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Study on the function and origin of dendritic cells

Research Project

Project/Area Number 04304031
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Breeding science
Research InstitutionYamagata University

Principal Investigator

IMAI Yutaka  Professor, Department of Pathology, Yamagata University School of Medicine, 医学部, 教授 (30045603)

Co-Investigator(Kenkyū-buntansha) TSUNODA Rikiya  Assistant Professor, Fukushima Medical College, 助教授 (40045779)
SUDA Akio  Assistant Professor, Yamagata University School of Medicine, 医学部, 助教授 (80045715)
SHIOHARA Tetsuo  Assistant Professor, Kyorin University School of Medicine, 医学部, 助教授 (10118953)
IIJIMA Masafumi  Assistant Professor, Showa University School of Medicine, 医学部, 助教授 (20010449)
ASAI Junpei  Professor, Magoya University, School of Medicine, 医学部, 教授 (40022793)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 1994: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1993: ¥6,000,000 (Direct Cost: ¥6,000,000)
KeywordsDendritic cells / Follicular dendritic cells / Langerhans cell / Interdigitating cell / Thy-1^+ epidermal dendritic cell / Veiled cell / Function / Cellular origin / リンパ濾胞樹状細胞 / 相互連結性樹状細胞 / 表皮Langerhans細胞
Research Abstract

(1)Standardization of Japanese terminology of dendritic cells
The Japanese names of dendritic cells were standardized.
(2)Follicular dendritic cell(FDC) [Cellular origin] The experiments of injection of bone marrow cells into SCID mice and the splenic implantation suggested that FDCs might be derived from the stationary cells or mesenchymal cells in lymphatic tissues, but not from bone marrow cells. [Function] The dataindicate that FDCs act as the nurse cell for B cells. The expression of IL-4 mRNA is confirmed on murine GC T cells. [Follicular dendritic cells in diseases] It is confirmed that human immuno-deficiency virus [HIV]-1-Ioaded FDCs migrate into the lymphatic circulation in the progressive stage of acquired immmunodeficlency syndrome.
(3)Langerhans cell(LC)[Differentiation] The linkage of squamous metaplasia of tracheal and urinary bladder mucosal epithelium to the generation of LC is observed in vitamin A deficient rats. The generation and differentiation of LC unlike munocytes … More /macrophages are dependent on granulocyte-macrophage(GM)-CSF but not on M-CSF.[Function] The assay to evaluate the in vitro LC migration activity using Balb/cmouse earlobes was established. [Langerhans cells in diseases] The rapid diagnosis useful for immediate treatment for skin graft rejection is established. Letterer-Siwe disease is proliferative disorder because some cells are positve for proliferating cell nuclear antigen.
(4)Interdigitating cell(IDC)[Cellular origin] Ligation of afferent lymphatics reveals the possibillity of direct differentiation, not via LCs, of IDCs from precursors in peripheral blood. [Differentiation] The dendritic cell differentiation factor is composed of two subcomponents. [Cell markers and characterization] Some monoclonal antibodies against stromal cells forming spienic framework are also prepared, demonstrating the plemorphism and the differentiation adapted to surrounding microenvironment of framework forming cells.
(5)Thy-1^+ dendritic epidermal cell(Thy-1^+ DEC)[Generation and differentiation] Both S100beta^+ dendritic cells(LCs)and Thy-1^+ DECs participate in immune response in allogeneic akin implantation. In the early stage(2 months)of bone marrow transplantation most of epidermal T cells are CD8_<alpha> ^+ beta^-, and in the later stage CD8_<alpha> ^+ beta^+ T cells gradually increase.
(6)Dendritic cells in various diseases [Pustulosis palmarls et plantaris] Morphometrical analysis of tonsillar lesions demonstrates the specific extension of secondary T-nodule and the marked increasing IDCs. [Rheumatold arthritis] A part of multinucleated giant cells in rheumatoid arthritis synovium have the immunophenotype as dendritic cell and release cytokine to promote the proliferation of synovial cells. [Idiopathic portal hypertension] In this disease IDCs markedly increase in the splenic lymphoid sheath. [Dendritic cells in tumors] Two types of dendritic cells, that is, LC-type and IDC-type dendritic cells, are found in the cancer tissues including thyroid and esophageal carcinomas. The Ia-antigen expression on cancer cells and the release of TNF-_<alpha>, GM-CSF and IL-1 from cancer cells may regulate the occurrence of dendritic cells. Less

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report

Research Products

(50 results)

All Other

All Publications (50 results)

  • [Publications] Tsunoda R,et al: "Human follicular dendritic cells in vitro." Dendritic Cells. 4. 43-51 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Imazeki N,et al: "New monoclonal antibodies directed against mouse follicular dendritic cells." J Histochem Cytochem. 42. 329-335 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mori S: "Demonstration of isolated follicular dendritic cells in lymphatic vessels around human HIV-infected lymph nodes." Virchows Arch A. 424. 397-401 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sakai T,et al: "Histological features of palatine tonsils in pustulosis palmaris et plantaris:A morphometric study." Int Pathol. 44. 186-193 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Teraki Y,et al: "Drug-induced expression of intercellular adhesion molecule-on lesional keratinocytes in fixed drug eruption." Am J Pathol. 145. 550-560 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hasunuma T,et al: "Establishment and characterization of synovial cell clones with integrated human T-cell leukemia virus." Clin Immunol Immunopathol. 72. 90-97 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 山川光徳ら: "現代病理学大系 第4巻" リンパ節:循環障害, 9 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 今井 大ら: "現代病理学大系 第4巻" リンパ球・樹状細胞(印刷中),

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ohbayashi M,Ito M,Nakayama A,Kasai K,Asai J :"Immunohistochemical and functional studies on rat high endothelial venules using monoclonal antibodies." Virchows Arch B Cell Pathol. 63. 297-306 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kasajima T,Andoh A,Tateo Y,Nishikawa T :"The localization of lymphokines in murine germinal centers." Adv Exp Med Biol. 329. 371-376 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Imai Y,Maeda K,Yamakawa M,Karube Y,Matsuda M,Dobashi M,Sato H,Terashima K :"Heterogeneity and cellular origin of follicular dendritic cells." Adv Exp Med Biol. 329. 339-344 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Senoo A,Imazaki N,Matsuura Y,Fuse Y :"A serial section study on mice Langerhans cell granules after DNFB painting." Adv Exp Med Biol. 329. 219-224 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hosokawa S,Shinzato M,Kaneko C,Shamoto M :"Migration and maturation of Langerhans cells in squamous metaplasia of the rat trachea by vitamin A deficiency." Virchows Arch B Cell Pathol. 63. 159-166 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Nakayama A,Hirabayashi N,Ito M,Kasai K,Fujino M,Ohbayashi M,Asai J :"White pulp reconstitution after human bone marrow transplantation." Am J Pathol. 143. 1111-1120 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Miyatani K,Takahashi K,Yanai H,Yoshino T,Akagi T :"Partial purification and characterization of dendritic cell differentiation factor" Acta Med Okayama. 48. 67-72 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kawaguchi M,Sakai T,Sakamaki A,Ishizawa S,Baba Y,Masuda Y,Koizumi F :"Expanded primary T nodules in the palatine tonsils from patients with IgA nephropathy." Acta Otolaryngol(Stockh)Suppl. 508. 36-42 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ueda A,Ito M,Ishiguro N,Miura Y,Asai J,Miura T :"Thy-1 antigen dendritic cells and rejection of composite tissue limb allografts in rats." Transplantation. 56. 124-127 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Shiohara T,Moriya N,Hayakawa J,Arahari K,Yagita H,Nagashima M,Ishikawa H :"Bone marrow-derived dendritic epidermal T cells express T cell receptor-alpha beta/CD3 and CD8. Evidence for their extrathymic maturation." J Immunol. 150. 4323-4330 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Takahashi K,Naito M,Shultz LD,Hayashi S,Nishikawa S :"Differentiation of dendritic cell populations in macrophage colony stimulating factor-deficient mice homozygous for the osteopetrosis(op)mutation." J Leukcyte Biol. 53. 19-28 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Imai Y,Yamakawa M :"Dendritic cells in esophageal cancer and lymph node tissues." n vivo. 7. 239-248 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Imazaki N,Takeuchi A,Senoo A,Fuse Y :"New monoclonal antibodies directed against mouse follicular dendritic cells." J Histochem Cytochem. 42. 329-335 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Mori S :"Demonstration of isolated follicular dendritic cells in lymphatic vessels around human immunodeficiency virus-infected lymph nodes." Virchows Arch A. 424. 397-401 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sakai T,Kawaguchi M,Ishizawa S,Kaji T,Kitagawa K,Koizumi F :"Histological features of palatine tonsils in pustulosis palmaris et lantaris : A morphometric study." Pathol Int. 44. 186-193 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tamaki K,Saitoh A,Gaspari AA,Yasaka N,Furue M :"Migration of Thy-1^+ dendritic epidermal cells(Thy-1^+ DEC) : Ly48 and TNF-_<alpha> are responsible for the migration of Thy-1^+ DEC to the epidermis." J Invest Dermatol. 103. 290-294 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Hasununa T,Nakajima T,Aono H,Sato K,Matsubara T,Yamamoto K,Nishioka K :"Establishment and characterization fo synovial cell clones with integrated human T-cell leukemia virus type-1." Clin Immunol Immunopathol. 72. 90-97 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Masuda A,Kasajima T :"Morphometric analysis of cystadenolymphoma(Warthin's tumor)Subclassification and characterization of the lymphoid stroma in comparison with gastric lymphoid follicles." Path Res Pract. 190. 457-465 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tsunoda R,et al: "Human follicular dendritic cells in vitro." Dendritic Cells. 4. 43-51 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Imazeki N,et al: "New monoclonal antibodies directed against mouse follicular dendritic cells." J Histochem Cytochem. 42. 329-335 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Mori S: "Demonstration of isolated follicular dendritic cells in lymphatic vessels around human HIV-infected lymph nodes." Virchows Arch A. 424. 397-401 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Sakai T,et al: "Histological features of palatine tonsils in pustulosis palmaris et plantaris:A morphometric study." Int Pathol. 44. 186-193 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Teraki Y,et al: "Drug-induced expression of intercellular adhesion molecule-1 on lesional keratinocytes in fixed drug eruption." Am J Pathol. 145. 550-560 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hasunuma T,et al: "Establishment and characterization of synovial cell clones with integrated human T-cell leukemia virus." Clin Immunol Immunopathol. 72. 90-97 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 山川光徳ら: "現代病理学大系 第4巻" リンパ節:循環障害, 9 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 今井 大ら: "現代病理学大系 第4巻" リンパ球:樹状細胞(印刷中),

    • Related Report
      1994 Annual Research Report
  • [Publications] Imai Y,et al.: "Dendritic cells in esophageal cancer and lymph node tissues." in vivo. 7. 239-248 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yamakawa M,et al.: "Dendritic cells in various human thyroid diseases." in vivo. 7. 249-256 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Hayakawa J,et al.: "Identification of a novel population of CD8α^+β^- bone marrow-derived dendritic epidermal cells.This unique population is subsequently outnumbered by thymus-independent expansion of the CD8α^+β^+ dendritic epidermal cells." J Immunol. 151. 5984-5992 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Nakayama A,et al.: "White pulp reconstitution after human bone marrow transplantation." Am J Pathol. 143. 1111-1120 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Masuda A,et al.: "Follicular demdritic cell function and murine AIDS." Immunology. 81. 41-46 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sakai T,et al.: "Histological features of palatine tonsils in pustulosis palmaris et plantaris:A morpholometric study." Pathol Internat. 44. 186-193 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Imai Y,et al.: "Dendritic cells(vol.2)" Ohkaze Medical Publisher, 100 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Imai Y,et al.: "Dendritic cells(vol.3)" Sakabe Publishing House Inc., 115 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Imai Yutaka,et al.: "Dendritic cells in esophageal cancer and lymph node tissues." in vivo. 7. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tetsuo Shiohara,et al.: "Bone marrow-derived dendritic epidermal T cells express TCR-αβ/CD3 and CD8:evidence for their extrathymic maturation." J Immunology. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Mikio Shamoto,et al.: "Langerhans cells in the lymph node:mirror section and immunoelectron microscopic studies." Virchows Arch(B)Cell Path & Mol Path. 61. 337-341 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kiyoshi Takahashi,et al.: "Differentiation of dendritic cell populations in macrophage colony stimulating factor-deficient mice homozygous for the osteopetrosis(op)mutation." J Leukocyte Biol. 53. 19-28 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Rikiya Tsunoda,et al.: "Emperipolesis of lymphoid cells by human follicular dendritic cells in vitro." Virchows Arch(B)Cell Path & Mol Path. 62. 69-78 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Nobuo Imazeki,et al.: "Is the follicular dendritic cell a primarily stationary cell?" Immunology. 62. 508-510 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yutaka Imai,et al.: "Dendritic cell(vol.1)" Ohkaze Medical Publisher, 78 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yutaka Imai,et al.: "Dendritic cell(vol.2)" Ohkaze Medical Publisher, (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1993-03-31   Modified: 2016-04-21  

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