• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Character and pathogenic role of novel human retrovirus saparated from the BALF cells of patient with interstitial pneumonia.

Research Project

Project/Area Number 04454254
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionJuntendo University

Principal Investigator

KIRA Shiro  Juntendo Univ.Sch.of Med.Prof., 医学部, 教授 (20095011)

Co-Investigator(Kenkyū-buntansha) NUKIWA T  Tohoku Univ.Sch of Med Professor, 加齢医学研究所, 教授 (40129036)
TAMURA N  School of Medicine Lecturer, 医学部, 講師 (10188435)
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1993: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1992: ¥3,400,000 (Direct Cost: ¥3,400,000)
KeywordsInterstitial pneumonia / type C retrovirus / BAL / synsytial cell / SLE / reverse transcriptase / C型レトロウイルス粒子 / 気管支肺胞洗浄液細胞 / 逆転写酵素活性 / 合胞体細胞 / ヒト・レトロウイルス / 肺胞隔炎 / 内在性レトロウイルス
Research Abstract

Novel type C retroviral particles were detected in the bronchoalveolar lavage fluid (BALF) of a patient who had SLE with interstitial pneumonia (IP). Syncytial cell formation in the BALF and positive reverse transcriptase (RT) activity in the supernatant of the cultured cells were observed. Type C retrovirus-like particles were observed on the surfaces of U937 cells after coculture with the BALF cells of our patient. High RT activity was also observed in the supernatant of cocultured cells. No antibody to known human retroviruses or proviral sequences was detected. Serum antibody to this putative type C retrovirus was detected in 24% of SLE patients and 27% of IP patients. Specific screening systems for antibodies to this virus, such as Western blotting is being developed. Inspite of our effort for cDNA cloning of this virus, we have not yet got specific sequence of this virus. In this study, this novel type C retroviral particle was shown to be one of the pathogenic agents for SLE or interstitial pneumonia.

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report

Research Products

(7 results)

All Other

All Publications (7 results)

  • [Publications] 田村、尚亮: "間質性肺疾患と内在性レトロウイルス" 最新医学. 49. 307-312 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] N.Tamura et al.: "Identifucation and gene exprission of interleukin-6 in the bronchoalveolar lavage fluid of patients with sarcoedosis." Sarcoidosis. 9. 501-502 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] A.Iwase et al.: "Expression and gene regulation of proliferating cell nuclear antigen in alveolar macrophage and lymphocyte in sarcoidosis." Sarcoidosis. 9. 503-504 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 田村 尚亮: "肉芽腫性肺疾患の発生にウイルスは関与するか?" 日本サルコイドーシス学会会誌.

    • Related Report
      1992 Annual Research Report
  • [Publications] 田村 尚亮: "サルコイドーシスにおけるT細胞レセプターを介した抗厚認識の多様性" 日本胸部疾患学会雑誌.

    • Related Report
      1992 Annual Research Report
  • [Publications] 鈴木 孝次 他: "間質性肺疾患における内在性レトロウイルス活性化に関する基礎的検討" 日本胸部疾患学会雑誌. 31. 392(S)- (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 田村 尚亮 他: "サルコイドーシスにおけるウイルスの関与に関する検討" 日本胸部疾患学会雑誌. 31. 281(S)- (1993)

    • Related Report
      1992 Annual Research Report

URL: 

Published: 1992-03-31   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi