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DEVELOPMENT OF EARLY DETECTION OF ADULT RESPIRATORY DISTRESS SYNDROME

Research Project

Project/Area Number 04454253
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionYOKOHAMA CITY UNIVERSITY

Principal Investigator

SUZUKI Shunsuke  Yokohama City University, School of Medicine, Associate Professor, 医学部, 助教授 (30125588)

Co-Investigator(Kenkyū-buntansha) SUZUKI Junichi  Yokohama City University, School of Medicine, Assistant Professor, 医学部, 助手 (80235952)
OKUBO Takao  Yokohama City University, School of Medicine, Professor, 医学部, 教授 (40006705)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1993: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1992: ¥2,900,000 (Direct Cost: ¥2,900,000)
KeywordsARDS / light-scattering stereology / alveolar surface tension / surfactant / alveolar surface-to-volume radio / 成人呼吸窮迫症候群 / 肺水腫
Research Abstract

In adult respiratory distress syndrome (ARDS), the decrease in activity of surfaceactive material (surfactant), which increases the alveolar surface tension and decrease the alveolar surface-to-volume (S/V) ratio, is observed in the early stage. In our previous study, we developed the light scattering stereology which measures the optical mean free path, lambda(equivalent to an inverse of the S/V ratio). In the present study, we aimed to develop a detection method of permeability pulmonary edema in ARDS,using the light-scattering stereology.
In mechanically ventilated dogs with open chest, we modified the light-scattering stereology, and were able to measure lambda continuously. The S/V ratio was smaller in inspiration than in expiration, suggesting a greater surface tension in inspiration. In ventilated lungs, the surface tension became less than the tissue force of the septa as the ventilatory frequency increases.To examine the effect of surfactant on the S/V ratio, we washed the lung with saline. After saline lavage, the S/V ratio decreased, suggesting that the alveolar surface tension increases by lavage of surfactant. In ARDS model of oleic acid (OA) -induced pulmonary edema, the S/V ratio decreased but the saline-filled pressure-volume curve did not differ between control and OA-induced edema. It is likely that the activity of surfactant may decrease by exudation of plasma, resulting in an increase in alveolar surface tension. In dogs injected by lipopolysaccharide (LPS), the S/V ratio decreased before hypoxemia and the decrease in lung compliance occurred. Thus, light-scattering stereology is able to measure the S/V in live animals and detect the change in surface tension. We concluded that pulmonany edema may be detected in early phase by using the light-scattering stereology.

Report

(3 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] 大久保隆男,鈴木俊介,赤堀 正,他3名: "成人呼吸窮迫症候群(ARDS)の早期診断法に関する研究-光散乱法による肺水腫の検出法の開発-." 臨床成人病. 22. 1465-1466 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T Akahori, S Suzuki,M Suzuki,T Okubo: "Dynamic behvior of the alveolar surface to volume ratio in live dogs." J Appl Physiol. 75. 1624-1629 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 鈴木俊介: "光散乱法による肺胞マイクロメカニクスの測定." 呼吸. 14. 21-26 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Okubo: "A research of early diagnosis of adult respiratory distress syndrome using light-scattering stereology" Rinshoseijin. 22. 1465-1466 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Akahori: "Dynamic behavior of the alveolar surface to volume ratio in live dogs." J.Appl.Physiol. 75. 1624-1629 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] S.Suzuki: "Micromechanics using light-scattering stereology" Kokyu. 14. 21-26 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Akahori,S.Suzuki,M.Suzuki,T.Okubo: "Dynamic behavior alveolar surface-to-volume ratio in live dogs by light-scattering stereology" Journal of Applied Physiology. 75. 1624-1629 (1993)

    • Related Report
      1994 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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