| Project/Area Number |
04453029
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
有機化学一般
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| Research Institution | Science University of Tokyo |
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Principal Investigator |
MUKAIYAMA Teruaki Science Univ.of Tokyo Professor, 理学部, 教授 (60016003)
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| Co-Investigator(Kenkyū-buntansha) |
小林 修 東京理科大学, 理学部, 助教授 (50195781)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥7,200,000 (Direct Cost: ¥7,200,000)
Fiscal Year 1993: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1992: ¥3,700,000 (Direct Cost: ¥3,700,000)
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| Keywords | Acidic catalyst / Carboxylic ester / Glycosylation / 1,2-Cis glycoside / 2-Amino sugar / Ribose / Arabinose / 触媒的フリーデルクラフツ反応 / 触媒反応 / エステル化 / チオエステル / 芳香族ケトン / 対イオン |
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| Research Abstract |
In this research, new synthetic reactions using acitive acidic catalysts have been developed By using these novel catalysts, high efficiency has been attained.
1. In the presence of a catalytic amount of TiCl_4 and a stoichiometric amount of p-trifluoromethylbenzoic anhydride, aniline reacted with carboxylic acid trimethylsilylesters to give the corresponding carboxylic anilides in high yields.
2. In the presence of an active catalyst prepared from SiCl_4 and AgClO_4 and a stoichiometric amount of p-trifluoromethylbenzoic anhydride, carboxylic acids or their trimethylsilyl esters reacted with aromatic compounds to afford the corresponding Friedel-Crafts adducts in high yields.
3. In the presence of a catalytic amount of trityl salt, epoxides reacted with silylated nucleophiles to give the adducts, via carbon-carbon and carbon-oxygen bonds formation and rearrangement.
4. Several stereoselective glycosylation reactions of 2-amino sugars, arabinose, ribose, etc. were developed by using active catalysts under mild conditions.
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