| Project/Area Number |
04304001
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
遺伝学
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
MATSUDA Hirotugu Kyushu Univ., Fac.of Sci., Emeritus Professor, 理学部, 名誉教授 (10027336)
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| Co-Investigator(Kenkyū-buntansha) |
FUSHIMI Yuzuru Saitama Univ., Fac.of Engineering, Professor, 工学部, 教授 (80011641)
YAHARA Tetsukazu Kyushu Univ., Fac.of Sci., Professor, 理学部, 教授 (90158048)
TAKAHATA Naoyuki Graduate Univ.for Advanced Studies, Professor, 教育研究交流センター, 教授 (30124217)
ISHII Kazushige Nagoya Univ., Sch., of Informat.and Sci., Professor, 情報文化学部, 教授 (00037285)
YAMAZAKI Tsuneyuki Kyushu Univ., Fac.of Sci., Professor, 理学部, 教授 (10108649)
舘田 英典 九州大学, 理学部, 助教授 (70216985)
厳佐 庸 九州大学, 理学部, 教授 (70176535)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 1994: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1993: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1992: ¥6,000,000 (Direct Cost: ¥6,000,000)
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| Keywords | Variable Environment / Pcpulation Genetics / Molecular Evolution / Neutral Theory / Adaptive Theory / Mutation / Sexual Reproduction / Life History Strategy |
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| Research Abstract |
Population genetics theory of variable environments were studied laying emphasis on the weak mutation limit, which has closer correspondence with available data at DNA sites than the strong mutation limit hitherto studied.The stationary solution of a parity model is obtained whose basic parameters include fluctuation rate in addition to mutation rate, selection intensity, and population size of conventional theory. In this model it became clear how evolution rate and polymorphism depend on these parameters. It became possible to explain the reason why evolution rate is usually smaller than the mutation rate, and to discuss the correlation of the evolution rate to the functional constraint and polymorphism beyond the framework of the neutral theory. Two-site model was also studied, through which some new insights were obtained in the concerted evolution and hitchhike effect. Data analyzes were done laying emphasis on the substitution type dependence of the feature of evolution rate and polymorphism. They included amylase loci of Drosophila, HLA loci, loci of pathogenic viruses, and of wheat. However, no unanimous conclusion as to the cause of molecular evolution has yet been reached.
For the evolution of quantative traits mathematical models of variable environments were studied in which the phenotypic values are continuous real numbers. Some new conditions and feature of polymorphism was obtained in such models. The effect of variable environments were theoretically studied on the life history strategy of organisms and on polymorphism of phage population in the cellstat. The effect of parasites on the maintenance of sexual reproduction of hosts was studied in the fieldwork of Eupatorium against its viral infection.
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