| Project/Area Number |
04404062
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
麻酔学
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| Research Institution | UNIVERSITY OF TEIKYO MEDICAL SCHOOL |
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Principal Investigator |
OKADA Kazuo Dept.of Anesthesia UNIVERSITY OF TEIKYO MEDICAL SCHOOL Professor, 医学部, 教授 (30082093)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Katsura Dept.of Anesthesia UNIVERSITY OF TEIKYO MEDICAL SCHOOL Professor, 医学部, 助手 (10246043)
KIKUTA Yoshinori Dept.of Anesthesia UNIVERSITY OF TEIKYO MEDICAL SCHOOL Professor, 医学部, 助手 (30129994)
INADA Eiichi Dept.of Anesthesia UNIVERSITY OF TEIKYO MEDICAL SCHOOL Professor, 医学部, 助教授 (40193552)
IN-NAMI Hiroshi Dept.of Anesthesia UNIVERSITY OF TEIKYO MEDICAL SCHOOL Professor, 医学部, 助教授 (60102240)
大島 孝 帝京大学, 医学部, 助手 (40223804)
手塚 新吉 帝京大学, 医学部, 研究助手
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥28,000,000 (Direct Cost: ¥28,000,000)
Fiscal Year 1994: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1992: ¥23,000,000 (Direct Cost: ¥23,000,000)
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| Keywords | Anesthetic management / Mass-spectrometer / VO_2 / Uptake of anesthetics / VCO_2 / Obesity / Epinaphrine / Isoflurane / Sevoflurane / Hypocapnia / 呼吸動態 / 麻酔薬の動薬力学 |
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| Research Abstract |
1. Using a mass-spectrometer in combination with a computer system, uptake and elimination of two inhalational anesthetic agents (isoflurane and sevoflurane) were investigated in clinical anesthesia. Although the rate of uptake of the two agents decreased with time, the rate of decrease in uptake was smaller in obese patients than in non-obese patients. The rate of rise with time in alveolar concentration of anesthetic ( F_A ) was more gradual in obese patients than in non-obese patients. These results suggest that uptake of volatile anesthetics by adipose tissues was more active in obese patients than in non-obese patients. The fact that the rate of rise in F_A/F_I with time during isoflurane inhalation was smaller than during sevoflurane inhalation might have resulted from a difference in blood/gas partition coefficient between two agents.
2. The effect of infiltration of epinephrine solution into oral submucosal tissues on oxygen consumption ( VO_2) and CO_2 production ( VCO_2 ) was studied in patients scheduled for oral surgery. The epinephrine infiltration produced increases in both VO_2 and VCO_2 and these effect persisted for at least 30 minutes. It is assumed that the increases in both VO_2 and VCO_2 after epinephrine infiltration were mainly due to an increase in systemic metabolism induced by epinephrine.
3. Effect of hypocapnia on VO_2 was investigated in clinical anesthesia. A moderate degree of hypocapnia ( PaCO_2 = 30 mmHg ) did not produce a significant increase in VO_2 in patients under isoflurane or sevoflurane anesthesia.
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