| Project/Area Number |
04453096
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
UENO Akihiko Tokyo Institute of Tecnnology, 生命理工学部, 教授 (50091658)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Hiroshi Tokyo Institute of Technology, 生命理工学部, 技官 (70201910)
NAKAMURA Asao Tokyo Institute of Technology, 生命理工学部, 助手 (50155818)
IKEDA Tsukasa Tokyo Institute of Technology, 生命理工学部, 助手 (40151295)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥7,000,000 (Direct Cost: ¥7,000,000)
Fiscal Year 1994: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1992: ¥2,900,000 (Direct Cost: ¥2,900,000)
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| Keywords | cyclodextrin / color change / indicator / inclusion complex / host-guest / steroid / molecular recognition / p-nitrophenol / p-ニトロフェノール / 分子認識 / センサー / サーモクロミズム / 電荷移動錯体 / 包接化合物 / 超分子 / 包接 / メチルレッド / pH指示薬 / 錯体 |
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| Research Abstract |
Cyclodextrins (CDs) are spectroscopically inert, but they can be converted into spectroscopically active compounds by modification with cheomophores. In this study, we prepared several dye-modified CDs to construct color-change indicators for molecules.
We found that the chromophore-modified CDs change the location of the chromophore from their own hydrophobic cavity to the outside water environment upon guest accommodation. This environmental change around the chromophore moiety usually causes perturbation in its spectroscopic property. On this basis, methyl-red modified CD changes color from yellow to red upon guest binding in acidic media. On the other hand, p-nitrophenol-modified alpha-CD and beta-CD undergo guest-induced color (yellow)-to-colorless change under neutral pH conditions. Futhermore, we prepared phenolphthalein-modified beta-CD,which also undergoes color (purple)-to-colorless change upon guest binding. All these hosts exhibit different affinities for guest species, and consequently they can be used as color-change indicators for molecules.
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