| Project/Area Number |
04454146
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
環境生理学(含体力医学･栄養生理学)
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| Research Institution | University of Occupational and Environmental Health |
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Principal Investigator |
YAMASHITA Hiroshi Univ. of Occupa. and Environ. Health, 1st Dep. of Physiol., Professor, 医学部, 教授 (00030841)
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| Co-Investigator(Kenkyū-buntansha) |
NAGATOMO Toshihisa Univ.of Occupa.and Environ. Health, 1st Department of Physiology, Assistant, 医学部, 助手 (50258604)
UETA Youichi Univ. of Occupa. and Environ. Health, 1st Dep. of Physiol., Assistant, 医学部, 助手 (10232745)
INENAGA Kiyotoshi Kyushu Dental Collage, Dep. of Physiol., 1st Dep. of Physiol., Professor, 歯学部, 教授 (90131903)
KANNAN Hiroshi Miyazaki Medical Collage, 1st Dep. of Physiol., Professor, 医学部, 教授 (00049058)
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| Project Period (FY) |
1992 – 1994
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| Project Status |
Completed (Fiscal Year 1994)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1994: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1993: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1992: ¥3,000,000 (Direct Cost: ¥3,000,000)
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| Keywords | cytokine / supraoptic nucleus / renal sympathetic nerve activity / microdialysis / paraventricular nucleus / inbred polydipsic mice / adjuvant arthritis / hypothalamo-pituitary-adrenal axis / 遺伝多飲マウス / 免疫異常 / ラットアジュバント関節炎 / c-fos蛋白 / バゾプレッシン / mRNA / 視床下部 / ストレス |
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| Research Abstract |
We studied the role of immunocytokine on the neuroendocrine sysytem by approaching as follows :
1. Interleukin-1beta (IL-1beta) directly excited hypothalamic supraoptic neurons.
2. IL-1beta increased the heart rate, blood pressure, body temperature and renal sympathetic nerve activity via prostaglandins. Moreover, sympathetic nervous system playd an important role in the IL-1beta induced response.
3. IL-1beta induced a transient decrease followed by a gradual increase in noradrenalin content in the paraventricular nucleus.
4. An inbred strain of mice (STR/N) is characterized by polydipsia and the possible involvement of the central nervous system (CNS) in the polydipsia has been studied in our experiments. Furthermore, we demonstrated impaired T cell functions and the interactions between the immune system and the CNS in STR/N mice.
5. During adjuvant arthritis in Lewis rats, behavior (body temperature, physical activity, feeding and drinking behaviors) and plasma hormone levels (plasma ACTH and corticosterone) changed synchronously in two phases ; primary (day 0 - 5) and secondary phases (day 11 - ). Spleen macrophages produced IL-1, but serum IL-1 activity could not be detected on any days during the arthritis. Expression of c-fos protein was activated in the several brain regions including the OVLT,MnPO,PVN,NTS and AP.
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