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STUDY FOR BODY EFFECTS OF ORGANIC ARSINES IN SEMICONDUCTOR MANUFACTURING

Research Project

Project/Area Number 04454227
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 公衆衛生学
Research InstitutionST.MARIANNA UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

YAMAMURA Yukio  ST.MARIANNA UNIVERSITY SCHOOL OF MEDICINE, PUBLIC HEALTH PROFESSOR, 医学部, 教授 (40081658)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Keiko  聖マリアンナ医科大学, 医学部, 助手 (90197137)
YAMAUCHI Hiroshi  聖マリアンナ医科大学, 医学部, 講師 (90081661)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1993: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1992: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsalkylarsine / trimethylarsine / trisdimethylaminoarsine / semiconductor / hemolysis / biological monitoring / toxicity / 溶血毒 / アルシン / 半導体産業 / 生体影響 / 溶血作用 / 脱エチル化
Research Abstract

Trimethylarsine (TMAs) was found to be oxidized in vivo to form trimethylarsine oxide (TMAO), which was excreted chiefly in the urine. Trisdimethylaminoarsine (TDAAs) was hydrolyzed in vivo to produce inorganic arsenic ; which was then methylated to form dimethylated arsenic, which was excreted into the urine. the erythrocyte fragility test showed that TMAs as well as TDAAs was markedly hemolytic following a single sc does equivalent to its LD50, but that neither of these compounds was hemolytic when administered at sc dosages equivalent to 1/10 of the respective LD50's for 10 consecutive days. Under this dosage regimen, both compounds proved only slightly hemolytic. The relatively low acute and subacute toxicity of TMAs and TDAAs appear to be result from relatively short duration of their metabolic products gas as arsine. Results of the present study suggested that the toxicity of alkylarsines varies greatly with their metabolic products, and that the alkylarsines might be relatively less toxic in humans, relative to arsine gas.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] Y.Yamamura et al.: "Toxicity and metabolism of alkylarsine" Environmental Health Perspective. (in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 山村行夫 他: "ひ素化合物による健康障害" 産業医レビュー. 2. 1-22 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] H.Yamauchi et al.: "Toxicity and metabolism of inorganic and organic arsenical" Advances in Environmental Sciences and Technology. (in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] H.Yamauchi et al.: "Biological indicator of III-V semiconductor exposure/toxicity" Hazard Assessment and Control Technology in Semiconductor Manufacturing(ACGIH). 11. 109-120 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 山村行夫、山内博: "砒素化合物の最近のトピックス" 労働の科学. 48. 17-21 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 山内博: "総合食品安全事典 第4章 食品の加工と保存-ヒ素ミルク事件" 産業調査会 事典出版センター, (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 高橋啓子: "Toxicology Today-中毒学から生体防御の科学へ-「ヒ素」" 金芳堂(印刷中), (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] H.Yamauchi, K.Takahashi, E.A.Conner, M.Akkerman, Y.Yamamura and B.A.Fowler: "Biological indicators of III-V semiconductor exposure toxicity" Hazard Assessment and Control Technology in Semiconductor Manufacturing II.ACGIH, Ohio, USA. 109-120 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] H.Yamauchi and B.A.Fowler: "Toxicity and metabolism of arsenicals." Advances in Environmental Sciences and Technology, Wiley, New York. (in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Y.Yamamura, H.Yamauchi and K.Takahashi: "Toxicity and metabolism of alkylarsine." Environmental Health Perspective. (in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Y.Yamamura et al.: "Toxicity and metabolism of alkylarsine" Environmental Health Perspective. (in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 山村行夫他: "ひ素化合物による健康障害" 産業医学レビュー. 2. 1-22 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Yamauchi et al.: "Toxicity and metabolism of inorganic and organic arsenical" Advances in Environmental Sciences and Technology. (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Yamauchi et al.: "Biological indicator of III-V semiconductor exposure/toxicity" Hazard Assessment and Control Technology in Semiconductor Manufacturing(ACGIH). 11. 109-120 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 山村行夫、山内 博: "砒素化合物の最近のトピックス" 労働の科学. 48. 17-21 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 山内 博: "総合食品安全事典 第4章 食品の加工と保存-ヒ素ミルク事件" 産業調査会 事典出版センター, (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 高橋 啓子: "Toxicology Today-中毒学から生体防御の科学へ-「ヒ素」" 金芳堂(印刷中), (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yukio Yamamura et al.: "Toxicity and metabolism of alkylarsine" Environmental Health Perspective. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 山村 行夫他: "ひ素化合物による健康障害" 産業医学. 5. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Suzuki,N.: "Possible pathogenic role of cationic anti-DNA autoantibodies in the development of nephritis in patients with systemic lupus erythematosus" J. Immunol.

    • Related Report
      1992 Annual Research Report
  • [Publications] 坂根 剛: "ヒト全身性エリテマトーデス ー 最近の展開" Medical Immunology. 23. 321-323 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 坂根 剛: "ヒト全身性エリテマトーデス ー 病原性抗DNA抗体の性状と産生機序" Medical Immunology. 23. 339-347 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 鈴木 登: "抗DNA抗体の組織障害機序の新しい考え方" Chronic Disease. 3. 394-398 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 坂根 剛: "サイトカインと病態形成:膠原病" 医学のあゆみ(別冊 サイトカインー基礎から臨床応用まで). 別冊. 141-146 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 坂根 剛: "Topics:第36回日本リウマチ学会" 免疫Immunology Frontier. 2. 380-381 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 坂根 剛: "自己免疫疾患の基礎と臨床:自己免疫疾患の最前線" 最新医学. 48. 5-7 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 永渕 裕子: "慢性関節リマウチ:T細胞とRA滑膜炎" カレントテラピー. 11. 453-458 (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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