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Research on the mechanism of bullous diseases---Immunological and biological studies---

Research Project

Project/Area Number 04405007
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field 広領域
Research InstitutionJICHI MEDICAL SCHOOL

Principal Investigator

YAOITA Hideo  Jichi Medical School, 医学部, 教授 (00010249)

Co-Investigator(Kenkyū-buntansha) KIYOSAWA Tomoharu  Jichi Medical School, 医学部, 病院助手 (90221217)
YAMANE Yasuhiro  Jichi Medical School, 医学部, 病院助手 (70220431)
MURATA Satoru  Jichi Medical School, 医学部, 助手 (70254919)
SUZUKI Masayuki  Jichi Medical School, 医学部, 助手 (40171251)
KATAYAMA Hiroshi  Jichi Medical School, 医学部, 講師 (50142401)
出光 俊郎  自治医科大学, 医学部, 助手 (20237027)
北島 康雄  自治医科大学, 医学部, 助教授 (70111797)
狩野 俊幸  自治医科大学, 医学部, 病院助手 (10204596)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥22,500,000 (Direct Cost: ¥22,500,000)
Fiscal Year 1994: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1992: ¥18,000,000 (Direct Cost: ¥18,000,000)
Keywordsbullous diseases / autoimmune / IgG subclass / complements / adhesion molecules / signal transduction / cytoskeleton / cell to cell, cell to stroma interaction / 水疱症 / 自己免疫 / 接着分子 / IgG Subclass / 補体 / Signal transduction / cytoskelton / cell to cell cell to stroma interaction / 自己免役 / chemotaxis / cell to cell interaction / 細胞骨格
Research Abstract

There are two types of bullous diseases, such as autoimmune bullous diseases and congenital bullous diseases. As for the autoimmune diseases we could get some evidences that some sort of signal transduction must occur in the keratinocyte after the bullous diseases auto-antibodies bind to the antigens which are the adhesion molecules. (1994, JD,1994 annual meeting for bullous diseases, 1995 JID in preparation). To our knowledge, this is the first evidence in the world. Also we found the differences of the function between the IgG subclasses of the antibodies. (1994 Autoimmunity, 1995 in preparation). Taken together, We are getting the first evidences of the new mechanism for the bullous diseases and of the new type of reaction in the immunology. As for the congenital bullous diseases We found the disturbance of keratin filaments (1989 Arch Dermatol Res) which lead to the discovery of keratin gene defects(1992 JID) and a patient with new type of the disease (1993 Br J.Dermatol, 1995 in preparation). As for the matter related to the both type of the bullous diseases, we found the new type of disturbance of keratin filaments which is not related to keratin gene defects but related to desmosome destruction, (1992 JDS). In another words, We are getting the first evidences of the functional relationship between desmosome and keratin, which may lead to the discovery of a new type of adhesion molecules. We also got the evidence of keratinocyte origin of proteoglycan in the basement membrane of epidermal-dermal junction which must be important in bullous diseases. (1995 sent to JID). These findings help to understand cell to stroma interaction

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report

Research Products

(45 results)

All Other

All Publications (45 results)

  • [Publications] Yaoita.H.et al: "The new hypothesis on the nole of adhesion molecules in the dermal-epidermal separation (Special lecture at 20th Annual Meeting for chinese Dermatological Society)" Chin.J.Dermatology. (in press). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamane,Y.et al: "The cellular origins of basement membrane proteoglycans" J.Invest.Dermatol.(sent to). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kitajima,Y.et al: "A possible cell-biologic mechanism inrolred in blister formation of bullous pemphigoid;anti-180-KD BPA antibody is an initiator." Dermatology. 103(2). 187-190 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suziki,M.et al: "Relationship between antigens and IgG subclasses in bullous pemphigoid." Auto immunity. 18. 217-225 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Jinbu.Y.et al: "Different effects of pemphigus antibody and plasmin on the distribution of keratin intermediate filaments and desmoplakins between cultures oral and epidermal keratinocytes." Journal of Dermatological Scienc. 3. 6-12 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kitajima.Y.et al: "Phorbol ester-and calcium-induced reorganization of 180-KDa bullous pemphigoid antigen on the ventral surface of cultured human keratinocytes as studied by immunofluorescence and immunoelectron Microscopy." Experimental cell research. 203. 17-24 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 矢尾板英夫: "水疱症 最新内科学大系 78巻" 中山書店, 313-323 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 矢尾板英夫: "口腔炎 舌炎 最新内科学大系 40巻" 口腔炎 舌炎, 121-133 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yaoita.H.: "The new hypothesis on the nole of adhesion molecules in the dermal-epidermal separation (Special lecture at 20th Annual Meeting for chinese Dermatological Society)" Chin.J.Dermatology. (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yaoita.H.: "Adhesion molecules in D-E separation in bullous pemphigoid (invited lecture) :" The Proc.VII Int.Cong.Dermat.New Dehli. (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yamane, Y., Yaoita, H.and Couchman JR.: "The cellular origins of basement membrane proteoglycans" J.Invest.Dermatol.(sent to). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Demitsu, T., Murata.S., Kiyosawa.T., Yamada T., Sato H., Hiraga.T., Yamane.Y.and Yaoita.H.: "Mast cells in malignant schwannoma." J.Dermatology. (sent to). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Tokuda.Y., Kawachi.S., Ito.T., Saida.T,Saike M,Yaoita.H., Matsuyama.I and Tsuchiya S.: "Chronic bullous dermatosis associated with non-scarring mucosal blisters and circulating IgG Anti-sub-Iamina Densa Antibody" British Journal. (sent to). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suziki.M., Harada.S.Kanazawa.K., Kitajima.Y.and Yaoita.H.: "Relationship between antigens and IgG subclasses in bullous pemphigoid." Auto immunity. 18. 217-225 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kitajima.Y., Hirako.Y., Owaribe.K.and Yaoita.H.: "A possible cell-biologic mechanism inrolred in blister formation of bullous pemphigoid ; anti-180-KD BPA antibody is an initiator." Dermatology. 189 (suppl 1). 46-49 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Katayama.H., Hase.T., Yaoita.H.: "Detachment of cultured normal human keratinocytes by contact with TNFalpha-stimulated noutrophils in the presence of platelet-activating factor." J.I.D.103 (2). 187-190 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yaoita.H.: "Bullous diseases" The new internal medicine edited by Imura.H.et al. 313-323 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yaoita.H.: "Immuno and labelling electron microscopy." Dermatology : Progress & Perspectives Edited by W.H.C.Burgdorf and S.I.Katz. Parthenon Publishing1137-1141,1993. Proc.18th World Cong.Dept.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kitajima.Y., Jokura.Y.and Yaoita.H.: "Epidermolysis bullose simplex, Dowling-Meara type. A report of two cases with different types of tonofilament clumping." British Journal of Dermatology. 128. 79-85 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kitajima.Y., Owaribe.K., Nishizawa.Y., Jokura.Y.and Yaoita.H.: "Phorbol ester-and calcium-induced reorganization of 180-KDa bullous pemphigoid antigen on the ventral surface of cultured human keratinocytes as studied by immunofluorescence and immunoelectron Microscopy." Experimental cell research. 203. 17-24 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Jinbu.Y., Kitajima.Y., Kato S., Akasaka.Y.and Yaoita.H.: "Different effects of pemphigus antibody and plasmin on the distribution of keratin intermediate filaments and desmoplakins between cultures oral and epidermal keratinocytes." Journal of Dermatological Science. 3. 6-12 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suziki.M., Harada.S.and Yaoita.H.: "Purification of bullous pemphigoid IgG subclasses and their capability for complement fixation" Acta Dermato-Venereologiea. 72. 245-249 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yaoita H: "The new hypothesis on the role of adhesion molccules in the dcrmal‐epidcrmal separation (Special Lecture at 20th Annual Mecting for Chinese Dermatological Socicty)" 中華民国皮膚科学会誌. (in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 矢尾板英夫: "動物皮膚炎I" 日本薬剤師会誌. 46. 15-23 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 加倉井真樹 他: "肺癌を合併した類天疱瘡の剖検例" 臨床皮膚科. 48. 887-890 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 梅本尚可 他: "Erythema gyratum repens様形態を呈したlinear IgA bullous dermatosisの1例" 皮膚科の臨床. 36. 291-295 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Katayama H et al: "Detachment of caltured normal human keratinocytes by contact with TNFα‐stimulatedneutrophils in the presence of platelet activating factor" J.Invest.Dermatol. 103. 187-190 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Suzuki M et al: "Relationship between antigens and IgG subclasses in bullous pemphigoid" Autoimmunity. 18. 217-225 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yaoita H.: "Adlhesion molecules in D・E separation in bullous pemphigoid.(invited lecture)Proceeding of VII iniernational congress of Dermatology" Committie for the VII international congress of Dermatology(in press), (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 矢尾板英夫: "皮膚疾患最新の治療95‐96" 南江堂(印刷中), (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 加倉井真樹、他: "Linear IgA Bullous Dermatosis." 臨床皮膚科. 47(1). 9-16 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 加倉井真樹、他: "妊娠性疱疹" 臨床皮膚科. 47(13). 1161-1167 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kitajima Y.etal: "Differential Regulation of 180KD and 230KD Bullous Pemphigoid Antigens in the Formation and Disintegration of Hemidesmosomes." Journal of Investigative Dermatology. 101(3). 415- (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Katayama H,etal: "Detachment of Cultured normal human Keratinocytes by Contact withTNF alpha-Stimulated Neutrophils in the Presence of PAF." Journal of Investigative Dermatolohy. 101(3). 452- (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 鈴木正之、他: "Common variable Immunodeficiencyに併発した環状紅班の1例" 臨床皮膚科. 47(12). 1069-1071 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 出光俊郎、他: "Pustular Vasculitis with clinical Featuer of Pustular Psoriasis and Stevnoclvicular Hyperostosis." Dermatology. 186. 213-216 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 矢尾板英夫: "中山書店" 最新内科学大系78. 11 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 矢尾板英夫: "中山書店" 最新内科学大系40. 13 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 矢尾板 英夫: "天疱瘡・類天疱瘡" 臨床検査. 35. 317-319 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y,kitajima etal: "Epidermolysis bullosa simplex,Dowliyg-Meara type.A report of two cases with different types of tonofilament clumping." British Journal of Dermatology. 128. 79-85 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] M.Suzuki er al: "Purification of Bullous Pemphigoid LgG Subclasses and Their Capability Complement Fixation" Acta Derm.Venereol(Stockh). 72. 245-249 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 片山 洋,他: "pemphigoid Nodularisの1例" 皮膚科の臨床. 34. 1778-1779 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 加倉井 真樹,他: "Linear LgA Bullous Dermatosis-自験3例の報告と本邦報告例の検討-" 臨床皮膚科. 47. 9-16 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 矢尾板 英夫: "新内科学大系第49巻" 中山書店, 13 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 矢尾板 英夫: "新内科学大系第78巻(印刷中)" 中山書店, (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1992-03-31   Modified: 2016-04-21  

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