunit of N-methyl-D-aspartate(NMDA) receptor channel in a Baculovirus system." Mol. Brain Res.(印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yoshimura,Y.: "Dependance of LTP induction on postsynaptic depolarization: A proforated patch clamp study in visual cortical slices of young rats." J.Neurophysiol.71. 1638-1645 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Funauchi,M.: "Effects of an inhibitor for calcium/calmodulin-dependent protein phosphatase calcineurin, on induction of long-term potentiation in rat visual cortex." Neurosci. Res.19. 269-278 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Haruta,H.: "Induction of LTD but not LTP through metabotropic glutamate receptors in visual cortex." Neuro Report. 5. 1829-1832 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Harada,A.: "Altered microtubule organization in small-calibre axons of mice lacking tau protein." Nature. 36. 488-491 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kondo,S.: "KIF3A is a new microtubules based fast anterograde motor in the nerve axons." J. Cell Biol.125. 1095-1107 (1994)

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      1994 Annual Research Report
  • [Publications] Nangaku,M.: "KIF1B;A new microtubule plus-end directed monomeric motor for mitochondria transport." Cell. 79. 1209-1220 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Suzuki,H.: "Involvement of enzymatic degradation in the inactivation of tachykinin neurotransmitters in neonatal rat spinal cord." Br. J. Pharmacol.113. 310-316 (1994)

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      1994 Annual Research Report
  • [Publications] Hosoki,R.: "Effects of RP 67580,a tachykinin NK_1 receptor antagonist, on a primary afferent-evoked response of ventral roots in the neonatal rat spinal cord." Br. J. Pharmacol.113. 1141-1146 (1994)

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      1994 Annual Research Report
  • [Publications] Kawasaki,T.: "Regulation of calcium channel in sarcoplasmic reticulum by calsequestrin." Biochem. Biophys. Res. Commun.199. 1120-1127 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kasai,M.: "Effects of KC1 concentrations on gating properties of calcium release channels in sarcoplasmic reticulum vesicls." J. Biochem.177(印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hidari,K.: "A unique biosynthetic pathway for gangliosides exists in Xenopus leavis oocytes." FEBS Letters. 353. 25-28 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Nagai,Y.: "Significance of ganglioside-mediated glycosignal transduction in neuronal differentiation and development." “Biological Function of Gangliosides" (ed. Svennerholm, L. et al, Elsevier Sci., pp. 409,1994), Progress in Brain Reseach.101. 119-126 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Nara,K.: "Expression cloning of a CMP-NeuAc: NeuAcα2-3Galβ1-4GlcBl1'Cerα2, 8-sialyltransferase(GD3 Synthase) from human melanoma cells." Proc. Natl. Acad. Sci. USA. 91. 7952-7956 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Mochida,S.: "Impairment of syntaxin by botulinum neurotoxin Cl or antibodies inhibits acetylcholine release but not Ca^<2+> channel activity." Neurosci.65. (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Nakade,S.: "Cyclic AMP-dependent phosphlylation of an immunoaffinity purified type I homoterameric inositol 1,4,5-trisphosphate receptor increases Ca^<2+> flux in reconstituted lipid vesicles." J. Biol. Chem.269. 6735-6742 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Michikawa,T.: "Transmembrane topology and site of N-Glycosylation of inositol 1,4,5-trisphosphate receptor" J. Biol. Cham.269. 9184-9189 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Fukuda,M.: "Inostiol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II." J. Biol. Chem.269. 29206-29211 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Arakane,F.: "Glycolipids isolated from Aplysia kurodai can activate cyclic adenosine 3',5'-monophosphosphate-dependent protein kinase from rat brain." J.Neurochem.62. 86-93 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yamada,S.: "Structural analysis of a novel triphosphonoglycosphingolipid from the egg of the sea hare, Aplysia kurodai." J. Biochem.117(印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ito,M.: "Is LTD associated with learning in the cerebellum?" Cellular and Molecular Mechanisms underlying Higher Neural Function. (eds. A. I. Selveston & P.Ascher, John Wiley & Sons). 15-40 (1994)

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      1994 Annual Research Report
  • [Publications] Karachot,L.: "Stimulus parameters for induction of long-term depression in in vitro slices of rat cerebellum." Neurosci. Res.21. 161-168 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ajima,A.: "A unique role of protein phosphatase in induction of cerebellar long-term depression." Neuro Report. (印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Oyamada,H.: "Primary structure and distribution of ryanodine-binding protein isoforms of the bullfrog skeletal muscle." J. Biol. Chem.269. 17206-17214 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tsukioka,M.: "pH dependence of inositol 1,4,5-trisphosphate-induced Ca^<2+> release in permeabilized smooth muscle cells of the guinea-pig." J. Physiol.475,3. 369-375 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kasai,Y.: "Effects of cyclopiazonic acid on rhythmic contractions in uterine smooth muscle bundles of the rqt." Br. J. Pharmacol.112. 1132-1136 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yamamoto,C.: "Suppression of hippocampal synaptic transmission by the spider toxin ω-agatoxin-IV-A." Brain Res.634. 349-352 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ohno-Shousaku,T.: "A comparison between potencies of external calcium, strontium and barium to support GABAergic synaptic transmission in rat cultured hippocampal neurons." Neurosci. Res.20. 223-229 (1994)

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      1994 Annual Research Report
  • [Publications] Ohno-Shousaku,T.: "Contributions of multiple calcium channel types to GABAergic transmission in rat cultured hippocampal neurons." Neurosci. Lett.181. 145-148 (1994)

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      1994 Annual Research Report
  • [Publications] Nelson,T.J.: "Characterization of a GTP-binding protien implicated in both memory storage and interorganelle vesicle transport." Proc. Natl. Acad. Sci. USA. 91. 9287-9291 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yamashima,T.: "Temperature-dependent Ca^<2+> mobilization induced by hypoxia-hypoglycemia in the monkey hippocampal slices." Biochem. Biophys. Res. Commun.205. 1843-1849 (1994)

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      1994 Annual Research Report
  • [Publications] Fikes,J.D.: "Distribution of gentamicin to the cochlea of the chicken embryo." Toxicol. Pathol.22. 15-22 (1994)

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      1994 Annual Research Report
  • [Publications] Honda,Z.: "Transfected platelet-activating factor receptor activates mitogen-activated protein(MAP) kinase and MAP kinase kinase in Chinese hamster ovary cells." J. Biol. Chem.269. 2307-2315 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Bito, H.: "Functional coupling of a rat hippocampal somatostain receptor to inhibition of adenylate cyclase, activation of arachidonate release and mitogen-activated(MAP) kinase." J. Biol. Chem.269. 12727-12730 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Takano, T.: "Role of cytoplasmic-tail phosphorylation sites of platelet-activating factor receptor in agonist-induced desensitization." J. Biol. Chem.269. 22453-22458 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ferby,I.: "Wortmannin inhibits mitogen-activated protein kinase induced by platelet-activating factor in guinea-pig neutrophils." J. Biol. Chem.269. 30485-30488 (1994)

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      1994 Annual Research Report
  • [Publications] Nomura,A.: "Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells." Cell. 77. 361-369 (1994)

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      1994 Annual Research Report
  • [Publications] Nakanishi,S.: "Metabotropic glutamate receptors: synaptic transmission, modulation, and plasticity." Neuron. 13. 1031-1037 (1994)

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      1994 Annual Research Report
  • [Publications] Kaba,H.: "Induction of an olfactory memory by the activation of a metabotropic glutamate receptor." Science. 265. 262-264 (1994)

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      1994 Annual Research Report
  • [Publications] Ostuka,M.: "The Tachykinin Receptors, “Pharmacological characterization of receptors in the spinal cord of the newborn rat."" Ed.: S. H. Buck, Humana press, 15 (1994)

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      1994 Annual Research Report
  • [Publications] 葛西 道生: "膜学実験シリーズ 1「光散乱法」" 共立出版, 63 (1994)

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      1994 Annual Research Report
  • [Publications] O.Shimada et al.: "Developmental changes of proteins associated with N-type calcium channels in the rat brain." Biomed.Res.14. 37-48 (1993)

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      1993 Annual Research Report
  • [Publications] Nakano,R.et al.O.Shimada et al.: "A novel mutation in Cu/Zn superoxide dismutase gene in Japanese familial amyotrophic lateral sclerosisDifferences in the distribution of proteins associated with ω-conotoxin receptors in rat pituitary cells." Biochem.Biophys.Res.Commun.Biomed.Res.(in press)14. 265-272 (19941993)

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      1993 Annual Research Report
  • [Publications] Watanabe,M.et al.H.P.M.Horikawa et al.: "Distinct spatio-temporal expressions of five NMDA receptor channel subunit mRNAs in the cerebellumA complex of rab3A,VAMP/synaptobrevin-2 and syntaxins in brain presynaptic terminals." J.Comparative NeurologyFEBS Lett.(in press)330. 236-240 (19941993)

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      1993 Annual Research Report
  • [Publications] Watanabe,M.et al.T.Abe,H.Saisu and H.P.M.Horikawa: "Distinct distributions of five NMDA receptor channel subunit mRNAs in the brainstemSynaptocanalins(N-type Ca channel-associated proteins)form a complex with SNAP-25 and synaptotaqmin." J.Comparative NeurologyAnn.N.Y.Acad.Sci.(in press)707. 373-375 (19941993)

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      1993 Annual Research Report
  • [Publications] Watanabe,M.et al.O.Shimada et al.: "Distinct gene expression of the N-methyl-D-aspartate receptor channel subunit in peripheral neurons of the mouse sensory ganglia and adrenal glandImmunohistochemical localization of the proteins associated with brain N-type calcium channels." Neurscience LettersAnn.N.Y.Acad.Sci.(in press)707. 376-378 (19941993)

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      1993 Annual Research Report
  • [Publications] Watanabe,M.et al.: "Distinct spatio-temporal distributions of the NMDA receptor channel subunit mRNAs in the mouse cervical cord" J.Comparative Neurology. (in press). (1994)

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      1993 Annual Research Report
  • [Publications] Ishida,N.et al.: "Circadian expression of NMDA recptor mRNAs,ε3 and ζ1,in the suprachiasmatic nucleus of rat brain" Neurosci.Lett.(in press). (1994)

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      1993 Annual Research Report
  • [Publications] Watanabe,M.et al.: "Differential distributions of the NMDA receptor channel subunit mRNAs in the mouse retina." Brain Res.634. 328-332 (1994)

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      1993 Annual Research Report
  • [Publications] Araki,K.et al.: "Selective expression of the glutamate receptor channel δ2 subunit in cerebellar Purkinje cells." Biochem.Biophtys.Res.Commun.197. 1267-1276 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Takano,H.et al.: "Chromosomal localization of the ε1,ε3 and ζ1 subunit genes of the human NMDA receptor channel." Biochem.Biophtys.Res.Commun.197. 922-926 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yamakura,T.et al.: "Phosphorylation of the carboxyl-terminal domain of the ζ1 subunit is not responsible for potentiation by TPA of the NMDA receptor channel." Biochem.Biophtys.Res.Commun.196. 1537-1544 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Watanabe,M.et al.: "Distinct distributions of five N-methyl-D-aspartate receptor channel subunit mRNAs in the forebrain." J.Comp.Neurol.338. 377-390 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Watanabe,M.et al.: "Distinct spatio-temporal distributions of the NMDA receptor channel subunit mRNAs in the brain." Ann.NY Acad.Sci.707. 463-466 (1993)

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      1993 Annual Research Report
  • [Publications] Kawamoto,S.et al.: "Expression of the α1 and α2 subunits of the AMPA-selective glutamate receptor channel in insect cells using a Baculovirus vector" Ann.NY Acad.Sci.707. 460-462 (1993)

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      1993 Annual Research Report
  • [Publications] Mishina,M.et al.: "Molecular and functional diversity of the NMDA receptor channel" Ann.NY Acad.Sci.707. 136-152 (1993)

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      1993 Annual Research Report
  • [Publications] Yamakura,T.et al.: "Different sensitivities of NMDA receptor channel subtypes to noncompetitive antagonists" NeuroReport. 4. 687-690 (1993)

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      1993 Annual Research Report
  • [Publications] Mori,H.et al.: "Involvement of the carboxyl-terminal region in modulation by TPA of the NMDA receptor channel" NeuroReport. 4. 519-522 (1993)

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      1993 Annual Research Report
  • [Publications] Mori,H.et al.: "Activation of MAP kinase and arachidonate release via two G-protein-coupled receptors expressed in rat hippocampus(in press)" Ann.N.Y.Acad.Sci.(1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Bito H.et al.: "Functional coupling of a rat hippocampal somatostatin receptor to inhibition of adenylate cyclase and activation of MAP kinase" J.Biol.Chem.269(in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Honda,Z.et al.: "Transfected PAF receptor activates MAP kinase and MAP kinase kinase in CHO cells" J.Biol.Chem.269(in press). (1994)

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      1993 Annual Research Report
  • [Publications] Yokomizo,T.et al.: "Enzymatic inactivation of Ieukotviens B_4 by a novel enzyme found in the porcine kidney." J.Biol.Chem.268. 18128-18135 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Mori,M.et al.: "Energy-dependent export of leukotriene B_4 in Xenopus oocytes" Biochim.Biophys.Acta.1168. 23-29 (1993)

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      1993 Annual Research Report
  • [Publications] Mutoh,H.et al.: "Two different promoters direct expression of two distinct forms of mRNAs of human PAF receptor" FEBS Lett.322. 129-134 (1993)

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      1993 Annual Research Report
  • [Publications] D.L.Alkon et al.: "Characterization of a GTP binding protein implicated in both memory strage and intersrganelle vesicle transport" Proc.Natl.Acad.of Sci.USA. (in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] M.Shimoda et al.: "Inhibition of the Ca-activated K^+ channel by sapecin B,an insect antibacterial protein" FEBS Lett.(in press). (1994)

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      1993 Annual Research Report
  • [Publications] T.Yoshioka et al.: "Biophysical aspect of information flow from receptor to channel" Annals of New York Academy of Science. 707. 328-340 (1993)

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      1993 Annual Research Report
  • [Publications] C.Collin et al.: "The role of calcium in probonged modification of a GABA ergic synapse" J.Physiol.(Paris). 86. 139-145 (1992)

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      1993 Annual Research Report
  • [Publications] W.F.Voorhout et al.: "Subcellular localization of glycolipids as revealed by immuns-electron microscopy" Trends in Glycoscience and Glycotechnology. 4. 553-546 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kamiya,H.,Sawada,S.and Yamamoto,C.: "Long-lasting potentiation of synaptic transmission in the Schaffer collateral-commissural pathway of the guinca pig hippocampus by activation of postsynaptic N-methyl-D-aspartate receptor." Synapse. 13. 186-194 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yamamoto,C.,Sawada,S.and Ohno-Shosaku,T.: "Quantal analysis of modulating action of adenosine on the mossy fiber synapse in hippocampal slices." Hippocampus. 3. 87-92 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yamamoto,C.,Sawada,S.and Ohno-Shosaku,T.: "Electrophysiological features of habenular neurons of the guinea pig:high efficacy of synaptic transmission and variable configuration of unitary spikes." Neurosci.Lett.154. 179-182 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ohno-Shosasku,T.,Sawada,S.and Yamamoto,C.: "ATP-sensitive K^+ channel activators suppress the GABAergic inhibitory transmission by acting on both presynaptic and postsynaptic sites in rat cultured hippocampal neurons." Neurosci.Lett.159. 139-142 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yamamoto,C.,Sawada,S.and Ohno-Shosaku,T.: "Suppression of hippocampal synaptic transmission by the spider toxin ω-agatoxin-IV-A." Brain Res.634. 349-352 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ito,M.: "movement and thought:identical control mechanisms by the cerebellum" Trends in Neurosci.16. 447-450 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ito,M.: "Synaptic plasticity in the cerebellar cortex and its role in motor learning" Canad.J.Neurological Sci.Sup.3. 70-74 (1993)

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      1993 Annual Research Report
  • [Publications] Ito,M.: "New concepts in cerebellar function" Rev.Neurol.(Paris). 149. 596-599 (1993)

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      1993 Annual Research Report
  • [Publications] Ito,M.: "Neurophysiology of the nodlofloccular system" Rev.Neurol.(Paris). 149. 692-697 (1993)

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      1993 Annual Research Report
  • [Publications] Higuchi R.,Inukai K.,Jhou X.J.,Honda M.,Komori T.,Tsuji S.,Nagai Y.: "Structure and biological activity of ganglioside molecular species." Liebigs Ann.Chem.359-366 (1993)

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      1993 Annual Research Report
  • [Publications] Ii T.,Ohashi Y.,Nagai Y.: "Observation of a novel adduct-ion in negative-ion electrospray mass spectrometry of neutral glycolipids" Organic Mass Spectrometry. 28. 927-928 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kusunoki S.,Chiba A.,Hirabayashi Y.,Irie F.,Kotani M.,Kawashima I.,Tai T.,Nagai Y.: "Generation of a monoclonal antibody specific for a new class of monor ganglioside antigens,GQ1bα and GT1aα:its binding to dorsal and lateral horn or human thoracic cord." Brai Research. 623. 83-88 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ii T.,Ohashi Y.,Matsuzaki Y.,Ogawa T.,Nagai Y.: "Electrospray mass spectrometry of pentacosasaccharides of blood group I-activity and related compounds." Organic Mass Spectrometry. 28. 1340-1344 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Natomi H.,Saitoh T.,Sugano K.,Iwamori M.,Fukayama M.,Nagai Y.: "Systematic analysis of glycosphingolipids in the human gastrointestinal tract:enrichment of sulfatides with hydroxylated longer-chain fatty acids in the gastric and duodenal mucosa." Lipids. 28. 737-742 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Iwamori M.,Kiguchi K.,Nozawa S.,Hirohashi S.,Shimosato Y.,Nagai Y.: "Compensatory occurrence of IV^2-Fuoα,II^3 NeuAoα-Gg_4Cer and human fetal antigen Lc_4Cer in small cell carcinomas of the human lung." Cancer Research. 53. 5903-5907 (1993)

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      1993 Annual Research Report
  • [Publications] Otsuka M.and Yoshioka K.: "Neurotransmitter functions of mammalian tachykinins." Physiol.Rev.73. 229-308 (1993)

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      1993 Annual Research Report
  • [Publications] Guo J.-Z.et al.: "Depression of primary afferent-evoked responses by GR71251 in the isolated spinal cord of the neonatal rat." Br.J.Pharmacol.110. 1142-1148 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kurihara T.et al.: "Muscarinic excitatory and inhibitory mechanisms involved in afferent fibre-evoked depolarization of motoneurones in the neonatal rat spinal cord." Br.J.Pharmacol.110. 61-70 (1993)

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      1993 Annual Research Report
  • [Publications] Suzuki H.et al.: "Pharmacological characteristics of tachykinin receptors mediating acetylcholine release from neonatal rat spinal cord." Eur.J.Pharmacol.241. 105-110 (1993)

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      1993 Annual Research Report
  • [Publications] Yanagisawa M.et al.: "Pharmacological properties of a slow C-fiber response induced by stimulation of greater splanchnic nerve in an isolated spinal cord-nerve preparation of the newborn rat." Regul Pept.46. 285-286 (1993)

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      1993 Annual Research Report
  • [Publications] Zhao F.-Y.et al.: "Involvement of NK_1 receptors in synaptic transmission in the guinea pig coeliac ganglion." Neurosci.Res.18. 245-248 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Futoshi Arakane et al.: "Glycolipids isolated from Aplysia kurodai can antivate cyclic adenosine 3',5'-monophosphate-dependent protein kinase from rat brain." J.Neurochem.62. 86-93 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Hirose,K.et al.: "Caffeine inhibits Ca^<2+>-mediated potentiation of inositol 1,4,5-trisphosphate-induced Ca^<2+> release in permeabilized vascular smooth muscle cells" Biochem.Biophtys.Res.Commun.194. 726-732 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Iino,M.et al.: "Critical intracellular Ca^<2+> concentration for all-or none Ca^<2+> spiking in single smooth muscle cells" The EMBO Journal. 12. 5287-5291 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ueno,T.et al.: "Partial characterization of a rabbit liver Ca^<2+>-calmodulin-dependent kinase with myosin light chain phosphorylating activity" Biochemistry and Molecular Biology International. 29. 1145-1152 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Nakajima,Y.,et al.: "Molecular characterization of a novel retinal metabotropic qlutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate." J.Biol.Chem.268. 11868-11873 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Hayashi,Y.,et al.: "Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb." Nature. 366. 687-690 (1993)

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      1993 Annual Research Report
  • [Publications] Okamoto,N.,et al.: "Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction." J.Biol.Chem.269. 1231-1236 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Okihara,T.Ohkawa,and M.Kasai: "Effects of calmodulin on Ca^<2+>-dependent Cl^--sensitive anion channels in the Chara plasmalemma:A patch-clamp study" Plant Cell.Physiol.34. 75-82 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] M.Kasai and K.Nunogaki: "Channel opening process is responsible for the slow component in the flux measurement of membrane vesicles." J.Theor.Biol.161. 461-480 (1993)

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      1993 Annual Research Report
  • [Publications] M.Kasai and T.Kawasaki: "Effects of ryanodine on permeability of choline and glucose through ealcium channel in sarcoplasmic reticulum vesicles." J.Biochem.113. 327-333 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] R.Tokioka,A.Matsuo,K.Kiyosue,M.Kasai and T.Taguchi: "Synaptic formation in dissociated cell cultures of embryonic chick cerebral neurons." Dev.Brain Res.74. 146-150 (1993)

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      1993 Annual Research Report
  • [Publications] J.Hidaka,T.Ide,T.Kawasaki,T.Taguchi and M.Kasai: "Characterization of a Cl^--channel from rabbit transverse tubules in the planar lipid bilayer systom." Biochem.Biophys.Res.Commun.191. 977-982 (1993)

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      1993 Annual Research Report
  • [Publications] M.Sato and M.Kasai: "Making synaptic vesicles fuse with lipid bilayers.Reply." Biophys.J.65. 375-377 (1993)

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      1993 Annual Research Report
  • [Publications] Takemura,R.: "Reorganization of brain spectrin (fodrin) during differentiation of PC12 cells." Neuroscience. 52. 381-391 (1993)

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      1993 Annual Research Report
  • [Publications] Umeyama,T.: "Dynamics of microtubules bundled by microtubule associated protein 2 C(MAP2)." Journal of Cell Biology. 120. 451-465 (1993)

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      1993 Annual Research Report
  • [Publications] Okabe,S.: "Do photobleached fluorescent microtubules move?:Re-evaluation of fluorescence laser photobleaching both in vitro and in growing Xenopus axon." Journal of Cell Biology. 120. 1177-1186 (1993)

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      1993 Annual Research Report
  • [Publications] Okabe,S.: "Dynamics of the neuronal intermediate filaments." Journal of Cell Biology. 121. 375-386 (1993)

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      1993 Annual Research Report
  • [Publications] Nakata,T.: "A novel member of dynamin-family of GTP-binding protein is expressed specifically to testis." Journal of Cell Science. 105. 1-5 (1993)

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      1993 Annual Research Report
  • [Publications] Noda,Y.: "Localization of dynamin:Widespread distribution in neurons and association with membraneous organelles transported anterogradely." Neuroscience. 55. 113-127 (1993)

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      1993 Annual Research Report
  • [Publications] Zhang,Z.: "The primary structure of rat brain dynein heavy chain,a cytoplasmic motor enzyme." Proceeding of the National Academy of Science of the USA. 90. 7928-7932 (1993)

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      1993 Annual Research Report
  • [Publications] Hirokawa,N.: "Axonal transport and the cytoskeleton." Current Opinion in Neurobiology.3. 724-731 (1993)

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      1993 Annual Research Report
  • [Publications] Hirokawa,N.: "Mechanism of axonal transport.Identification of new molecular motors and regulations of transports." Neuroscience Research. 18. 1-9 (1993)

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      1993 Annual Research Report
  • [Publications] Miyasaka,H.: "Interaction of the tail domain of high molecular weight subunits of neurofilaments with the C-terminal region of tubulin and its regulation by tau protein kinase II." Journal of Biological Chemistry. 268. 22695-22702 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Hirokawa,N.: "Microtubule organization and dynamics dependent on microtubule-associated proteins." Current Opinion in Cell Biology. 6. 74-82 (1994)

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      1993 Annual Research Report
  • [Publications] Nakata,T.: "Thermal Drift is enough to drive microtubules in the absense" Biophysical Journal. 65. 2504-2510 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Harada,A.: "Tau is not essential for polarized neuronal cell morphogenesis but important for microtubule organization and stabilization in small caliber axons." Nature. (in press). (1994)

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      1993 Annual Research Report
  • [Publications] Hagiwara,H.: "Interaction between cytoplasmic dynein and tau or MAP2 for the binding to microtubules." Journal of Biological Chemistry. (in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yamada,M.et al.: "Migration of genetically labeled glioma cells after implantation murine brain" J.of Neurosci.Res.(in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Nakade,S.et al.: "Cyclic AMP-dependent phospholylation of an immunoaffinity purified type I homotetrameric inositol 1,4,5-trisphosphate receptor increases Ca^<2+> flux in reconstituted lipid vesicles" J.Biol.Chem.(in press). (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yuzaki,M.et al.: "Cerebellar astrocytes specifically support the survival of Purkinje cells in culture" Biochem.Biophtys.Res.Commun.197. 123-129 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Miyao,Y.et al.: "Selective expression of foreign genes in glioma cells:Use of the muse myelin basic protein gene promoter to direct toxic gene expression" J.of Neurosci.Res.36. 472-479 (1993)

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      1993 Annual Research Report
  • [Publications] Okamoto M.et al.: "Internucleosomal DNA cleavage involved in ischemia-induced neuronal death" Biochem.Biophtys.Res.Commun.196. 1356-1362 (1993)

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      1993 Annual Research Report
  • [Publications] Yamamoto-Hino,M.et al.: "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors" Receptors and Channels. in press. (1993)

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      1993 Annual Research Report
  • [Publications] Mikoshiba,K.et al.: "Inositol trisphosphate receptor and Ca^<2+> signalling" Phil.Trans.R.Soc.Lond.B. 340. 345-349 (1993)

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      1993 Annual Research Report
  • [Publications] Ryo,Y.et al.: "Expression of the metabotropic Glutamate receptor mGluR1 and the inotropic glutamate receptor GluR1 in the brain during the postnatal development of normal mouse and in the cerebellum from mutant mice" J.Neurocsi.Res.36. 19-32 (1993)

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      1993 Annual Research Report
  • [Publications] Wojcikiewicz,R.et al.: "Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degration" J.Biol.Chem.(in press). (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sumita K.et al.: "Structure of a mammalian TBP(TATA-binding protein)gene:Isolation of the mouse TBP genome." Nucleic Acid Research. 21. 2769 (1993)

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      1993 Annual Research Report
  • [Publications] Yuzaki M.et al.: "A stimulus paradigm inducing LTD in cerebellar slices spedifically evokes an increase in BDNF mRNA in granule and Purkinje cells." Biochem.Biophys.Res.Commun.(in press). (1993)

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      1993 Annual Research Report
  • [Publications] Kagawa T.et al.: "Fate of Jimpy Type Oligodendrocyte in Jimpy Heterozygote" J.Neurochem.(in press). (1993)

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      1993 Annual Research Report
  • [Publications] Hamada E.et al.: "Activation of Ca^<2+>-dependent K^+ Current by Acetylcholine and Histamine in a Human Gastric Epithelial cell Line" J.General Physiology. 102. 667-692 (1993)

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      1993 Annual Research Report
  • [Publications] Goujet-Zalc C.et al.: "The proximal Region of the MBP Gene Promoter is Sufficient to Induce Oligodendroglial-specific Expression in Transgenic Mice" Euro.J.Neurosci.5. 624-632 (1993)

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      1993 Annual Research Report
  • [Publications] Rodrigo J.et al.: "Distribution of the Inositol 1,4,5-Trisphosphate Receptor,P_<400'> in Adult Rat Brain." J.Comp.Neurol.336. 1-25 (1993)

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      1993 Annual Research Report
  • [Publications] Shimizu H.et al.: "Structures of N-Linked Suger Chains Expressed Mainly in Mouse Brain" J.Biochem.114. 334-338 (1993)

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      1993 Annual Research Report
  • [Publications] Hata,R.et al.: "Differential Vulnerability in the Hindbrain Neurons and Local Cerebral Blood Flow During Bilateral Vertebral Occlusion in Gerbils" Neuroscience. 56. 423-439 (1993)

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      1993 Annual Research Report
  • [Publications] Kume S.et al.: "The Xenopus IP_3 Receptor:structure,function and localization in oocytes and eggs" Cell. 73. 555-570 (1993)

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      1993 Annual Research Report
  • [Publications] Fujita Y.et al.: "Primary Structure and Functional Expression of the-Conotoxin-Sensitive N-Type Calcium Channel from Rabbit Brain" Neuron. 10. 585-598 (1993)

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      1993 Annual Research Report
  • [Publications] Furuichi T.et al.: "Widespread expression of inositol 1,4,5-trisphosphate receptor type 1 gene(insp3rl)in the mouse central nervous system" Receptors and Channels. 1. 12-24 (1993)

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      1993 Annual Research Report
  • [Publications] Yoshikawa S.et al.: "Isolation of a Drosophila Gene Encoding a Head-Specific Guanylyl Cyclase" J.Neurochem.60. 1570-1573 (1993)

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      1993 Annual Research Report
  • [Publications] Nakajima K.et al.: "Novel isoforms of mouse myelin basic protein predominantly expressed in embryonic stage" J.Neurochem.60. 1554-1563 (1993)

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      1993 Annual Research Report
  • [Publications] White,A.M.et al.: "Comparion of ins(1,4,5)P3 receptors from rat cerebellum and bovine adrenal cortex." Biochem.Biophys.Acta.1175. 307-311 (1993)

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      1993 Annual Research Report
  • [Publications] Suburo A.M.et al.: "Immunohistochemical localization of the inositol 1,4,5-trisphosphate receptor in the human nervous system" Brain Res.601. 193-202 (1993)

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      1993 Annual Research Report
  • [Publications] Ito,M.: "Memory Concept-1993 Basic and Climical Aspects" Properties of long-term depression in the cerebellum, 10 (1993)

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      1993 Annual Research Report
  • [Publications] 永井克孝,箱守仙一郎,木幡陽/編: "グリコバイオロジーシリーズ2:糖鎖の細胞における運命" 講談社サイエンティフィック, 224 (1993)

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      1993 Annual Research Report
  • [Publications] 永井克孝,箱守仙一郎,木幡陽/編: "グリコバイオロジーシリーズ3:細胞社会のグリコバイオロジー" 講談社サイエンティフィック, 238 (1993)

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      1993 Annual Research Report
  • [Publications] Suzuki H.and Otsuka M.: "Methods in neurotransmitter and neuropeptide research." Elsevier, 443-455 (1993)

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      1993 Annual Research Report
  • [Publications] Otsuka M.et al.: "The Tachykinin Receptors." Humana Press(in press), (1994)

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      1993 Annual Research Report
  • [Publications] Endo,M.: "MALIGNANT HYPERTHERMIA A Genitic Membrane Disease" CRC Press,Boca Ratpm, 331 (1994)

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      1993 Annual Research Report
  • [Publications] Sakimura,K.,et al.: "Primary structure and expression of the γ2 subunit of the glutamate receptor channel selective for kainate." Neuron. 8. 267-274 (1992)

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      1992 Annual Research Report
  • [Publications] Morita,T.,et al.: "Cloning and functional expression of cDNA encoding the mouse β2 subunit of the kainate-selective glutamate receptor channel." Mol.Brain Res.14. 143-146 (1992)

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      1992 Annual Research Report
  • [Publications] Yamazaki,M.,et al.: "Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family." Biochem.Biophys.Res.Commun.183. 886-892 (1992)

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      1992 Annual Research Report
  • [Publications] Yamazaki,M.,et al.: "Cloning,expression and modulation of a mouse NMDA receptor subunit." FEBS Lett.300. 39-45 (1992)

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      1992 Annual Research Report
  • [Publications] Meguro,H.,et al.: "Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs." Nature. 357. 70-74 (1992)

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      1992 Annual Research Report
  • [Publications] Kutsuwada,T.,et al.: "Molecular diversity of the NMDA receptor channel." Nature. 358. 36-41 (1992)

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      1992 Annual Research Report
  • [Publications] Mori,H.,et al.: "Identification by mutagenesis of a Mg^<2+> block site of the NMDA receptor channel." Nature. 358. 673-675 (1992)

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      1992 Annual Research Report
  • [Publications] Uchino,S.,et al.: "Mutations in a putative agonist binding region of the AMPA-selective glutamate receptor channel." FEBS Lett.308. 253-257 (1992)

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      1992 Annual Research Report
  • [Publications] Morita,T.,et al.: "Synaptocanalin I,a protein associated with brain ω-conotoxin-sensitive calcium channels." Biomed.Res.13. 357-364 (1992)

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      1992 Annual Research Report
  • [Publications] Ikeda,K.,et al.: "Cloning and expression of the ε4 subunit of the NMDA receptor channel." FEBS Lett.313. 34-38 (1992)

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      1992 Annual Research Report
  • [Publications] Watanabe,M.,et al.: "Developmental changes in distribution of the NMDA receptor channel subunit mRNAs in the brain." NeuroReport. 3. 1138-1140 (1992)

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      1992 Annual Research Report
  • [Publications] Alkon D.L.,et al.: "Long-term transformation of an inhibitory into an exicitatory GABAergic synaptic response." Proc.Natl.Acad.Sci.U.S.A.89. 11862-11866 (1992)

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      1992 Annual Research Report
  • [Publications] Voorhout W.F.,et al.: "Subcellular localization of glycolipids as revealed by immunoelectronmicroscopy." TIGG. 4. 533-546 (1992)

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      1992 Annual Research Report
  • [Publications] Takagi H.,et al.: "Delayed appearance of G-protein coupled signal transduction system in developing cerebellar Purkinje cell dendrites." Neurosci.Res.15. 206-212 (1992)

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      1992 Annual Research Report
  • [Publications] Suzuki N.,et al.: "Augmantation of transient low-threshold Ca^<2+> current induced by GTP-binding protein signal transduction system in GH_3 pituitary cells." Biochem.Biophys.Res.Commun.187. 529-536 (1992)

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      1992 Annual Research Report
  • [Publications] Miyazawa A.,et al.: "Monoclonal antibody analysis of phosphatidylserine and protein kinase C localizations in developing rat cerebellum." J.Neurochem.59. 1547-1554 (1992)

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      1992 Annual Research Report
  • [Publications] Inoue H.,et al.: "Partial purification and characterization of membrane-associated diacylglycerol kinase of Drosophila heads." Biochim.Biophys.Acta.1122. 219-224 (1992)

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      1992 Annual Research Report
  • [Publications] Bito,H.,et al.: "Platelet-activating factor(PAF)receptor in ret brain:PAF mobilizes intracellular Ca2+ in hippocampal neurons." Neuron. 9. 285-294 (1992)

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      1992 Annual Research Report
  • [Publications] Sakanaka,C.,et al.: "Three typer of Gi protein of the quinea pig lung;cDNA cloning and analysis of their tissue distribution." Biochim.Biophys.Acta. 1175. 61-66 (1992)

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      1992 Annual Research Report
  • [Publications] Nakamura,M.,et al.: "Endotoxin transduces Ca2+ signaling via platelet-activating factor receptor." FEBS Lett.314. 125-129 (1992)

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      1992 Annual Research Report
  • [Publications] Shimizu,T.: "Platelet-activating factor receptor and signal transduction." Biochem.Pharmacol.44. 1001-1008 (1992)

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      1992 Annual Research Report
  • [Publications] Yamamoto,C.,Sawada,S.and Kamiya,H.: "Enhancement of postsynaptic responsiveness during long-term potentiation of mossy fiber synapses in guinea pig hippocampus." Neurosci.Lett.138. 111-114 (1992)

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      1992 Annual Research Report
  • [Publications] Kamiya,H.,Sawada,S.and Yamamoto,C.: "An empirical test for the reliability of quantal analysis based on Pascal statistics." J.Neurosci.Methods. 42. 19-26 (1992)

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      1992 Annual Research Report
  • [Publications] Hirata,K.,Sawada,S.and Yamamoto,C.,: "Quantal analysis of supperssing action of baclofen on mossy fiber synapses in guinea pig hippocampus." Brain Res.578. 33-40 (1992)

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      1992 Annual Research Report
  • [Publications] Ohno-Shosaku,T.and Yamamoto,C.: "Identification of an ATP-sensitive K^+ channel in rat cultured cortical neurons." Pflugers Arch.422. 260-266 (1992)

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      1992 Annual Research Report
  • [Publications] Tamura,H.et al.: "Activity-dependent potentiation and depression of visual cortical responses to optic nerve stimulation in kittens." Journal of Neurophysiology. 68. 1603-1612 (1992)

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      1992 Annual Research Report
  • [Publications] Funauchi,M.et al.: "Long-term depression is induced in Ca2+/ calmodulin kinase-inhibited neurons in visual cortex." NeuroReport. 3. 173-176 (1992)

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      1992 Annual Research Report
  • [Publications] Tsumoto,T.: "Long-term potentiation and long-term depression in the neocortex." Progress in Neurobiology. 39. 209-228 (1992)

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      1992 Annual Research Report
  • [Publications] Hata,Y.et al.: "Development of local horizontal interactions in cat visual cortex studied by cross-correlation analysis." Journal of Neurophysiology. 69. 40-56 (1993)

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      1992 Annual Research Report
  • [Publications] Ito,M.,et al.: "Protein kinases and protein phosphatase inhibitors mediating long-term desensitigation in cerebellar Purkinje cells." Neurosci.Res.14. 27-38 (1992)

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      1992 Annual Research Report
  • [Publications] Nakaoka,T.,et al.: "Bimodal regulation of protein phosphorylation by a ganglioside in rat brain membrane." J.Neurosci.31. 724-730 (1992)

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      1992 Annual Research Report
  • [Publications] Tsuji,S.,et al.: "A novel glycosignaling system:GQ1b-dependent neuritogenesis of human reuroblastoma cell line,goto is closely associated with GQ1b-dependent ecto-type protein phosphorylation." Neurochem.Int.Vol.21No.4. 549-554 (1992)

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      1992 Annual Research Report
  • [Publications] Kusunoki,S.,et al.: "Developmental changes of fucosylated glycoconjugates in rabbit dorsal root ganglia." Neurosci.Res.15. 74-80 (1992)

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      1992 Annual Research Report
  • [Publications] Yanagisawa M.et al.: "The isolated spinal cord-skin preparation of the newborn rat and effects of some algogenic and analgesic substances." Eur.J.Pharmacol.220. 111-117 (1992)

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      1992 Annual Research Report
  • [Publications] Yanagisawa M.et al.: "Enzymatic inactivation of tachykinin neurotransmitters in the isolated spinal cord of the newborn rat." Neurosci.Res.15. 289-292 (1992)

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      1992 Annual Research Report
  • [Publications] Sakuma M.et al.: "Substance P-evoked release of GABA from isolated spinal cord of the newborn rat." Neuroscience. 45. 323-330 (1991)

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      1992 Annual Research Report
  • [Publications] Kobayashi N.et al.: "Substance P-evoked release of acetylcholine from isolated spinal cord of the newborn rat." Neuroscience. 45. 331-337 (1991)

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      1992 Annual Research Report
  • [Publications] Yoshioka K.et al.: "Curaneous nerve-evoked cholinergic inhibition of monosynaptic reflex in the neonatal rat spinal cord." Neuroscience. 38. 195-203 (1990)

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      1992 Annual Research Report
  • [Publications] Yanagisawa M.et al.: "Pharmacological profile of a tachykinin antagonist,spantide,as examined on rat spinal motoneurones." Br.J.Pharmacol.100. 711-716 (1990)

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      1992 Annual Research Report
  • [Publications] Shigeko Araki,et al.: "Characterization of two novel pyruvylated glycosphingo-lipids containing 2′-aminoethylphosphoryl(→6)-galactose from the nervous system of Aplysia kurodai." Journal of Biochemistry. 112. 461-469 (1992)

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      1992 Annual Research Report
  • [Publications] Yamazawa,T.,Iino,M.and Endo,M.: "Presence of functionally different compartment of the Ca^<2+> store in single intestinal smooth muscle cells." FEBS Lett.301. 181-184 (1992)

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      1992 Annual Research Report
  • [Publications] Iino,M.,Takano Ohmuro,H.,Kawana,Y.and Endo,M.: "Enhancement of Ca^<2+> -induced Ca^<2+> release in calpain treated rabbit skinned muscle fibers." Biochem.Biophys.Res.Coomun.185. 713-718 (1992)

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      1992 Annual Research Report
  • [Publications] Kawana,Y.,Iino,M.,Horiuti,K.,Matsumura,N.,Ohta,T.,Matsui,: "Acceleration in calcium-induced calcium release in the biopsied mucle fibers from patients with malignant hyperthermia." K.and Endo,M.Biomed.Res.13. 287-297 (1992)

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      1992 Annual Research Report
  • [Publications] Iino,M.,and Endo,M.: "Calcium-dependent immedicate feedback control of inositol 1,4,5,-trisphosphate-induced Ca^<2+> release." Nature. 360. 76-78 (1992)

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      1992 Annual Research Report
  • [Publications] Endo,M.: "Calcium-induced calcium release mechanism in skeletal muscle and its modification by drugs." Muscular Contraction(Simmons,R.M.ed.)Cambridge University Press. 67-82 (1992)

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      1992 Annual Research Report
  • [Publications] Shigetada Nakanishi: "Molecular diversity of glutamate receptors and implications for brain function." Science. 258. 597-603 (1992)

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      1992 Annual Research Report
  • [Publications] Yasuto Tanabe,et al.: "A family of metabotropic glutamate receptors." Neuron. 8. 169-179 (1992)

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      1992 Annual Research Report
  • [Publications] Ichiro Aramori,et al.: "Signal transduciton and pharmacological characteristics of a metabotropic glutamate receptor mGlurl in transfected Chinese hamster ovary cells." Neuron. 8. 757-765 (1992)

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      1992 Annual Research Report
  • [Publications] Yasunori Hayashi,et al.: "Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells." British Journal of Pharmacology. 107. 539-543 (1992)

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      1992 Annual Research Report
  • [Publications] Takaaki Abe,et al.: "Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca^<2+> signal transduction." Journal of Biological Chemistry. 267. 13361-13368 (1992)

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      1992 Annual Research Report
  • [Publications] Kazuhiro Sakurada,et al.: "Alterlation of Ca^<2+> permeability and sensitivity to Mg^<2+> and channel blockers by a single amino acid substitution in the N-methyl-D-aspartate receptor." Journal of Biological Chemistry. 268. 410-415 (1993)

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      1992 Annual Research Report
  • [Publications] M.Kasai他: "K^+ channel involvement in induction of synaptic enhancement by mast cell degranulating(MCD)peptide" Neurosci.Res.13. 207-216 (1992)

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      1992 Annual Research Report
  • [Publications] M.Kasai他: "Permeation of neutral molecules through calcium channel in sarcoplasmic reticulum vesicles" J.Biochem.112. 197-203 (1992)

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      1992 Annual Research Report
  • [Publications] M.Kasai他: "Ion channels on synaptic vesicle membranes studied by planar lipid bilayer mothod" Biophys.J.63. 1500-1505 (1992)

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      1992 Annual Research Report
  • [Publications] M.Kasai他: "Immunological identification of a Cl^- channel protein in electric organs of Narke japonica" Biochem.Biophys.Res.Commun.188. 1228-1234 (1992)

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      1992 Annual Research Report
  • [Publications] Takeuchi,M.,et al.: "The 72KD microtuble associated protein from porcine brain." J.Neurochem.58. 1510-1516 (1992)

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      1992 Annual Research Report
  • [Publications] Ikabe,S.,et al.: "Differential behavior of photoactivated microtubules in growing axon of mouse and frog neurons." J.Cell Biol.117. 105-120 (1992)

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      1992 Annual Research Report
  • [Publications] Hirokawa,N.,et al.: "Microtubules on the move?" Curr.Biol.2. 193-195 (1992)

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      1992 Annual Research Report
  • [Publications] Nakata,T.,et al.: "Organization of cortical cytoskeleton of cultured chromaff in cells and involvement in secretion as revealed by quick-freeze,deep-etching,and double-label immunoelectron microscopy" J.Neurosci.12. 2186-2197 (1992)

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      1992 Annual Research Report
  • [Publications] Oshima,T.,et al.: "Immunocytochemical localization of 205 kDa microtubule-associated protein(205kDa MAP)in the guinea pig organ of corti." Brain Res.590. 53-65 (1992)

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      1992 Annual Research Report
  • [Publications] Maeda,K.,et al.: "Dynamin:its enzymatic activity and interaction with microtubules." Mol.Biol.Cell. 3. 1181-1194 (1992)

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      1992 Annual Research Report
  • [Publications] Kanai,Y.,et al.: "Microtubule bundling by tau proteins in vivo:analysis of the functional domains." EMBO J.11. 3953-3961 (1992)

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      1992 Annual Research Report
  • [Publications] Aizawa,H.,et al.: "Kinesin family in murine central nervous system." J.Cell Biol.119. 1287-1296 (1992)

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      1992 Annual Research Report
  • [Publications] Tanaka,Y.,et al.: "Chronological expression of microtubule-associated proteins(MAPs)in EC cell p 19 after neuronal induction by retinoic acid." Brain Res.596. 269-278 (1992)

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      1992 Annual Research Report
  • [Publications] Sato-Yoshitake,R.,et al.: "Phosphorylation of kinesin regulates its binding to synaptic vesicles." J.Biol.Chem.267. 23930-23926 (1992)

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      1992 Annual Research Report
  • [Publications] Chin,J.,et al.: "Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons." Nature. 360. 674-677 (1992)

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      1992 Annual Research Report
  • [Publications] Takemura,R.,et al.: "Increased microtubule stability and alpha tubulin acetylation in cells transfected with microtubule-associated proteins MAP1B,MAP2 or tau." J.Cell Sci.103. 952-964 (1992)

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      1992 Annual Research Report
  • [Publications] Takemura,R.,et al.: "Reorganization of brain spectrin(fodrin)during differentiation of PC12 cells." Neurosci.52. 381-391 (1993)

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      1992 Annual Research Report
  • [Publications] Umeyama,T.et al.: "Dynamics of microtubules bundled by microtubule associated protein 2 C(MAP2)." J.Cell Biol.120. 451-465 (1993)

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      1992 Annual Research Report
  • [Publications] Okabe,S.,et al.: "Do photobleached fluorescent microtubules move?:Re-evaluation of fluorescence laser photobleaching both in vitro and in growing Xenopus axon." J.Cell Biol.(1993)

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      1992 Annual Research Report
  • [Publications] Noda,Y.,et al: "Localization of dynamin:Widespread distribution in neurons and association with membraneous organelles transported anterogradely." Neurosci.(1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Okabe,S.,et al.: "Dynamic of the neuronal intermediate filaments." J.Cell Biol.(1993)

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      1992 Annual Research Report
  • [Publications] Nakata,T.,et al.: "T-dynamin,a novel member of dynamin-family protein is expressed specific to testis." J.Cell Sci.(1993)

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      1992 Annual Research Report
  • [Publications] Muyazaki,S.,et al.: "Block of Ca^<2+> wave and Ca^<2+> oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs." Science. 257. 251-255 (1992)

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      1992 Annual Research Report
  • [Publications] Yoshikawa,S.,et al.: "Molecular cloning and characterization of inositol 1,4,5-trisphosphate receptor in Drosophila melanogaster." J.Biol.Chem.267. 16613-16619 (1992)

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      1992 Annual Research Report
  • [Publications] Fujimoto,T.,et al.: "Localization o Inositol 1,4,5-trisphosphate receptor-like protein in plasmealemmal caveolae." J.Cell Biol.119. 1507-1513 (1992)

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      1992 Annual Research Report
  • [Publications] Wojcikiewicz,R,J,H.,et al.: "Inositol 1,4,5-trisphosphate receptor immunoreactivity in SH-SY5Y human neuroblastoma cells is reduced by chronic muscarinic receptor activation." J.Neurochem.59. 383-386 (1992)

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      1992 Annual Research Report
  • [Publications] A.Kuniyasu et al.: "Structural characterization of the dihydropyridine receptor-linke calcium channel from porcine heart." J.Biochem.112. 235-242 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] H.Tokumaru,K.Anzai,T.Abe,Y.Kirino: "Purification of the cardiac 1,4-dihydropyridine receptor using immunoaffinity chromatography with a monoclonal antibody against the α_2s subunit of the skeletal muscle dihyaropyridune receptor." Eur.J.Pharmacol.227. 363-370 (1992)

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      1992 Annual Research Report
  • [Publications] Ito,M.: "Neurosciences,Paths of Discovery II" Birkhauser,Boston., 622 (1992)

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      1992 Annual Research Report
  • [Publications] Mei Satake: "The Molecular Basis of Neuronal Connectivity" KOHKO-DO Niigata, 208 (1992)

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      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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