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Long-term effects of intracerebral bioactive substances

Research Project

Project/Area Number 04304037
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 内科学一般
Research InstitutionTHE UNIVERSITY OF THE AIR

Principal Investigator

KITO Shozo  The University Div.of Professor of the Air, Health Sciences, 教養学部, 教授 (00010140)

Co-Investigator(Kenkyū-buntansha) TOHYAMA Masaya  Osaka Univ., Dept.of Med., Professor, 医学部, 教授 (40028593)
FUJISAWA Hitoshi  Asahikawa, Dept.of Medicine, Professor Medical College, 教授 (10027039)
KURIYAMA Kinya  Kyoto Pre.Univ.of Medicine, Professor, 教授 (20079734)
SATO Masamichi  Kyoto Univ., Dept.of Pharmacol., Professor, 薬学部, 教授 (80025709)
NOMURA Yasuyuki  Hokkaido Univ., Dept. of Pharmacol., Professor, 薬学部, 教授 (00034041)
米田 幸雄  摂南大学, 薬学部, 助教授 (50094454)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥19,000,000 (Direct Cost: ¥19,000,000)
Fiscal Year 1993: ¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1992: ¥13,000,000 (Direct Cost: ¥13,000,000)
Keywordslong-term effects / protooncogenes / nicotine / long-term potentiation / GABA receptor / excitatory amino acids / substance P / kinase IV / dexamethasone / NO 合成酵素 / 長期増強 / DBI mRNA / Myc / CABA^A受容体 / c-fos / GABAAα1サブユニットmRNA / AP-1 / interleukin-1β / zif / 268 / カイネースIV
Research Abstract

It has been known that cell stimulation by growth factors and hormones often causes changes of gene expression which lead to long-term effects of cell response.
Much attentions have been forcused on this kind of responses from viewpoints of basic and clinical pharmacology. The particularly important is that several kinds of protooncogenes are participated in chemical signal transduction as well as mechanism of drug addiction.
In this study, mechanisms of cell responses evoked by various neuroactive substances in the central nervous system were investigated from viewpoints of chemistry, molecular biology, electrophysiology and morphology and following results were obtained. (1) Nicotine inhibited dexamethasoneinduced kainic acid cytotoxcity dose-dependently. On the other hand, single injection of estrogen into rat caused cytoprotection of amygdala neurons at lower doses and cytotoxicity at higher doses. (2) By means of electrophsiologcal studies using hippocampal slices, it was found that … More cholinergic regulation is participated in long-term potentiation at mossy fiber-CA3 synapes. (3) Changes of intracellular GABA receptor structure due to alcoholic addiction was studied. As the results, alcoholic addiction caused changes of both GABA_A and GABA_B receptors. It was assumed that such disorders of suppressive function are connected to development of alcoholic abstinence. (4) Mechanism of long-term effects of excitatory amino acids in the brain was studied from viewpoints of gene transduction. (5) Expression of mRNA of gamma1 and gamma2 subunit of GABA_A receptors and AMPA type glutamic acid receptors, Glu R1, 2 were examined in the dorsal root ganglion neurons and spinal dorsal horn neurons. (6) To examine substance P's effect on the brain, mechanism of substance P receptor expression was examined using U-87 MG cells. (7) Effect of pentylentetrazole and kainic acid administration on various gene expression in the hippocampus was studied. (8) Expression of c-fos mRNA induced by cycolohexamide was inhibited by cenelifide. (9) Kinase IV was purfied from rat brain. This kinase was found to be a multifunctional protein kinase specifically distributed in the brain. Less

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (121 results)

All Other

All Publications (121 results)

  • [Publications] Miyoshi,R.: "Effect of caerulein on expression of the immediate early genes c-fos and zif/268 in the rat brain." Neuroscience Letters. 145. 205-208 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Miyoshi,R.: "Effect of estrogen on immediate early gene expression in the rat brain." Society for Neuroscience Abstracts. 18. 57.1 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kito,S.: "Effect of glucocorticoid on in vivo release of neurotransmitters from the rat hippocampus." Society for Neuroscience Abstracts. 18. 57.4 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kito,S.: "A cytoprotective effect of nicotine on hippocampal neurons." Society for Neuroscience Abstracts. 19. 772.15 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Miyoshi,R.: "Effect of nicotine on neurotransmitter release from the rat hippocampus." Society for Neuroscience Abstracts. 19. 384.6 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kito,S.: "Effects of glucocorticoid on hippocampal neurons:in vivo and in vitro studies." Neurochemical Research. 18. 832 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Urushihara,H.: "Selective potentiation of N-methyl-D-aspartate-induced current by protein kinase C in xenopus oocytes injected with rat brain RNA." The Journal of Biological Chemistry. 267. 11697-11700 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kumagai,C.: "Involvement of growth-associated protein-43 with irreversible neurite outgrowth by dibutyryl cyclic AMP and phorbol ester in NG108-15 cells." Journal of Neurochemistry. 59. 41-47 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kaneda,T.: "Presence of m3 subtype muscarinic acetylcholine receptors and receptor-mediated increases in the cytoplasmic concentration of Ca^<2+> in jurkat,a human leukemic helper T lymphocyte line." Molecular Pharmacology. 43. 356-364 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tohda,C.K.: "Increase in neurite formation and acetylcholine release by transfection of growth-associated protein-43 cDNA into NG108-15 cells." Journal of Neurochemistry. 61. 526-532 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nomura,Y.: "Inducible nitric oxide synthase in glial cells." Neuroscience Research. 18. 103-107 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Harada,J.: "Affinity cross-linked δ-opioid receptor in NG108-15 cells is low molecular weight(25kDa)and coupled to GTP-binding proteins." European Journal of Pharmacology-Molecular Pharmacology Section. 227. 301-307 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ueda,M.: "Bifemelane enhances high K^+-evoked release of glutamate from mossy fiber synaptosomes of guinea-pig hippocampus." European Journal of Pharmacology. 219. 271-277 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kaneko,S.: "Metabotropic responses to acetylcholine and serotonin of xenopus oocytes injected with rat brain mRNA are transduced by different G-protein subtypes." FEBS Leters. 299. 179-182 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Okano,K.: "Pharmacological evidence for involvement of excitatory amino acids in aversive responses induced by intrathecal substance P in rats." Biol.Pharm.Bull.16. 861-865 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yabuuchi,K.: "In situ hybridization study of interleukin-1 β mRNA induced by kainic acid in the rat brain." Molecular Brain Research. 20. 153-161 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Minami,M.: "In situ hybridization study of κ-opioid receptor mRNA in the rat brain." Neuroscience Letters. 162. 161-164 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Minami,M.: "Cloning and expression of a cDNA for the rat κ-opioid receptor." FEBS Letters. 329. 291-295 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kuriyama,K.: "Functional alterations in cerebral GABA_A receptor complex associated with formation of alcohol dependence:analysis using GABA-dependent ^<36>Cl-influx into neuronal membrane vesicles." Alcohol & Alcohlism. 27. 335-343 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirouchi,M.: "Muscimol-induced reduction of GABA_A receptor α_1-subunit mRNA in primary cultured cerebral cortical neurons." Molecular Brain Research. 15. 327-331 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirouchi,M.: "Alteration of GABA_A receptor α_1-subunit mRNA in mouse brain following continuous ethanol inhalation." European Journal of Pharmacology-Molecular Pharmacology Section. 247. 127-130 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Mizutani,H.: "Alterations in cerebral GABA_B receptor binding during the formation of alcohol dependence." Pharmacology Communications. 3. 139-146 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Pingping,Z.: "Presence of the binding of a variety of ligands related to ionotropic excitatory amino acid receptors in rat retina." Brain Research. 576. 168-172 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ogita,K.: "Inhibition by calmodulin antagonists of〔^3H〕MK-801 binding in brain synaptic membranes." Journal of Neurochemistry. 59. 1008-1016 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Enomoto,R.: "Differential modulation by divalent cations of〔^3H〕MK-801 binding in brain synaptic membranes." Journal of Neurochemistry. 59. 473-481 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Enomoto,R.: "Differential potentiation by spermidine of abilities of a variety ofdisplacers for〔^3H〕MK-801 binding in hippocampal synaptic membranes." Neurosceince Research. 16. 217-224 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Pingping,Z.: "Comparative studies on binding of 3 different ligands to the N-methyl-D-aspartate recognition domain in brain synaptic membranes treated with triton X-100." Brain Research. 609. 253-261 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoneda,Y.: "Excitatory amino acid receptor binding in hippocampus of gerbils with transient global brain ischemia." Brain Research. 613. 21-31 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Matsumoto,K.: "A novel family of heparin-binding growth factors,pleiotrophin and midkine,is expressed in the developing rat cerebral cortex." Dev.Brain Res.(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sato,K.: "The differential expression patterns of messenger RNA_s encoding non-N-methyl-D-aspartate glutamate receptor subunits(GluR1-4)in the rat brain." Neuroscience. 52. 515-539 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fujita,M.: "Ontogeny of dopamine transporter mRNA expression in the rat brain." Molecular Brain Research. 19. 222-226 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 小河宏城: "インターロイキン-1βによるサブスタンスP受容体の発現制御" 神経科学. 32. 446-447 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ogo,H.: "Modulation of substance p receptor in human astrocytoma cells by antisense oligodeoxynucleotides." General Pharmacology. in press. (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Miyoshi,R.: "Effect of caerulein on expression of the immediate early genes c-fos and zif/268 in the rat brain." Neuroscience Letters. 145. 205-208 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Miyoshi,R.: "Effect of estrogen on immediate early gene expression in the rat brain." Society for Neuroscience Abstracts. 18. 57.1 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Asanuma,M.: "Late onset and long-lasting suppressive effects of ceruletide,an analogue of cholecystokinin,on c-fos mRNA expression in the rat striatum." Neuroscience Letters. 138. 233-236 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Asanuma,M.: "Effects of chronic catecholamine depletions on muscarinic Ml-receptor and its mRNA in rat brain." Journal of the Neurological Sciences. 110. 205-214 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ogawa,N.: "Effects of dihydroergotoxine on central cholinergic neuronal systems and discrimination learning test in aged rats." Brain Research. 586. 229-234 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirata,H.: "Effect of chronic ceruletide treatment on dopaminergic neuro-transmitters,receptors and their mRNAs in the striatum of rats with dyskinesia induced by iminodipropionitrile." Brain Research. 604. 197-204 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ogawa,N.: "The preventive effect of cyclosporin A,an immunosuppressant,on the late onset reduction of muscarinic acetylcholone receptors in gerbil hippocampus after transient forebrain ischemia." Neuroscience Letters. 152. 173-176 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Chou,H.: "Rapid response of striatal muscarinic M_1-receptor mRNA to muscarinic cholinergic agents in rat brain." Molecular Brain Research. 19. 211-214 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 石田敦彦: "Ca^<2+>/カルモデュリン依存性プロテインキナーゼIIの構造とアミン代謝" 蛋白質核酸酵素. 37. 1577-1589 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 藤澤仁: "多機能性カルモジュリン依存性タンパク質リン酸化酵素" 生化学. 64. 14-25 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Miyano,O.: "Purification and characterization of a brain-specific multi-functional calmodulin-dependent protein kinase from rat cerebellum." The Journal of Biological Chemistry. 267. 1198-1203 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fujisawa,H.: "Regulation of the activities of Ca^<2+>/calmodulin-dependent multi-functional protein kinases." Biomedical Research. 14. 99-102 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Okuno,S.: "Requirement of brain extract for the activity of brain calmodulin-dependent protein kinase IV expressed in escherichia coli^2." J.Biochem.114. 167-170 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kameshita,I.: "Autophosphorylation of calmodulin-dependent protein kinase IV from rat cerebral cortex^1." J.Biochem.113. 583-590 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kito,S.: "Neurotransmitter Rreceptors:Neuroreceptor Mechanisms in Brain edited by Kito,S.,Segawa,T.and Olsen,R.W." Plenum Press,New York, 10 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Miyoshi,R.: "The Basal.Ganglia III,edited by Bernardi,G.,Carpenter,M.B.,Di Chiara,G.,Morelli,M.and Stanzione,P." Plenum Press,New York, 7 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kito,S.: "Biochemistry,Pharmacology and Behavior,edited by Kameyama,T.,Nabeshima,T.,Domino,E.F." NPP Books., 9 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Miyoshi, R., Kito, S., Doudou, N.and Nomoto, T.: "Influence of age on N-methyl-D-asparate antagonist binding sites in the rat brain studied by in vitro autoradiography." Synapse. 8. 212-217 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Miyoshi, R., Kito, S., Muraki, T., Weiser, M.and Joh, T.H.: "Effect of caerulein on expression of the immediate early genes c-fos and zif/268 in the rat brain." Neuroscience Letters. 145. 205-208 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kito, S.and Miyoshi, R.: "Effect of glucocorticoid on hippocampal neurons : in vivo and in vitro studies." Neurochemical Research. 18. 832 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tohda, C.K., Tohda, M.and Nomura, Y.: "Increase in neurite formation and acetylcholine release by transfection of growth associated protein 43 cDNA into NG108-15 cells." Journal of Neurochemistry. 61. 526-532 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Okano, K., Kuraishi, Y.and Satoh, M.: "Pharmacological evidence for involvement of excitatory amino acids in aversive responses induced by intrathecal substance P in rats." Biol.Pharm.Bull.16. 861-865 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Mizutani, H., Hashimoto, T., Nakayasu, H.and Kuriyama, K.: "Alterations in cerebral GABA_B receptor binding during the formation of alcohol dependence." Pharmacology Communications. 3. 139-146 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Pingping, Z., Ogita, K., Han, D.and Yoneda, Y.: "Comparative studies on binding of 3 different ligands to the N-methyl-D-aspartate recognition domain in brain synaptic members treated with triton X-100." Brain Research. 609. 253-261 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fujita, M., Shimada, S., Nishimura, T., Uhl, G.R.and Tohyama, M.: "Ontogeny of dopamine transporter mRNA expression in the rat brain." Molecular Brain Research. 19. 222-226 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ogo, H., Hirai, Y., Miki, S., Nishio, H., Akiyama, M.and Nakata, Y.: "Modulation of substance p receptor in humans astrocytoma cells by antisense oligodeoxynucleotides." General Pharmacology. (in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Miyoshi, R., Fujii, E., Muraki, T.and Kito, S.: "Effect of estrogen on immediate early gene expression in the rat brain." Society for Neuroscience Abstracts. 18. 57.1 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Chou, H., Ogawa, N., Asanuma, M., Hirata, H., Kondo, Y.and Mori, A.: "Rapid response of striatal muscarinic M_1-receptor mRNA to muscarinic cholinergic agents in rat brain." Molecular Brain Research. 19. 211-214 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kameshita, I.and Fujisawa, H.: "Autophosphorylation of calmodulin-dependent protein kinase IV from rat cerebral cortex.^1" J.Biochem.113. 583-590 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kito,S.: "A cytoprotective effect of nicotine on hippocampal neurons." Society for Neuroscience Abstracts. 19. 772.15 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Miyoshi,R.: "Effect of nicotine on neurotransmitter release from the rat hippocampus." Society for Neuroscience Abstracts. 384.6 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kito,S.: "Effect of glucocorticoid on hippocampal neurons:in vivo and in vitro studies." Neurochemical Research. 18. 801-860 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tohda,C.K.: "Increase in neurite formation and acetylcholine release by transfection of growth-associated protein-43cDNA into NG108-15 cells." Joumal of Neurochemistry. 61. 526-532 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Nomura,Y.: "Inducible nitric oxide synthase in glial cells." Neuroscience Research. 18. 103-107 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Okano,K.: "Pharmacological evidence for involvement of:excitatory amino acids in:aversive responses induced by intrathecal substance P in rats." Biol.Pharm.Bull.16. 861-865 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yabuuchi,K.: "In situ hybridization study of interleukin-1beta mRNA induced by kainic acid in the rat brain." Molecular Brain Research. 20. 153-161 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Minami,M.: "In situ hybridization study of kappa-opioid receptor mRNA in the rat brain." Neuroscience Letters. 162. 161-164 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Minami,M.: "Cloning and experssion ofa cDNA for the rat kappa-opioid receptor." FEBS Letters. 329. 291-295 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Nakamoto,H.: "Possible involvement of descending monoaminergic systems to spinal dorsal horn in antinociception by peroral(6)-shogaol in rats." Pain Research. 8. 93-98 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Matsuoka,N.: "Role of somatostatin in the augmentation of hippocampal long-term potentiation by FR121196,a putative cognitive enhancer." European Joumal of Pharmacology. 241. 27-34 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Maeda,T.: "Bidirectional modulation of long-term potentiation by carbachol via M_1and M_2muscarinic receptors in guinea pig hippocampal mossy fiber-CA3 synapses." Brain Research. 619. 324-330 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ozaki,M.: "A vaccinia virus vector for efficiently introducing into hippocampal slices." Biochemical and Biophysical Research Communications. 193. 653-660 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Nakamura,S.: "Potentiation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-selective glutamate receptor function by a nootropic drug,.idebenone." Biol Pharm.Bull.17. 70-73 (1994)

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      1993 Annual Research Report
  • [Publications] Hirouchi,M.: "Alteation of GABA_Areceptor alpha_1-subunit mRNA in mouse brain following continuous ethanol inhalation." European Journal of Pharmacology-Molecular! Pharmacology Section. 247. 127-130 (1993)

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      1993 Annual Research Report
  • [Publications] Mizutani,H.: "Alterations in cerebral GABA_Breceptor binding during the formation of alchol dependence." Pharmacology Communications. 3. 139-146 (1993)

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      1993 Annual Research Report
  • [Publications] Enomoto,R.: "Differential potentiation by spermidine of abilities of a variety of displacers for 〔^3H〕MK-801 binding in hippocampal synaptic membranes." Neurosceince Research. 16. 217-224 (1993)

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      1993 Annual Research Report
  • [Publications] Pingping,Z.: "Comparative studies on binding of 3 different ligands to the N-methyl-D-aspartate recognition domain in brain synaptic membranes treated with triton X-100." Brain Research. 609. 253-261 (1993)

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      1993 Annual Research Report
  • [Publications] Yoneda,Y.: "Excitatory amino acid receptor binding in hippocampus of gerbils with transient global brain ischemia." Brain Research. 613. 21-31 (1993)

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      1993 Annual Research Report
  • [Publications] Yoneda,Y.: "Support for radiolabeling of a glycine recognition domain on the N-methyl-D-aspartate receptor ionophore complesx by 5,7-〔^3H〕dichlorokynurenate in rat brain." Journal of Neurochemistry. 60. 634-645 (1993)

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      1993 Annual Research Report
  • [Publications] Suzuki,T.: "Potentiation by polyamines of an interaction of noncompetitive antagonists at the N-methyl-D-aspartate receptor ionophore complex with phosphatidylserin" Neurochem.Int.23. 427-440 (1993)

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      1993 Annual Research Report
  • [Publications] Yoneda,Y.: "Selectively high expression of the transcription factor AP1 in telencephalic structures of epileptic E1 mice." Neuroscience Letters. 161. 161-164 (1993)

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      1993 Annual Research Report
  • [Publications] Pingping,Z.: "Further evidence for multiple forms of an N-methyl-D-aspartate recognition domain in rat brain using membrane bindng techniques." Journal of Neurochemistry. 61. 1865-1873 (1993)

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      1993 Annual Research Report
  • [Publications] Sato,K.: "The differential expression patterns of messenger RNA_Sencoding non-N-methyl-D-aspartate glutamate receptor subunits(GluRl-4)in the rat brain." Neuroscience. 52. 515-539 (1993)

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      1993 Annual Research Report
  • [Publications] Fujita,M.: "Ontogeny of dopamine transporter mRNA expression in the rat brain." Molecular Brain Research. 19. 222-226 (1993)

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      1993 Annual Research Report
  • [Publications] Ogo,H.: "Modulation of substance preceptor in human astrocytoma cells by antisense oligodeoxynucleotides." General Pharmacology in press. (1994)

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      1993 Annual Research Report
  • [Publications] Miyoshi,R.: "Effect of caerulein on expression of the immediate-early genes c-fos and zif/268 in the rat brain." Neuroscience Letters. 145. 205-208 (1992)

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      1993 Annual Research Report
  • [Publications] Miyoshi,R.: "Effect of estrogen on immediate early gene expression in the rat brain." Society for Neuroscience Abstracts. 18. 57.1 (1992)

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      1993 Annual Research Report
  • [Publications] Asanuma,M.: "Ischemia-induced changes in alpha-tubulin and beta-actin mRNA in the gerbil brain and effects of bifemelane hydrochloride." Brain Research. 600. 243-248 (1993)

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      1993 Annual Research Report
  • [Publications] Hirata,H.: "Effect of chronic ceruletide treatment on dopaminergic neurotransmitters,receptors and their mRNAs in the striatum of rats with dyskinesia induced by iminodipropionitrile." Brain Research. 604. 197-204 (1993)

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      1993 Annual Research Report
  • [Publications] Ogawa,N.: "The preventive effect of cyclosporin A,an immunosuppressant,on the late onset reduction of muscarinic acetylcholone receptors in gerbil hippocampus after transient forebrain ischemia." Neuroscience Letters. 152. 173-176 (1993)

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      1993 Annual Research Report
  • [Publications] Chou,H.: "Rapid response of striatal muscarinic M_1-receptor mRNA to muscarinic cholinergic agents in rat brain." Molecular Brain Research. 19. 211-214 (1993)

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      1993 Annual Research Report
  • [Publications] Fujisawa,H.: "Ragulation of the activities of Ca^<2+>/calmodulin-dependent multifunctional protein kinases." Biomedical Research. 14. 99-102 (1993)

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      1993 Annual Research Report
  • [Publications] Okuno,S.: "Raquirement of brain extract for the activity of brain calmodulin-dependent protein kinase IV expressed in escherichia coli." J.Biochem.114. 167-170 (1993)

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      1993 Annual Research Report
  • [Publications] Kameshita,I.: "Autophosphorylation of calmodulin-dependent protein kinase IV from rat cerebral cortex." J.Biochem.113. 583-590 (1993)

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      1993 Annual Research Report
  • [Publications] Miyoshi,R.,Kito,S.,Nomoto,T.,: "Cholecystokinin increases intracellular Ca^<2+> concentration in cultured striatal neurons" Neuropeptides. 18. 115-119 (1991)

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      1992 Annual Research Report
  • [Publications] Miyoshi,R.,Kito.S.,Nomoto,T.,Weiser,M.,Joh,T.: "Effect of caerulein on expression of the immediate early genes c-fos and zif/268 in the rat brain" Neuroscience Letter. 145. 205-208 (1992)

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      1992 Annual Research Report
  • [Publications] Miyoshi,R.,Kito,S.,Tanaka,A.: "Effect of neurotensin on dopamine and muscarinic acetylcholine receptors in the rat striatum" Basal Ganglia III、27. 39. 371-378 (1992)

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      1992 Annual Research Report
  • [Publications] Kumsagai,C.,Tohda,M.,Isobe,M.Nomura,Y.: "Involvement of GAP-43 with irreversible neurite outgrowth by dibutyryl cAMP and phorbol ester in NG108-15 cells." J.Neurochem. 59(1). 41-47 (1992)

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      1992 Annual Research Report
  • [Publications] Urusihara,H.,Tohda,M.,Nomura,Y.: "Selective potentiation of NMDA-induced currents by protein kinase C in Xenopus oocytes injected with rat brain RNA." J.Biol.Chem.267. 11697-11700 (1992)

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      1992 Annual Research Report
  • [Publications] 野村 靖幸: "記憶の細胞分子薬理" BIOmedica. 7(7). 708-713 (1992)

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      1992 Annual Research Report
  • [Publications] Katuki,H.,Kaneko,S.Sato,M.: "Involvement of postsymaptic in hippocampal long-term potenttlation." Brain Research. 581. 108-114 (1992)

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      1992 Annual Research Report
  • [Publications] Ueda,M.,Fujii,T.,Kuraishi,Y.,Satoh,M.: "Bifemelane enhances high K+-evoked release of glutamate from mossy fiber synaptosomes of guinea pig hippocampus." European J.of Parma.219. 271-277 (1992)

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      1992 Annual Research Report
  • [Publications] Kaneko,S.,Takahashi,H.,Satoh,M.: "Metabotropic responses to acetylcholine and serotonin of Xenopus oocytes injected with rat brain mRNA are transduced by different G-protein subtypes." FEBS Letters. 299. 179-182 (1992)

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      1992 Annual Research Report
  • [Publications] Yoneda,Y.,Ogita,K.: "Attempts to isolate the NMDA receptor complex from rat brain." Mol.Neuropharmacol.2. 65-70 (1992)

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      1992 Annual Research Report
  • [Publications] Tamaru,M.,Yoneda,Y.,Ogita,K.,Shimizu,J.,Matsutani,T.,Nagata,Y.: "Excitatory amino acid receptors in brains of rats with methylazoxy-methanol-induced microencephaly." Neurosci.Res.14. 13-25 (1992)

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      1992 Annual Research Report
  • [Publications] Yoneda,Y.,Suzuki,T.,Ogita,K.,Han,D.: "Support for rakiolabaeling of a glycine recognition domain on the N-methyl-D-aspartate receptor ionophore complex by [ ^3H]5,7-dichlorokynurenate in rat brain." J.Neurochem.60. 634-645 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Araki,T.,Tohyama,M.: "Region-specific expression of GABA_A receptor α_3 and α_4 subunits mRNAs in the rat brain" Mole.Brain Res.,. 12. 293-314 (1992)

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      1992 Annual Research Report
  • [Publications] Araki,T.,Kiyama,H.,Tohyama,M.: "The GABA_A receptor γ_1 subunit is expressed by distinct neuronal populations" Mole.Brain Res.15. 121-132 (1992)

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      1992 Annual Research Report
  • [Publications] Zhang,J.H.,Sato,M.,Tohyama,M.: "Co-expression of the α_1 and β_2 subunit genes of the GABA_A reaceptor in the magnocellular preoptic nucleus" Mole.Brain Res.15. 171-173 (1992)

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      1992 Annual Research Report
  • [Publications] Hirouchi,M.,Hashimoto,T.: "Alteration in expression of GABA_A receptor alphal-subunit nRNA in following continuous ethanol administration" Europ.J.Pharmacol.(1993)

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      1992 Annual Research Report
  • [Publications] Mizutani,M.,Hashimoto,T.fNakayasu,H.,Kuriyama,K.: "Alterations in cerebral GABA_B receptor binding during the formation of alcohol dependence." Pharmacology Communications. (1993)

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      1992 Annual Research Report
  • [Publications] Hirouchi,H.,Ohkuma,S.,Kuriyama,K.: "Muscimol-induced reduction of GABA_A reaceptor alpha_1-subunit mRNA in in primary cultured neurons" Mole.Brain Res. 15. 327-331 (1992)

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      1992 Annual Research Report
  • [Publications] Nakata,Y.,Takamatsu,H.,Kuroyanagi,N.,Nishio.H.,Segawa,T.,Akizawa;,T.: "Isolation of substance P binding protein from rat brain" J.Pharmacol.59. 313-319 (1992)

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      1992 Annual Research Report
  • [Publications] Ogo,H.,Kuroyanagi,N.,Nishio,H.,Hirai,Y.,Akiyama,M.,Nakata,Y.: "Characterization of funtional substance P recepjtors in human astrocytoma cell line" J.Pharmacol.(suppl.). 61. 68 (1993)

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      1992 Annual Research Report
  • [Publications] Yamawaki,Y.,m Ogawa,N.: "Successful treatment of levodopa-inducednefuroleptic malignant syndrome(NMS)and disseminated intravascular coagulation(DIC)in a patient with Parkinson'disease" Internal Medicine. 31. 1298-1302 (1992)

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      1992 Annual Research Report
  • [Publications] Asanuma,M.,Wgawa,N.,Hirata,H.,Chou,H.,Kondo,Y.,Mori,A.: "Ischemia-induced changes in α-tubulin and β-actin mRNA in the gerbil brain and effects of bifemelane hydrochrolide" Brain Res.600. 243-248 (1993)

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      1992 Annual Research Report
  • [Publications] 小川 紀雄,森 昭胤: "パーキンソン病とフリーラジカル" 神経精神薬理. 14. 735-744 (1993)

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      1992 Annual Research Report
  • [Publications] Kito,S.,Miyoshi,R.: "Neurotransmitter Receptors:Neuroreceptor Mechanism in Brain" Plenum Press, 495 (1991)

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      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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