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Suppression of diabetes by serum thymic factor

Research Project

Project/Area Number 04454116
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 基礎獣医学
Research InstitutionUniversity of Tokyo

Principal Investigator

ONODERA Takashi  The Univ.of Tokyo, Fac.of Agri.Professor, 農学部, 教授 (90012781)

Co-Investigator(Kenkyū-buntansha) YUKAWA Masayoshi  Nihon Univ.Colleg of Agr., and Vet, Prof., 農獣医学部, 助教授 (50107249)
MATSUMOTO Yoshitsugu  The Univ.of Tokyo, Fac.of Agri.Assoc.Prof., 農学部, 助教授 (00173922)
ONO Kenichiro  The Univ.of Tokyo, Fac.of Agri.Professor, 農学部, 教授 (50111480)
DOI Kunio  The Univ.of Tokyo, Fac.of Agri.Professor, 農学部, 教授 (70155612)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1993: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1992: ¥3,400,000 (Direct Cost: ¥3,400,000)
Keywordsinterferon / pseudorabies virus / serum thymic factor / macrophage / NK cell / macrophage activity / anti-asialo GM1 / VSV / 1型糖尿病
Research Abstract

Susceptibility to pseudorabies virus (PRV) infection in mice, which were continuously depleted of natural killer (NK) cell activity by injection of anti-asialo GM1, was examined. Effects of serum thymic factor (FTS) on susceptibility of mice to PRV were also investigated. In mice with depleted NK cell activity, the mortality of PRV-infected mice was markedly high, whereas that of FTS-pretreated mice was significantly lower than the controls. Reduced susceptibility to PRV was demonstrated in mice treated with anti-asialo GM1 antisera before the PRV infection. Such a reduced susceptibility was not observed in mice inoculated with the antisera on day 1 post-infection. To analyze the FTS-induced resistance to PRV infection, NK cell activity, macrophage activity, and interferon (IFN) productions were studied. Interferon production and NK cell activity were enhanced in the FTS-pretreated mice, suggesting that interferon may play an important role in this FTS-induced resistance to PRV infection.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 小野寺 節: "Resistance to pseudorabies virus with enhanced interferon production and natural killer cell activity in mice treated with serum thymic factor." Microbiol.Immunol.38. 47-53 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 湯川 真嘉: "Protective effects of serum thymic factor against leptospira interrogans serovar infection in mongolian gerbils." Vet.Microbiol.11(3)(印刷中). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 柴田 勲: "A serological survey on encephalomyocarditis virus infection of pigs in Japan." J.Vet.Med.Sci.55. 117-118 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 湯川 真嘉: "Impairment of macrophage function in mongolian gerbils." Vet.Immunol.Immunopathol.33. 353-364 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 小野寺 節、池田 敏夫: "免疫工学の進歩(分担執筆)" 多田富雄,谷口克編,医学書院, 230 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yukawa, M., Onodera, T., Suzuki, K., Yokomizo, Y,Suzuki, M.and Mochizuki, K.: "Impairment of macrophage function in mongolian gerbils." Vet.Immunol.Immunopathol.33. 353-364 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shibata, I., Segami, Y.and Onodera, T.: "A serological survey on encephalomyocarditis virus infection of pigs in Japan." J.Vet.Med.Sci.55. 117-118 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yukawa, M., Mochizuki, K., Kosaka, T., Awaya, A., Kobayashi, H.and Onodera, T.: "Protective effects of serum thymic factor against leptospira interrogans serovar infection in mongolian gerbils." Ver.Microbiol. 11. 3 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Onodera, T., Yoshihara, K., Suzuki, T., Awaya, A., Kobayashi, H.and Yukawa, M.: "Resistance to pseudorabies virus with enhanced interferon production and natural killer cell activity in mice treated with serum thymic factor in mice." Microbiol.Immunol.38. 47-53 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Onodera, T., Ikeda, T., Tada, T., Taniguchi, M.(Eds.): Menekikougaku no shinpo.Igakusyoin, 230 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 小野寺節 他5名: "Resistance to pseudorabies virus with enhanced interferon production and natural killer cell activity in mice treated with serum thymic factor." Microbiol.Immunol.38. 47-53 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 湯川真嘉 他5名: "Protective effects of serum thymic factor against leptospira interrogans serovar infection in mongolian gerbils." Vet.Microbiol.11(3) (印刷中). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 柴田勲 他2名: "A serological survey on encephalomyocarditis virus infection of pigs in Japan." J.Vet.Med.Sci.55. 117-118 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 湯川真嘉 他5名: "Impairment of macrophage function in mongolian gerbils." Vet.Immunol.Immunopathol.33. 353-364 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 小野寺節、池田敏夫、: "免疫工学の進歩(分担執筆)" 多田富雄、谷口克編、医学書院, 230 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Shibata,I., Saegami,Y. Onodera,T.: "A serol ogical survey on encephalomyocarditis virus infection of pigs in Japan." J.Vet.Med.Sci.55. 102-110 (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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