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Recent change of Risk factors of Ischemic Cordio-and Cerebrovasular Diseases

Research Project

Project/Area Number 04304036
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 公衆衛生学
Research InstitutionUniversity of Tsukuba

Principal Investigator

SHIMAMOTO Takashi  University of Tsukuba, Institute of Community Medicene, Professor, 社会医学系, 教授 (50143178)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Yoji  Yamanashi Medical College Department of Pathology, Professor, 病理学, 教授 (10008237)
KODAMA Kazunori  Radiation Effects Research Foundation.Department of Clinical Studies, Director, 臨床研究部, 部長 (70161940)
UEDA Kazuo  Kyushu University Medical School, Professor, 医療技術短期大学部, 教授 (10038812)
IIDA Minoru  Center for Adult Deseases, Osaka, Dept of Epidemiology and Mass Examination, Dir, 集検1部, 部長
KOMATI Yoshio  Osaka Prefectual Institute, President, 所長 (50134242)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 1994: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1993: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1992: ¥6,000,000 (Direct Cost: ¥6,000,000)
KeywordsLacunar infarction / Thrombeembolic infarction / Risk factors / Cohort study / Serum fatty acids / Plasma fibrinogen / Tissue plasminogen / Asymptomatic infarction / 脳卒中 / 虚血性心疾患 / 脳塞栓 / 皮真性脳血栓
Research Abstract

The data from a long-term epidemiologic studies in populations in ibaraki, Akita, Osaka, Kochi, Hiroshima, Nagasaki, Fukuoka was analyzed and the following results were obtained.
1) The proportion of cerebral infarction among total stroke increased in each population. According to computer tomography (CT) findings, the proportion was highest in lacunar infarction, and progressively lower in embolic infarction and in thrombotic infarction. The proportion of lacunar infarction was higher in Japanese populations than in Western populations. Incidence of ischemic heart disease has increased in urban male employees, but has not changed in other populations.
2) A cohort of 25,811 men and women aged 40-69 was followed 9 to 10 years and 779 stroke and 307 ischemic heart disease incidence cases were obtained. Significant risk factors shown by regression analyzes were hypertension for lacunar infarction, high serum total cholesterol, alcohol intake, left ventricular hypertrophy for thrombotic infa … More rction, and atrial infarction and left ventricular hypertrophy for embolic infarction. Risk factors for ischemic heart disease were high serum total cholesterol, high blood pressure, and cigarette smoking.
3) According to a prospective nested case-control study in rural populations, the proportion of serum polyunsaturated fat, in particular n-6 fatty acids was lower in stroke incidence cases, either hemorrhagic or non-hemorrhagic stroke than in controls.
In urban populations, the proportion of n-3 fatty acids tended to be lower in ischemic heart disease cases than in controls. Plasma fibrinogen concentrations were higher in patients of ischemic heart disease than in control.
4) Related factors for serum fatty acids, plasma fibrinogen and tissue plasminogen activator inhibitor I included cigarette smoking, alcohol intake and fish intake.
Pathologic study showed that a probable cause of vascular dementia was nonsymptomatic lacunar infartion in basal ganglia which was acceralated by aging and hypertension. Less

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] 山海知子,嶋本喬,小町喜男他: "CT所見を中心とした脳卒中の疫学的研究-コホート内症例対照研究による脳出血、脳梗塞の病型別発生要因の検討" 日本公衆衛生雑誌. 39. 410-420 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 佐藤真一,飯田稔,小町喜男他: "脂肪酸構成からみた栄養摂取と循環器疾患の関連に関する研究-虚血性心疾患の集団内症例対照研究" 公衆衛生. 57. 871-875 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 磯博康,嶋本喬,小町喜男他: "Plasma Fibrinogen and its Correlntes in Japanese and US Population Samples" Arteriosclerosis and Thrombosis. 70. 475-480 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 上田一雄: "循環器疾患の危険因子、本邦における特徴とその変遷" 日本循環器管理研究協議会雑誌. 29. 57-67 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 児玉和紀: "Stroke Trends in Japan" Ann.Epidemiol.3. 524-528 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 吉田洋二他: "脳卒中病態の変遷に関する基礎的研究" 臨床成人病. 24. 1418-1423 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 上田一雄: "日本人における高血圧の予後と将来展望" メディカルトリビューン, 202 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sankai T,Shimamoto T,Komati Y,et al.: "A Nested Case-control Study of Risk Factors for Intracerebral Hemorrhage and Cerebral Infaction Classified by Computed Tomographic Findings." Jpn J Public Health. 39. 410-420 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sato S,Iida M,Komati Y,et al: "The relation of serumfatly acid composition with diet and Cardiovascular disease, a nested casecontrol study on coronary heart diseases." Public Health. 57. 871-875 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Iso H,Shimamoto T,Komati Y,et al: "Plasma Fibrinogen and its correlates in Japanese and US Population Samples" Arteriosclerosis and Thrombosis. 70. 475-480 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ueda K.: "Risk (TD) factor for Cardiorascular Desease characteristics and trends in Japan." J Jpn Assoc Cerebro-cardiorascular Dis. 29. 57-67 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kodama K.: "Stroke Trends in Japan" Ann.Epidemiol. 3. 524-528 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshida Y.et al.: "Fundmental study on changes in pathogenesis of stroke." Ryinsho Seijinbyo. 24. 1418-1423 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ueda K.: "Probnosis and perspectives of hypertension in Japan" Medical Tribune. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 佐藤眞一他 12名: "心筋梗塞の危険因子としての血漿フィブノーゲン値に関する症例対照研究" Journal of Epidcwiology(Suppl). 4(1). 79-80 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 佐藤眞一: "循環器疾患の発症・死亡とがん死亡全死亡に関わる生活環境因子" Journal of Epidcwiology(Suppl). 5(1). 46-47 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 小池和子他 10名: "循環器疾患の予防を目的とした血液凝固線溶系活性因子に関する疫学研究(第4報)" 日本公衆衛生雑誌(特別附録). 41(10). 583 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ueda K他 2名: "The Hisayama study-A 30-year experience on stroke epidemiolgy im Japan" Hyperteusion Research(Suppl). 17. 11-21 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 上田一雄: "循環器疾患の危険因子 本邦における特徴とその返遷" 日本循環器管理研究協議会雑誌. 29. 57-67 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 吉田洋二他3名: "脳卒中病変の返遷に関する基礎的研究" 臨床成人病. 24(10). 1418-1423 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 磯博康 他: "Plasma Fibrinogen and Its Coerelates in Japanese and US Population Samples" Arteriosclercsis and Thrcmbcsis. 13. 783-790 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 磯博康 他: "Antigens of Tissue Plasmincgen Activator and plasminogen Activator Inhibitor1:Correlates in Nonsmoking Japanese and Caucasian Men and Women" Thrembs Haemost. 70. 475-480 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 北村明彦 他: "都市住民における脳卒中の病型別発生状況について-CT所見に基づいて検討-" 日本公衛誌. 40. 627 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 児玉和紀: "Stroke Trends in Japan" Ann Epidemiol. 3. 524-528 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 正和信英,吉田洋二: "脳血管性痴呆の病理-とくに白質病変の成り立ち-" Clin Neurosci. 11. 1324-1328 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 貴家基,吉田洋二: "ラクナ梗塞の脳内動脈病変と危険因子" 治療学. 27. 149-152 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 上田一雄: "高血圧の予後と治療-α.遮断薬-" 日本人における高血圧の予後と将来展望,尾前照雄監修,メディカルトリビューン, 202(11-36) (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 上田一雄 他: "Stroke:Populations,Cohort,and Clinical trials" Risk factors for stroke and transient attack JP(Ed),Butter with Heineman, 263(80-110) (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 小池 和子 他,嶋本 喬: "動脈硬化性疾患予防を目的とした血液凝固線溶系因子に関する疫学研究" 日本公衆衛生雑誌 特別附録. 39(10). 427 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 佐藤 眞一 他,飯田 稔,小町 喜男: "脂肪酸構成からみた栄養摂取と循環器疾患の関連に関する研究ー虚血性心疾患の集団内症例対照研究(都市)ー" 日本公衆衛生雑誌 特別附録. 39(10). 450 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 山海 和子 他,嶋本 喬,小町 喜男: "CT所見を中心とした脳卒中の疫学的研究ーコホート内症例対照研究による脳出血、脳梗塞の病型別発生要因の検討" 日本公衆衛生雑誌. 39(7). 410-420 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 児玉 和紀,加藤 寛夫: "広島・長崎の固定集団における循環器疾患の予防に関する疫学的研究" 日本循環器管理研究協議会雑誌. 27(3). 203 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 上田 一雄: "久山町における脳血管障害の変貌" 脳卒中. 13(6). 464-469 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 嶋本 喬,小池 和子,磯 源康,飯田 稔,小西 正光,小町 喜男: "循環器疾患のリスクファクターとしての血漿フィブクノーゲ値および線溶系活性に関する疫学的研究" 筑波大学代謝特別プロジェクト研究報告(IV), 5 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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