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Method of establishing exposure limits for inhaled chamecal sustances

Research Project

Project/Area Number 04304035
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionKEIO UNIVERSITY

Principal Investigator

SAKURAI Haruhiko  MEDICINE, PROFESSOR, 医学部, 教授 (70051357)

Co-Investigator(Kenkyū-buntansha) MORIMOTO Kanehisa  OSAKA UNIVERSITY, MEDICINE PROFESSOR, 医学部, 教授 (20143414)
MATSUSHITA Toshio  KAGOSHIMA UNIIVERSITY, MEDICINE PROFESSOR, 医学部, 助教授 (10022790)
TAKEUCHI Yasuhiro  NAGOYA UNIVERSITY, MEDICINE PROFESSOR, 医学部, 教授 (90022805)
SATO Akio  YAMANASHI MED.UNIV, MEDICNE PROFESSOR, 医学部, 教授 (40020747)
IKEDA Masayuki  KYOTO UNIVERSITY, MEDICINE PROFESSOR, 医学部, 教授 (00025579)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 1993: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1992: ¥6,000,000 (Direct Cost: ¥6,000,000)
KeywordsExposure Limit / Inhalation / Metal / Oranic Solvent / Neuro-Toxicity / Sensitization / Mixed Exposure / Biological Monitoring / 神経請性
Research Abstract

For the purpose of improving the reliability of current exposure limits or to newly recommend limits for novel chemicals, following supecific problems were investigated. To make reasonable inter-species extrapolation from experimental animals to humans, it was shown that the differences of metabolism and toxicokinetic data between the both species are fundamental. This finding was obtained by model experiments using two organic solvents, m-xylene and chloroform.
The toxicities of the transient metals generally differ according to the valency states.
Mercury vapor and inoganic mercury compounds were shown to have different toxicity, and it was proposed that proper exposure limits should be set considering this difference. The hypersensitivity to chemicals poses a difficult problem when exposure limits for these chemicals ara considered. Cobalt, one of the sensitizing metals, is an example of this type of chemicals. The method of establishing exposure limits for cobalt was studied on cobalt-exposed workers in reference with several life style determinants. The exposure limits for such polular metal elements as lead and cadmium have been fairly well established, but the usefulness of biological monitoring by the use of blood, urine and other biological specimens has been morre recognized recently. Cohort observation on he workers exposed to these two metals clearly indicated that the biological monitoring is super to ambient air monitoring in accuracy of risk evaluation of individual workers.
The neurotoxicity of organic solvents were investigated and the usefulness of glia markers as a sensitive toxicity parameter was made clear. The toxicity of the mixture of tolene and xylene was studied on the exposed workers and a proposal was made on the exposure limit for the mixture of these chemicals. Finally, a list of sensitizing chemicals wasmade as the supplement for the list of occupational exposure limits recommended by Japan Association of Occupational Health.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (88 results)

All Other

All Publications (88 results)

  • [Publications] Shirakawa T.et al.: "Lifestyle effect on total IgE lifestyles have acumulative impact on controlling total IgE levels." Allergy. 46. 561-569 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shirakawa T.et al.: "Specific IgE antibodies to nickel in workers with known reactivity to cobalt." Clin Exp Allergy. 22. 213-218 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kusaka Y.et al.: "Healthy Lifestyles Are Associated With Higher Natural Killer Cell Activity." Prev Med. 21. 602-615 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kusaka Y.et al.: "A pilot study to evaluate Japanese standard radiographs of pneumoconioses(1982)according to the ILO(1980)international classification of radiographs of pneumoconioses." Ann Occup Hyg. 36. 425-431 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shirakawa T.et al.: "Combined Effect of Smoking Habits and Occupational Exposure to Hard Metal on Total IgE Antibodies." Chest. 101. 1569-1576 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Huang J.et al.: "Dose dependent effects of chronic exposure to toluene on neuronal and glial cell maker proteins in the central nervous system of the rats." Brit J Ind Med. 49. 282-286 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Huang J.et al.: "Chronic Exposure to n-Hexane Induces Changes in Nerve-Specific Marker Proteins in the Distal Peripheral Nerve of the Rat." Human Exp Toxicol. 11. 323-327 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Watanabe C.et al.: "Chenge in the Level of Tissue Selenium after a Single Administration of Mercuric Chloride in Mice." Bull Environ Contam Toxcol. 51. 24-29 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takebayashi T.et al.: "Evaluation of δ-aminolaevulinic acid in blood of workers exposed to lead." Brit J Ind Med. 50. 49-54 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakurai S.: "Quality assurance of biological monitoring in view of risk management." Int Arch Occup Environ Health. 65. S77-S82 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ukai H.et al.: "Dose-Dependent Increase in Subjective Symptoms among Toluene-Exposed Workers." Environ Res. 60. 274-289 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Uchida Y.et al.: "Symptoms and signs in workers exposed predominantly to xylenes." Int Arch Occup Environ Health. 64. 597-605 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Morimoto K.et al.: "Chromosome alterations in peripheral lymphocytes as indices of lifestyle and genotoxicity." Int Arch Occup Environ Health. 65. S37-S41 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeshita T.et al.: "Phenotypic differences in low Km aldehyde dehydrogenase in Japanese workers." Lancet. 341. 837-838 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shirakawa T.et al.: "Effect of lifestlye on levels of specific IgE antibodies." Allergy. 48. 177-182 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeuchi T.et al: "Increased formation of 8-hydroxyguanosine an oxidative DNA damage in lymphoblasts form Fanconi's anemia patients due to possible catalase deficiency." Carcinogenesis. 14. 1115-1120 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeuchi T.et al.: "Spin trapping of superoxide released by opsonized asbestos from human promyelocytic leukemia cell line." HL60 Biochem Biophys Res Com. 194. 57-64 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ezoe S.et al.: "Behavioral life-style and mental health status of Japanese factory workers." Prev Med. (in press). (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Huang J.et al.: "Experimental study on respiratory sensitivity to inhaled toluene diisocyanate." Arch Toxicol. 67. 373-378 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Aoyama K.et al.: "Provocation of Respiratory Allergy in Guinea Pigs Following Inhalation of Free Toluene Diisocyanate." Arch Environ Contam Toxicol. (in printing). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Huang J.et al: "Nerve-Specific Marker Proteins as Indicators of Organic Solvent Neurotoxicity." Environ Res. 63. 82-87 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kondo H.et al.: "Toluene induces behavioral activation without affecting striatal dopamine metabolism in the rat:Behavioral and Neurochemical studies." Brain Res. (Submitted).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kaneko T.et al.: "Enzyme induction by ethanol consumption affects the pharmacokinetics of inhaled m-xylene only at high levels of exposure." Arch Toxicol. 67. 473-477 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 森本 兼曩 他: "ライフスタイルと免疫学的防御機構" ライフサイエンス出版社, 7 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tanizawa T.et al.: "Behhavioral Medicine:An integrated biobehavioral approach to health and illness." Elsevier Science Publishers B.V., 6 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Abe G.et al.: "Chromosomal aberrations Basic and applied aspects." Springer-Verlay,Berlin(inpress), (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 志賀 健 他: "環境と健康" HBJ出版局, 38 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shirakawa T.et al.: "Lifestyle effect on total IgE lifestyles have acumulative impact on controlling total IgE levels." Allergy. 46. 561-569 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shirakawa T.et al.: "Specific IgE antibodies to nickel in workers with known ractivity to cobalt." Clin Exp Arrergy. 22. 213-218 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kusaka Y.et al.: "Healthy Lifestyles Are Associated With Higher Natural Killer Cell ctivity." Prev Med. 21. 602-615 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kusaka Y.et al.: "A pilot study to evaluate Japanese standard radiographs of pneumoconioses (1982) according to the ILO (1980) international classification of radiographs of pneumoconioses." Ann Occup Hyg. 36. 425-431 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shirakawa T.et al.: "Combined Effect of Smoking Habits and Occupational Exposure to Hard Metal on Total IgE Antibodies." Chest. 101. 1569-1576 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Huang J.et al.: "Dose dependent effects of chronic exposure to toluene on neuronal and glial cell maker proteins in the central nervous system of the rats." Brit J Ind Med. 49. 282-286 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Huang J.et al.: "Chronic Exposure to n-Hexane Induces Changes in Nerve-Specific Marker Proteins in the Distal Peripheral Nerve of the Rat." Human Exp Toxicol. 11. 323-327 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Watanabe C.et al.: "Chenge in the Level of Tissue Selenium after a Single Administration of Mercuric Chloride in Mice." Bull Environ Contam Toxcol. 51. 24-29 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takebayashi T.et al.: "Evaluation of delta-aminolaevulinic acid in blood of workers exposed to lead." Brit J Ind Med. 50. 49-54 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakurai S.: "Quality assurance of biological monitoring in view of risk management." Int Arch Occup Environ Health. 65. S77-S82 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ukai H.et al.: "Dose-Dependent Increase in Subjective Symptoms among Toluene-Exposed Workers." Environ Res. 60. 274-289 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Uchida Y.et al.: "Symptoms and signs in workers exposed predominantly to xylenes." Int Arch Occup Environ Health. 64. 597-605 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Morimoto K.et al.: "Chromosome alternations in peripheral limphocytes as indices of lifestyle and genotoxicity." Int Arch Occup Environ Health. 65. S37-S41 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeshita T.et al.: "Phenotypic differences in low Km aldehyde dehydrogenase in Japanese workers." Lancet. 341. 837-838 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shirakawa T.et al.: "Effect of lifestyle on levels of specific IgE antibodies." Allergy. 48. 177-182 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeuchi T.et al.: "Increased formation of 8-hydroxyguanosine an oxidative DNA damage in lymphoblasts form Fanconi's anemia patients due to possible catalase deficiency." Carcinogenesis. 14. 1115-1120 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeuchi T.et al.: "Spin trapping of superoxide released by opsonized asbestos from fuman promyelocytic leukeimia cell line." HL60 Biophys Res Com. 194. 57-64 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ezoe S.et al.: "Behavioral life-style and mental health status of Japanese factory workers." Prev Med. (in press). (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Huang J.et al.: "Experimental study on respiratory sensitivity to inhaled toluene diisocyanate." Arch Toxicol. 67. 373-378 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Aoyama K.et al.: "Provocation of Respiratory Allergy in Guinea Pigs Following Inhalation of Free Toluene Diisocyanate." Arch Environ Contam Toxicol. (in printing). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Huang J.et al.: "Nerve-Specific Marker Proteins as Indicators of Organic Solvent Neurotoxicity." Environ Res. 63. 82-87 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kondo H.et al.: "Toluene induces behavioral activation without affecting striatal dopamine metabolism in the rat : Behavioral and Neurochemical studies." Brain Res. (Submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kaneko T.et al.: "Enzyme induction by ethanol consumption affects the pharmacokinetics of inhaled m-xylene only at high levels of exposure." Arch Toxicol. 67. 473-477 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] H.Ukai et al.: "Dose‐dependent increase in subjective symptoms among toluene‐exposed workers." Environ Res. 60. 274-289 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Y.Uchida et al.: "Symptoms and signs in workers exposed predominantly to xylenes." Int Arch Occup Environ Health. 64. 597-605 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Takebayashi et al.: "Evaluation of delta‐aminolaevulinic acid in blood of workers exposed to lead." British J Ind Medicine. 50. 49-54 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] C.Watanabe et al.: "Change in the Level of Tissue Selenium after a Single Administration of Mercuric Chloride in Mice." Bull.Environ.Contam.Toxicol.51. 24-29 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Morimoto et al.: "Chromosome alterations in peripheral lymphocytes as indices of lifestyle and genotoxicity." Int.Arch Occup Env.Health. 65. 37-41 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Takeshita et al.: "Phenotypic differnces in low Km aldehyde dehydrogenase in Japanese workers." Lancet. 341. 837-838 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.shirakawa et al.: "Effect of life stye on levels of speciffic IgE antibodies" Allergy. 48. 177-182 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Takeuchi et al.: "Increased formation of d‐hydroxydeoxyguanosine an oxidative DNA damage in lymphoblasts from Fanconi〓s anemia patients due to possible catalase deficiency." Carcinogenesis. 14. 1115-1120 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Takeuchi et al.: "Spin trapping of superoxide released by opsomized asbestos from human promyelocytic leukemia cell line." HL60 Biochem.Biophys.Res.Com.194. 57-64 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] S.Ezoe et al.: "Behaviral life‐style and mental health atatus of Japanese factory workers." Prev Med. (in press). (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Huang J.et al.: "Experimental study on respiratory sensitivity to inhaled toluene diisosyanate." Arch Toxicol. 67. 373-378 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Aoyama K.et al.: "Provocation of respiratory allergy in guinea pigs following inhalation of free toluene diisocyanate." Arch Environ Contam Toxicol.(in printing). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Huang J.et al.: "Dose dependent effects of chronic exposure to toluene on neuronal and glial cell marker proteins in the central nervous system of rats." Brit J Ind Med. 49. 282-286 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Huang J.et al.: "Chronic exposure to n‐hexane induces changes in nerve specific marker proteins in the distal peripheral nerve of the rats." Human Exp toxicol. 11. 323-327 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Huang J.et al.: "Nerve‐specific marker proteins as indicators of organic solvents neurotoxicity." Environ Res. 63. 82-87 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kondo H.et al.: "Toluene induces behavioral activation without affecting striatal dopamine metabolism in the rat:Behabioral and neurochemical studies." Brain Res(Submitted).

    • Related Report
      1993 Annual Research Report
  • [Publications] Kaneko T.et al.: "Enzyme induction by ethanol consumption affects the pharmacokinetics of inhaled m‐xylene only at high levels of exposure.Arch Toxicol." Arch Toxicol. 67. 473-477 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 松下敏夫・他: "外国における感作性物質の許容濃度表への標示。" 産業医学. 36. 275 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 青山公治・他: "職業感作物質の許容濃度表への反映の試み。" 産業医学. 36. 274 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 青山公治・他: "TDIによる呼吸器アレルギーに関する実験的研究 II.許容濃度設定に関する実験モデルの検討。" 産業医学. 35. 368 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 黄俊・他.: "TDIによる呼吸器アレルギーに関する実験的研究 I.感作濃度に依存した抗体産生と呼吸反応。" 産業医学. 35. 367 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sakurai H.: "Quality assurance of biolpgical monitoring in view of risk management." Int Arch Occup Environ Health. 65. S77-S82 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] G.Abe et al.: "Chromosomal aberrations Basic and applied aspects" Springer‐Verlay,Berlin(in press), (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 志賀健他: "環境と健康" HBJ出版局, 38 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 金子 誉,王 培玉,佐藤 章夫: "化学物質の請性と体内動態の外挿に関する研究一m-キシレンの吸入曝露と経口投与の比較。" 日本衛生学雑誌. 48. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Shirakawa and K.Morimoto: "Lifestyle effect on total IgE Lefestyles have a cumulative impact on controlling total IgE levels." Allergy. 46. 561-569 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Shirakawa,Y.Kusaka and K.Morimoto: "Specific IgE antibodies to nickel in workers with known reactivity to cobalt." Clinical and Experimental Allergy. 22. 213-218 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Kusaka,H.Kondou and K.Morimoto.: "Healty lifestyles are associated with higher natural killer cell activity." Preventive Medicine. 21. 602-615 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Kusaka and K.Morimoto: "A pilon study to evaluate Japanese standard radiographs of pneumoconioses(1982)according to the ILO(1980)international classification of radiographs of pneumoconioses." Ann.Occup.Hyg.36. 425-431 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Shirakawa,Y.Kusaka and K.Morimoto: "Combined effect of smoking habits and occupational exosure to hard mental on total IgE antibodies." Chest. 101. 1569-1576 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] J.Huand,N.Asaeda,Y.Takeuchi,E.Shibata,N.Hisanaga,Y.Ono&K.Kato: "Dose dependent effects of chronic exposure to toluene on neuronal and gleal cell marker proteins in the central nervous system of rats." British journal of Industrial medicine. 49. 282-286 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] J.Huand,E.Shibata,K.Kato,N.Asaeda&Y.Takeuchi: "Chronic Exposure to n-Hexane Induces Changes in Nerve-Specific Marker Proteinsin the Distal Peripheral Nerve of the Rat." Human&Experimental toxicology. 11. 323-327 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 近藤 英隆 他: "マイクロダイアリシス法によるトルエン投与ラットの脳内アミン変動の測定" 第66回日本産業衛生学会講演集. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] C.Watanabe,T.Udono,H.Shioiri and H.Satoh: "Chenge in the level of tissue selenium after a ingle administration of mercuric chloride in mice." bulletn of Environmental Contamination and Toxicology. 51. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 渡辺 知保,佐藤 洋: "マウスにおける年機水銀投与が内因性セレンの分布に及ぼす影響" 日本衛生学雑誌. 47. 172 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 内田 陽子,鵜飼 博彦,中塚 晴夫,渡辺 孝夫,池田 正之: "トルエン、キシレンの混合曝露による生体影響" 第66回日本産業衛生学会講演集. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 森本 兼曩,白川 太郎,日下 幸則,近藤 弘: "ライフスタイルと免疫学的便御機構" ライフサイエンス出版株式会社, 7 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Tanizawa,S.Kuraki,K.Morimoto and K.Yokoyama.: "Behavioral Medicine:An integrated biobehavioal approach to health and illness." Elsevier Science Publishers B.V., 6 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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