| Project/Area Number |
04403006
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
有機化学一般
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
OHNO Atsuyoshi Inst.Chem.Res., Kyoto Univ., 化学研究所, 教授 (70027077)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMURA Mutsuo Fac.Sci., Niigata Uoiv., 理学部・化学科, 助教授 (30215503)
HDTA Yasuo Iost.Chem.Res., Kyoto Univ., 化学研究所, 助教授 (10127277)
KAWAI Yasushi Inst.Chem.Res., Kyoto Univ., 化学研究所, 助手 (20240830)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥39,000,000 (Direct Cost: ¥39,000,000)
Fiscal Year 1994: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1993: ¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 1992: ¥30,000,000 (Direct Cost: ¥30,000,000)
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| Keywords | Oxidation / Reduction / Awial asymmetry / Carbonyl Group / Sulfinyl Group / Stereospecific / Stereochemistry / NAD (P)^+ Coenzyme / 反応機構 / 基底状態 / 遷移状態 / 酸化還元 / 酵素の化学進化 / 立体制御 / X線結晶構造回析 / 絶対配置 / 酵素 / 補酵素 / 酸化還元反応 / 不斉反応 |
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| Research Abstract |
Mechanism of biologically important (net) hydride transfer from NADH or NADPH to a substrate has been discussed from the viewpoint of physical organic chemistry. It is emphasized that the (net) hydride transfer involves an electron-transfer complex as an intermediate of the reaction. The intermediate plays a crucial role in determining stereochemistry of the reaction. Orientation of dipolar functional group such as carbonyl or sulfinyl selects molecular face to afford the complexation, then defines the face of reaction. Steric balkiness is of the second importance in defining the face of reaction. The mechanism observed is named as nonsteric stereochemistry. Molecular interactions observed in organic reactions and discussed herein is closely related to those in biological reactions.
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