| Project/Area Number |
04454218
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Saga Medical School |
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Principal Investigator |
TOMOKUNI Katsumaro Saga Med. Sch., Professor, 医学部, 教授 (40032891)
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| Co-Investigator(Kenkyū-buntansha) |
IHIBA Masayoshi Saga Med. Sch., Research Associate, 医学部, 助手 (60184628)
HIRAI Yukio Saga Med. Sch., Research Associate, 医学部, 助手 (90156638)
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| Project Period (FY) |
1992 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 1993: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1992: ¥4,600,000 (Direct Cost: ¥4,600,000)
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| Keywords | lead workers / thymine metabolism / urinary beta-aminoisobutyric acid / porphyrin metabolism / delta-aminolevulinic acid in plasma / lead in blood / biological monitoring / 尿中beta-アミノイソ酪酸 / 血漿中delta-アミノレグリン酸 / バイオロジカルモニタリング / 鉛暴露 / 血中鉛 / β-アミノイソ酪酸 / 尿中排泄 / 評価指標 |
|---|
| Research Abstract |
To investigate the new biological markers for evaluating the health effects by occupational exposure to lead, we determined urinary concentration of beta-aminoisobutyric acid (AIBA) which was a normal degradation product of thymine, and the concentration of delta-aminolevulinic acid (ALA) in urine and plasma. The urinary excretion of AIBA was increased with increasing exposure to lead. The determination of urinary AIBA in lead workers, therefore, may offer a new approach for evaluating the health effect of lead.
In addition, the determination of plasma ALA, as well as urinary ALA, in lead workers was very useful for the biological monitoring of health effect by lead.
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