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Hemodynamic and Humoral factors in Coronary Collateral Development

Research Project

Project/Area Number 04454261
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionYamagata University

Principal Investigator

TOMOIKE Hitonobu  Yamagata Univ.Sch.of Med., Prof., 医学部, 教授 (90112333)

Co-Investigator(Kenkyū-buntansha) YAMAGUCHI Seiji  Yamagata Univ.Sch.of Med., Instructor, 医学部, 助手 (30239892)
NAKAMURA Hidenori  Yamagata Univ.Sch.of Med., Instructor, 医学部, 助手 (30240675)
IKEDA Kozue  Yamagata Univ.Sch.of Med., Assistant Prof., 医学部, 講師 (30184419)
太田 郁郎  山形大学, 医学部, 講師 (70143097)
小熊 正樹  山形大学, 医学部, 講師 (10160821)
佐藤 忍  山形大学, 医学部, 助教授 (90113951)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1993: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1992: ¥5,200,000 (Direct Cost: ¥5,200,000)
Keywordscollateral circulation / angio genesis / myocardial ischemia / coronary curculation / myocardial function / 局所心機能 / 血管成長因子 / WHHL / 高脂血症 / 血行動態
Research Abstract

The effects of pre-existing collateral and the perfusion size on the ischemia-induced collateral development were studied in a canine model. The dogs were instrumented under sterile surgery with pairs of ultrasonic crystals to measure regional wall motion in the territory of the left circumflex(LCX) and left anterior descending coronary arteries. An implantable miniature micromanometer was used to measure left ventricular (LV) pressure. Two to 3weeks after surgery, 2min coronary occlusion (CO) of the LCX was repeated every 32 min automatically using an AM/AM telemetry command system. Regional wall motion and LV pressure were monitored via a FM/FM telemetry system consecutively day and night. The functional state of pre-existing collaterals which estimated by the level of % reduction of regional wall motion at the end of the first 2min CO, ranged from-11 to -141%. The perfusion size of the LCX ranged from 35 to 54%. Number of coronary occlusion needed for collateral development was exponentially related to the functional state of pre-existing collaterals(r=0.77, P<0.01), but not to the perfusion size.
When the collateral function was functionally matured in the same model as above, an episode of 2 min coronary occlusion was stopped. After 24 hours'interruption of occlusion stimuli, the functional state of collaterals remained deteriorated. Thus, the presence of ischemic stimuli is important to maintein the developed state of collateral function.
To elucidate how the diseased state such as hyperlipidemia(WHHL rabbits) modulates the speed of collateral development, we adopted rabbit for an experimental model.We successfully devised miniaturized sensors for assessing instantaneous coronary bood flow or ventricular pump function. Thus, we are able to study not only regional wall motion, but also humoral factors related to collateral function in purely-bred animal models.

Report

(3 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report

Research Products

(28 results)

All Other

All Publications (28 results)

  • [Publications] Yamaguchi S.,et al.: "Resetting of regional preload due to ventricular shape change alters diastolic and systolic performance." Am.J.Phyisiol.265. H1624-H1637 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kuga T.,et al.: "Role of coronary artery spasm in progression of organic coronary stenosis and acute myocardial infarction in a swine model:Importance of mode onset and duration of coronary artery spam." Circulation. 87. 573-582 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kubota I.,et al.: "Role of ATP-sensitive K^+ channel on ECG ST segment elevation during a bout of myocardial ischemia:A study on epicardial mapping in dogs." Circulation. 88. 1845-1851 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukai T.,et al.: "Serotonin-induced coronary spasm in a swine model:A minor role of defective endothelium-derived relaxing factor." Circulation. 88. 1992-1930 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kuga T.,et al.: "Inhibitory effects of heparin,aspirin and ketanserin on coronary artery vasoconstriction after arterial balloon injury in hypercholesterolemic miniature pigs." J.Am.Coll.Cardiol.22. 291-295 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeishi Y.,et al.: "Adenosin-echocardiography for the detection of coronary artery disease." J Cardiol. 24. 1-7 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tomoike H.,et al.: "Collateral Circulation" Kluwer Academic Publishers, 283 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yamaguchi S, et al: "Resetting of regional preload due to ventricular shape change alters diastolic and systolic performance." Am J Physiol. 265. H1624-H1637 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kuga T, et al: "Role of coronary spasm in progression of organic coronary stenosis and acute myocardial infarction in a swine model : Importance of mode onset and duration of coronary artery spasm." Circulation. 87. 573-582 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kubota I, et al: "Role of ATP-sensitive K^+ channel on ECG ST segment elevation during a bout of myocardial ischemia : A study on epicardial mapping in dogs." Circulation. 88. 1845-1851 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fukai T, el at: "Serotonin-induced coronary spasm in a swine model : A minor role of defective endothelium-derived relaxing factor." Circulation. 88. 1992-1930 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kuga T, et al: "Inhibitory effects of heparin, aspirin and ketanserin on coronary artery vasoconstriction after arterial balloon injury in hypercholesterolemic miniature pigs." J Am Coll Cardiol. 22. 291-295 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeishi Y, et al: "Adenosin-echocardiography for the detection of coronary artery disease." J Cardiol. 24. 1-7 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tomike H, et al: "Collateral Circulation" Kluwer Academic Publishers. 283. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kubota,I.,et al.: "Role of ATP-sensitive K^+ channel on ECG ST segment elevation during a buot of myocardial ischemia: A study on epicardial mapping in dogs." Circulation. 88. 1845-1851 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Fukai,T.,et al.: "Serotonin-induced coronary spasm in a swine model: A minor role of defective endothelium-derived relaxing factor." Circulation. 88. 1922-1930 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kuga,T.,et al.: "Inhibitory effects of heparin,aspirin and ketanserin on coronary artery vaso-constriction after arterial balloon injury in hypercholesterolemic miniature pigs." J.Am.Coll.Cardiol.22. 291-295 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Takeishi,Y.,et al.: "Ratio of lung to heart thallium-201 uptake on exercise and dipyridamole stress imaging in coroanry artery disease: Implication of SPECT." Jpn.Circ.J.57. 379-378 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Abe,S.,et al.: "Comparison of adenosine and treadmill exercise thallium-201 stress tests for the detection of coronary artery disease." Jpn.Circ.J.57. 1111-1119 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ando,H.,et al.: "Assessment of preload reserve in myocardial ischemia: The relation between proload preserve and ischemic size differs between anterior descending and circumflex coronary artery occlusion in a canine model." Jpn.Circ.J.57. 1164-1172 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tomoike,H.: "Collateral Circulation" Functional aspects of collateral develpment in animal models., 283 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tomoike,H.: "Coronary spasm and integrity of endothelial function." Jpn.Circ.J.56. 175-177 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takeishi,Y.: "Intravenous aminophylline affects myocardial washout of thallium-201 after dipyridamole infusion." Am.J.Noninvas.Cardiol.6. 116-121 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yamaki,M.: "Relation between recovery sequence estimated from body surface potentials and T wave shape in patients with negative T waves and normal subjects." Circulation. 85. 1768-1774 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Hosoya,Y.: "Spectral analysis of 87-lead body surface signal-aver-aged ECGs in patients with previous anterior myocardial infarction as a marker of ventricular tachycardia." Circulation. 85. 2060-2064 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Egashira,K.: "Mechanism of ergonovine-induced hyperconstriction of the large epicardial coroanry artery in conscious dogs a month after arterial injury." Circ.Res.71. 435-442 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 友池 仁暢: "副血行路の発達機序" 脈管学. 32. 1203-1205 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tomoike,H.: "Collateral Circulation" Kluwer Academic Publishers, 283 (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1992-03-31   Modified: 2016-04-21  

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