| Project/Area Number |
04304052
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | TOHOKU UNIVERSITY (1994)
Hokkaido University (1992-1993) |
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Principal Investigator |
KASAI Noriyuki TOHOKU UNIVERSITY SCHOOL OF MEDCINE,PROFESSOR, 医学部, 教授 (60001947)
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| Co-Investigator(Kenkyū-buntansha) |
KAMATAKI Tetsuya FACULTY OF PHARMACOLOGY HOKKAIDO UNIVERSITY,PROFESSOR, 薬学部, 教授 (00009177)
SUGIYAMA Yuichi FACULTY OF PHARMACOLOGY UNIVERSITY OF TOKYO,PROFESSOR, 薬学部, 教授 (80090471)
ANDO Susumu TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY,THE HEAD OF A DIVISION, 部長 (30073000)
YOSHIDA Michihiro HOKKAIDO UNIVERSITY FACULTY OF SCIENCE,PROFESSOR, 理学部, 教授 (60001765)
MORIWAKI Kazuro FUKUYAMA UNIVERSITY FACULTY OF TECHNOLOGY,PROFESSOR, 工学部, 教授 (50000229)
林崎 良英 理化学研究所, 研究員 (70192705)
西村 正彦 浜松医科大学, 助教授 (20073661)
下田 耕治 慶応義塾大学, 医学部, 助手 (00129470)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 1994: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1993: ¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1992: ¥6,000,000 (Direct Cost: ¥6,000,000)
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| Keywords | EXTRAPOLATION / SPECIES DIFFERENCES / GENE / PHARMACOKINETICS / GENETIC HOMOLOGY / LABORAATORY ANIMALS / STRAIN DIFFERENCES / ANIMAL SCALE UP / 遺伝的相同性 / 遺伝情報 / 薬物代謝酵素 / 薬物代謝能 / 疾患遺伝子 / 膜酵素 / 肝臓薬物代謝酵素 / 遺伝子地図 / ジーンバンク / 動物脳シナプス膜脂質 |
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| Research Abstract |
EXTRAPOLATION MEANS TO PRESUME THE RESULTS ON HUMAN BEINGS FROM THE RESULTS OF EXPERIMENTATION USING LABORATORY ANIMALS.HOWEVER,AN ACCURATE EXTRAPOLATION IS PREVENTED BY THE SPECIES DIFFERENCES BETWEEN HUMAN BEINGS AND ANIMALS.WE INVESTIGATED THE WAY OF EXTRAPOLATION BY THE COMPARISON OF THE PHARMACOKINETICS AND THE GENETIC ANALYSIS BETWEEN HUMAN BEINGS AND LABORATORY ANIMALS.
THIS RESEARCH LASTED FOR THREE YEARS,AND WE DEVELOPED NEW FIELD FOR LABORATORY ANIMAL SCIENCE.BUT MORE RESEARCH IS NEEDED FOR ESTABLISHMENT OF THE NEW METHODS OF EXTRAPOLATION.WE HELD A SYMPOSIUM ON THE EXTRAPOLATION AT TOKYO,AND ABOUT 250 RESEARCERS PARTICIPATED IN THIS SYMPOSIUM.I THINK THIS IS FIRST SYMPOSIUMON THE EXTRAPOLATION IN JAPAN.
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