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Amylin in hyperglycemia or hyperinsulinemia induced by brain surgery of rats.

Research Project

Project/Area Number 04454117
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 基礎獣医学
Research InstitutionUniversity of Osaka Prefecture

Principal Investigator

OHTA Mitsuaki  University of Osaka Prefecture, Agriculture, Associate Professor, 農学部, 助教授 (20134504)

Co-Investigator(Kenkyū-buntansha) KISO Yasuo  University of Osaka Prefecture, Agriculture, Research Associate, 農学部, 助手 (10142374)
SHIOTA Masakazu  University of Osaka Prefecture, Agriculture, Associate Professor, 農学部, 講師 (10137242)
MATSUDA Hiroshi  Tokyo Univ.of Agri.and Tech., Agriculture, Assistant Professor, 農学部, 助教授 (80145820)
村上 昇  宮崎大学, 農学部, 助手 (80150192)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1993: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1992: ¥4,800,000 (Direct Cost: ¥4,800,000)
Keywordshyperglycemia / hypoglycemia / insulin / amylin / polymer / catecholamines / hypothalamus / serotonin / マイクロダイアリシス / 神経伝達物質 / ランゲルハンス島 / ノルエピネフリン / インシュリン非依存性糖代謝
Research Abstract

To assess the involvement of the sympathetic nervous system in the control of secretion of hormones which affect carbohydrate metabolism and roles of amylin in hyperglycemia or hyperinsulinemia, responses to the implantation of a super-absorbent polymer (SAP) near the ventromedial hypothalamus (VMH) were compared with those to electrolytic lesions in the VMH area.
Electrolytic lesions of the VMH resulted in marked hyperinsulinemia and hyperamylinemia and, at day 7 and later after the operation, an elevation of plasma glucagon lcvel. Epinephrine concentration in the plasma was reduced whereas that of norepincphrine remained unaltcred ; these alterations were accompanied by mild hypoglycemia. Implantation of SAP near the VMH caused opposite changes : decreases in the circulating levels of pancreatic hormones (insulin glucagon and amylin), large increases in circulating catecholamines and mild hyperglycemia. It is suggested that implantation of SAP mimics a state of chronic VMH stimulation. In the latter animals, glucose tolerance after an i. p. injection of the sugar was markedly improved and was associated with decreased levels of plasma insulin. It is postulated that improved glucose tolerance involves stimulation by high levels of circulating catecholamines of insulin-independent pathways participating in sugar disposal from blood. Amylin-implants in SAP-injected rats recovered the glucose tolerance.
The overall conclusion of the study is that the new model of apparent chronic stimulation of the VMH provides strong support for the hypothesis that this region of the brain is an important center in the control of carbohydrate metabolism and blood glucose homeostasis.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] M.Ohta et al.: "Effect of Ca^<++> channel blockers on energy level and stimulated insulin secretion in isolated rat islets of Langerhans." The Journal of Pharmacology and Experimental Therapeutics. 264. 35-40 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Y.Matsui et al.: "Responses to catecholamines in perfused livers of hypothalamic-lesioned rats." American Journal of Physiology Regulatory Integrative Comparative Physiology. 265. R117-R123 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Ohta et al.: "Effect of Ca^<++> channcl blockrs on cnergy level and stimulated insulin secretion in isolated rat islets of Langerhans." J.Pharmacol.Exp.Ther.264. 35-40 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Y.Matsui ct al.: "Responses to catecholamines in perfused livers of hypothalamic-lesioned rats" Am.J.Physiol.265. R117-R123 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Ohta et al.: "Effect of Ca^<++> channel blockers on energy level and stimulated insulin secretion in isolated rat islets of Langerhans." J.Pharmacol.Exp.Ther.264. 35-40 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Y.Matsui et al.: "Responses to catecholamines in perfused livers of hypothalamic-lesioned rats." Am.J.Physiol.265. R117-R123 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 太田 光明: "Relationship between energy level and insulin secretion in isolated rat islets of Langerhans.Mahipulation of 〔ATP〕/〔ADP〕〔Pi〕 by 2-deoxy-D-glucose." Biochemical Pharmacology. 43. 1859-1864 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 太田 光明: "Effect of Ca^<2+> channel blockers on energy level and stimulated insulin secretion in isulated rat inlets of Langerhans." The Journal of phavmacology and Experimental therapeutics.

    • Related Report
      1992 Annual Research Report
  • [Publications] 松井 良光: "Responses to catecholamhes inperfused livers of hypothalamic lerioned rats." American Journal of Physiology.

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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