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Structure, function and evolution of ribosomal proteins chracteristic for eukaryotic ribosomes.

Research Project

Project/Area Number 04304055
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 物質生物化学
Research InstitutionYamanashi Medical University

Principal Investigator

TSURUGI Kunio  Yamanashi Medical University Proffesor, 医学部, 教授 (10018690)

Co-Investigator(Kenkyū-buntansha) UCHIUMI Toshio  Niigata University School of Medicine Research Assistant, 医学部, 助手 (50143764)
WADA Akira  Kyoto University, Faculty of Science Research Assistant, 理学部, 助手 (80025387)
TANAKA Tatsuo  University of the Ryukyus, School of Medicine, Proffesor, 医学部, 教授 (70018688)
OTAKA Eiko  Hiroshima University Research Institute for Nuclear Medicine and Biology, Proffe, 原医研, 教授 (30034630)
TAKAGI Masamichi  University of Tokyo, Faculty of Agriculture, Proffesor, 農学部, 教授 (50018339)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 1994: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1993: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1992: ¥5,000,000 (Direct Cost: ¥5,000,000)
KeywordsEukaryotic cell / Ribosomal proteins / Cycloheximide / Gene cloning / Evolution / 2-D PAGE / Acidic ribosomal proteins
Research Abstract

Some yeasts possese a inducible cycloheximide(CYH)-resistant ribosome and the gene resiponsible to this has been isolated which encoded one of two genes of the ribosomal protein L41. The two L41 genes are different in a substitution of the 58th glutamine codon for the proline codon and the one containing glutamine was responsible for CYH-resistance. The nucleotide sequences responsible for the inducibility by addition of CYH were found in the promoter regions which contained GT-rich and Gcn4p binding sequences.
Eukaryotic cells possess a family of acidic ribosomal proteins and the members contained evolutionarily conserved hydrophobic zippers and hydrophobic hook-and-eye struc-tures in the amino-terminal half, which are assumed to be involved in their association. They formed complex including L12 and located in the highly conserved "GTPase domain" as-sociating with a unique internal loop comprised by 1867-1914 residues of 28S rRNA.
Radical-free and highly reducing (RFHR) 2-D gel electrophoresis was developed which enabled us to clearly and reproducibly separate ribosomal proteins. With this method four new ribosomal proteins (A,B,C and D) were found in E.coli ribosome and one (SCS28) were in plant chloroplast ribosomes. Ribosomal proteins of yeast and rat liver ribosomes were also re-analyzed to determine precise number of the proteins.
Several genes for ribosomal proteins were isolated from chicken liver (L5, L7a, L30 and L37a) and yeast (YL16 and YL8), and their amino acid sequences were deduced from the nucleotide sequences. Including these proteins, equivalents among ribosomal proeins from various organism were systematically compiled using a universal code system(UCS). From the analysis an evolutionary profile of ribosomal proteins was proposed.

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (95 results)

All Other

All Publications (95 results)

  • [Publications] S.Kawai: "Drastic alteration of cycloheximide sensitivity by substitution of one amino asid in the L41 ribosmal protein of yeast." J.Bacteriology. 174. 254-262 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Tsurugi: "Hydrophobic zippers and hook-and-eye: evolutionarily conserved protein sequence motifs in eukaryotic acidic ribosomal proteins which are assumed to be involved--." Protein Seq.Data Anal.5. 33-38 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Tsurugi: "Domain and modular structure of acidic ribosomal proteins of the yeast Saccharomyces cerevisiae." Yamanashi Med.J.7. 151-156 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Hashizume: "Conformational studies on the acidic proteins of rat liver ribosomal large subunit: Fluorometric evidences for heterodimeric interaction of P1 and P2 r-prtoeins." Reports of Faculty of Science,Shizuoka Univ.26. 51-56 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Hashimoto: "Yeast ribosomal proteins: XIV.Complete nucleotide sequences of the two genes encoding Saccharomyces cerevisiae YL16." Biochim.Biophys.Acta. 1132. 195-198 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Kenmochi: "The stucture and complete sequence of the gene encoding chicken ribosomal protein L5." Gene. 119. 215-219 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] S.Toku: "The primary structure of chicken ribosomal protein L37a." Biochim.Biophys.Acta. 1132. 88-90 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Ozaki: "Promoter selectivity of the stationary-phase forms of Escherichia coli RNA polymerase and conversion in vitro of the S1 form enzyme into a log-phase form." Nucleic Acids Research. 20. 257-261 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Uchiumi: "Direct evidence for interaction of the conserved GTPase domain within 28S RNA with mammalian ribosomal acidic phosphoproteins and L12." J.Biol.Chem.267. 19179-19185 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Furukawa: "Ribosomal protein P2,a novel iron-binding protein." Arch.Biochem.Biophys.298. 182-186 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Tsurugi: "An evolutionary study on the gene family of 13 kDa-type acidic ribosomal proteins of the yeast Saccharomyces cerevisiae: Evidence for a gene conversion." Biochem.Arch.9. 297-302 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] E.Otaka: "The ribosomal proteins: I.An introduction to a compilation of the protein species equivalents from various organisms by a universal code system." Protein Seq.Data Anal.5. 285-300 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] E.Otaka: "The ribosomal proteins: II.Alignments of the equivalents of ribosomal large subunit proteins from E.coli,compilted by a universal code system." Protein Seq.Data Anal.5. 301-313 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] E.Otaka: "The ribosomal proteins: Major protein species are maintained throughout all organisms on the earth,according to evolutionary analyses." Mol.Biol.(Life Sci.Adv.). 12. 145-163 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Machida: "The structure of the gene encoding chicken ribosomal protein L37a." Eur.J.Biochem.213. 77-80 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Shinbara: "Down-regulation of ubiquitin gene expression during differentiation of human leukemic cells" FEBS Lett.322. 235-239 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Nakasone: "The structure of the gene encoding chicken ribosomal protein L30." Biochim.Biophys.Acta. 1174. 75-78 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Kenmochi: "A common nuclear factor that binds to the transcriptional control regions of ribosomal protein L5 and 5S RNA genes." Biochem.Biophys.Res.Commun.194. 1131-1134 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Maeda: "The complete nucleotide sequence of chicken ribosomal protein L7a gene and the multiple factor binding sites in the 5'-flanking region." Biochimie. 75. 785-790 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Yamagishi: "Regulation of the Escherichia coli rmf gene encoding the ribosome modulation factor: growth phase-and growth rate-dependent control" The EMBO J.12. 625-630 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] A.Wada: "A 5-kDa protein (SCS23) from the 30S subunit of the spinach chloroplast ribosome." FEBS-Lett.319. 115-118 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Saito: "Increased expression of acidic ribosomal protein (PO) mRNA after phorbol ester treatment of cultured rat thyroid (FRTL-5) cells." Biochem.Biophys.Res.Commun.203. 780-788 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Nakasone: "The structure of chicken ribosomal protein L30." Ryukyu Med.J.14. 43-48 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Kajitani: "Regulation of the Escherichia coli hfg gene encoding the host factor for Q-beta." J.Bacteriology. 176. 531-534 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Uchiumi: "A Functional site of the GTPase-associated center within 28S ribosomal RNA probed with and anti-RNA autoantiboby.21GC25:EMBO J." 13. 3389-3394 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Sato: "Serological association of lupus autoantibodies to a limited functional domain of 28S ribosomal RNA and to the ribosomal proteins bound to the domain." Clin.Exp.Immunol.98. 35-39 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 剱 邦夫: "真核細胞の酸性リボソームタンパク質の構造と機能" 生化学. 66. 342-354 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Mizuta: "The evolutionary relationships between homologs of ribosomal YL8 protein and YL8-like proteins." Curr.Genet.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] E.Otaka: "NATO ASI series,H71 Protein synthesis" Springer Verlag-Berlin, 16 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] E.Otaka: "The translational appartus" Plenum Publishing Corporation, 15 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 高木 正道: "医学微生物学の新しい展開" 菜根出版, 587 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 高木 正道: "21世紀に向かう酵母研究" 学会出版センター, 252 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] S.Kanai, S.Murao, M.Mochizuki, I.Shibuya, K.Yano & M.Takagi: "Drastic alteration of cycloheximide sensitivity by subst-itution of one amino acid in the L41 ribosomal protein of yeasts." J.Bacteriology. 174. 254-262 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Tsurugi: "Hydrophobic zippers and hook-and-eye : evolutionarily conserved protein sequence motifs in eukaryotic acidic ribosomal proteins which are assumed to be involved in the association of the protein family." Protein Seq.Data Anal. 5. 33-38 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Tsurugi: "Domain and modular structure of acidic ribosomal proteins of the yeast Saccharomyces cerevisiae." Yamanashi Med.J.7. 151-156 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] H.Hashizume, T.Yasukawa, K.Tsurugi & H.Itagaki: "Conformational studies on the acidic proteins of rat liver ribosomal large subunit : Fluorometric evidence for hetero-dimeric interaction of P1 and P2 ribosomal proteins." Reports of the Faculty of Science, Shizuoka Univ.26. 51-56 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Hashizume, K.Suzuki, K.Mizuta & E.Otaka: "Yeast ribosomal proteins : XIV.Complete nucleotide sequence of the two genes encoding Saccharomyces cerevisiae YL16." Biochim. Biophys. Acta. 1132. 195-198 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Kenmochi, N.Maeda & T.Tanaka: "The structure and complete sequence of the gene encoding chicken ribosomal protein L5." Gene. 119. 215-219 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] S.Toku & T.Tanaka: "The structure of the gene encoding chicken ribosomal protein L37a." Biochim. Biophys. Acta. 1132. 88-90 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Ozaki, N.Fujita, A.Wada & A.Ishihama: "Promoter selectivity of the stationary-phase forms of E.coli RNA polymerase and conversion in vitro of the S1 form enzyme into a log-phase enzyme-like form." Nuleic Acids Res.20. 257-261 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Uchiumi & R.Kominami: "Direct evidence for interaction of the conserved GTPase domain within 28S RNA with mammalian ribosomal acidic phosphoproteins and L12." J.Biol.Chem.267. 19179-19185 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Furukawa, T.Uchiumi, R.Tokunaga & S.Taketani: "Ribosomal protein P2, a novel iron-binding protein." Arch. Biochem. Biophys. 298. 182-186 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Tsurugi: "An evolutionary study on the gene family of 13 kDa-type acidic ribosomal proteins of the yeast Saccharomyces cerevisiae : Evidence for a gene conversion." Biochem. Arch. 9. 297-302 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] E.Otaka, T.Hashimoto & K.Mizuta: "The ribosomal proteins : I.An introduction to a compilation of the protein species equivalents from various organisms by a universal code system." Protein Seq. Data Anal.5. 285-300 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] E.Otaka, T.Hashimoto, K.Mizuta & K.Suzuki: "The ribosomal proteins : II.Allignments of the equivalents of ribosomal large subunit proteins from E.coli, compiled by a universal code system." Protein Seq. Data Anal.5. 301-313 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] E.Otaka, T.Hashimoto, K.Mizuta & K.Suzuki: "The ribosomal proteins : Major protein species are maintained throughout all organisms on the earth, according to evolutionary analyzes." Mol. Biol. (Life Sci.Adv.). 12. 145-163 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Machida, S.Toku, N.Kenmochi & T.Tanaka: "The structure of the gene encoding chicken ribosomal protein L37a." Eur.J.Biochem.213. 77-80 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Shinbara, C.Sata, M.Takashima, T.Tanaka & A.Ichihara: "Down-regulation of ubiquitin gene expression during differentiation of human leukemia cells." FEBS Lett. 322. 235-239 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Nakasone, N.Kenmochi, S.Toku & T.Tanaka: "The structure of the gene encoding chicken ribosomal protein L30." Biochim. Biophys. Acta. 1174. 75-78 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Kenmochi, N.Maeda & T.Tanaka: "A common nuclear factor that binds to the transcriptional control regions of ribosomal protein L5 and 5S RNA genes." Biochem. Biophys. Res. Commun. 194. 1131-1134 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] N.Maeda, N.Kenmochi, S.Toku & T.Tanaka: "The complete nucleotide sequence of chicken ribosomal protein L7a gene and the multiple factor binding sites in the 5'-flanking region." Biochimie. 75. 785-790 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Yamagishi, H.Matsushita, A.Wada, M.Sakagami, N.Fujita & A.Ishihama: "Regulation of the E.coli rmf gene encoding the ribosome modulation factor : growth phase-and growth rate-dependent control." EMBO J.12. 625-630 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] A.Wada, K.Koyama, Y.Maki, Y.Shimoi, A.Tanaka & H.Tsuji: "A 5-kDa protein (SCS23) from the 30S subunit of the spinach chloroplast ribosome." FEBS Lett. 319. 115-118 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Saito, M.Ikeda, T.Endo, K.Tsurugi & T.Onaya: "Increased expression of acidic ribosomal protein (P0) mRNA after phorbol ester treatment of cultured rat thyroid cells." Biochem. Biophys. Res.Commun. 203. 780-788 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Nakasone, N.Kenmochi, S.Toku & T.Tanaka: "The structure of chicken ribosomal protein L30." Ryukyu Med.J.14. 43-48 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.Kajitani, A.Kato, A.Wada, Y.Inokuchi & A.Ishihama: "Regularion of the Escherichia coli hfg gene encoding the host factor for Qbeta." J.Bacteriology. 176. 531-534 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Uchiumi & R.Kominami: "A functional site of the GTPaes-associated center within 28S ribosomal RNA probed with an anti-RNA autoantibody." EMBO J.13. 3389-3394 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Sato, T.Uchiumi, M.Arakawa & R.Kominami: "Serological association of lupus autoantibodies to a limited functional domain of 28S ribosomal RNA and to the ribosomal proteins bound to the domain." Clin.Exp.Immunol. 98. 35-39 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] K.Mizuta, T.Hashimoto & E.Otaka: "The evolutionary relationship between homologs of ribosomal YL8 protein and YL8-like proteins." Curr. Genet. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Uchiumi,T.: "A Functional Site of the GTPase‐associated Center within 28S ribosomal RNA probed with an Anti‐RNA Autoantibody." ENBO J.13. 3389-3394 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Sato,T.: "Serological Association of Lupus Autoantibodies to a Limited Functional Domain of 28S Ribosomal RNA and to the Ribosomal Proteins Bound to the Domain." Clin.Exp.Immunol.98. 35-39 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 劍 邦夫: "真核細胞の酸性リボソームタンパク質の構造と機能." 生化学. 66. 342-354 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 佐藤健比呂: "全身性エリテマトーデス患者血清中のリボソーム構成成分に対する自己抗体の解析." 新潟医学会雑誌. 108. 194-199 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Odani,S.: "On the Molecular Origin of Charge Heterogenity of Rat Liver Fatty AcidBindingProtein(Z‐protein)." Arch.Biochem.Biophys.309. 81-84 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Honma,Y.: "Evidence for Conformational Change of Fatty Acid‐Binding Protein Accompanying Binding of Hydrophobic Ligands." J.Biochem.116. 1025-1029 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Eiko Otaka: "The ribosomal proteins:Major protein species are maintained throughout all organisms on the earth,according to evolutionary analyses." Mol.Biol.(Life Sci.Adv.). 12. 145-163 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Keiko Mizuta: "The evolutionary relationships between homologs of ribosomal YL8 protein and YL8‐like proteins." Current Genetics. (in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Mitsui: "The GTS1 gene,which contains a Gly-Thr repeats,affects the timing of budding and cell size----." Molecular and Cellular Biology. 14. 5569-5578 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Nakasone: "The structure of chicken ribosomal protein L30" Ryukyu Med.J.14. 43-48 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] S.Kawai: "Drastic alteration of cycloheximide sensitivity by subustitution of amino acid in the L14 ribosomal protein of yeast." J.Bacteriology. 174. 254-262 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] E.Otaka: "The ribosomal proteins:I.An introduction to a compilation of the protein species equivalents various organisms---." Protein Seq.Data Analysis. 5. 285-300 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] E.Otaka: "The ribosomal proteins:II.Alignments of the equivalents of ribosomal large subunit proteins from E.coli,compiled by---." Protein Seq.Data Analysis. 5. 301-313 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] M.Machida: "The structure of the gene encoding chicken ribosomal protein L37a." Eur.J.Biochem.213. 77-80 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] N.Shimbara: "Down-regulation of ubiquitin gene expression during differentiation of human leukemia cells." FEBS Lett.322. 75-78 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] N.Kenmochi: "A common nuclear factor that binds to the transcriptional control regions of ribosomal protein L5 and 5S rRNA genes" Biochim.Biophys.Res.Commun.194. 1131-1134 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] N.Maeda: "The complete nucleotide sequence of chicken ribosomal protein L7a gene and the multiple factor binding sites in its 5'-region." Biochimie. 75. 785-790 (1993)

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  • [Publications] A.Wada: "A 5-kDa protein(SCS23)from the 30S subunit of the spinach chloroplast ribosome." FEBS Lett.319. 115-118 (1993)

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  • [Publications] M.Yamaguchi: "Regulation of the E.coli rmf gene encoding the ribosome modulation factor(RMF):Growth phase and growth-rate dependent control." EMBO J.12. 625-630 (1993)

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  • [Publications] M.Kajitani: "Regulation of E.coli hfg gene encoding the host factor for Qb." J.Bacteriology. 176 (in press). (1994)

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  • [Publications] S.Odani: "On the molecular origin of charge heterogenity of rat-liver fatty acid binding protein." Arch.Biochem.Biophys.308 (in press). (1993)

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  • [Publications] 剱 邦夫: "真核細胞の酸性リボソーム蛋白の構造と機能" 生化学. 66 (印刷中). (1993)

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  • [Publications] E.Otaka: "NATO ASI series,Vol.H71 Protein synthesis and Targeting" Springer-Verlag Berlin Heidelberg, 16 (1993)

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  • [Publications] E.Otaka: "The translational appartus" Plenum Publishing Corporation (in press), 15 (1993)

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  • [Publications] S.Kawai: "Dramatic alteration of cycloheximide.sesitivity by substitution of one amino acid in L41 ribosomal protein of yeast." Journal Bacteriology. 174. 254-262 (1992)

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  • [Publications] Keiko Mizuta: "Yeast ribosomal proteins:XIII.Saccharomyces cerevisiae YL8A,interrupted with two introns encodes a homolog of mammalian L7." Nucleic Acids Research. 20. 1011-1016 (1992)

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  • [Publications] Tetsuo Hashimoto: "Yeast ribosomal proteins:XIV.Complete nucleotide sequences of the gene encoding Saccharomyces cerevisiae YL16." Biochimica et Biophysica Acta. 1132. 195-198 (1992)

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  • [Publications] Eiko Otaka: "The ribosomal proteins:I.An introduction to a compilation of the protein species equivalents from various organisms by a universal code system" Protein Sequences & Data Analysis. 5. (1993)

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  • [Publications] Naoya Kenmochi: "The structure and complete sequence of the gene encoding chichen ribosomal protein L5" Gene. 119. 215-219 (1992)

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  • [Publications] Seikichi Toku: "The primary structure of chicken ribosomal protein L37a." Biochemica et Biophysica Acta. 1132. 88-90 (1992)

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  • [Publications] Maki Machida: "The structure of the gene encoding chicken ribosomal protein L37a." European Journal of Biochemistry.

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  • [Publications] Toshio Uchiumi: "Direct evidence for interation of the conserved GTPase domain within 28S RNA with mammalian ribosomal acidic phosphoproteins and L12." Journal of Biological Chemistry. 267. 19179-19185 (1992)

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  • [Publications] Takao Furukawa: "Ribosomal protein P2,a novel iron-binding protein." Archives for Biochemistry and Biophysics. 298. 182-186 (1992)

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  • [Publications] Akira Wada: "A 5-kDa protein (SCS23) from the 30S subunit of the spinach chloroplast ribosome." FEBS Letters. (1993)

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  • [Publications] M.Yamagishi: "Regulation of the Escherichia coli rmf gene encoding the ribosome modulation factor (RMF):Growth phase - and growth rate - dependent control" EMBO Journal. (1993)

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  • [Publications] Kunio Tsurugi: "Hydrophobic zippers and hook-and-eye:evolutionarily conserved protein sequence motifs in eukaryotic acidic ribosomal proteins." Protein Sequences & Data Analysis. 5. 33-38 (1992)

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Published: 1992-04-01   Modified: 2016-04-21  

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