| Project/Area Number |
04454115
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
基礎獣医学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OZAKI Hiroshi Univ.Tokyo Fac.Agr.Associate Prof., 農学部, 助教授 (30134505)
|
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| Co-Investigator(Kenkyū-buntansha) |
HORI Masatoshi Univ.Tokyo Fac.Agr.Assistant Prof., 農学部, 助手 (70211547)
KARAKI Hideaki Univ.Tokyo Fac.Agr.Prof., 農学部, 教授 (60011912)
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| Project Period (FY) |
1992 – 1993
|
| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1993: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1992: ¥5,100,000 (Direct Cost: ¥5,100,000)
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| Keywords | endothelin / receptor / smooth muscle / endothelium / pharmacology / calcium |
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| Research Abstract |
It is generally accepted that endothelin A receptors (ET_A) are more abundant in smooth muscle and the activation of this receptor subtype contributes to smooth muscle contraction. On the other hand ET_Bs are distributed in endothelial cells and these receptors contribute to the production of NO or prostacyclin. We first demonstrated in this study that ET_B is subdivided into ET_<B1> and ET_<B2> by using selective endothelin blockers. Further, it was found that ET_As are also subdivided into ET_<A1> and ET_<A2>. We also found that endothelins act selectively on the EA_A receptor to increase[Ca^<2+>]_i in the endothelium of rabbit aortic valve. The above findings may contribute to the understanding of physiological and pathophysiological role of endothelin.
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