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免疫制御・寛容の分子機構

Research Project

Project/Area Number 04354032
Research Category

Grant-in-Aid for Co-operative Research (B)

Allocation TypeSingle-year Grants
Research InstitutionKyushu University

Principal Investigator

笹月 健彦  九州大学, 生体防御医学研究所, 教授 (50014121)

Co-Investigator(Kenkyū-buntansha) 平野 俊夫  大阪大学, 医学部, 教授 (40136718)
岸本 忠三  大阪大学, 医学部, 教授 (10093402)
本庶 佑  京都大学, 医学部, 教授 (80090504)
奥村 康  順天堂大学, 医学部, 教授 (50009700)
多田 富雄  東京大学, 医学部, 教授 (10009136)
Project Period (FY) 1992
Project Status Completed (Fiscal Year 1992)
Keywords免疫制御 / 免疫寛容 / 免疫病
Research Abstract

最近10年間の免易学的ならびに分子生物学的研究の進歩は、免疫応答系を構成する各要素についての構造および機能に関する理解をもたらした。すなわち免疫グロブリン遺伝子やT細胞レセプター遺伝子の全構造と再編成の機序、免疫細胞の機能分化に伴うレセプターや表面抗原マーカーの発現機序、リンパ球の分化成熟の分子機構、多数のサイトカインとその受容体の遺伝子構造と発現および機能、HLA分子の構造と免疫応答の遺伝的制御機構などについての多くの知見が得られている。しかしながら、これらの要素が個体レベルでどのように関連し合い、免疫応答を調節しているのか、その破綻がどのようにして免疫病の発症につながるのか、あるいは各要素を個体レベルでどのように調和を保たせながら免疫病を補正しているのか等については、ほとんど理解されていないのが現状である。従って、本研究班では、次年度に発足する重点領域研究「免疫制御・寛容の分子機構」のための研究研画の検討および研究班、研究班員の構成の立案のため、班員による3回の班会議を行った。その結果、免疫制御と寛容の分子機構の解明のために、免易制御、免疫寛容、免疫病の3つの柱についてそれぞれの分子機構を解明する研究研画を立案した。さらに我国における国際的にも高く評価される免疫学者・分子生物学者・細胞遺伝学者の多くが集結した「免疫制御・寛容の分子機構」ワークショップを開催し、先鋭的な研究を円滑に行うための研究対象、研究方法論、今後の研究動向などに関する充分な討議を行った。

Report

(1 results)
  • 1992 Annual Research Report
  • Research Products

    (38 results)

All Other

All Publications (38 results)

  • [Publications] Hatae K: "Genetic control of non-responsiveness to hepatitis B virus vaccine by an extended HLA haplotype" Eur J Immunol. 22. 1899-1905 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Senju S: "Allele-specific expression of the cytoplasmic exon of HLA-DQB1 gene" Immunogenetics. 36. 319-325 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoshida M: "Polymerase Chain reaction based analysis of polymorphism in the HLA-B gene" Hum Immunol. 34. 257-266 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Odum N: "Signal tranaduction by HLA class II molecules in human T cells:induction of LFA-1-dependent and independent adhesion" Hum Immunol. 35. 71-84 (1992)

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      1992 Annual Research Report
  • [Publications] Dong RP: "HLA-A and DPB1 loci confer susceptibility to Graves'disease" Hum Immunol. 35. 165-172 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Fukui Y: "T cell repertoire in a transgenic C57BL/6 mice expressing the HLA-DRA gene on the X chromosome" Immunogenetics. 37. 204-211

    • Related Report
      1992 Annual Research Report
  • [Publications] Hoshino: "A practical HLA-DRB and -DQB matching test in kidney transplantation" Transpl Proc. 25. 191-193 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kimura A: "PCR-SSCP analysis of HLA-DP genes and its application to matching study en transplantation" Transpl Proc. 25. 199-202 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Suzuki S: "Assay of cell surface-bouno immunoliposomes using monoclonal antibody reactive with a crosslinking reagent" Chem Pharm Bull. 40. 1893-1896 (1992)

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      1992 Annual Research Report
  • [Publications] Ueno H: "Enhanced binding to antigen of monoclonal antibodies modified with a crosslinker" Biochm Biophys Res Comm.

    • Related Report
      1992 Annual Research Report
  • [Publications] Tada T: "Suppression of immune respcnses by cloned T cells and their products" Behring Inst Mitt. 91. 78-86 (1992)

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      1992 Annual Research Report
  • [Publications] Hu FY: "Establishment of stable CD8^+ xuppressor T cell clones and the analysis of their suppressive function" J Immunol Methods. 152. 123-134 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Inoue T: "Distinction of mouse CD8^+ suppressor effector T cell clones from cytotoxic T cell clones by cytokine production and CD45 isoforms" J Immunol.

    • Related Report
      1992 Annual Research Report
  • [Publications] Isobe M: "A short course of anti-ICAM/anti-LFA-1 treatment leads to specific acceptance of cardiac allograft" Science. 255. 1125-1127 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takahashi K: "CD4 and CD8 regulate interleukin 2 responses of T cells" Proc Natl Acad Sci. 89. 5557-5561 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kato K: "CD48 is a counter-receptor for mouse CD2 and involoved in T cell activation" J Exp Med. 176. 1241-1249 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Miyake S: "β1 integrin-mediated interaction with extracellular matrix proteins regulates cytokine gene expression in synovial fluid cells of rheumatoid arthritis pationes" J Exp Med.

    • Related Report
      1992 Annual Research Report
  • [Publications] Ryu K: "Inhibition of throsine phosphorylation prevents IFN-γ-induced HLA DR molecule expression" J Immunol. 150. 1253-1262 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Matsubara K: "A rapid and sensitive method for HLA-DRB1 typing by acridinium-ester-laveled DNA probes" Hum Immunol. 35. 132-139 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ishizuka R: "Biochemical analysis of HLA-DR antigens using one-dimensional isoelectric focusing gel electrophoresis" Tissue Antigen. 39. 220-224 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Murakami M: "Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice" Nature. 357. 77-80 (1992)

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      1992 Annual Research Report
  • [Publications] Furukawa: "The drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development" Cell. 69. 1191-1197 (1992)

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      1992 Annual Research Report
  • [Publications] Honjo T: "Seppuku and autoimmunity" Science. 258. 591-592 (1992)

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      1992 Annual Research Report
  • [Publications] Kishimoto T: "Interleukin 6 and its receptor:A paradigm for cytokines" Science. 258. 593-597 (1992)

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      1992 Annual Research Report
  • [Publications] Taga T: "Functional inhibition of hematopoietic and neurotrophic cytokines by blocking IL-6 signal transducer gp130" Proc Natl Acad USA. 89. 10998-11001 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Oritani K: "Retinoic acid inhibits interleukin 6-induced macrophage differentiation and apoptosis in a murine hematopoietic cell line Y6" Blood. 80. 2298-2305 (1992)

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      1992 Annual Research Report
  • [Publications] Kaisho T: "Human bone marrow stromal cell lines from myeloma and rheumatoid arthritis which can support murine pre B cell growth" J Immunol. 149. 4088-4095 (1992)

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      1992 Annual Research Report
  • [Publications] Hirano T: "The Biology of interleukin 6" Chemical Immunol. 51. 153-180 (1992)

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      1992 Annual Research Report
  • [Publications] Hirano T: "Interleukin 6 and autoimmunity and plasma cell neoplasias" Res Immunol. 143. 759-763 (1992)

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      1992 Annual Research Report
  • [Publications] Okabe T: "A pre-B cell specific DNA binding protein EBB-1,which binds to the promoter of the Vpre B gene" Europ J Immunol. 22. 37-43 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ichiki T: "The effect of cytokines and mitogens on the induction of C_ε germline transcripts in a human Burkitt lymphoma B cell line" Int Immunol. 4. 747-754 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Nakashima M: "In vitro expansion of melanoma specific,HLA restricted CD8^+ cytotoxic T lymphocytes" Cellul Immunol.

    • Related Report
      1992 Annual Research Report
  • [Publications] Ichiki T: "Regulation of the expression of human C_ε germline transcripts;Identification of a novel IL-4 responsive element" J Immunol.

    • Related Report
      1992 Annual Research Report
  • [Publications] Kakimoto K: "The effect of anti-adhesion molecule antibody on the development of collagen-induced arthritis" Cell Immunol. 142. 326-337 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Mori L: "Expression of a transgenic T cell receptor chain enhances collagen-induced arthritis" J Exp Med. 176. 381-388 (1992)

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      1992 Annual Research Report
  • [Publications] Ohmura T: "A 68-kD GTP-Binding protein associated with the T cell receptor complex" J Exp Med. 176. 887-891 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Shinbori T: "Development of the cell contact-mediated accessory function for T-cell proliferation in a human promyelocytic leukaemia cell line,HL-60,by 1,25-dihydroxyvitamin D_3" Immunology. 75. 619-625 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yamada M: "Accessory function of human glioma cells for the induction of CD3-mediated T cell proliferatior:a prtential role of glial cells in T cell activation in the central nervous system" J Neuroimmunol. 38. 263-274 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1994-03-23   Modified: 2016-04-21  

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