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Clarification of functions of biological trace elments.

Research Project

Project/Area Number 04404037
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

ITOKAWA Yoshinori  Faculty of Medicine, Professor, 医学部, 教授 (80025593)

Co-Investigator(Kenkyū-buntansha) MORI Keiichiro  Faculty of Medicine, Assust. Professor, 医学部, 講師 (80159186)
KONDO Hisao  Faculty of Medicine, Instructor, 医学部, 助手 (20205561)
YOKOI Katsuhiko  Faculty of Medicine, Instructor, 医学部, 助手 (10200883)
KIMURA Mieko  Faculty of Medicine, Assoc. Professor, 医学部, 助教授 (60025658)
小澤 和恵  京都大学, 医学部, 教授 (00026858)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥31,000,000 (Direct Cost: ¥31,000,000)
Fiscal Year 1993: ¥7,000,000 (Direct Cost: ¥7,000,000)
Fiscal Year 1992: ¥24,000,000 (Direct Cost: ¥24,000,000)
Keywordsbiological trace elemenmts / rubidium / manganese / selenium / muscle atrophied by immobilization / トルラ酵母 / ビタミンフリーカゼイン / 輸液 / 必須微量元素 / 鉄結合蛋白質 / 鉄 / 亜鉛 / 銅
Research Abstract

Studies on rubidium : Compared to the rats frd rubidium supplemented diet, the rats fed rubidium-nonsupplemented diet had lower rubidium concentration in tissues. They possessed higher potassium in plasma, kidney and tibia They had higher urea nitrogen in plasma. These results suggest rubidium depletion impairs renal function and affects mineral status.
Studies on manganese : To clarify the influence of manganese on the central nervous system, manganese (0, 0.22, 0.22 and 0.66 mg Mn/kg. representing 0, X1, X10, X30 of the usual clinical dose, respectively) was administered intravenously to rats once a day 4 weeks. Intravenous administration of manganese at 0.22 and 0.66 mg/kg increased the manganese concentration in several regions of the brain. However, no significant changes in EEG power distribution of the striatum, hippocampus and cerebral, in behavior and in histopathological finding were not observed in any of the groups treated with manganese.
Studies on selenium : Rats were divided into 4 groups fed diets using vitamin-fres on casein or torula yeast as the protein source and containing selenium at sufficient or deficient. The results indicated that selenium deficiency induced the mineral imbalance in rats, especially an increase in iron and decrease in manganese, which was more severe in torula yeast fed rats than vitamin free casein fed rats.
Studies on muslce atrophied by immobilization : Rats whose one ankle joints were immobilized in the extended position were killed after various days. Trace elements levels were measured. The rate of atrophyincreased rapidly. In whole muscle, iron concentration kept increasingand zinc and manganese increased temporarily. Increased oxidative stress in atrophy might result from an increased iron level.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] H.Kondo: "Trace element movement and oxidative stress in skeletal muscle atrophied by immobilization." Am.J.Physiol.262. E583-E590 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] H.Kondo: "Role of iron in oxidative stress in skeletal muscle atrophied by immobilization" Pflugers Arch.421. 295-297 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 松田 晃彦: "ラット脳波,行動および脳内マンガン濃度に及ぼすマンガン多回投与の影響" Biomed.Res.Trace Elements. 3. 29-39 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 木村 美恵子: "鉄摂取量の違いによるマグネシウム欠乏ラットの血清生化学性状の変化" マグネシウム. 11. 19-29 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Z.Zhu: "Effect of selenium and protein deficiency on selenium and glutathione peroxidase in rats." Biolog.Trace Elements Res.36. 15-23 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Z.Zhu: "Mineral status in selenium deficient rats compared to selenium-sufficient rats red vitamin-free casein based on torula yeast based diet." Biolog.Trace Elements Res.37. 219-231 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 糸川嘉則編集: "食品・食品添加物(毒性試験講座16)" 地人書館, 245 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 糸川嘉則編著: "公衆衛生学" 光生舘, 223 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kondo, H., et al.: "Trace element movement and oxidative stress in skeletal muscle atrophied by immobilization." Am. J.Physiol.262. E583-E590 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kondo, H., et al.: "Role of iron in oxidative stress in skeletal muscle atrophied by immobilization." Pfluegers Arch.421. 295-297 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Matsuda, A., et al.: "Iufluence of repeated intravenous administration of manganese of electroencephalograms, behavior and brain manganese concentration in rats." Biomed. Res. Trace Element.3. 29-39 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Zhu, Z., et al.: "Effect of selenium and protein deficiency on selenium and glutathione peroxidase in rats." Biolog. Trace Elements Res.36. 15-23 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Zhu, Z., et al: "Mineral status in selenim deficient rars compared to seleium sufficient rats fed vitamin-free casein based or torula yease based diet." Biolog. Trace Elements Res.37. 219-231 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kimura, M., et al.: "Effects of iron intake on serum biochemical parameters in magnesium deficient rars." J.Jao. Soc. Mg Res. 11. 19-29 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Itokawa, Y.(ed): Food and Food Additives. Chijin Shokan, 245 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Itokawa, Y.(ed): Public Health. Kiseikan, 223 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Z.Zhu: "Effect of selenium and protein deficiency on selenium and glutathione peroxidase in rats." Biological Trace Element Research. 36. 15-23 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Z.Zhu: "Mineral status in selenium-deficient rats compared to selenium-sufficient rats fed vitamin-free casein-based or torula yeast-based diet." Biological Trace Element Research. 37. 219-231 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] I.Shimaoka: "Purification of a copper binding peptide from the mushroom Grifola frondosa and its effect on copper absorption." Journal of Ncltirtional Biochemistry. 4. 33-38 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Kondo: "Antioxidant enzyme systems in skeletal muscle atroplired by immobilization." Pflugers Arch. 422. 404-406 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 松田 晃彦: "マンガン欠乏に関する基礎的研究 第1報 ラットによるマンガン欠乏症の検討" Biomedical Research on Trace Elements. 4. 7-15 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Kondo: "Trace element movement and oxidative stress in skeletal muscle strophied by immobiliqation." Am.J.Physiol.262. E583-E590 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] H.Kondo: "Role of iron in oxidative stress in skeletal muscle atrophied by immobiliqation." Pbluegers Arch.421. 295-297 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 木村 美恵子: "鉄摂取量の違いによるマグネシウム欠乏ラットの血清生化学性状の変化" マグネシウム. 11. 19-29 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 松田 晃彦: "ラット脳波,行動および脳内マンガン濃度に及ぼすマンガン多回投与の影響" Biomed.Res.Trace Elements.3. 29-39 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 松田 晃彦: "完全静脈栄養用微量元素製剤TE-5の微量元素欠乏飼料飼育ラットに対する効果" 日本衛生学雑誌. 47. 695-703 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 近藤 久雄: "廃用性筋萎縮における酸化的ストレスについて(ベルツ賞受賞論文)" Deutsche Mediqinische Wocehnschrift(日本語翻訳版). 15. 95-108 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 糸川 嘉則,編集: "食品,食品添加物(毒性試験講座16)" 地人書館, 245 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 糸川 嘉則,編著: "公衆衛生学(栄養士養成シリーズ)" 光生館, 223 (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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