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Potency of calcification in aeticular chondrocyte

Research Project

Project/Area Number 04404060
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

OKA Masanori  Research C.for Biomed. Eng. Artificial Organs. Professor, 生体医療工学研究センター, 教授 (20088537)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Takashi  Research C.for Biomed. Eng. Artificial Organs. Associate Professor, 生体医療工学研究センター, 助教授 (10201675)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 1993: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1992: ¥7,000,000 (Direct Cost: ¥7,000,000)
KeywordsChondrocytes / Repair of joint / Calcification / Hyaline cartilaqe / Mesenchymal tissue / 未分化問葉細織
Research Abstract

The main purpose of this study is how to repair damaged joint sunace. For this purpose, we perlormed three kinds of experiments. First, isogenic and allogenic chondrocytes cultured in collagen gel were transplanted into osteo-chondral defects made on patellar groove in inbred strain rats. Till 12 months postperatively, the healing behaviors were histologically observed, including immunohistochemistry to detect type 2 collagen.Long term observation showed that allografted defects healed as successfully as isografted one, although subchondral bone formation was delayd in the foemer at the 12 weeks stage. On the other hand, no control defects which had been implanted with only collagen gel or left open, healed with hyaline carfilage. ln the second experiment, to investigate difference in potent calcification of chondrocytes depending on the cell layr, we performed autograft of arficular carfilage in situ and also implanted up-side-down the graft. As a result, aimost complete repair was obtained in in-situ grafted group, whereas the joint surface were covered by fibro-osseous tissue for the up-side-down grafted group. This result suggests the difference in the character of chondrocytes accoding to the layr. lnthe third experiment, callo-osseous tissue obtained 10 days after iliac osteotomy were implanted to osteo-chondral defects made on patellar groove of raddit's femur, using 88 rabbits. defects where immature callus callus were implanted were healed by hyaline cartilage 3 months postoperativery. These results give us much information, to repair osteochondral defects on joint surface and showed the diffrence of cell character, depending on cartilage cell layr.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (88 results)

All Other

All Publications (88 results)

  • [Publications] Noguchi.T: "Repair of oeteochondral defects with grafts of cultured chondrocytes.Comparison of allograft and isograft." Clin.Orthop.and RR.301. (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] OKA.M.: "Biomechanics of natural and artificial joints." Biomechanics in Orthopedics. 282-298 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Matsusue.Y.: "In vitro and in vivo studies on bioabsorbable ultra-high strength poly(L-lactide)rods." J.Biomed.Mot.Res. 26. 1553-1567 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 速水 尚: "関節組織の衝撃吸収機構に関する研究" 日本臨床バイオメカニクス学会誌. 14. 137-141 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 田中 高廣: "超高速カメラによる関節の衝撃吸収機構の可視化" 日本臨床バイオメカニクス学会誌. 14. 149-153 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 外村 孝次: "関節面の接触を考慮した応力解析-表面置換型人工股関節のデザインについて" 生体材料. 10. 122-136 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 岡 正典: "生体関節と人工関節の負荷機構(第5報)" 日本臨床バイオメカニクス学会誌. 14. 131-136 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Ohura: "Bioactivity of CaO・SiO_2 glasses added with various ions." J.Mat.Science. 3. 95-100 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 岡 正典: "高分子量ヒアルロン酸の関節潤滑機構に及ぼす効果" 日本リウマチ関節外科会誌. 12. 259-266 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 速水 尚: "人工関節軟骨" 日本臨床バイオメカニクス学会誌. 14. 143-147 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 速水 尚: "関節材料の衝撃吸収機能に関する研究3.PVA-hydrogelの損失係数に及ぼす分子量と含水率の効果" 生体材料. 11. 79-84 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] J.Delecrin: "Measurement of synovial fluid volume:A new Dilution Method adapted to fluid permeation from the synovial cavity." J.Rhe matology. 19. 1746-1752 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 新谷 浩也: "生体関節と人工関節の潤滑機構(第5報)" 日本臨床バイオメカニクス学会誌. 14. 225-228 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 速水 尚: "関節材料の衝撃吸収能に関する研究1.音響加振式損失係数測定装置の試作" 生体材料. 10. 311-318 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 田中 高広: "関節の緩衝特性に関する研究" 生体材料. 11. 280-291 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 山本 泰: "インプラント周囲の骨修復に関する力学的シミュレーション" 日本臨床バイオメカニクス学会誌. 14. 19-24 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Ikenaga: "Localized hyperthemic treatment of experimental bone tumors with ferromagnetic caramics." J.Orthop.Res.11. 849-855 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 岡 正典: "生体関節と人工関節のバイオメカニクス(日整会研修講演)" 日整会誌. 67. 535-547 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 速水 尚: "関節材料の衝撃吸収能に関する研究2正常人関節組織の衝撃吸収能に及ぼす間質水と組織の複合構造化の効果" 生体材料. 11. 14-19 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Shimizu: "Time-dependent change in the mechanical properties of zirconia ceramic" J.Biomed.Mat.Res.27. 729-734 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Kitsugi: "Diphosphonate on bonding between glass-caramics containing apatite and Wollastonite and mature male rabbite bone." Calcif.Tissue.Int.52. 378-385 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Oka: "Load-bearing mechanism of natural and artifical joints." Hip Biomechanics Springer. 255-263 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Ikeuchi: "A model analysis of squeeze film effect in a hip joint" Thin films in Tribology. 513-520 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Ikeuchi: "An experimental study of contact condition and friction in hip prosthesis" Thin films in Tribology. 521-527 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Naguchi. T: "Repair of oeteochondral defects with grafts of cultured chondrocyes. Comparison of allograft and isograft." Clin. Orthop. and RR.301.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Oka. M: "Biomecanics of natural and articial joints." Biomecanics in Orthopedics.282-298 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Matsusue. Y: "In vitro and in vivo studies on vioavsorbable ultra-high strength poly(L-lactide)rods." J.Biomed. Mot. Res. 26. 137-141 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ohura. K: "Bioactivity of CaO ・ SiO grasses addsd with various ions." J.Mat. Sience.3. 95-100 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] J.Delecrin.: "Measurment of synovial fluid volume : A new Dilution Method adapted to fluid permeation from the synovial cavity." J.Rhematology.19. 1746-1752 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Ikenaga.: "Localized hyperthemic treatment of experimental bone tumors with ferromagnetic caramics." J.Orthop Res.11. 849-855 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Simizu.: "Time-dependent change in mechanical preperties of zirconia ceramic." J.Biomed. Mat. Res. 27. 729-734 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Kitsugi.: "Diphosphonate on bonding brtween glass-caramics containing apatite and Wollastonite and mature maletabbite bone." Calcif.Tissue.Int. 52. 378-385 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Oka: "Load-bearing mechanism of natural and artifical joints." Hip Biomechanics Springer.255-263 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Ikeuchi.: "A model analysis of squeeze film effect in a hip joint." Thin films in Tribology.513-520 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Ikeuchi.: "An experimental study of contact condition and friction in hip prosthesis." Thin Films in Tribology.521-527 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Noguchi.T.: "Repair of osteochondral defects with grafts of cultured chondrocytes.Comparison of allograft and isograft." Clin.Orthop.and RR.301. (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Oka.M.: "Biomechanics of natural and artificial joints." Biomechanics in Orthopedics.282-298 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Matsusue,Y: "In vitro and in vivo studies on bioabsorbable ultra-high strength poly(L-lactide)rods." J.Biomed.Mot.Res.26. 1553-1567 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 速水 尚: "関節組織の衝撃吸収機構に関する研究" 日本臨床バイオメカニクス学会誌. 14. 137-141 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 田中 高廣: "超高速カメラによる関節の衝撃吸収機構の可視化" 日本臨床バイオメカニクス学会誌. 14. 149-153 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 外村 孝次: "関節面の接触を考慮した応力解析-表面置換型人工股関節のデザインについて-" 生体材料. 10. 122-136 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] M.Ikenaga: "Localized hyperthermic treatment of experimental bone tumors with ferromagnetic caramics." J.Orthop.Res.11. 849-855 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 岡 正典: "生体関節と人工関節のバイオメカニクス(日整会研修講演)" 日整会誌. 67. 535-547 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 速水 尚: "関節材料の衝撃吸収能に関する研究2-正常人関節組織の衝撃吸収能に及ぼす間質水と組織の複合構造化の効果-" 生体材料. 11. 14-19 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Shimizu: "Time-dependent change in the mechanical properties of zirconia ceramic." J.Biomed.Mat.Res.27. 729-734 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Kitsugi: "Diphosphonate on bonding between glass-caramics containing apatite and Wollastonite and mature male rabbit bone." Calcif.Tissue.Int.52. 378-385 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] M.Oka: "Load-bearing mechanism of natural and artificial joints." Hip Biomechanics Springer. 255-263 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 岡 正典: "高分子量ヒアルロン酸の関節潤滑機構に及ぼす効果" 日本リウマチ関節外科会誌. 12. 259-266 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 速水 尚: "人工関節軟骨PVAハイドロゲルの衝撃吸収機能に関する研究" 日本臨床バイオメカニクス学会誌. 14. 143-147 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 速水 尚: "関節材料の衝撃吸収機能に関する研究3-PVA-hydrogelの損失係数に及ぼす分子量と含水率の効果-" 生体材料. 11. 79-84 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] J.Delecrin: "Measurment of synovial fluid volume:A new Dilution Method adapted to fluid permeation from the synovial cavity." J.Rhenmetology. 19. 1746-1752 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 新谷 浩也: "生体関節と人工関節の人工関節の潤滑機構(第5報)" 日本臨床バイオメカニクス学会誌. 14. 225-228 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 速水 尚: "関節材料の衝撃吸収能に関する研究1-音響加振式損失係数測定装置の試作-" 生体材料. 10. 311-318 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 岡 正典: "日本臨床バイオメカニクス学会誌(14巻)" 生体関節と人工関節の負荷機構(第5報), 131-136 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Ohura: "J.Mat.Science(vol3)" Bioactivity of CaO・SiO_2 glasses added with various ions., 95-100 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Ikeuchi: "Thin films in Tribology" A model analysis of squeeze film effect in a hip joint., 513-520 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Ikeuchi: "Thin Films in Tribology" An experimental study of contact condition and friction in hip prosthesis., 521-527 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 田中 高広: "生体材料(11巻)" 関節の緩衝特性に関する研究, 280-291 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 山本 泰: "日本臨床バイオメカニクス学会誌(14巻)" インプラント周囲の骨修復に関する力学的シミュレーション, 19-24 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] J.Delecrin: "Measurement of Synovial Fluid Volume :A New Dilution Method Adapted to Fluid Permeation from the Synovial Cavity." J.Rheumatology. 19(11). 1746-1752 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] M.Oka: "Biomechamics of Natural and Artificial Joints." Biomachanics in Orthopedics. 282-298 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] M.Oka: "Low Wear Rate of UHMWPE Against Zircomia Ceramic (Y-PSZ)." Bioceramics. 5. 373-379 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Ohura: "Bioactivity of Cao Sio_2 glasses added with various ions." J.Material Science. 3. 95-100 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Shimizu: "Time Dependent Changes in the Mechanical Properties of Zirconia Ceramic." Bioceramics. 5. 353-359 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Matsuda: "Severe Metallosis Observed 17 Years after Replacement of the Knee with a Tumor Prosthesis:A Case Report." J.long-term effects of Med.Implamts. 1. 295-303 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Matsusue: "In vitro and in vivo studies on bioabsorbable ultra-high-strength poly(L-lactide)rods." J.of Biomedical Materials Research. 26. 1553-1567 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 外村 孝次: "関節面の接触を考慮した応力解析-表面置換型人工股関節のデザインについて-" 生体材料. 10(3). 122-136 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 速水 尚: "関節材料の衝撃吸収能に関する研究1-音響加振式損失係数測定装置の試作-" 生体材料. 10(6). 311-318 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "生体関節と人工関節の負荷機構(第4報)" 整形外科バイオメカニクス. 13. 343-347 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "生体関節と人工関節の潤滑機構(第4報)" 整形外科バイオメカニクス. 13. 375-380 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "骨軟骨接合部の力学的結合について" 整形外科バイオメカニクス. 13. 299-304 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 池内 健: "人工股関節の潤滑状態" 整形外科バイオメカニクス. 13. 327-330 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Takahashi: "Changes of intraosseous vasculature and perivascular bone to ssue following different doses of IOR." Strahlentherap.Onkol.168. 461 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Yoshii: "Glass-Ceramic implant in Acetabular Bone Defect:An Experimental Study." J.appl.Biomaterials. 3. 245-249 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "人工関節軟骨-〔誌説〕" 日本リウマチ関節外科学会雑誌. 11(3). 209-210 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "生体関節と人工関節のバイオメカニクス(教育研修講演)" 日本整形外科学会誌. 66(8). S1323 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 木次 敏明: "AWガラスセラミックスと骨との結合に対するEHDPの影響について(第2報)" 日本整形外科学会誌. 66(8). S2111 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 清水 光一郎: "ジルコニアの経時的変化" 日本整形外科学会誌. 66(8). S1124 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "人工関節軟骨の開発(第5報)" 日本整形外科学会誌. 66(8). S1134 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 高橋 忍: "実験的術中照射における末梢神経の放射的障害" 日本整形外科学会誌. 66(8). S1192 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 松田 康孝: "A-Wガラスセラミックをボトムコーティングした人工股関節に関する研究" 日本整形外科学会誌. 66(8). S1279 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 木次 敏明: "ハイドロオキシアパタイト、トライカルシウムフォスフェイトと骨との結合機序について-EHDPを用いての研究" 66(8). S1119 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "有機系材料整形外科医用材料マニュアル" 金原書店, 224 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "徐放性薬剤と整形外科における応用整形外科医用材料マニュアル" 金原書店, 224 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "縫合糸整形外科医用材料マニュアル" 金原書店, 224 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "止血材料と接着材料整形外科医用材料マニュアル" 金原書店, 224 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "人工軟骨とその将来マルホ整形外科整形外科セミナー第93集(No.1022)" マルホ, (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "骨格系人工材料の革新第23回日本医学会総会会誌III" 日本医学会総会, (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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