| Project/Area Number |
04454215
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | University of Tokyo |
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Principal Investigator |
MANABE Shigeo Univ.of Tokyo Dept.of Hyg., Associate professor, 医学部・(医), 助教授 (90165928)
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| Co-Investigator(Kenkyū-buntansha) |
長橋 捷 東京大学, 医学部(医), 助手 (90009994)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1993: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1992: ¥5,000,000 (Direct Cost: ¥5,000,000)
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| Keywords | carcinogen / Heterocyclic amine / Airborne particles / Air pollution / Diesel-exhaust / Cigarette smoke |
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| Research Abstract |
In the last 15 years a series of mutagenic heterocyclic amines have been found in cooked meat an fish. A number of these compounds have been shown to be multisite rodent carcinogens. Among them, PhIP (2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine), A alpha C(2-amino-9H-pyrido[2,3-b]indole) and MeA alpha C (2-amino-3-methyl-9H-pyrido[2,3-b]indole) are considered to be important mutagenic-carcinogenic heterocyclic amines because of their high content in various cooked foods. This project is focused on the distribution and formation mechanism of these carcinogens in the environment such as air. We have clearly demonstrated the followings :
(1)A alpha C and MeA alpha C are present measured in airborne particles, rain water soil and cigarette-smoke-polluted indoor air.
(2)PhIP has been measured in airborne particles, diesel-exhaust particles, and incineration ash from garbage-burning plants. PhIP was found in all kinds of samples.
(3)These findings described above suggest that carcinogenic heterocyclic amines are formed through combustion of various materials such as food, grass and petroleum.
(4)Either sugar or aldehyde is an important reactant i PhIP formation.
(5)Pentose in nucleic acids may participate in PhIP forming reactions.
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