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Effect of Magnesium Deficiency on Immunoreaction

Research Project

Project/Area Number 04454217
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 土壌・肥料
Research InstitutionKyoto University

Principal Investigator

KIMURA Mieko  Kyoto Univ.Fac.of Medicine, Assoc.professor, 医学部, 助教授 (60025658)

Co-Investigator(Kenkyū-buntansha) YOKOI K.  Kyoto Univ.Fac.of Medicine, Instructor, 医学部, 助手 (10200883)
ITOKAWA Y.  Kyoto Univ.Fac.of Medicine, professor, 医学部, 教授 (80025593)
MASUDA T.  Kyoto Univ.Fac.of Medicine, Assoc.Professor, 医学部, 助教授 (00027319)
平池 秀和  鈴鹿医療技術大学, 教授
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Keywordsnutritional status / magnesium deficiency / immunity / spleen cell / spleen T cell / macrophage / mitogene / cytokine / 免疫
Research Abstract

Recently, with the changes of food habits and life styles, heart disease and cancer in Japan are increasing, and it is pointed out that good nutritional status will be very important to prevent of these diseases and to keep immunompetence. On the other hand, it is well known that magnesium plays the key role as an activator of nealy all enzymes, and under magnesium deficiency umbalance of these systems, such as, spleen hypertrophy, leukocytosis, lymphocyte abnomality, malfunction of neurotracmission, and changes in immune responses will be also expected.
Spleen cells and macrophage (Mphi) from rats fed magnesium deficient diet and normal diet for 1 or 2 weeks were collected in this study. Mitogene(ConA, LPS) and cytokines(IL-2, IL-3) productions in spleen cells, and IL-1 and IL-6 productions in Mphi were measured. Response to ConA of spleen cells of magnesium deficient rats was markedly enhanced in the compared with those of normal rats. Il-2 value in spleen cells, and IL-1 and IL-6 productions in Mphi of magnesium deficient rats were slightly higher. In interaction of T cells of spleen and Mphi, response to ConA of Mphi of magnesium deficient rats was decreased compared to normal rats.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (36 results)

All Other

All Publications (36 results)

  • [Publications] 木村美恵子、横井克彦: "ストレスの栄養条件(カルシウムおよびマグネシウム欠乏)による修飾" Therapeutic Reserch. 12. 2759-2773 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 木村美恵子、横井克彦: "マグネシウム欠乏ラットの生体内ミネラルアンバランスに及ぼす鉄摂取量の影響" JJSMgR. 10. 19-27 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Z.Zhu,M.Kimura: "Effect of selenium and protein deficiency on selsnium and glutathione peroxidase in rats." Bio Tra Elem Res. 36. 15-23 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] N.Jin,M.Kimura: "A gel filtration high performance liquid chromatographic method for determination of hepatic and renal metallothionein of rat and in comparison with the cadmium-sturation method." Bio Tra Elem Res. 36. 183-190 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Murakami,H.Maruyama: "Effects of intrathymicinjection of organ-specific autoantigens,parietal cells,at the neonatal stage on autoreactive effector and suppressor T call precursors." Eur.J.Immunol.23. 809-814 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Murakami,M.Hosono: "Concomitant enhancement of the response to Mls-1^a antigens and the induction of post-thymectomy autoimmune gastritis in BALB/c mice." Clin.Exp.Immunol.92. 500-505 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 木村美恵子: "公衆衛生学(環境衛生、学校保護:分担)" 光生館, 223 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 木村美恵子: "生体微量元素(マグネシウム、カルシウム:分担)" 廣川書店, 376 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Murakami, H.Maruyama, A.Nishio, K.Kuribyashi, M.Inaba, K.Inada, M.Hosono, K.Shinagawa, M.Sakai, T.Masuda: "Effects of intrathymicinjection of organ-specific autoantigens, parietal cells, at the neonatal stage on autoreactive effector and suppressor T call precursors." Eur.J.Immunol.23. 809-814 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Murakami, M.Hosono, H.Maruyama, Y.Mori, A.Nishio, M.Fukumoto, Y.Watanabe, M.Inaba, K.Kuribyashi, M.Sakai, T.Masuda: "Concomitant enhancement of the response to Mls-1^a antigens and the induction of post-thymectomy autoimmune gastritis in BALB/c mice." Clin.Exp.Immunol. 92. 500-505 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Thu Xun, H.Maruyama, M.Ueda, M.Fukumoto, T.Masuda: "Interspecies-specific ovarian autoantigens involved in neonatal thymectomy-induced murine autoimmune oophoritis." AJRI. 29. 211-218 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Z.Zhu, M.Kimura, Y.Itokawa: "Effect of selenium and protein deficiency on selenium and glutathione peroxidase in rats." Bio Tra Elem Res. 36. 15-23 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Z.Zhu, M.Kimura, Y.Itokawa: "Selenium concentration and glutathione peroxidase activity in selenium and magnesium deficient rats." Bio Tra Elem Res. 37. 209-217 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Z.Zhu, M.Kimura, Y.Itokawa: "Mineral status in selenium-deficient rats compared to selenium-sufficient rats fed vitamin-free casein-based or torula yeast-based diet." Bio Tra Elem Res. 37. 219-231 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] N.Jin, M.Kimura, Y.Itokawa: "A gelfiltration high-performance liquid chromatographic method for determination of hepatic and renal methallothionein of rat and in comparison with the cadmiumsaturation method." Bio Tra Elem Res. 37. 183-190 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Takeda, M.Kimura, Y.Itokawa: "Unbalance of calcium, magnesium and phosphorus in bone and other tissues of rats induced by low protein and calcium deficiency." J Nutr Sci Vitaminol. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] H.Maruyama, K.Toda, K.Uno, K.Miyake, K.Matsushima, K.yamamoto, K.J.Mori, T.Masuda: "Murine endothelial cell line cells, F-2 : interaction with leukocytes and cytokines production." Microbiol.Immunol.37. 895-903 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Y.Teramura, Y.Watanabe, N.Kan, T.Masuda, K.Kuribyashi: "Interferon-gammma-producing tumor induces host tumor specific T cell responses." Jpn.J.Cancer Res.84. 689-696 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] S.Yanagawa, K.Kakimi, H.Tanaka, A.Murakami, Y.Nakagawa, Y.Yuno, Y.Yamada, H.Hiai, K.Kuribyashi, T.Masuda, A.Ishimoto: "Mouse mammary tumor virus with rearranged long terminal repeats causes murine lymphoma" J.Virology.1993. 112-118 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Iwashiro, T.Kondo, T.Shimizu, H.Yamagishi, K.Takahashi, Y.Matusbayashi, T.Masuda, A.Otaka, N.Fjii, A.Ishimoto, M.Miyazawa, M.N.Robertson, B.Chesebro, K.Kuribyashi: "Mulitiplicity of virus-encoded helper T-cell epitopes expressed on EBL-3 tumor cells." J.Virology.1993. 4533-4542 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 木村美恵子 横井克彦他: "ストレスの栄養条件(カルシウムおよびマグネシウム欠乏)による修飾" Therapeutic Research. 9. 2759-2773 (1991)

    • Related Report
      1993 Annual Research Report
  • [Publications] 木村美恵子 横井克彦他: "鉄摂取量の違いによるマグネシウム欠乏ラットの血清生化学性状の変化" JJSMgR. 11. 19-29 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Murakami,H.Maruyama 他: "Effects of intrathymicinjection of organ-specific autoantigens,parietal cells,at the neonatal stage on autoreactive effector and suppressor T call precursors." Eur.J.Immunol.23. 809-814 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Murakami,M.Hosono 他: "Concomitant enhancement of the response to Mls-l^a antigens and the induction of postthymectomy autoimmune gastritis in BALB/c mice." Clin.Exp.Immunol.92. 500-505 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Z.Zhu,M.Kimura Y.Iotkawa: "Effect of selenium and protein deficiency on selenium and glutathione peroxidase in rats." Bio.Tra.Elem.Res.36. 15-23 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] N.Jin,M.Kimura,Y.Itokawa: "A gel filtration high-performance liquid chromatographic method for determination of hepatic and renal metallothionein of rat and in comparison with the cadmium-saturation" Bio Tra Elem Res. 36. 183-190 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 木村美恵子: "公衆衛生学(環境衛生,学校保健:分担)" 光生館, 223 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 木村美恵子: "生体微量元素(カルシウム、マグネシウム:分担)" 廣川書店, 376 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Yokoi,M.Kimura,Y.Itokawa: "Effect of dietary iron deficiency on mineral levels in tissues of rat." Biol Trace Elem Res. 29. 257-265 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Yokoi,M.Kimura,Y.Itokawa: "Determination of nonheme iron using inductively coupled palsma-atomic emission spectrometry" Biol Trace Elem Res. 31. 265-279 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 木村 美恵子,横井 克彦 糸川 嘉則: "マグネシウム欠乏ラットの生体内ミネラルバランスに及ぼす鉄摂取量の影響" マグネシウム(JJSMgR). 10. 19-27 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 木村 美恵子,横井 克彦 朱 宗健,糸川 嘉則: "ストレスの栄養条件(カルシウムおよびマグネシウム欠乏)による修飾" Therapeutic Reserch. 9. 2759-2773 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 木村 美恵子,横井 克彦 早瀬 稔,糸川 嘉則: "鉄摂取量の違いによるマグネシウム欠乏ラットの血清生化学性状の変化" マグネシウム(JJSMgR). 11. 19-29 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 藤沢 由美子,坂本 元子 増田 徹,木村 美恵子 糸川 嘉則: "マグネシウム欠乏ラットにおける細胞性免疫因子の変動" 第47回日本栄養食糧学会抄録. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 木村 美恵子 訳(木村 修一,小林修平 監修): "最新栄養学ーマグネシウムー" 健帛社, (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 木村 美恵子(梅井 弘,田中 英彦 編集): "生体微量元素ーマグネシウムー" 広川書店, (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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